Q3UHK3 (GREB1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein GREB1

Gene names

Name:	Greb1
Synonyms:	Kiaa0575

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1954 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the GREB1 family.
Sequence caution	The sequence BAC41432.2 differs from that shown. Reason: Partially unspliced pre-RNA.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1954	1954	Protein GREB1		PRO_0000320945
Regions
	Transmembrane	1873 – 1893	21	Helical; Potential
	Compositional bias	1228 – 1235	8	Poly-Ser
Experimental info
	Sequence conflict	230	1	P → T in AAF44295. Ref.1
	Sequence conflict	230	1	P → T in BAE27854. Ref.2
	Sequence conflict	260	1	A → V in AAF44295. Ref.1
	Sequence conflict	360	1	V → A in AAF44295. Ref.1
	Sequence conflict	659	1	E → G in BAE27854. Ref.2
	Sequence conflict	844	1	F → Y in AAF44295. Ref.1
	Sequence conflict	1154	1	A → V in AAF44295. Ref.1
	Sequence conflict	1154	1	A → V in BAE27854. Ref.2
	Sequence conflict	1154	1	A → V in BAC41432. Ref.4
	Sequence conflict	1170	1	S → P in AAF44295. Ref.1
	Sequence conflict	1170	1	S → P in BAE27854. Ref.2
	Sequence conflict	1170	1	S → P in BAC41432. Ref.4
	Sequence conflict	1201	1	G → D in AAF44295. Ref.1
	Sequence conflict	1201	1	G → D in BAE27854. Ref.2
	Sequence conflict	1417	1	Y → C in AAF44295. Ref.1
	Sequence conflict	1749	1	D → N in BAC28368. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q3UHK3 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 9EBBC2FF6F011E06	FASTA	1,954	216,927
	10 20 30 40 50 60 MGNSYAGQLK STRFEEVLHN SIEASLRSNT LVPRPIFSQL YLEAEQQLSS LEGGSRADNE 70 80 90 100 110 120 EEEEDGEGGL EPSSPPNAYQ LPPPPEGCCT TDGFCQAGKD LRLVSISSEP IEVPAGFLLV 130 140 150 160 170 180 GAKSPSLPDH LLVCAVDKRF LPDDNGHNAL LGFSGNCVGC GKKGFCYFTE FSNHINLKLT 190 200 210 220 230 240 TQPKKQKHLK YYLVRNAQGA LTKGPLICWK GSEFRGRQNS TNTCSSSLFP PLESSGSLAA 250 260 270 280 290 300 FPTEPVPGTN PSVPVGAQQA GPASDHPSVT TATGPAVFNG KDSPKHPQLV KSSLSALPRP 310 320 330 340 350 360 SALGILPNSG PPKKRHKGWS PESKSTTDGG FIQGGGNRAK HEGTSIPCVP QAGLVGPASV 370 380 390 400 410 420 TFPVVASGEP VSVPDNLLKI CKAKPVIFKG HGNFPYLCGN LNDVVVSPLL YTCYQNSQSL 430 440 450 460 470 480 ARAYEQHGAS TMQPISEETQ LLLTVYYLVQ LAADQVPLME DLEQIFLRSW RESHLTEIRQ 490 500 510 520 530 540 YQQAPPQPFP PATSTAAPVT SAQLPWLAGL AASSCNDSVH VIECAYSLAE GLSEMFRLLI 550 560 570 580 590 600 EGKLSKTNYV VIICACRNAA IDSCIAVTGK YQARILSESL LSPAEYQREV HYELVTGKVD 610 620 630 640 650 660 SLGTFFSSLC PEGDIDILLD KFHQENQGHV SSSFTASSTK KTAVLDASGV PVCTSYHQEP 670 680 690 700 710 720 RGVRPFQLAV AQKLLSHVCS IADSSTQNLD LGSFEKVDFL ICIPPSEVTY QQTVFHVWHS 730 740 750 760 770 780 GVLLELGLEK EPVTKQRAEQ HVLKLDTEAQ ARFKAFLQNS FQNPHTLFVL IHDHAHWDLV 790 800 810 820 830 840 SSAVHNIYSQ SDPSVGLVDR LLNCREVKEA PNIVTLHVTS FPYALQTQHT LISPYNEIHW 850 860 870 880 890 900 PISFSNGVDL YHESKKYFGL SEFIDSTLSG HSLPLLRYDS SFEAMVTALG KRFPRLHSAV 910 920 930 940 950 960 IRTFVLVQHY AAAMMAVSGL PQMKNHTSVE TLEITQNLLN SPKQCPCGHG LMVLLRVPCS 970 980 990 1000 1010 1020 PLAAVAYERL AHVRARLALE EHFEIILGHP SSGITVGKHF VKQLKMWQKI EDAEWRPQTY 1030 1040 1050 1060 1070 1080 LELEGLPCIL IFSGMDPHGE SLPRSLRYCD LRLINSSCLV RTALEQELGL AAYFVSNDIP 1090 1100 1110 1120 1130 1140 LEKGPKNEAL ESDGEKLSST DEDEEAGTEG CFEAGSTSEQ RGPVKRERSH SHDSASSSLS 1150 1160 1170 1180 1190 1200 SRASGSVLYG ESLAQPSGPP QGELTRSPPS CGPAEEGRAP GEIQRLRVSQ GSTVISRHSP 1210 1220 1230 1240 1250 1260 GLVPQPDSSL RTGRRSLQVP AAPSSQLSSS SGSSSTCAVP TANVLVLQAS QCSMAKACRQ 1270 1280 1290 1300 1310 1320 PPIVFLPKLV YDMLLSTDSS GLPKSASLLP SPSVMWTSSF RPLLSKMMTS TEQSLYYRQW 1330 1340 1350 1360 1370 1380 TVPRPSHMDY GNRAEGRVDS FHPRRLLLSG PPQIGKTGAY LQFLSILSRM LIRLTEVDVY 1390 1400 1410 1420 1430 1440 DEEEINTSFR EESEWRYLQL ADPWPDLELF QKMPFDYIIH DPKYEDASLI CSHPQTIKSE 1450 1460 1470 1480 1490 1500 DRGMSRKPED LYVRRQTARM RLSKYAAYNT YHHCEQCQQY MGFHPHYQLS ESTLHVFAFS 1510 1520 1530 1540 1550 1560 CSMLGEEVQL HFIIPKSKEH HFVFSQPGGQ LESMRLPLVT DKSHEHIKSP TFTPTTGRHE 1570 1580 1590 1600 1610 1620 HGLFNLYHAM DGANHLHVLV VKEYEMAIYK KYWPNHIMLV LPSIFNSAGV GAAHFLIKEL 1630 1640 1650 1660 1670 1680 CYHNLELERN RQEELGVKPQ DVWPFIVIAD DSCVMWNVAD VDCAGERSRE FSWSERNVSL 1690 1700 1710 1720 1730 1740 KYIMLHIEAS PNITHYALLG MRKWASKTRG REVQEPFSRC HVHDFIILNV DLTQNVQYNQ 1750 1760 1770 1780 1790 1800 NRFTCDDVDF NLRVHSAGLL LCRFNRFSVM KKQIAVGGHR SFHITSKVSD SSVAIVPSQY 1810 1820 1830 1840 1850 1860 ICAPDSKHTF LAAPAQLLLE KFLQYHSHRF FPLSLKNHSH PVLSVDCYLN LGPQISVCYV 1870 1880 1890 1900 1910 1920 SSRPHSLNIS CSDMVFSGLL LYLCDSFVGA SFLKKFHFLK GATLCVICQD RNSLRQTVVR 1930 1940 1950 LELEDEWQFR LRDEFQTANA KEDRPLFFLT ARHI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genetic, physical, and transcript map of the fld region on mouse chromosome 12." Peterfy M., Phan J., Oswell G.M., Xu P., Reue K. Genomics 62:436-444(1999) [PubMed: 10644441] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain and Cecum.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6.
[4]	"Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H. DNA Res. 9:179-188(2002) [PubMed: 12465718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1004-1954. Tissue: Embryonic tail.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF180470 mRNA. Translation: AAF44295.1. AK033573 mRNA. Translation: BAC28368.1. AK147337 mRNA. Translation: BAE27854.1. AC122228 Genomic DNA. No translation available. AC157352 Genomic DNA. No translation available. AB093248 Transcribed RNA. Translation: BAC41432.2. Sequence problems.
IPI	IPI00404810.
RefSeq	NP_056579.2. NM_015764.4.
UniGene	Mm.428062.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3UHK3.
PTM databases
PhosphoSite	Q3UHK3.
Proteomic databases
PRIDE	Q3UHK3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000048064; ENSMUSP00000044454; ENSMUSG00000036523. ENSMUST00000162112; ENSMUSP00000124348; ENSMUSG00000036523.
GeneID	268527.
KEGG	mmu:268527.
Organism-specific databases
CTD	9687.
MGI	MGI:2149712. Greb1.
Rouge	Search...
Phylogenomic databases
eggNOG	roNOG05662.
GeneTree	ENSGT00390000008041.
HOGENOM	HBG357576.
HOVERGEN	HBG107963.
InParanoid	Q3UHK3.
Gene expression databases
ArrayExpress	Q3UHK3.
Bgee	Q3UHK3.
Genevestigator	Q3UHK3.
Family and domain databases
InterPro	IPR024839. GREB1. IPR024841. GREB1/GREB1-like. [Graphical view]
PANTHER	PTHR15720. PTHR15720. 1 hit. PTHR15720:SF1. PTHR15720:SF1. 1 hit.
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

GREB1_MOUSE

Accession

Primary (citable) accession number: Q3UHK3
Secondary accession number(s): E0CYB3 , Q8BZT6, Q8CHE7, Q9JLG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	July 27, 2011
Last modified:	January 25, 2012
This is version 42 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program