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Protein

CaM kinase-like vesicle-associated protein

Gene

Camkv

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Does not appear to have detectable kinase activity.

Cofactori

Ca2+By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CaM kinase-like vesicle-associated protein
Gene namesi
Name:Camkv
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2384296 Camkv

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002500951 – 512CaM kinase-like vesicle-associated proteinAdd BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei392PhosphoserineCombined sources1
Modified residuei446PhosphothreonineBy similarity1
Modified residuei470PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3UHL1
PaxDbiQ3UHL1
PeptideAtlasiQ3UHL1
PRIDEiQ3UHL1

PTM databases

iPTMnetiQ3UHL1
PhosphoSitePlusiQ3UHL1
SwissPalmiQ3UHL1

Expressioni

Gene expression databases

BgeeiENSMUSG00000032936
CleanExiMM_CAMKV
ExpressionAtlasiQ3UHL1 baseline and differential
GenevisibleiQ3UHL1 MM

Interactioni

Subunit structurei

Interacts with calmodulin, in the presence of calcium.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231689, 4 interactors
IntActiQ3UHL1, 7 interactors
MINTiQ3UHL1
STRINGi10090.ENSMUSP00000040430

Structurei

3D structure databases

ProteinModelPortaliQ3UHL1
SMRiQ3UHL1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 286Protein kinasePROSITE-ProRule annotationAdd BLAST263

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi335 – 490Ala-richAdd BLAST156

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
ENOG410XRMJ LUCA
GeneTreeiENSGT00760000118944
HOGENOMiHOG000233016
HOVERGENiHBG108055
InParanoidiQ3UHL1
KOiK08812
OMAiFGCVTLG
OrthoDBiEOG091G097B
PhylomeDBiQ3UHL1
TreeFamiTF314166

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Q3UHL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFGCVTLGD KKNYNQPSEV TDRYDLGQVI KTEEFCEIFR AKDKTTGKLH
60 70 80 90 100
TCKKFQKRDG RKVRKAAKNE IGILKMVKHP NILQLVDVFV TRKEYFIFLE
110 120 130 140 150
LATGREVFDW ILDQGYYSER DTSNVVRQVL EAVAYLHSLK IVHRNLKLEN
160 170 180 190 200
LVYYNRLKNS KIVISDFHLA KLENGLIKEP CGTPEYLAPE VVGRQRYGRP
210 220 230 240 250
VDCWAIGVIM YILLSGNPPF YEEVEEDDYE NHDKNLFRKI LAGDYEFDSP
260 270 280 290 300
YWDDISQAAK DLVTRLMEVE QDQRITAEEA ISHEWISGNA ASDKNIKDGV
310 320 330 340 350
CAQIEKNFAR AKWKKAVRVT TLMKRLRAPE QSGTAATQSA SDAATPGAAG
360 370 380 390 400
GAIAAAAAAA AAGGAASASG ASATAATEGG AGCAAKSDDI ASADRSATPA
410 420 430 440 450
TDGSATPATD GSVTPATDGS ITPATDGSVT PATDRSATPA TDGRATPATE
460 470 480 490 500
ESTVPATQSS ALPAAKAAAT PEPAVAQPDS TALEGATGQA PPSSKGEEAT
510
GCAQESQRVE TS
Length:512
Mass (Da):54,819
Last modified:September 19, 2006 - v2
Checksum:iCFEFD4C43CC889A9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti479D → G in BAE27846 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147323 mRNA Translation: BAE27846.1
BC017634 mRNA Translation: AAH17634.1
BC111033 mRNA Translation: AAI11034.1
CCDSiCCDS40763.1
RefSeqiNP_663596.1, NM_145621.2
XP_006511785.1, XM_006511722.2
UniGeneiMm.274540

Genome annotation databases

EnsembliENSMUST00000035700; ENSMUSP00000040430; ENSMUSG00000032936
GeneIDi235604
KEGGimmu:235604
UCSCiuc009rnk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCAMKV_MOUSE
AccessioniPrimary (citable) accession number: Q3UHL1
Secondary accession number(s): Q8VD20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 19, 2006
Last modified: March 28, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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