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Protein

RING finger protein 44

Gene

Rnf44

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri355 – 39642RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 44
Gene namesi
Name:Rnf44
Synonyms:Kiaa1100
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2145310. Rnf44.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407RING finger protein 44PRO_0000273414Add
BLAST

Proteomic databases

PRIDEiQ3UHJ8.

PTM databases

iPTMnetiQ3UHJ8.
PhosphoSiteiQ3UHJ8.

Expressioni

Gene expression databases

BgeeiQ3UHJ8.
CleanExiMM_RNF44.
ExpressionAtlasiQ3UHJ8. baseline and differential.
GenevisibleiQ3UHJ8. MM.

Structurei

3D structure databases

ProteinModelPortaliQ3UHJ8.
SMRiQ3UHJ8. Positions 332-401.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi123 – 296174Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri355 – 39642RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00730000110459.
HOGENOMiHOG000231638.
HOVERGENiHBG059283.
InParanoidiQ3UHJ8.
KOiK19041.
PhylomeDBiQ3UHJ8.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UHJ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPWTLAVTK WPPSAPVGHW RVSTRLSSSP GQLWGRPSNL SVEEHRASAP
60 70 80 90 100
AGRSPRMLHP ATQQSPFMVD LHEQVHQGPV PLSYTVTTVT TQGFPLPTSQ
110 120 130 140 150
HIPGCSAQQL PACSVMFSGQ HYPLCCLPPP QLIQACTMQQ LPGPYHTYPH
160 170 180 190 200
LISSDHYILH PPPPAPPPQP THMAPLGQFV SLQTQHPRMP LQRLDNEMDL
210 220 230 240 250
RGDQHPLGSF TYSTSATGPA LSPSVPLHYL PHDPLHQELS FGVPYSHMMP
260 270 280 290 300
RRLSTQRYRL QQPLPPPPPP PPPSYYPSFL PYFLSMLPMS PTTVGPTISL
310 320 330 340 350
DLDVDDVEME NYEALLNLAE RLGDAKPRGL TKADIEQLPS YRFNPDSHQS
360 370 380 390 400
EQTLCVVCFS DFEVRQLLRV LPCNHEFHAK CVDKWLKANR TCPICRADAS

EVPREAE
Length:407
Mass (Da):45,497
Last modified:October 11, 2005 - v1
Checksum:i0F161D01F3E72CA6
GO
Isoform 2 (identifier: Q3UHJ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.
     131-131: Missing.

Show »
Length:350
Mass (Da):39,200
Checksum:iC31626EC60CA3008
GO
Isoform 3 (identifier: Q3UHJ8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Note: No experimental confirmation available.
Show »
Length:351
Mass (Da):39,328
Checksum:iBE9305D2AC62E69A
GO

Sequence cautioni

The sequence AAH17630.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH35548.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC98100.1 differs from that shown. Reason: Frameshift at position 36. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5656Missing in isoform 2 and isoform 3. 2 PublicationsVSP_022550Add
BLAST
Alternative sequencei131 – 1311Missing in isoform 2. 2 PublicationsVSP_022551

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129290 mRNA. Translation: BAC98100.1. Frameshift.
AK147349 mRNA. Translation: BAE27859.1.
AK160090 mRNA. Translation: BAE35621.1.
AK160115 mRNA. Translation: BAE35639.1.
AK171943 mRNA. Translation: BAE42740.1.
BC017630 mRNA. Translation: AAH17630.1. Different initiation.
BC035548 mRNA. Translation: AAH35548.1. Different initiation.
CCDSiCCDS49266.1. [Q3UHJ8-2]
CCDS49267.1. [Q3UHJ8-3]
RefSeqiNP_001139497.1. NM_001146025.1.
NP_001139498.1. NM_001146026.1. [Q3UHJ8-1]
NP_001139499.1. NM_001146027.1. [Q3UHJ8-3]
NP_598825.2. NM_134064.2. [Q3UHJ8-2]
XP_011242750.1. XM_011244448.1. [Q3UHJ8-1]
XP_011242751.1. XM_011244449.1. [Q3UHJ8-3]
XP_011242752.1. XM_011244450.1. [Q3UHJ8-3]
XP_011242753.1. XM_011244451.1. [Q3UHJ8-2]
UniGeneiMm.25366.

Genome annotation databases

EnsembliENSMUST00000037422; ENSMUSP00000043974; ENSMUSG00000034928. [Q3UHJ8-2]
ENSMUST00000128257; ENSMUSP00000116850; ENSMUSG00000034928. [Q3UHJ8-2]
ENSMUST00000134862; ENSMUSP00000114259; ENSMUSG00000034928. [Q3UHJ8-3]
ENSMUST00000150806; ENSMUSP00000123198; ENSMUSG00000034928. [Q3UHJ8-3]
ENSMUST00000177950; ENSMUSP00000136732; ENSMUSG00000034928. [Q3UHJ8-2]
GeneIDi105239.
KEGGimmu:105239.
UCSCiuc007qot.2. mouse. [Q3UHJ8-2]
uc007qou.2. mouse. [Q3UHJ8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129290 mRNA. Translation: BAC98100.1. Frameshift.
AK147349 mRNA. Translation: BAE27859.1.
AK160090 mRNA. Translation: BAE35621.1.
AK160115 mRNA. Translation: BAE35639.1.
AK171943 mRNA. Translation: BAE42740.1.
BC017630 mRNA. Translation: AAH17630.1. Different initiation.
BC035548 mRNA. Translation: AAH35548.1. Different initiation.
CCDSiCCDS49266.1. [Q3UHJ8-2]
CCDS49267.1. [Q3UHJ8-3]
RefSeqiNP_001139497.1. NM_001146025.1.
NP_001139498.1. NM_001146026.1. [Q3UHJ8-1]
NP_001139499.1. NM_001146027.1. [Q3UHJ8-3]
NP_598825.2. NM_134064.2. [Q3UHJ8-2]
XP_011242750.1. XM_011244448.1. [Q3UHJ8-1]
XP_011242751.1. XM_011244449.1. [Q3UHJ8-3]
XP_011242752.1. XM_011244450.1. [Q3UHJ8-3]
XP_011242753.1. XM_011244451.1. [Q3UHJ8-2]
UniGeneiMm.25366.

3D structure databases

ProteinModelPortaliQ3UHJ8.
SMRiQ3UHJ8. Positions 332-401.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ3UHJ8.
PhosphoSiteiQ3UHJ8.

Proteomic databases

PRIDEiQ3UHJ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037422; ENSMUSP00000043974; ENSMUSG00000034928. [Q3UHJ8-2]
ENSMUST00000128257; ENSMUSP00000116850; ENSMUSG00000034928. [Q3UHJ8-2]
ENSMUST00000134862; ENSMUSP00000114259; ENSMUSG00000034928. [Q3UHJ8-3]
ENSMUST00000150806; ENSMUSP00000123198; ENSMUSG00000034928. [Q3UHJ8-3]
ENSMUST00000177950; ENSMUSP00000136732; ENSMUSG00000034928. [Q3UHJ8-2]
GeneIDi105239.
KEGGimmu:105239.
UCSCiuc007qot.2. mouse. [Q3UHJ8-2]
uc007qou.2. mouse. [Q3UHJ8-1]

Organism-specific databases

CTDi22838.
MGIiMGI:2145310. Rnf44.
RougeiSearch...

Phylogenomic databases

GeneTreeiENSGT00730000110459.
HOGENOMiHOG000231638.
HOVERGENiHBG059283.
InParanoidiQ3UHJ8.
KOiK19041.
PhylomeDBiQ3UHJ8.

Miscellaneous databases

ChiTaRSiRnf44. mouse.
PROiQ3UHJ8.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UHJ8.
CleanExiMM_RNF44.
ExpressionAtlasiQ3UHJ8. baseline and differential.
GenevisibleiQ3UHJ8. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Strain: C57BL/6J and NOD.
    Tissue: Osteoclast and Spleen.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Eye and Kidney.

Entry informationi

Entry nameiRNF44_MOUSE
AccessioniPrimary (citable) accession number: Q3UHJ8
Secondary accession number(s): Q3TAC8
, Q3TVH9, Q6ZPX8, Q8VD22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 11, 2005
Last modified: June 8, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.