Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q3UHK1

- MYCT_MOUSE

UniProt

Q3UHK1 - MYCT_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Proton myo-inositol cotransporter

Gene

Slc2a13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

H+-myo-inositol cotransporter. Can also transport related stereoisomers (By similarity).By similarity

GO - Molecular functioni

  1. substrate-specific transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_258190. Inositol transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Proton myo-inositol cotransporter
Short name:
H(+)-myo-inositol cotransporter
Short name:
Hmit
Alternative name(s):
H(+)-myo-inositol symporter
Solute carrier family 2 member 13
Gene namesi
Name:Slc2a13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:2146030. Slc2a13.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6565CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei66 – 8621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini87 – 11428ExtracellularSequence AnalysisAdd
BLAST
Transmembranei115 – 13521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini136 – 1372CytoplasmicSequence Analysis
Transmembranei138 – 15821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini159 – 1679ExtracellularSequence Analysis
Transmembranei168 – 18821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini189 – 20113CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei202 – 22221Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini223 – 2286ExtracellularSequence Analysis
Transmembranei229 – 24921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini250 – 31364CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei314 – 33421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini335 – 35218ExtracellularSequence AnalysisAdd
BLAST
Transmembranei353 – 37321Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini374 – 3829CytoplasmicSequence Analysis
Transmembranei383 – 40321Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini404 – 49794ExtracellularSequence AnalysisAdd
BLAST
Transmembranei498 – 51821Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini519 – 53820CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei539 – 55921Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini560 – 5623ExtracellularSequence Analysis
Transmembranei563 – 58321Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini584 – 63754CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 637637Proton myo-inositol cotransporterPRO_0000261317Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi422 – 4221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi447 – 4471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi474 – 4741N-linked (GlcNAc...)Sequence Analysis
Modified residuei629 – 6291PhosphoserineBy similarity
Modified residuei634 – 6341PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ3UHK1.
PaxDbiQ3UHK1.
PRIDEiQ3UHK1.

PTM databases

PhosphoSiteiQ3UHK1.

Expressioni

Gene expression databases

BgeeiQ3UHK1.
ExpressionAtlasiQ3UHK1. baseline and differential.
GenevestigatoriQ3UHK1.

Structurei

3D structure databases

ProteinModelPortaliQ3UHK1.
SMRiQ3UHK1. Positions 87-399, 498-599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00590000083062.
HOGENOMiHOG000202868.
HOVERGENiHBG031722.
InParanoidiQ3UHK1.
KOiK08150.
OMAiAQDELND.
OrthoDBiEOG7VDXNV.
PhylomeDBiQ3UHK1.
TreeFamiTF314916.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 2 hits.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UHK1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRKASEDVE YTLRSLSSLM GERRRRQPEP GAPGGERSLL AAESAASLQG
60 70 80 90 100
AELERAARRQ FQRDETPAFV YAAAAFSALG GFLFGYDTGV VSGAMLLLRR
110 120 130 140 150
QMRLGAMWQE LLVSGAVGAA AVAALAGGAL NGALGRRSAI LLASALCTVG
160 170 180 190 200
SAVLAAAANK ETLLAGRLVV GLGIGIASMT VPVYIAEVSP PNLRGRLVTI
210 220 230 240 250
NTLFITGGQF FASVVDGAFS YLQKDGWRYM LGLAAIPAVI QFLGFLFLPE
260 270 280 290 300
SPRWLIQKGQ TQKARRILSQ MRGNQTIDEE YDSIRNSIEE EEKEATAAGP
310 320 330 340 350
IICRMLSYPP TRRALVVGCG LQMFQQLSGI NTIMYYSATI LQMSGVEDDR
360 370 380 390 400
LAIWLASITA FTNFIFTLVG VWLVEKVGRR KLTFGSLAGT TVALIILALG
410 420 430 440 450
FLLSAQVSPR VTFRPTTPSD QNTTCTGYSY CNECMLDPDC GFCYKINGSA
460 470 480 490 500
VIDSSCVPVN KASTTEAAWG RCDNETKFKA EGAHWAYSFC PTPYSWTALV
510 520 530 540 550
GLVLYLVFFA PGMGPMPWTV NSEIYPLWAR STGNACSAGI NWIFNVLVSL
560 570 580 590 600
TFLHTAEYLT YYGAFFLYAG FAAVGLLFVY GCLPETKGKK LEEIESLFDH
610 620 630
RLCSCGAADS DEGRYIEYIR VKGSNYHLSD NDASDVE
Length:637
Mass (Da):69,062
Last modified:April 20, 2010 - v2
Checksum:iCF13253E46E934D2
GO

Sequence cautioni

The sequence BAE27856.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147341 mRNA. Translation: BAE27856.1. Different initiation.
CCDSiCCDS27761.2.
RefSeqiNP_001028805.2. NM_001033633.3.
UniGeneiMm.360596.

Genome annotation databases

EnsembliENSMUST00000109283; ENSMUSP00000104906; ENSMUSG00000036298.
GeneIDi239606.
KEGGimmu:239606.
UCSCiuc007xhy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147341 mRNA. Translation: BAE27856.1 . Different initiation.
CCDSi CCDS27761.2.
RefSeqi NP_001028805.2. NM_001033633.3.
UniGenei Mm.360596.

3D structure databases

ProteinModelPortali Q3UHK1.
SMRi Q3UHK1. Positions 87-399, 498-599.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q3UHK1.

Proteomic databases

MaxQBi Q3UHK1.
PaxDbi Q3UHK1.
PRIDEi Q3UHK1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000109283 ; ENSMUSP00000104906 ; ENSMUSG00000036298 .
GeneIDi 239606.
KEGGi mmu:239606.
UCSCi uc007xhy.2. mouse.

Organism-specific databases

CTDi 114134.
MGIi MGI:2146030. Slc2a13.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00590000083062.
HOGENOMi HOG000202868.
HOVERGENi HBG031722.
InParanoidi Q3UHK1.
KOi K08150.
OMAi AQDELND.
OrthoDBi EOG7VDXNV.
PhylomeDBi Q3UHK1.
TreeFami TF314916.

Enzyme and pathway databases

Reactomei REACT_258190. Inositol transporters.

Miscellaneous databases

ChiTaRSi Slc2a13. mouse.
NextBioi 384195.
PROi Q3UHK1.
SOURCEi Search...

Gene expression databases

Bgeei Q3UHK1.
ExpressionAtlasi Q3UHK1. baseline and differential.
Genevestigatori Q3UHK1.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view ]
Pfami PF00083. Sugar_tr. 2 hits.
[Graphical view ]
PRINTSi PR00171. SUGRTRNSPORT.
SUPFAMi SSF103473. SSF103473. 2 hits.
TIGRFAMsi TIGR00879. SP. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiMYCT_MOUSE
AccessioniPrimary (citable) accession number: Q3UHK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: April 20, 2010
Last modified: November 26, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3