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Protein

Protein GREB1

Gene

Greb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in estrogen-stimulated cell proliferation.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GREB1
Gene namesi
Name:Greb1
Synonyms:Kiaa0575
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2149712. Greb1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1873 – 189321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19541954Protein GREB1PRO_0000320945Add
BLAST

Proteomic databases

PaxDbiQ3UHK3.
PRIDEiQ3UHK3.

PTM databases

iPTMnetiQ3UHK3.
PhosphoSiteiQ3UHK3.

Expressioni

Gene expression databases

BgeeiQ3UHK3.
ExpressionAtlasiQ3UHK3. baseline and differential.
GenevisibleiQ3UHK3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044454.

Structurei

3D structure databases

ProteinModelPortaliQ3UHK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1228 – 12358Poly-Ser

Sequence similaritiesi

Belongs to the GREB1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF9T. Eukaryota.
ENOG410Z1PN. LUCA.
GeneTreeiENSGT00390000008041.
HOGENOMiHOG000090251.
HOVERGENiHBG107963.
InParanoidiQ3UHK3.
OMAiNYTSVET.
OrthoDBiEOG76X5Z7.
PhylomeDBiQ3UHK3.
TreeFamiTF329531.

Family and domain databases

InterProiIPR028422. GREB1.
[Graphical view]
PANTHERiPTHR15720. PTHR15720. 2 hits.
PfamiPF15782. GREB1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UHK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNSYAGQLK STRFEEVLHN SIEASLRSNT LVPRPIFSQL YLEAEQQLSS
60 70 80 90 100
LEGGSRADNE EEEEDGEGGL EPSSPPNAYQ LPPPPEGCCT TDGFCQAGKD
110 120 130 140 150
LRLVSISSEP IEVPAGFLLV GAKSPSLPDH LLVCAVDKRF LPDDNGHNAL
160 170 180 190 200
LGFSGNCVGC GKKGFCYFTE FSNHINLKLT TQPKKQKHLK YYLVRNAQGA
210 220 230 240 250
LTKGPLICWK GSEFRGRQNS TNTCSSSLFP PLESSGSLAA FPTEPVPGTN
260 270 280 290 300
PSVPVGAQQA GPASDHPSVT TATGPAVFNG KDSPKHPQLV KSSLSALPRP
310 320 330 340 350
SALGILPNSG PPKKRHKGWS PESKSTTDGG FIQGGGNRAK HEGTSIPCVP
360 370 380 390 400
QAGLVGPASV TFPVVASGEP VSVPDNLLKI CKAKPVIFKG HGNFPYLCGN
410 420 430 440 450
LNDVVVSPLL YTCYQNSQSL ARAYEQHGAS TMQPISEETQ LLLTVYYLVQ
460 470 480 490 500
LAADQVPLME DLEQIFLRSW RESHLTEIRQ YQQAPPQPFP PATSTAAPVT
510 520 530 540 550
SAQLPWLAGL AASSCNDSVH VIECAYSLAE GLSEMFRLLI EGKLSKTNYV
560 570 580 590 600
VIICACRNAA IDSCIAVTGK YQARILSESL LSPAEYQREV HYELVTGKVD
610 620 630 640 650
SLGTFFSSLC PEGDIDILLD KFHQENQGHV SSSFTASSTK KTAVLDASGV
660 670 680 690 700
PVCTSYHQEP RGVRPFQLAV AQKLLSHVCS IADSSTQNLD LGSFEKVDFL
710 720 730 740 750
ICIPPSEVTY QQTVFHVWHS GVLLELGLEK EPVTKQRAEQ HVLKLDTEAQ
760 770 780 790 800
ARFKAFLQNS FQNPHTLFVL IHDHAHWDLV SSAVHNIYSQ SDPSVGLVDR
810 820 830 840 850
LLNCREVKEA PNIVTLHVTS FPYALQTQHT LISPYNEIHW PISFSNGVDL
860 870 880 890 900
YHESKKYFGL SEFIDSTLSG HSLPLLRYDS SFEAMVTALG KRFPRLHSAV
910 920 930 940 950
IRTFVLVQHY AAAMMAVSGL PQMKNHTSVE TLEITQNLLN SPKQCPCGHG
960 970 980 990 1000
LMVLLRVPCS PLAAVAYERL AHVRARLALE EHFEIILGHP SSGITVGKHF
1010 1020 1030 1040 1050
VKQLKMWQKI EDAEWRPQTY LELEGLPCIL IFSGMDPHGE SLPRSLRYCD
1060 1070 1080 1090 1100
LRLINSSCLV RTALEQELGL AAYFVSNDIP LEKGPKNEAL ESDGEKLSST
1110 1120 1130 1140 1150
DEDEEAGTEG CFEAGSTSEQ RGPVKRERSH SHDSASSSLS SRASGSVLYG
1160 1170 1180 1190 1200
ESLAQPSGPP QGELTRSPPS CGPAEEGRAP GEIQRLRVSQ GSTVISRHSP
1210 1220 1230 1240 1250
GLVPQPDSSL RTGRRSLQVP AAPSSQLSSS SGSSSTCAVP TANVLVLQAS
1260 1270 1280 1290 1300
QCSMAKACRQ PPIVFLPKLV YDMLLSTDSS GLPKSASLLP SPSVMWTSSF
1310 1320 1330 1340 1350
RPLLSKMMTS TEQSLYYRQW TVPRPSHMDY GNRAEGRVDS FHPRRLLLSG
1360 1370 1380 1390 1400
PPQIGKTGAY LQFLSILSRM LIRLTEVDVY DEEEINTSFR EESEWRYLQL
1410 1420 1430 1440 1450
ADPWPDLELF QKMPFDYIIH DPKYEDASLI CSHPQTIKSE DRGMSRKPED
1460 1470 1480 1490 1500
LYVRRQTARM RLSKYAAYNT YHHCEQCQQY MGFHPHYQLS ESTLHVFAFS
1510 1520 1530 1540 1550
CSMLGEEVQL HFIIPKSKEH HFVFSQPGGQ LESMRLPLVT DKSHEHIKSP
1560 1570 1580 1590 1600
TFTPTTGRHE HGLFNLYHAM DGANHLHVLV VKEYEMAIYK KYWPNHIMLV
1610 1620 1630 1640 1650
LPSIFNSAGV GAAHFLIKEL CYHNLELERN RQEELGVKPQ DVWPFIVIAD
1660 1670 1680 1690 1700
DSCVMWNVAD VDCAGERSRE FSWSERNVSL KYIMLHIEAS PNITHYALLG
1710 1720 1730 1740 1750
MRKWASKTRG REVQEPFSRC HVHDFIILNV DLTQNVQYNQ NRFTCDDVDF
1760 1770 1780 1790 1800
NLRVHSAGLL LCRFNRFSVM KKQIAVGGHR SFHITSKVSD SSVAIVPSQY
1810 1820 1830 1840 1850
ICAPDSKHTF LAAPAQLLLE KFLQYHSHRF FPLSLKNHSH PVLSVDCYLN
1860 1870 1880 1890 1900
LGPQISVCYV SSRPHSLNIS CSDMVFSGLL LYLCDSFVGA SFLKKFHFLK
1910 1920 1930 1940 1950
GATLCVICQD RNSLRQTVVR LELEDEWQFR LRDEFQTANA KEDRPLFFLT

ARHI
Length:1,954
Mass (Da):216,927
Last modified:July 27, 2011 - v2
Checksum:i9EBBC2FF6F011E06
GO

Sequence cautioni

The sequence BAC41432.2 differs from that shown.Partially unspliced pre-RNA.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti230 – 2301P → T in AAF44295 (PubMed:10644441).Curated
Sequence conflicti230 – 2301P → T in BAE27854 (PubMed:16141072).Curated
Sequence conflicti260 – 2601A → V in AAF44295 (PubMed:10644441).Curated
Sequence conflicti360 – 3601V → A in AAF44295 (PubMed:10644441).Curated
Sequence conflicti659 – 6591E → G in BAE27854 (PubMed:16141072).Curated
Sequence conflicti844 – 8441F → Y in AAF44295 (PubMed:10644441).Curated
Sequence conflicti1154 – 11541A → V in AAF44295 (PubMed:10644441).Curated
Sequence conflicti1154 – 11541A → V in BAE27854 (PubMed:16141072).Curated
Sequence conflicti1154 – 11541A → V in BAC41432 (PubMed:12465718).Curated
Sequence conflicti1170 – 11701S → P in AAF44295 (PubMed:10644441).Curated
Sequence conflicti1170 – 11701S → P in BAE27854 (PubMed:16141072).Curated
Sequence conflicti1170 – 11701S → P in BAC41432 (PubMed:12465718).Curated
Sequence conflicti1201 – 12011G → D in AAF44295 (PubMed:10644441).Curated
Sequence conflicti1201 – 12011G → D in BAE27854 (PubMed:16141072).Curated
Sequence conflicti1417 – 14171Y → C in AAF44295 (PubMed:10644441).Curated
Sequence conflicti1749 – 17491D → N in BAC28368 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180470 mRNA. Translation: AAF44295.1.
AK033573 mRNA. Translation: BAC28368.1.
AK147337 mRNA. Translation: BAE27854.1.
AC122228 Genomic DNA. No translation available.
AC157352 Genomic DNA. No translation available.
AB093248 Transcribed RNA. Translation: BAC41432.2. Sequence problems.
CCDSiCCDS36408.1.
RefSeqiNP_056579.2. NM_015764.4.
XP_006515156.1. XM_006515093.2.
XP_006515157.1. XM_006515094.2.
XP_006515158.1. XM_006515095.2.
XP_006515159.1. XM_006515096.2.
XP_006515160.1. XM_006515097.2.
XP_006515161.1. XM_006515098.2.
UniGeneiMm.428062.
Mm.490218.

Genome annotation databases

EnsembliENSMUST00000048064; ENSMUSP00000044454; ENSMUSG00000036523.
ENSMUST00000162112; ENSMUSP00000124348; ENSMUSG00000036523.
GeneIDi268527.
KEGGimmu:268527.
UCSCiuc029rrb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180470 mRNA. Translation: AAF44295.1.
AK033573 mRNA. Translation: BAC28368.1.
AK147337 mRNA. Translation: BAE27854.1.
AC122228 Genomic DNA. No translation available.
AC157352 Genomic DNA. No translation available.
AB093248 Transcribed RNA. Translation: BAC41432.2. Sequence problems.
CCDSiCCDS36408.1.
RefSeqiNP_056579.2. NM_015764.4.
XP_006515156.1. XM_006515093.2.
XP_006515157.1. XM_006515094.2.
XP_006515158.1. XM_006515095.2.
XP_006515159.1. XM_006515096.2.
XP_006515160.1. XM_006515097.2.
XP_006515161.1. XM_006515098.2.
UniGeneiMm.428062.
Mm.490218.

3D structure databases

ProteinModelPortaliQ3UHK3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044454.

PTM databases

iPTMnetiQ3UHK3.
PhosphoSiteiQ3UHK3.

Proteomic databases

PaxDbiQ3UHK3.
PRIDEiQ3UHK3.

Protocols and materials databases

DNASUi268527.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048064; ENSMUSP00000044454; ENSMUSG00000036523.
ENSMUST00000162112; ENSMUSP00000124348; ENSMUSG00000036523.
GeneIDi268527.
KEGGimmu:268527.
UCSCiuc029rrb.1. mouse.

Organism-specific databases

CTDi9687.
MGIiMGI:2149712. Greb1.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IF9T. Eukaryota.
ENOG410Z1PN. LUCA.
GeneTreeiENSGT00390000008041.
HOGENOMiHOG000090251.
HOVERGENiHBG107963.
InParanoidiQ3UHK3.
OMAiNYTSVET.
OrthoDBiEOG76X5Z7.
PhylomeDBiQ3UHK3.
TreeFamiTF329531.

Miscellaneous databases

PROiQ3UHK3.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UHK3.
ExpressionAtlasiQ3UHK3. baseline and differential.
GenevisibleiQ3UHK3. MM.

Family and domain databases

InterProiIPR028422. GREB1.
[Graphical view]
PANTHERiPTHR15720. PTHR15720. 2 hits.
PfamiPF15782. GREB1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic, physical, and transcript map of the fld region on mouse chromosome 12."
    Peterfy M., Phan J., Oswell G.M., Xu P., Reue K.
    Genomics 62:436-444(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain and Cecum.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
    DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1004-1954.
    Tissue: Embryonic tail.

Entry informationi

Entry nameiGREB1_MOUSE
AccessioniPrimary (citable) accession number: Q3UHK3
Secondary accession number(s): E0CYB3
, Q8BZT6, Q8CHE7, Q9JLG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.