Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Fibronectin

Gene

Fn1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
FibronectinImported
Gene namesi
Name:Fn1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:95566. Fn1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 23612334Sequence analysisPRO_5007702514Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PeptideAtlasiQ3UHL6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 9141Fibronectin type-IInterPro annotationAdd
BLAST
Domaini96 – 13944Fibronectin type-IInterPro annotationAdd
BLAST
Domaini140 – 18344Fibronectin type-IInterPro annotationAdd
BLAST
Domaini185 – 22945Fibronectin type-IInterPro annotationAdd
BLAST
Domaini230 – 27445Fibronectin type-IInterPro annotationAdd
BLAST
Domaini306 – 34540Fibronectin type-IInterPro annotationAdd
BLAST
Domaini355 – 40349Fibronectin type-IIInterPro annotationAdd
BLAST
Domaini415 – 46349Fibronectin type-IIInterPro annotationAdd
BLAST
Domaini468 – 51144Fibronectin type-IInterPro annotationAdd
BLAST
Domaini516 – 55843Fibronectin type-IInterPro annotationAdd
BLAST
Domaini559 – 60244Fibronectin type-IInterPro annotationAdd
BLAST
Domaini610 – 717108Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini721 – 81191Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini812 – 90392Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini908 – 99790Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini998 – 108790Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1088 – 117487Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1175 – 126591Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1268 – 136093Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1361 – 144888Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1449 – 154294Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1543 – 163492Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1635 – 172288Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1723 – 181694Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1817 – 190387Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1904 – 199794Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini2077 – 217195Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini2178 – 222245Fibronectin type-IInterPro annotationAdd
BLAST
Domaini2223 – 226543Fibronectin type-IInterPro annotationAdd
BLAST
Domaini2267 – 230741Fibronectin type-IInterPro annotationAdd
BLAST

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00830000128240.
HOGENOMiHOG000234344.
HOVERGENiHBG005731.

Family and domain databases

Gene3Di2.10.10.10. 2 hits.
2.60.40.10. 16 hits.
InterProiIPR000083. Fibronectin_type1.
IPR003961. FN3_dom.
IPR000562. FN_type2_col-bd.
IPR013783. Ig-like_fold.
IPR013806. Kringle-like.
[Graphical view]
PfamiPF00039. fn1. 12 hits.
PF00040. fn2. 2 hits.
PF00041. fn3. 16 hits.
[Graphical view]
SMARTiSM00058. FN1. 12 hits.
SM00059. FN2. 2 hits.
SM00060. FN3. 16 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 10 hits.
SSF57440. SSF57440. 2 hits.
PROSITEiPS01253. FN1_1. 12 hits.
PS51091. FN1_2. 12 hits.
PS00023. FN2_1. 2 hits.
PS51092. FN2_2. 2 hits.
PS50853. FN3. 16 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UHL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRGPGPGRL LLLAVLCLGT SVRCTEAGKS KRQAQQIVQP QSPVAVSQSK
60 70 80 90 100
PGCFDNGKHY QINQQWERTY LGNALVCTCY GGSRGFNCES KPEPEETCFD
110 120 130 140 150
KYTGNTYKVG DTYERPKDSM IWDCTCIGAG RGRISCTIAN RCHEGGQSYK
160 170 180 190 200
IGDKWRRPHE TGGYMLECLC LGNGKGEWTC KPIAEKCFDH AAGTSYVVGE
210 220 230 240 250
TWEKPYQGWM MVDCTCLGEG NGRITCTSRN RCNDQDTRTS YRIGDTWSKK
260 270 280 290 300
DNRGNLLQCV CTGNGRGEWK CERHALQSAS AGSGSFTDVR TAIYQPQTHP
310 320 330 340 350
QPAPYGHCVT DSGVVYSVGM QWLKSQGNKQ MLCTCLGNGV SCQETAVTQT
360 370 380 390 400
YGGNSNGEPC VLPFTYNGRT FYSCTTEGRQ DGHLWCSTTS NYEQDQKYSF
410 420 430 440 450
CTDHAVLVQT RGGNSNGALC HFPFLYNNRN YTDCTSEGRR DNMKWCGTTQ
460 470 480 490 500
NYDADQKFGF CPMAAHEEIC TTNEGVMYRI GDQWDKQHDL GHMMRCTCVG
510 520 530 540 550
NGRGEWACIP YSQLRDQCIV DDITYNVNDT FHKRHEEGHM LNCTCFGQGR
560 570 580 590 600
GRWKCDPIDQ CQDSETRTFY QIGDSWEKFV HGVRYQCYCY GRGIGEWHCQ
610 620 630 640 650
PLQTYPGTTG PVQVIITETP SQPNSHPIQW NAPEPSHITK YILRWRPKTS
660 670 680 690 700
TGRWKEATIP GHLNSYTIKG LTPGVIYEGQ LISIQQYGHR EVTRFDFTTS
710 720 730 740 750
ASTPVTSNTV TGETAPYSPV VATSESVTEI TASSFVVSWV SASDTVSGFR
760 770 780 790 800
VEYELSEEGD EPQYLDLPST ATSVNIPDLL PGRKYIVNVY QISEEGKQSL
810 820 830 840 850
ILSTSQTTAP DAPPDPTVDQ VDDTSIVVRW SRPQAPITGY RIVYSPSVEG
860 870 880 890 900
SSTELNLPET ANSVTLSDLQ PGVQYNITIY AVEENQESTP VFIQQETTGT
910 920 930 940 950
PRSDNVPPPT DLQFVELTDV KVTIMWTPPD SVVSGYRVEV LPVSLPGEHG
960 970 980 990 1000
QRLPVNRNTF AEITGLSPGV TYLFKVFAVH QGRESNPLTA QQTTKLDAPT
1010 1020 1030 1040 1050
NLQFVNETDR TVLVTWTPPR ARIAGYRLTA GLTRGGQPKQ YNVGPLASKY
1060 1070 1080 1090 1100
PLRNLQPGSE YTVTLVAVKG NQQSPKATGV FTTLQPLRSI PPYNTEVTET
1110 1120 1130 1140 1150
TIVITWTPAP RIGFKLGVRP SQGGEAPREV TSDSGSIVVS GLTPGVEYTY
1160 1170 1180 1190 1200
TIQVLRDGQE RDAPIVNRVV TPLSPPTNLH LEANPDTGVL TVSWERSTTP
1210 1220 1230 1240 1250
DITGYRITTT PTNGQQGTSL EEVVHADQSS CTFENLNPGL EYNVSVYTVK
1260 1270 1280 1290 1300
DDKESAPISD TVVPAVPPPT DLRFTNIGPD TMRVTWAPPP SIELTNLLVR
1310 1320 1330 1340 1350
YSPVKNEEDV AELSISPSDN AVVLTNLLPG TEYLVSVSSV YEQHESIPLR
1360 1370 1380 1390 1400
GRQKTGLDSP TGFDSSDITA NSFTVHWVAP RAPITGYIIR HHAEHSVGRP
1410 1420 1430 1440 1450
RQDRVPPSRN SITLTNLNPG TEYVVSIIAV NGREESPPLI GQQATVSDIP
1460 1470 1480 1490 1500
RDLEVIASTP TSLLISWEPP AVSVRYYRIT YGETGGNSPV QEFTVPGSKS
1510 1520 1530 1540 1550
TATINNIKPG ADYTITLYAV TGRGDSPASS KPVSINYKTE IDKPSQMQVT
1560 1570 1580 1590 1600
DVQDNSISVR WLPSTSPVTG YRVTTTPKNG LGPSKTKTAS PDQTEMTIEG
1610 1620 1630 1640 1650
LQPTVEYVVS VYAQNRNGES QPLVQTAVTN IDRPKGLAFT DVDVDSIKIA
1660 1670 1680 1690 1700
WESPQGQVSR YRVTYSSPED GIRELFPAPD GEDDTAELQG LRPGSEYTVS
1710 1720 1730 1740 1750
VVALHDDMES QPLIGIQSTA IPAPTNLKFS QVTPTSFTAQ WIAPSVQLTG
1760 1770 1780 1790 1800
YRVRVNPKEK TGPMKEINLS PDSSSVIVSG LMVATKYEVS VYALKDTLTS
1810 1820 1830 1840 1850
RPAQGVITTL ENVSPPRRAR VTDATETTIT ISWRTKTETI TGFQVDAIPA
1860 1870 1880 1890 1900
NGQTPVQRSI SPDVRSYTIT GLQPGTDYKI HLYTLNDNAR SSPVIIDAST
1910 1920 1930 1940 1950
AIDAPSNLRF LTTTPNSLLV SWQAPRARIT GYIIKYEKPG SPPREVVPRP
1960 1970 1980 1990 2000
RPGVTEATIT GLEPGTEYTI YVIALKNNQK SEPLIGRKKT VQKTPFITNP
2010 2020 2030 2040 2050
GYDTENGIQL PGTTHQQPSV GQQMIFEEHG FRRTTPPTAA TPVRLRPRPY
2060 2070 2080 2090 2100
LPNVDEEVQI GHVPRGDVDY HLYPHVPGLN PNASTGQEAL SQTTISWTPF
2110 2120 2130 2140 2150
QESSEYIISC QPVGTDEEPL QFQVPGTSTS ATLTGLTRGV TYNIIVEALQ
2160 2170 2180 2190 2200
NQRRHKVREE VVTVGNAVSE GLNQPTDDSC FDPYTVSHYA IGEEWERLSD
2210 2220 2230 2240 2250
AGFKLTCQCL GFGSGHFRCD SSKWCHDNGV NYKIGEKWDR QGENGQRMSC
2260 2270 2280 2290 2300
TCLGNGKGEF KCDPHEATCY DDGKTYHVGE QWQKEYLGAI CSCTCFGGQR
2310 2320 2330 2340 2350
GWRCDNCRRP GAAEPSPDGT TGHTYNQYTQ RYNQRTNTNV NCPIECFMPL
2360
DVQADRDDSR E
Length:2,361
Mass (Da):260,128
Last modified:October 11, 2005 - v1
Checksum:iF595B263AB1D7CE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124821 Genomic DNA. No translation available.
AK147315 mRNA. Translation: BAE27841.1.
RefSeqiNP_001263338.1. NM_001276409.1.
NP_001263339.1. NM_001276410.1.
NP_001263341.1. NM_001276412.1.
UniGeneiMm.193099.

Genome annotation databases

EnsembliENSMUST00000187938; ENSMUSP00000140975; ENSMUSG00000026193.
GeneIDi14268.
UCSCiuc007bjv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124821 Genomic DNA. No translation available.
AK147315 mRNA. Translation: BAE27841.1.
RefSeqiNP_001263338.1. NM_001276409.1.
NP_001263339.1. NM_001276410.1.
NP_001263341.1. NM_001276412.1.
UniGeneiMm.193099.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ3UHL6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000187938; ENSMUSP00000140975; ENSMUSG00000026193.
GeneIDi14268.
UCSCiuc007bjv.2. mouse.

Organism-specific databases

CTDi2335.
MGIiMGI:95566. Fn1.

Phylogenomic databases

GeneTreeiENSGT00830000128240.
HOGENOMiHOG000234344.
HOVERGENiHBG005731.

Miscellaneous databases

ChiTaRSiFn1. mouse.
SOURCEiSearch...

Family and domain databases

Gene3Di2.10.10.10. 2 hits.
2.60.40.10. 16 hits.
InterProiIPR000083. Fibronectin_type1.
IPR003961. FN3_dom.
IPR000562. FN_type2_col-bd.
IPR013783. Ig-like_fold.
IPR013806. Kringle-like.
[Graphical view]
PfamiPF00039. fn1. 12 hits.
PF00040. fn2. 2 hits.
PF00041. fn3. 16 hits.
[Graphical view]
SMARTiSM00058. FN1. 12 hits.
SM00059. FN2. 2 hits.
SM00060. FN3. 16 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 10 hits.
SSF57440. SSF57440. 2 hits.
PROSITEiPS01253. FN1_1. 12 hits.
PS51091. FN1_2. 12 hits.
PS00023. FN2_1. 2 hits.
PS51092. FN2_2. 2 hits.
PS50853. FN3. 16 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. Ensembl
    Submitted (SEP-2014) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ3UHL6_MOUSE
AccessioniPrimary (citable) accession number: Q3UHL6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: July 6, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.