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Q3UHK1

- MYCT_MOUSE

UniProt

Q3UHK1 - MYCT_MOUSE

Protein

Proton myo-inositol cotransporter

Gene

Slc2a13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    H+-myo-inositol cotransporter. Can also transport related stereoisomers By similarity.By similarity

    GO - Molecular functioni

    1. substrate-specific transmembrane transporter activity Source: InterPro

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proton myo-inositol cotransporter
    Short name:
    H(+)-myo-inositol cotransporter
    Short name:
    Hmit
    Alternative name(s):
    H(+)-myo-inositol symporter
    Solute carrier family 2 member 13
    Gene namesi
    Name:Slc2a13
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:2146030. Slc2a13.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 637637Proton myo-inositol cotransporterPRO_0000261317Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi422 – 4221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi447 – 4471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi474 – 4741N-linked (GlcNAc...)Sequence Analysis
    Modified residuei629 – 6291PhosphoserineBy similarity
    Modified residuei634 – 6341PhosphoserineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ3UHK1.
    PRIDEiQ3UHK1.

    PTM databases

    PhosphoSiteiQ3UHK1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ3UHK1.
    BgeeiQ3UHK1.
    GenevestigatoriQ3UHK1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3UHK1.
    SMRiQ3UHK1. Positions 87-399, 498-599.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6565CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini87 – 11428ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini136 – 1372CytoplasmicSequence Analysis
    Topological domaini159 – 1679ExtracellularSequence Analysis
    Topological domaini189 – 20113CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini223 – 2286ExtracellularSequence Analysis
    Topological domaini250 – 31364CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini335 – 35218ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini374 – 3829CytoplasmicSequence Analysis
    Topological domaini404 – 49794ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini519 – 53820CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini560 – 5623ExtracellularSequence Analysis
    Topological domaini584 – 63754CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei66 – 8621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei115 – 13521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei168 – 18821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei202 – 22221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei229 – 24921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei314 – 33421Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei353 – 37321Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei383 – 40321Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei498 – 51821Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei539 – 55921Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei563 – 58321Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00590000083062.
    HOGENOMiHOG000202868.
    HOVERGENiHBG031722.
    InParanoidiQ3UHK1.
    KOiK08150.
    OMAiAQDELND.
    OrthoDBiEOG7VDXNV.
    PhylomeDBiQ3UHK1.
    TreeFamiTF314916.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 2 hits.
    [Graphical view]
    PRINTSiPR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 2 hits.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3UHK1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRKASEDVE YTLRSLSSLM GERRRRQPEP GAPGGERSLL AAESAASLQG    50
    AELERAARRQ FQRDETPAFV YAAAAFSALG GFLFGYDTGV VSGAMLLLRR 100
    QMRLGAMWQE LLVSGAVGAA AVAALAGGAL NGALGRRSAI LLASALCTVG 150
    SAVLAAAANK ETLLAGRLVV GLGIGIASMT VPVYIAEVSP PNLRGRLVTI 200
    NTLFITGGQF FASVVDGAFS YLQKDGWRYM LGLAAIPAVI QFLGFLFLPE 250
    SPRWLIQKGQ TQKARRILSQ MRGNQTIDEE YDSIRNSIEE EEKEATAAGP 300
    IICRMLSYPP TRRALVVGCG LQMFQQLSGI NTIMYYSATI LQMSGVEDDR 350
    LAIWLASITA FTNFIFTLVG VWLVEKVGRR KLTFGSLAGT TVALIILALG 400
    FLLSAQVSPR VTFRPTTPSD QNTTCTGYSY CNECMLDPDC GFCYKINGSA 450
    VIDSSCVPVN KASTTEAAWG RCDNETKFKA EGAHWAYSFC PTPYSWTALV 500
    GLVLYLVFFA PGMGPMPWTV NSEIYPLWAR STGNACSAGI NWIFNVLVSL 550
    TFLHTAEYLT YYGAFFLYAG FAAVGLLFVY GCLPETKGKK LEEIESLFDH 600
    RLCSCGAADS DEGRYIEYIR VKGSNYHLSD NDASDVE 637
    Length:637
    Mass (Da):69,062
    Last modified:April 20, 2010 - v2
    Checksum:iCF13253E46E934D2
    GO

    Sequence cautioni

    The sequence BAE27856.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK147341 mRNA. Translation: BAE27856.1. Different initiation.
    CCDSiCCDS27761.2.
    RefSeqiNP_001028805.2. NM_001033633.3.
    UniGeneiMm.360596.

    Genome annotation databases

    EnsembliENSMUST00000109283; ENSMUSP00000104906; ENSMUSG00000036298.
    GeneIDi239606.
    KEGGimmu:239606.
    UCSCiuc007xhy.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK147341 mRNA. Translation: BAE27856.1 . Different initiation.
    CCDSi CCDS27761.2.
    RefSeqi NP_001028805.2. NM_001033633.3.
    UniGenei Mm.360596.

    3D structure databases

    ProteinModelPortali Q3UHK1.
    SMRi Q3UHK1. Positions 87-399, 498-599.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q3UHK1.

    Proteomic databases

    PaxDbi Q3UHK1.
    PRIDEi Q3UHK1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000109283 ; ENSMUSP00000104906 ; ENSMUSG00000036298 .
    GeneIDi 239606.
    KEGGi mmu:239606.
    UCSCi uc007xhy.2. mouse.

    Organism-specific databases

    CTDi 114134.
    MGIi MGI:2146030. Slc2a13.

    Phylogenomic databases

    eggNOGi COG0477.
    GeneTreei ENSGT00590000083062.
    HOGENOMi HOG000202868.
    HOVERGENi HBG031722.
    InParanoidi Q3UHK1.
    KOi K08150.
    OMAi AQDELND.
    OrthoDBi EOG7VDXNV.
    PhylomeDBi Q3UHK1.
    TreeFami TF314916.

    Miscellaneous databases

    NextBioi 384195.
    PROi Q3UHK1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3UHK1.
    Bgeei Q3UHK1.
    Genevestigatori Q3UHK1.

    Family and domain databases

    InterProi IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 2 hits.
    [Graphical view ]
    PRINTSi PR00171. SUGRTRNSPORT.
    SUPFAMi SSF103473. SSF103473. 2 hits.
    TIGRFAMsi TIGR00879. SP. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiMYCT_MOUSE
    AccessioniPrimary (citable) accession number: Q3UHK1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3