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Protein

Leiomodin-2

Gene

Lmod2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Increases the rate of actin polymerization.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leiomodin-2
Alternative name(s):
Cardiac leiomodin
Short name:
C-LMOD
Gene namesi
Name:Lmod2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2135672. Lmod2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Leiomodin-2PRO_0000311341Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei11 – 111PhosphoserineCombined sources
Modified residuei15 – 151PhosphoserineCombined sources
Modified residuei24 – 241PhosphoserineBy similarity
Modified residuei407 – 4071PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3UHZ5.
PaxDbiQ3UHZ5.
PRIDEiQ3UHZ5.

PTM databases

iPTMnetiQ3UHZ5.
PhosphoSiteiQ3UHZ5.

Expressioni

Gene expression databases

BgeeiQ3UHZ5.
CleanExiMM_LMOD2.
GenevisibleiQ3UHZ5. MM.

Interactioni

Subunit structurei

May interact with tropomyosin alpha (TPM1/2) N-terminus.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031694.

Structurei

3D structure databases

ProteinModelPortaliQ3UHZ5.
SMRiQ3UHZ5. Positions 202-367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini524 – 54320WH2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 4747Interaction with tropomyosin alphaBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili91 – 14757Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 146133Glu-richAdd
BLAST
Compositional biasi392 – 45362Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the tropomodulin family.Curated
Contains 1 WH2 domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3735. Eukaryota.
ENOG410YAHM. LUCA.
GeneTreeiENSGT00760000119226.
HOGENOMiHOG000261624.
HOVERGENiHBG056172.
InParanoidiQ3UHZ5.
OMAiKQRQKRM.
OrthoDBiEOG725DHJ.
PhylomeDBiQ3UHZ5.
TreeFamiTF315841.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR030132. LMOD2.
IPR004934. TMOD.
[Graphical view]
PANTHERiPTHR10901. PTHR10901. 1 hit.
PTHR10901:SF12. PTHR10901:SF12. 1 hit.
PfamiPF03250. Tropomodulin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UHZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTFGYRRGL SKYESIDEDE LLASLSPEEL KELERELEDI EPDRNLPVGL
60 70 80 90 100
RQKSLTEKTP TGNFSREALM AYWEKESQKL LEKERLGECG KVAEEDKEES
110 120 130 140 150
EEELIFTESN SEVSEEVCTE DEEESQEEEE DSEEEEDSEE EEETTEATKH
160 170 180 190 200
INGTVSYNSV NTDNSKPKTF KSQIENINLT NGNSGRTQRN SESPAAIHPC
210 220 230 240 250
GNPTVIEDAL EKIRNNDPDT TEVNLNNIEN ITTQTLSRFA EALKENTVVK
260 270 280 290 300
TFSLANTHAD DAAAIAIADM LKVNEHITSV NVESNFITGK GILAIMRALQ
310 320 330 340 350
HNTVLTELRF HNQRHIMGSQ VEMEIVKLLK ENTTLLRLGY HFELPGPRMS
360 370 380 390 400
MTSILTRNMD KQRQKRMQEQ KQQEGHDGGA ALRTKVWQRG TPGSSPYASP
410 420 430 440 450
RQSPWSSPKV SKKVHTGRSR PPSPVAPPPP PPPPPLPPHM LPPPPPPPAP
460 470 480 490 500
PLPEKKLITR NIAEVIKQQE SAQRALQNGQ RKKKGKKVKK QPNNILKEIK
510 520 530 540 550
NSLRSVQEKK MEDSSRPSTP QRSVHENLME AIRGSSIRQL RRVEVPEALR
Length:550
Mass (Da):62,018
Last modified:October 11, 2005 - v1
Checksum:iBFA34F7BDFF25A1D
GO

Sequence cautioni

The sequence AAK00789.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti223 – 2231V → F in AAK00789 (PubMed:11318603).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147141 mRNA. Translation: BAE27711.1.
AF237628 mRNA. Translation: AAK00789.1. Different initiation.
CCDSiCCDS19944.1.
RefSeqiNP_444328.1. NM_053098.2.
UniGeneiMm.332941.

Genome annotation databases

EnsembliENSMUST00000031694; ENSMUSP00000031694; ENSMUSG00000029683.
GeneIDi93677.
KEGGimmu:93677.
UCSCiuc009bbu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147141 mRNA. Translation: BAE27711.1.
AF237628 mRNA. Translation: AAK00789.1. Different initiation.
CCDSiCCDS19944.1.
RefSeqiNP_444328.1. NM_053098.2.
UniGeneiMm.332941.

3D structure databases

ProteinModelPortaliQ3UHZ5.
SMRiQ3UHZ5. Positions 202-367.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031694.

PTM databases

iPTMnetiQ3UHZ5.
PhosphoSiteiQ3UHZ5.

Proteomic databases

MaxQBiQ3UHZ5.
PaxDbiQ3UHZ5.
PRIDEiQ3UHZ5.

Protocols and materials databases

DNASUi93677.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031694; ENSMUSP00000031694; ENSMUSG00000029683.
GeneIDi93677.
KEGGimmu:93677.
UCSCiuc009bbu.1. mouse.

Organism-specific databases

CTDi442721.
MGIiMGI:2135672. Lmod2.

Phylogenomic databases

eggNOGiKOG3735. Eukaryota.
ENOG410YAHM. LUCA.
GeneTreeiENSGT00760000119226.
HOGENOMiHOG000261624.
HOVERGENiHBG056172.
InParanoidiQ3UHZ5.
OMAiKQRQKRM.
OrthoDBiEOG725DHJ.
PhylomeDBiQ3UHZ5.
TreeFamiTF315841.

Miscellaneous databases

PROiQ3UHZ5.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UHZ5.
CleanExiMM_LMOD2.
GenevisibleiQ3UHZ5. MM.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR030132. LMOD2.
IPR004934. TMOD.
[Graphical view]
PANTHERiPTHR10901. PTHR10901. 1 hit.
PTHR10901:SF12. PTHR10901:SF12. 1 hit.
PfamiPF03250. Tropomodulin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Heart.
  2. "Leiomodins: larger members of the tropomodulin (Tmod) gene family."
    Conley C.A., Fritz-Six K.L., Almenar-Queralt A., Fowler V.M.
    Genomics 73:127-139(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 221-550.
  3. "Leiomodin/tropomyosin interactions are isoform specific."
    Kostyukova A.S.
    Arch. Biochem. Biophys. 465:227-230(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11 AND SER-15, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart.

Entry informationi

Entry nameiLMOD2_MOUSE
AccessioniPrimary (citable) accession number: Q3UHZ5
Secondary accession number(s): Q99PM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 11, 2005
Last modified: July 6, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.