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Protein

Proton myo-inositol cotransporter

Gene

Slc2a13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

H+-myo-inositol cotransporter. Can also transport related stereoisomers (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_294731. Inositol transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Proton myo-inositol cotransporter
Short name:
H(+)-myo-inositol cotransporter
Short name:
Hmit
Alternative name(s):
H(+)-myo-inositol symporter
Solute carrier family 2 member 13
Gene namesi
Name:Slc2a13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2146030. Slc2a13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6565CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei66 – 8621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini87 – 11428ExtracellularSequence AnalysisAdd
BLAST
Transmembranei115 – 13521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini136 – 1372CytoplasmicSequence Analysis
Transmembranei138 – 15821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini159 – 1679ExtracellularSequence Analysis
Transmembranei168 – 18821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini189 – 20113CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei202 – 22221Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini223 – 2286ExtracellularSequence Analysis
Transmembranei229 – 24921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini250 – 31364CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei314 – 33421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini335 – 35218ExtracellularSequence AnalysisAdd
BLAST
Transmembranei353 – 37321Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini374 – 3829CytoplasmicSequence Analysis
Transmembranei383 – 40321Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini404 – 49794ExtracellularSequence AnalysisAdd
BLAST
Transmembranei498 – 51821Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini519 – 53820CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei539 – 55921Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini560 – 5623ExtracellularSequence Analysis
Transmembranei563 – 58321Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini584 – 63754CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 637637Proton myo-inositol cotransporterPRO_0000261317Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi422 – 4221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi447 – 4471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi474 – 4741N-linked (GlcNAc...)Sequence Analysis
Modified residuei629 – 6291PhosphoserineBy similarity
Modified residuei634 – 6341PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ3UHK1.
PaxDbiQ3UHK1.
PRIDEiQ3UHK1.

PTM databases

PhosphoSiteiQ3UHK1.

Expressioni

Gene expression databases

BgeeiQ3UHK1.
ExpressionAtlasiQ3UHK1. baseline and differential.
GenevisibleiQ3UHK1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104906.

Structurei

3D structure databases

ProteinModelPortaliQ3UHK1.
SMRiQ3UHK1. Positions 87-399, 498-599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00590000083062.
HOGENOMiHOG000202868.
HOVERGENiHBG031722.
InParanoidiQ3UHK1.
KOiK08150.
OMAiRKYSLMI.
OrthoDBiEOG7VDXNV.
PhylomeDBiQ3UHK1.
TreeFamiTF314916.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 2 hits.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UHK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKASEDVE YTLRSLSSLM GERRRRQPEP GAPGGERSLL AAESAASLQG
60 70 80 90 100
AELERAARRQ FQRDETPAFV YAAAAFSALG GFLFGYDTGV VSGAMLLLRR
110 120 130 140 150
QMRLGAMWQE LLVSGAVGAA AVAALAGGAL NGALGRRSAI LLASALCTVG
160 170 180 190 200
SAVLAAAANK ETLLAGRLVV GLGIGIASMT VPVYIAEVSP PNLRGRLVTI
210 220 230 240 250
NTLFITGGQF FASVVDGAFS YLQKDGWRYM LGLAAIPAVI QFLGFLFLPE
260 270 280 290 300
SPRWLIQKGQ TQKARRILSQ MRGNQTIDEE YDSIRNSIEE EEKEATAAGP
310 320 330 340 350
IICRMLSYPP TRRALVVGCG LQMFQQLSGI NTIMYYSATI LQMSGVEDDR
360 370 380 390 400
LAIWLASITA FTNFIFTLVG VWLVEKVGRR KLTFGSLAGT TVALIILALG
410 420 430 440 450
FLLSAQVSPR VTFRPTTPSD QNTTCTGYSY CNECMLDPDC GFCYKINGSA
460 470 480 490 500
VIDSSCVPVN KASTTEAAWG RCDNETKFKA EGAHWAYSFC PTPYSWTALV
510 520 530 540 550
GLVLYLVFFA PGMGPMPWTV NSEIYPLWAR STGNACSAGI NWIFNVLVSL
560 570 580 590 600
TFLHTAEYLT YYGAFFLYAG FAAVGLLFVY GCLPETKGKK LEEIESLFDH
610 620 630
RLCSCGAADS DEGRYIEYIR VKGSNYHLSD NDASDVE
Length:637
Mass (Da):69,062
Last modified:April 20, 2010 - v2
Checksum:iCF13253E46E934D2
GO

Sequence cautioni

The sequence BAE27856.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147341 mRNA. Translation: BAE27856.1. Different initiation.
CCDSiCCDS27761.2.
RefSeqiNP_001028805.2. NM_001033633.3.
UniGeneiMm.360596.

Genome annotation databases

EnsembliENSMUST00000109283; ENSMUSP00000104906; ENSMUSG00000036298.
GeneIDi239606.
KEGGimmu:239606.
UCSCiuc007xhy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147341 mRNA. Translation: BAE27856.1. Different initiation.
CCDSiCCDS27761.2.
RefSeqiNP_001028805.2. NM_001033633.3.
UniGeneiMm.360596.

3D structure databases

ProteinModelPortaliQ3UHK1.
SMRiQ3UHK1. Positions 87-399, 498-599.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104906.

PTM databases

PhosphoSiteiQ3UHK1.

Proteomic databases

MaxQBiQ3UHK1.
PaxDbiQ3UHK1.
PRIDEiQ3UHK1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109283; ENSMUSP00000104906; ENSMUSG00000036298.
GeneIDi239606.
KEGGimmu:239606.
UCSCiuc007xhy.2. mouse.

Organism-specific databases

CTDi114134.
MGIiMGI:2146030. Slc2a13.

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00590000083062.
HOGENOMiHOG000202868.
HOVERGENiHBG031722.
InParanoidiQ3UHK1.
KOiK08150.
OMAiRKYSLMI.
OrthoDBiEOG7VDXNV.
PhylomeDBiQ3UHK1.
TreeFamiTF314916.

Enzyme and pathway databases

ReactomeiREACT_294731. Inositol transporters.

Miscellaneous databases

ChiTaRSiSlc2a13. mouse.
NextBioi384195.
PROiQ3UHK1.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UHK1.
ExpressionAtlasiQ3UHK1. baseline and differential.
GenevisibleiQ3UHK1. MM.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 2 hits.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiMYCT_MOUSE
AccessioniPrimary (citable) accession number: Q3UHK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: April 20, 2010
Last modified: June 24, 2015
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.