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Protein

DNA (cytosine-5)-methyltransferase

Gene

Dnmt1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

DNA-bindingUniRule annotation, S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA (cytosine-5)-methyltransferaseUniRule annotation (EC:2.1.1.37UniRule annotation)
Gene namesi
Name:Dnmt1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:94912. Dnmt1.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiQ3UHZ3.

Expressioni

Gene expression databases

GenevisibleiQ3UHZ3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004202.

Structurei

3D structure databases

ProteinModelPortaliQ3UHZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini648 – 69447CXXC-typeInterPro annotationAdd
BLAST
Domaini757 – 883127BAHInterPro annotationAdd
BLAST
Domaini975 – 1102128BAHInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IF68. Eukaryota.
COG0270. LUCA.
HOVERGENiHBG051384.
KOiK00558.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR031303. C5_meth_CS.
IPR022702. Cytosine_MeTrfase1_RFD.
IPR010506. DMAP1-bd.
IPR017198. DNMT1_meta.
IPR029063. SAM-dependent_MTases.
IPR002857. Znf_CXXC.
[Graphical view]
PfamiPF01426. BAH. 2 hits.
PF06464. DMAP_binding. 1 hit.
PF00145. DNA_methylase. 1 hit.
PF12047. DNMT1-RFD. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
PIRSFiPIRSF037404. DNMT1. 1 hit.
PRINTSiPR00105. C5METTRFRASE.
SMARTiSM00439. BAH. 2 hits.
SM01137. DMAP_binding. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51038. BAH. 2 hits.
PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
PS51058. ZF_CXXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UHZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPARTAPARV PALASPAGSL PDHVRRRLKD LERDGLTEKE CVREKLNLLH
60 70 80 90 100
EFLQTEIKSQ LCDLETKLHK EELSEEGYLA KVKSLLNKDL SLENGTHTLT
110 120 130 140 150
QKANGCPANG SRPTWRAEMA DSNRSPRSRR KPRGPRRSKS DSDTLFETSP
160 170 180 190 200
SSVATRRTTR QTTITAHFTK GPTKRKPKEE SEEGNSAESA AEERDQDKKR
210 220 230 240 250
RVVDTESGAA AAVEKLEEVT AGTQLGPEEP CEQEDDNRSL RRHTRELSLR
260 270 280 290 300
RKSKEDPDRE ARPETHLDED EDGKKDKRSS RPRSQPRDPA AKRRPKEAEP
310 320 330 340 350
EQVAPETPED RDEDEREEKR RKTTRKKLES HTVPVQSRSE RKAAQSKSVI
360 370 380 390 400
PKINSPKCPE CGQHLDDPNL KYQQHPEDAV DEPQMLTSEK LSIYDSTSTW
410 420 430 440 450
FDTYEDSPMH RFTSFSVYCS RGHLCPVDTG LIEKNVELYF SGCAKAIHDE
460 470 480 490 500
NPSMEGGING KNLGPINQWW LSGFDGGEKV LIGFSTAFAE YILMEPSKEY
510 520 530 540 550
EPIFGLMQEK IYISKIVVEF LQNNPDAVYE DLINKIETTV PPSTINVNRF
560 570 580 590 600
TEDSLLRHAQ FVVSQVESYD EAKDDDETPI FLSPCMRALI HLAGVSLGQR
610 620 630 640 650
RATRRVMGAT KEKDKAPTKA TTTKLVYQIF DTFFSEQIEK YDKEDKENAM
660 670 680 690 700
KRRRCGVCEV CQQPECGKCK ACKDMVKFGG TGRSKQACLK RRCPNLAVKE
710 720 730 740 750
ADDDEEADDD VSEMPSPKKL HQGKKKKQNK DRISWLGQPM KIEENRTYYQ
760 770 780 790 800
KVSIDEEMLE VGDCVSVIPD DSSKPLYLAR VTALWEDKNG QMMFHAHWFC
810 820 830 840 850
AGTDTVLRAT SDPLELFLVG ECENMQLSYI HSKVKVIYKA PSENWAMEGG
860 870 880 890 900
TDPETTLPGA EDGKTYFFQL WYNQEYARFE SPPKTQPTED NKHKFCLSCI
910 920 930 940 950
RLAELRQKEM PKVLEQIEEV DGRVYCSSIT KNGVVYRLGD SVYLPPEAFT
960 970 980 990 1000
FNIKVASPVK RPKKDPVNET LYPEHYRKYS DYIKGSNLDA PEPYRIGRIK
1010 1020 1030 1040 1050
EIHCGKKKGK VNEADIKLRL YKFYRPENTH RSYNGSYHTD INMLYWSDEE
1060 1070 1080 1090 1100
AVVNFSDVQG RCTVEYGEDL LESIQDYSQG GPDRFYFLEA YNSKTKNFED
1110 1120 1130 1140 1150
PPNHARSPGN KGKGKGKGKG KGKHQVSEPK EPEAAIKLPK LRTLDVFSGC
1160 1170 1180 1190 1200
GGLSEGFHQA GISETLWAIE MWDPAAQAFR LNNPGTTVFT EDCNVLLKLV
1210 1220 1230 1240 1250
MAGEVTNSLG QRLPQKGDVE MLCGGPPCQG FSGMNRFNSR TYSKFKNSLV
1260 1270 1280 1290 1300
VSFLSYCDYY RPRFFLLENV RNFVSYRRSM VLKLTLRCLV RMGYQCTFGV
1310 1320 1330 1340 1350
LQAGQYGVAQ TRRRAIILAA APGEKLPLFP EPLHVFAPRA CQLSVVVDDK
1360 1370 1380 1390 1400
KFVSNITRLS SGPFRTITVR DTMSDLPEIQ NGASNSEIPY NGEPLSWFQR
1410 1420 1430 1440 1450
QLRGSHYQPI LRDHICKDMS PLVAARMRHI PLFPGSDWRD LPNIQVRLGD
1460 1470 1480 1490 1500
GVIAHKLQYT FHDVKNGYSS TGALRGVCSC AEGKACDPES RQFSTLIPWC
1510 1520 1530 1540 1550
LPHTGNRHNH WAGLYGRLEW DGFFSTTVTN PEPMGKQGRV LHPEQHRVVS
1560 1570 1580 1590 1600
VRECARSQGF PDSYRFFGNI LDRHRQVGNA VPPPLAKAIG LEIKLCLLSS
1610
ARESASAAVK AKEEAATKD
Length:1,619
Mass (Da):183,308
Last modified:October 11, 2005 - v1
Checksum:iD49850074F76718F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147143 mRNA. Translation: BAE27713.1.
RefSeqiNP_001186360.2. NM_001199431.1.
NP_001186361.1. NM_001199432.1.
NP_001186362.1. NM_001199433.1.
NP_001300940.1. NM_001314011.1.
NP_034196.5. NM_010066.4.
UniGeneiMm.128580.
Mm.485562.

Genome annotation databases

GeneIDi13433.
KEGGimmu:13433.
UCSCiuc009ojp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147143 mRNA. Translation: BAE27713.1.
RefSeqiNP_001186360.2. NM_001199431.1.
NP_001186361.1. NM_001199432.1.
NP_001186362.1. NM_001199433.1.
NP_001300940.1. NM_001314011.1.
NP_034196.5. NM_010066.4.
UniGeneiMm.128580.
Mm.485562.

3D structure databases

ProteinModelPortaliQ3UHZ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004202.

Proteomic databases

PaxDbiQ3UHZ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13433.
KEGGimmu:13433.
UCSCiuc009ojp.2. mouse.

Organism-specific databases

CTDi1786.
MGIiMGI:94912. Dnmt1.

Phylogenomic databases

eggNOGiENOG410IF68. Eukaryota.
COG0270. LUCA.
HOVERGENiHBG051384.
KOiK00558.

Miscellaneous databases

ChiTaRSiDnmt1. mouse.
NextBioi283859.
SOURCEiSearch...

Gene expression databases

GenevisibleiQ3UHZ3. MM.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR031303. C5_meth_CS.
IPR022702. Cytosine_MeTrfase1_RFD.
IPR010506. DMAP1-bd.
IPR017198. DNMT1_meta.
IPR029063. SAM-dependent_MTases.
IPR002857. Znf_CXXC.
[Graphical view]
PfamiPF01426. BAH. 2 hits.
PF06464. DMAP_binding. 1 hit.
PF00145. DNA_methylase. 1 hit.
PF12047. DNMT1-RFD. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
PIRSFiPIRSF037404. DNMT1. 1 hit.
PRINTSiPR00105. C5METTRFRASE.
SMARTiSM00439. BAH. 2 hits.
SM01137. DMAP_binding. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51038. BAH. 2 hits.
PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
PS51058. ZF_CXXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.

Entry informationi

Entry nameiQ3UHZ3_MOUSE
AccessioniPrimary (citable) accession number: Q3UHZ3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: May 11, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.