Tiam1

Functionⁱ

GO - Molecular functionⁱ

Rho guanyl-nucleotide exchange factor activity Source: InterPro
signal transducer activity, downstream of receptor Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

activation of GTPase activity Source: InterPro
intracellular signal transduction Source: InterPro
regulation of Rho protein signal transduction Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Guanine-nucleotide releasing factorSAAS annotation

Molecular function

Guanine-nucleotide releasing factorSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Putative uncharacterized proteinImported
Gene namesⁱ	Name:Tiam1Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:103306. Tiam1.

Subcellular locationⁱ

GO - Cellular componentⁱ

intracellular Source: GOC

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	Q3UHH6.

PaxDbⁱ

Q3UHH6.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000002489.
Genevisibleⁱ	Q3UHH6. MM.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	344 – 452	PHInterPro annotationAdd BLAST	109
Domainⁱ	670 – 737	RBD (Ras-binding)InterPro annotationAdd BLAST	68
Domainⁱ	750 – 813	PDZ (DHR)InterPro annotationAdd BLAST	64
Domainⁱ	945 – 1139	DH (DBL-homology)InterPro annotationAdd BLAST	195

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	458 – 485	Sequence analysisAdd BLAST		28

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG410ITS1. Eukaryota. ENOG410XPCM. LUCA.
HOVERGENⁱ	HBG059279.
KEGG Orthology (KO) More...KOⁱ	K05731.

Family and domain databases

Gene3Dⁱ	2.30.29.30. 2 hits.
InterProⁱ	View protein in InterPro IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR001478. PDZ. IPR011993. PH_dom-like. IPR001849. PH_domain. IPR003116. RBD_dom. IPR033360. TIAM1.
PANTHERⁱ	PTHR22826:SF183. PTHR22826:SF183. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00595. PDZ. 1 hit. PF00169. PH. 2 hits. PF02196. RBD. 1 hit. PF00621. RhoGEF. 1 hit.
SMARTⁱ	View protein in SMART SM00228. PDZ. 1 hit. SM00233. PH. 2 hits. SM00455. RBD. 1 hit. SM00325. RhoGEF. 1 hit.
SUPFAMⁱ	SSF48065. SSF48065. 1 hit. SSF50156. SSF50156. 1 hit. SSF50729. SSF50729. 2 hits.
PROSITEⁱ	View protein in PROSITE PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit. PS50106. PDZ. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS50898. RBD. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q3UHH6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGLRPVSYTD SSVTPSVDGS IVLTAASVQS MPDSEESRLY GDDATYLAEG 
        60         70         80         90        100
GRRQCPYTSN GPTFMETASF KKKRSKSADI WREDSLEFSL SDLSQEHLTS 
       110        120        130        140        150
NEEILGSAEE KDCEEARGME TEASPRQLST CQRANSLGDL YAQKNSGVKA 
       160        170        180        190        200
NGGPRNRFSS YCRNLVSDIP DLAKHKMPPA AAEETPPYSN YNTLPCRKSH 
       210        220        230        240        250
CLSEGATNPQ ISLSKSMQGR RAKTTQDVNT GEGSEFADSG IEGATTDTDL 
       260        270        280        290        300
LSRRSNATNS SYSPPTGRAF VGSDSGSSST GDAARQGVYE NFRRELEMST 
       310        320        330        340        350
TNSESLEEAG SAHSDEQSSG TLSSPGQSDI LLTAAQGTVR KAGALAVKNF 
       360        370        380        390        400
LVHKKNKKVE SATRRKWKHY WVSLKGCTLF FYETDGRSGI DHNSVPKHAV 
       410        420        430        440        450
WVENSIVQAV PEHPKKDFVF CLSNSLGDAF LFQTTSQTEL ENWITAIHSA 
       460        470        480        490        500
CAAAVARHHH KEDTLRLLKS EIKKLEQKID MDEKMKKMGE MQLSSVTDSK 
       510        520        530        540        550
KKKTILDQIF VWEQNLEQFQ MDLFRFRCYL ASLQGGELPN PKRLLAFASR 
       560        570        580        590        600
PTKVAMGRLG IFSVSSFHAL VAARTGEIGV RRRTQAMSRS ASKRRSRFSS 
       610        620        630        640        650
LWGLDTTSKK KQGRPTINQV FGEGTDAVKR SLEGIFDDTV PDGKREKEVV 
       660        670        680        690        700
LPSVHQHNPD CDIWVHEYFT PSWFCLPNNQ PALTVVRPGD TARDTLELIC 
       710        720        730        740        750
KTHQLDHSAH YLRLKFLMEN RVQFYIPQPE EDIYELLYKE IEICPKVTQN 
       760        770        780        790        800
IHIEKSDAAA DNYGFLLSSV DEDGIRRLYV NSVKETGLAS KKGLKAGDEI 
       810        820        830        840        850
LEINNRAAGT LNSSMLKDFL SQPSLGLLVR TYPEPEGGVE LLENPPHRVD 
       860        870        880        890        900
GPVDLGESPL AFLTSNPGHS LSSEQGSSAE TAPEEGEGPD LESSDETDHS 
       910        920        930        940        950
SKSTEQVAAF CRSLHEMSPS DSSPSPQDAT SPQLATTRQL SDADKLRKVI 
       960        970        980        990       1000
CELLETERTY VKDLNCLMER YLKPLQKETF LTQDELDVLF GNLTEMVEFQ 
      1010       1020       1030       1040       1050
VEFLKTLEDG VRLVPDLEKL EKVDQFKKVL FSLGGSFLYY ADRFKLYSAF 
      1060       1070       1080       1090       1100
CASHTKVPKV LVKAKTDTAF KAFLDAQNPR QQHSSTLESY LIKPIQRVLK 
      1110       1120       1130       1140       1150
YPLLLRELFA LTDAESEEHY HLDVAIKTMN KVASHINEMQ KIHEEFGAVF 
      1160       1170       1180       1190       1200
DQLIAEQTGE KKEVADLSMG DLLLHTSVIW LNPPASLGKW KKEPELAAFV 
      1210       1220       1230       1240       1250
FKTAVVLVYK DGSKQKKKLV GSHRLSIYEE WDPFRFRHMI PTEALQVRAL 
      1260       1270       1280       1290       1300
PSADAEANAV CEIVHVKSES EGRPERVFHL CCSSPESRKD FLKSVHSILR 
      1310       1320       1330       1340       1350
DKHRRQLLKT ESLPSAQQYV PFGGKRLCAL KGARPAMSRA VSAPSKSLGR 
      1360       1370       1380       1390       1400
RRRRLARNRF TIDSDAISAS SPEKEPQQPA GGGDTDRWVE EQFDLAQYEE 
      1410       1420       1430       1440       1450
QDDIKETDIL SDDDEFCESL KGASVDRDLQ EQLQAASISQ RARGRRTLDS 
      1460       1470       1480       1490 
HASRMTQLKK QAALSGINGG LESASEEVIW VRREDFAPSR KLNTEI

Length:1,496

Mass (Da):166,909

Last modified:October 11, 2005 - v1

Checksum:ⁱ7BB89C7D7A2D89A4

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK147392 mRNA. Translation: BAE27881.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001139358.1. NM_001145886.1. NP_001139359.1. NM_001145887.1. NP_033410.2. NM_009384.3.
UniGeneⁱ	Mm.310902.

Genome annotation databases

GeneIDⁱ	21844.
KEGGⁱ	mmu:21844.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK147392 mRNA. Translation: BAE27881.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001139358.1. NM_001145886.1. NP_001139359.1. NM_001145887.1. NP_033410.2. NM_009384.3.
UniGeneⁱ	Mm.310902.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PaxDbⁱ	Q3UHH6.

PaxDbⁱ

Q3UHH6.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	21844.
KEGGⁱ	mmu:21844.

Organism-specific databases

CTDⁱ	7074.
MGIⁱ	MGI:103306. Tiam1.

Phylogenomic databases

eggNOGⁱ	ENOG410ITS1. Eukaryota. ENOG410XPCM. LUCA.
HOVERGENⁱ	HBG059279.
KEGG Orthology (KO) More...KOⁱ	K05731.

Miscellaneous databases

ChiTaRSⁱ	Tiam1. mouse.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000002489.
Genevisibleⁱ	Q3UHH6. MM.

Family and domain databases

Gene3Dⁱ	2.30.29.30. 2 hits.
InterProⁱ	View protein in InterPro IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR001478. PDZ. IPR011993. PH_dom-like. IPR001849. PH_domain. IPR003116. RBD_dom. IPR033360. TIAM1.
PANTHERⁱ	PTHR22826:SF183. PTHR22826:SF183. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00595. PDZ. 1 hit. PF00169. PH. 2 hits. PF02196. RBD. 1 hit. PF00621. RhoGEF. 1 hit.
SMARTⁱ	View protein in SMART SM00228. PDZ. 1 hit. SM00233. PH. 2 hits. SM00455. RBD. 1 hit. SM00325. RhoGEF. 1 hit.
SUPFAMⁱ	SSF48065. SSF48065. 1 hit. SSF50156. SSF50156. 1 hit. SSF50729. SSF50729. 2 hits.
PROSITEⁱ	View protein in PROSITE PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit. PS50106. PDZ. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS50898. RBD. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q3UHH6_MOUSE
Accessionⁱ	Q3UHH6Primary (citable) accession number: Q3UHH6
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 11, 2005
	Last sequence update:	October 11, 2005
	Last modified:	July 5, 2017
	This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB - Q3UHH6 (Q3UHH6_MOUSE)

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Putative uncharacterized protein

Select a section on the left to see content.

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Proteomic databases

Expressionⁱ

Gene expression databases

Family & Domainsⁱ

Domains and Repeats

Coiled coil

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3UHH6 (Q3UHH6_MOUSE)

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Putative uncharacterized protein

Tiam1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ