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Protein
Submitted name:

TNF receptor-associated factor 3

Gene

Traf3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
TNF receptor-associated factor 3Imported
Gene namesi
Name:Traf3Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:108041. Traf3.

PTM / Processingi

Proteomic databases

PeptideAtlasiQ3UHJ1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021706.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 9140RING-typeInterPro annotationAdd
BLAST
Domaini134 – 18956TRAF-typeInterPro annotationAdd
BLAST
Domaini389 – 534146MATHInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MATH domain.UniRule annotation
Contains RING-type zinc finger.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiENOG410ISDV. Eukaryota.
ENOG410YQ97. LUCA.
GeneTreeiENSGT00550000074359.
HOGENOMiHOG000231557.
HOVERGENiHBG058222.
KOiK03174.

Family and domain databases

Gene3Di2.60.210.10. 1 hit.
3.30.40.10. 1 hit.
3.90.890.10. 1 hit.
InterProiIPR002083. MATH/TRAF_dom.
IPR013323. SIAH-type.
IPR012227. TNF_rcpt--assoc_TRAF.
IPR008974. TRAF-like.
IPR027128. TRAF3.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
IPR001293. Znf_TRAF.
[Graphical view]
PANTHERiPTHR10131:SF76. PTHR10131:SF76. 1 hit.
PfamiPF02176. zf-TRAF. 1 hit.
[Graphical view]
PIRSFiPIRSF015614. TRAF. 1 hit.
SMARTiSM00061. MATH. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 2 hits.
PROSITEiPS50144. MATH. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS50145. ZF_TRAF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UHJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSKKMDAA GTLQPNPPLK LQPDRGAGSV LVPEQGGYKE KFVKTVEDKY
60 70 80 90 100
KCEKCRLVLC NPKQTECGHR FCESCMAALL SSSSPKCTAC QESIIKDKVF
110 120 130 140 150
KDNCCKREIL ALQVYCRNEG RGCAEQLTLG HLLVHLKNEC QFEELPCLRA
160 170 180 190 200
DCKEKVLRKD LRDHVEKACK YREATCSHCK SQVPMIKLQK HEDTDCPCVV
210 220 230 240 250
VSCPHKCSVQ TLLRSEGTNQ QIKAHEASSA VQHVNLLKEW SNSLEKKVSL
260 270 280 290 300
LQNESVEKNK SIQSLHNQIC SFEIEIERQK EMLRNNESKI LHLQRVIDSQ
310 320 330 340 350
AEKLKELDKE IRPFRQNWEE ADSMKSSVES LQNRVTELES VDKSAGQAAR
360 370 380 390 400
NTGLLESQLS RHDQMLSVHD IRLADMDLRF QVLETASYNG VLIWKIRDYK
410 420 430 440 450
RRKQEAVMGK TLSLYSQPFY TGYFGYKMCA RVYLNGDGMG KGTHLSLFFV
460 470 480 490 500
IMRGEYDALL PWPFKQKVTL MLMDQGSSRR HLGDAFKPDP NSSSFKKPTG
510 520 530 540
EMNIASGCPV FVAQTVLENG TYIKDDTIFI KVIVDTSDLP DP
Length:542
Mass (Da):61,564
Last modified:October 11, 2005 - v1
Checksum:i63DF0A68EF3422A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122023 Genomic DNA. No translation available.
AC127580 Genomic DNA. No translation available.
AK147362 mRNA. Translation: BAE27866.1.
RefSeqiNP_001273051.1. NM_001286122.1.
NP_035762.2. NM_011632.3.
XP_006515865.1. XM_006515802.1.
UniGeneiMm.27431.

Genome annotation databases

EnsembliENSMUST00000060274; ENSMUSP00000058361; ENSMUSG00000021277.
ENSMUST00000117269; ENSMUSP00000112517; ENSMUSG00000021277.
GeneIDi22031.
KEGGimmu:22031.
UCSCiuc007pcn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122023 Genomic DNA. No translation available.
AC127580 Genomic DNA. No translation available.
AK147362 mRNA. Translation: BAE27866.1.
RefSeqiNP_001273051.1. NM_001286122.1.
NP_035762.2. NM_011632.3.
XP_006515865.1. XM_006515802.1.
UniGeneiMm.27431.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021706.

Proteomic databases

PeptideAtlasiQ3UHJ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060274; ENSMUSP00000058361; ENSMUSG00000021277.
ENSMUST00000117269; ENSMUSP00000112517; ENSMUSG00000021277.
GeneIDi22031.
KEGGimmu:22031.
UCSCiuc007pcn.2. mouse.

Organism-specific databases

CTDi7187.
MGIiMGI:108041. Traf3.

Phylogenomic databases

eggNOGiENOG410ISDV. Eukaryota.
ENOG410YQ97. LUCA.
GeneTreeiENSGT00550000074359.
HOGENOMiHOG000231557.
HOVERGENiHBG058222.
KOiK03174.

Miscellaneous databases

ChiTaRSiTraf3. mouse.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.210.10. 1 hit.
3.30.40.10. 1 hit.
3.90.890.10. 1 hit.
InterProiIPR002083. MATH/TRAF_dom.
IPR013323. SIAH-type.
IPR012227. TNF_rcpt--assoc_TRAF.
IPR008974. TRAF-like.
IPR027128. TRAF3.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
IPR001293. Znf_TRAF.
[Graphical view]
PANTHERiPTHR10131:SF76. PTHR10131:SF76. 1 hit.
PfamiPF02176. zf-TRAF. 1 hit.
[Graphical view]
PIRSFiPIRSF015614. TRAF. 1 hit.
SMARTiSM00061. MATH. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 2 hits.
PROSITEiPS50144. MATH. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS50145. ZF_TRAF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  10. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ3UHJ1_MOUSE
AccessioniPrimary (citable) accession number: Q3UHJ1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: July 6, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.