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Q3UHK1

- MYCT_MOUSE

UniProt

Q3UHK1 - MYCT_MOUSE

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Protein

Proton myo-inositol cotransporter

Gene
Slc2a13
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

H+-myo-inositol cotransporter. Can also transport related stereoisomers By similarity.

GO - Molecular functioni

  1. substrate-specific transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Proton myo-inositol cotransporter
Short name:
H(+)-myo-inositol cotransporter
Short name:
Hmit
Alternative name(s):
H(+)-myo-inositol symporter
Solute carrier family 2 member 13
Gene namesi
Name:Slc2a13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:2146030. Slc2a13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6565Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei66 – 8621Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini87 – 11428Extracellular Reviewed predictionAdd
BLAST
Transmembranei115 – 13521Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini136 – 1372Cytoplasmic Reviewed prediction
Transmembranei138 – 15821Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini159 – 1679Extracellular Reviewed prediction
Transmembranei168 – 18821Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini189 – 20113Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei202 – 22221Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini223 – 2286Extracellular Reviewed prediction
Transmembranei229 – 24921Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini250 – 31364Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei314 – 33421Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini335 – 35218Extracellular Reviewed predictionAdd
BLAST
Transmembranei353 – 37321Helical; Name=8; Reviewed predictionAdd
BLAST
Topological domaini374 – 3829Cytoplasmic Reviewed prediction
Transmembranei383 – 40321Helical; Name=9; Reviewed predictionAdd
BLAST
Topological domaini404 – 49794Extracellular Reviewed predictionAdd
BLAST
Transmembranei498 – 51821Helical; Name=10; Reviewed predictionAdd
BLAST
Topological domaini519 – 53820Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei539 – 55921Helical; Name=11; Reviewed predictionAdd
BLAST
Topological domaini560 – 5623Extracellular Reviewed prediction
Transmembranei563 – 58321Helical; Name=12; Reviewed predictionAdd
BLAST
Topological domaini584 – 63754Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 637637Proton myo-inositol cotransporterPRO_0000261317Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi422 – 4221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi447 – 4471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi474 – 4741N-linked (GlcNAc...) Reviewed prediction
Modified residuei629 – 6291Phosphoserine By similarity
Modified residuei634 – 6341Phosphoserine By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ3UHK1.
PRIDEiQ3UHK1.

PTM databases

PhosphoSiteiQ3UHK1.

Expressioni

Gene expression databases

ArrayExpressiQ3UHK1.
BgeeiQ3UHK1.
GenevestigatoriQ3UHK1.

Structurei

3D structure databases

ProteinModelPortaliQ3UHK1.
SMRiQ3UHK1. Positions 87-399, 498-599.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00590000083062.
HOGENOMiHOG000202868.
HOVERGENiHBG031722.
InParanoidiQ3UHK1.
KOiK08150.
OMAiAQDELND.
OrthoDBiEOG7VDXNV.
PhylomeDBiQ3UHK1.
TreeFamiTF314916.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 2 hits.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UHK1-1 [UniParc]FASTAAdd to Basket

« Hide

MSRKASEDVE YTLRSLSSLM GERRRRQPEP GAPGGERSLL AAESAASLQG    50
AELERAARRQ FQRDETPAFV YAAAAFSALG GFLFGYDTGV VSGAMLLLRR 100
QMRLGAMWQE LLVSGAVGAA AVAALAGGAL NGALGRRSAI LLASALCTVG 150
SAVLAAAANK ETLLAGRLVV GLGIGIASMT VPVYIAEVSP PNLRGRLVTI 200
NTLFITGGQF FASVVDGAFS YLQKDGWRYM LGLAAIPAVI QFLGFLFLPE 250
SPRWLIQKGQ TQKARRILSQ MRGNQTIDEE YDSIRNSIEE EEKEATAAGP 300
IICRMLSYPP TRRALVVGCG LQMFQQLSGI NTIMYYSATI LQMSGVEDDR 350
LAIWLASITA FTNFIFTLVG VWLVEKVGRR KLTFGSLAGT TVALIILALG 400
FLLSAQVSPR VTFRPTTPSD QNTTCTGYSY CNECMLDPDC GFCYKINGSA 450
VIDSSCVPVN KASTTEAAWG RCDNETKFKA EGAHWAYSFC PTPYSWTALV 500
GLVLYLVFFA PGMGPMPWTV NSEIYPLWAR STGNACSAGI NWIFNVLVSL 550
TFLHTAEYLT YYGAFFLYAG FAAVGLLFVY GCLPETKGKK LEEIESLFDH 600
RLCSCGAADS DEGRYIEYIR VKGSNYHLSD NDASDVE 637
Length:637
Mass (Da):69,062
Last modified:April 20, 2010 - v2
Checksum:iCF13253E46E934D2
GO

Sequence cautioni

The sequence BAE27856.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK147341 mRNA. Translation: BAE27856.1. Different initiation.
CCDSiCCDS27761.2.
RefSeqiNP_001028805.2. NM_001033633.3.
UniGeneiMm.360596.

Genome annotation databases

EnsembliENSMUST00000109283; ENSMUSP00000104906; ENSMUSG00000036298.
GeneIDi239606.
KEGGimmu:239606.
UCSCiuc007xhy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK147341 mRNA. Translation: BAE27856.1 . Different initiation.
CCDSi CCDS27761.2.
RefSeqi NP_001028805.2. NM_001033633.3.
UniGenei Mm.360596.

3D structure databases

ProteinModelPortali Q3UHK1.
SMRi Q3UHK1. Positions 87-399, 498-599.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q3UHK1.

Proteomic databases

PaxDbi Q3UHK1.
PRIDEi Q3UHK1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000109283 ; ENSMUSP00000104906 ; ENSMUSG00000036298 .
GeneIDi 239606.
KEGGi mmu:239606.
UCSCi uc007xhy.2. mouse.

Organism-specific databases

CTDi 114134.
MGIi MGI:2146030. Slc2a13.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00590000083062.
HOGENOMi HOG000202868.
HOVERGENi HBG031722.
InParanoidi Q3UHK1.
KOi K08150.
OMAi AQDELND.
OrthoDBi EOG7VDXNV.
PhylomeDBi Q3UHK1.
TreeFami TF314916.

Miscellaneous databases

NextBioi 384195.
PROi Q3UHK1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q3UHK1.
Bgeei Q3UHK1.
Genevestigatori Q3UHK1.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view ]
Pfami PF00083. Sugar_tr. 2 hits.
[Graphical view ]
PRINTSi PR00171. SUGRTRNSPORT.
SUPFAMi SSF103473. SSF103473. 2 hits.
TIGRFAMsi TIGR00879. SP. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiMYCT_MOUSE
AccessioniPrimary (citable) accession number: Q3UHK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: April 20, 2010
Last modified: July 9, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi