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Protein

RING finger protein 44

Gene

Rnf44

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri355 – 396RING-type; atypicalPROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 44
Gene namesi
Name:Rnf44
Synonyms:Kiaa1100
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2145310. Rnf44.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002734141 – 407RING finger protein 44Add BLAST407

Proteomic databases

PRIDEiQ3UHJ8.

PTM databases

iPTMnetiQ3UHJ8.
PhosphoSitePlusiQ3UHJ8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034928.
CleanExiMM_RNF44.
ExpressionAtlasiQ3UHJ8. baseline and differential.
GenevisibleiQ3UHJ8. MM.

Structurei

3D structure databases

ProteinModelPortaliQ3UHJ8.
SMRiQ3UHJ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi123 – 296Pro-richAdd BLAST174

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri355 – 396RING-type; atypicalPROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00730000110459.
HOGENOMiHOG000231638.
HOVERGENiHBG059283.
InParanoidiQ3UHJ8.
KOiK19041.
PhylomeDBiQ3UHJ8.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF13639. zf-RING_2. 1 hit.
SMARTiView protein in SMART
SM00184. RING. 1 hit.
PROSITEiView protein in PROSITE
PS50089. ZF_RING_2. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UHJ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPWTLAVTK WPPSAPVGHW RVSTRLSSSP GQLWGRPSNL SVEEHRASAP
60 70 80 90 100
AGRSPRMLHP ATQQSPFMVD LHEQVHQGPV PLSYTVTTVT TQGFPLPTSQ
110 120 130 140 150
HIPGCSAQQL PACSVMFSGQ HYPLCCLPPP QLIQACTMQQ LPGPYHTYPH
160 170 180 190 200
LISSDHYILH PPPPAPPPQP THMAPLGQFV SLQTQHPRMP LQRLDNEMDL
210 220 230 240 250
RGDQHPLGSF TYSTSATGPA LSPSVPLHYL PHDPLHQELS FGVPYSHMMP
260 270 280 290 300
RRLSTQRYRL QQPLPPPPPP PPPSYYPSFL PYFLSMLPMS PTTVGPTISL
310 320 330 340 350
DLDVDDVEME NYEALLNLAE RLGDAKPRGL TKADIEQLPS YRFNPDSHQS
360 370 380 390 400
EQTLCVVCFS DFEVRQLLRV LPCNHEFHAK CVDKWLKANR TCPICRADAS

EVPREAE
Length:407
Mass (Da):45,497
Last modified:October 11, 2005 - v1
Checksum:i0F161D01F3E72CA6
GO
Isoform 2 (identifier: Q3UHJ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.
     131-131: Missing.

Show »
Length:350
Mass (Da):39,200
Checksum:iC31626EC60CA3008
GO
Isoform 3 (identifier: Q3UHJ8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Note: No experimental confirmation available.
Show »
Length:351
Mass (Da):39,328
Checksum:iBE9305D2AC62E69A
GO

Sequence cautioni

The sequence AAH17630 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH35548 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC98100 differs from that shown. Reason: Frameshift at position 36.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0225501 – 56Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST56
Alternative sequenceiVSP_022551131Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129290 mRNA. Translation: BAC98100.1. Frameshift.
AK147349 mRNA. Translation: BAE27859.1.
AK160090 mRNA. Translation: BAE35621.1.
AK160115 mRNA. Translation: BAE35639.1.
AK171943 mRNA. Translation: BAE42740.1.
BC017630 mRNA. Translation: AAH17630.1. Different initiation.
BC035548 mRNA. Translation: AAH35548.1. Different initiation.
CCDSiCCDS49266.1. [Q3UHJ8-2]
CCDS49267.1. [Q3UHJ8-3]
RefSeqiNP_001139497.1. NM_001146025.1.
NP_001139498.1. NM_001146026.1. [Q3UHJ8-1]
NP_001139499.1. NM_001146027.1. [Q3UHJ8-3]
NP_598825.2. NM_134064.2. [Q3UHJ8-2]
XP_011242751.1. XM_011244449.1. [Q3UHJ8-3]
XP_011242752.1. XM_011244450.1. [Q3UHJ8-3]
XP_011242753.1. XM_011244451.1. [Q3UHJ8-2]
XP_017170825.1. XM_017315336.1. [Q3UHJ8-3]
UniGeneiMm.25366.

Genome annotation databases

EnsembliENSMUST00000037422; ENSMUSP00000043974; ENSMUSG00000034928. [Q3UHJ8-2]
ENSMUST00000128257; ENSMUSP00000116850; ENSMUSG00000034928. [Q3UHJ8-2]
ENSMUST00000134862; ENSMUSP00000114259; ENSMUSG00000034928. [Q3UHJ8-3]
ENSMUST00000150806; ENSMUSP00000123198; ENSMUSG00000034928. [Q3UHJ8-3]
ENSMUST00000177950; ENSMUSP00000136732; ENSMUSG00000034928. [Q3UHJ8-2]
GeneIDi105239.
KEGGimmu:105239.
UCSCiuc007qot.2. mouse. [Q3UHJ8-2]
uc007qou.2. mouse. [Q3UHJ8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRNF44_MOUSE
AccessioniPrimary (citable) accession number: Q3UHJ8
Secondary accession number(s): Q3TAC8
, Q3TVH9, Q6ZPX8, Q8VD22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 11, 2005
Last modified: August 30, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot