Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q3UHK1 (MYCT_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proton myo-inositol cotransporter

Short name=H(+)-myo-inositol cotransporter
Short name=Hmit
Alternative name(s):
H(+)-myo-inositol symporter
Solute carrier family 2 member 13
Gene names
Name:Slc2a13
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length637 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

H+-myo-inositol cotransporter. Can also transport related stereoisomers By similarity.

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]

Sequence caution

The sequence BAE27856.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionsubstrate-specific transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 637637Proton myo-inositol cotransporter
PRO_0000261317

Regions

Topological domain1 – 6565Cytoplasmic Potential
Transmembrane66 – 8621Helical; Name=1; Potential
Topological domain87 – 11428Extracellular Potential
Transmembrane115 – 13521Helical; Name=2; Potential
Topological domain136 – 1372Cytoplasmic Potential
Transmembrane138 – 15821Helical; Name=3; Potential
Topological domain159 – 1679Extracellular Potential
Transmembrane168 – 18821Helical; Name=4; Potential
Topological domain189 – 20113Cytoplasmic Potential
Transmembrane202 – 22221Helical; Name=5; Potential
Topological domain223 – 2286Extracellular Potential
Transmembrane229 – 24921Helical; Name=6; Potential
Topological domain250 – 31364Cytoplasmic Potential
Transmembrane314 – 33421Helical; Name=7; Potential
Topological domain335 – 35218Extracellular Potential
Transmembrane353 – 37321Helical; Name=8; Potential
Topological domain374 – 3829Cytoplasmic Potential
Transmembrane383 – 40321Helical; Name=9; Potential
Topological domain404 – 49794Extracellular Potential
Transmembrane498 – 51821Helical; Name=10; Potential
Topological domain519 – 53820Cytoplasmic Potential
Transmembrane539 – 55921Helical; Name=11; Potential
Topological domain560 – 5623Extracellular Potential
Transmembrane563 – 58321Helical; Name=12; Potential
Topological domain584 – 63754Cytoplasmic Potential

Amino acid modifications

Modified residue6291Phosphoserine By similarity
Modified residue6341Phosphoserine By similarity
Glycosylation4221N-linked (GlcNAc...) Potential
Glycosylation4471N-linked (GlcNAc...) Potential
Glycosylation4741N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q3UHK1 [UniParc].

Last modified April 20, 2010. Version 2.
Checksum: CF13253E46E934D2

FASTA63769,062
        10         20         30         40         50         60 
MSRKASEDVE YTLRSLSSLM GERRRRQPEP GAPGGERSLL AAESAASLQG AELERAARRQ 

        70         80         90        100        110        120 
FQRDETPAFV YAAAAFSALG GFLFGYDTGV VSGAMLLLRR QMRLGAMWQE LLVSGAVGAA 

       130        140        150        160        170        180 
AVAALAGGAL NGALGRRSAI LLASALCTVG SAVLAAAANK ETLLAGRLVV GLGIGIASMT 

       190        200        210        220        230        240 
VPVYIAEVSP PNLRGRLVTI NTLFITGGQF FASVVDGAFS YLQKDGWRYM LGLAAIPAVI 

       250        260        270        280        290        300 
QFLGFLFLPE SPRWLIQKGQ TQKARRILSQ MRGNQTIDEE YDSIRNSIEE EEKEATAAGP 

       310        320        330        340        350        360 
IICRMLSYPP TRRALVVGCG LQMFQQLSGI NTIMYYSATI LQMSGVEDDR LAIWLASITA 

       370        380        390        400        410        420 
FTNFIFTLVG VWLVEKVGRR KLTFGSLAGT TVALIILALG FLLSAQVSPR VTFRPTTPSD 

       430        440        450        460        470        480 
QNTTCTGYSY CNECMLDPDC GFCYKINGSA VIDSSCVPVN KASTTEAAWG RCDNETKFKA 

       490        500        510        520        530        540 
EGAHWAYSFC PTPYSWTALV GLVLYLVFFA PGMGPMPWTV NSEIYPLWAR STGNACSAGI 

       550        560        570        580        590        600 
NWIFNVLVSL TFLHTAEYLT YYGAFFLYAG FAAVGLLFVY GCLPETKGKK LEEIESLFDH 

       610        620        630 
RLCSCGAADS DEGRYIEYIR VKGSNYHLSD NDASDVE 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK147341 mRNA. Translation: BAE27856.1. Different initiation.
RefSeqNP_001028805.2. NM_001033633.3.
UniGeneMm.360596.

3D structure databases

ProteinModelPortalQ3UHK1.
SMRQ3UHK1. Positions 74-599.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ3UHK1.

Proteomic databases

PaxDbQ3UHK1.
PRIDEQ3UHK1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000109283; ENSMUSP00000104906; ENSMUSG00000036298.
GeneID239606.
KEGGmmu:239606.
UCSCuc007xhy.2. mouse.

Organism-specific databases

CTD114134.
MGIMGI:2146030. Slc2a13.

Phylogenomic databases

eggNOGCOG0477.
GeneTreeENSGT00590000083062.
HOGENOMHOG000202868.
HOVERGENHBG031722.
InParanoidQ3UHK1.
KOK08150.
OMARKYSLMI.
OrthoDBEOG7VDXNV.
PhylomeDBQ3UHK1.
TreeFamTF314916.

Gene expression databases

ArrayExpressQ3UHK1.
BgeeQ3UHK1.
GenevestigatorQ3UHK1.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamPF00083. Sugar_tr. 2 hits.
[Graphical view]
PRINTSPR00171. SUGRTRNSPORT.
SUPFAMSSF103473. SSF103473. 2 hits.
TIGRFAMsTIGR00879. SP. 1 hit.
PROSITEPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio384195.
PROQ3UHK1.
SOURCESearch...

Entry information

Entry nameMYCT_MOUSE
AccessionPrimary (citable) accession number: Q3UHK1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: April 20, 2010
Last modified: April 16, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot