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Protein

Solute carrier family 22 member 23

Gene

Slc22a23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 23
Gene namesi
Name:Slc22a23
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1920352. Slc22a23.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei229 – 24921HelicalSequence analysisAdd
BLAST
Transmembranei253 – 27321HelicalSequence analysisAdd
BLAST
Transmembranei283 – 30321HelicalSequence analysisAdd
BLAST
Transmembranei310 – 33021HelicalSequence analysisAdd
BLAST
Transmembranei339 – 35921HelicalSequence analysisAdd
BLAST
Transmembranei466 – 48621HelicalSequence analysisAdd
BLAST
Transmembranei489 – 50921HelicalSequence analysisAdd
BLAST
Transmembranei541 – 56121HelicalSequence analysisAdd
BLAST
Transmembranei572 – 59221HelicalSequence analysisAdd
BLAST
Transmembranei601 – 62121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 689689Solute carrier family 22 member 23PRO_0000308316Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence analysis
Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ3UHH2.
PaxDbiQ3UHH2.
PRIDEiQ3UHH2.

PTM databases

iPTMnetiQ3UHH2.
PhosphoSiteiQ3UHH2.

Expressioni

Gene expression databases

BgeeiQ3UHH2.
CleanExiMM_SLC22A23.
ExpressionAtlasiQ3UHH2. baseline and differential.
GenevisibleiQ3UHH2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042742.

Structurei

3D structure databases

ProteinModelPortaliQ3UHH2.
SMRiQ3UHH2. Positions 230-378.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
ENOG410ZZ6M. LUCA.
GeneTreeiENSGT00390000014377.
HOGENOMiHOG000124569.
HOVERGENiHBG108437.
InParanoidiQ3UHH2.
KOiK08215.
OMAiCPPGRRF.
OrthoDBiEOG754HP0.
PhylomeDBiQ3UHH2.
TreeFamiTF335753.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UHH2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAIDRRREAA GSGAGRQPAP AEENGSLPPG DAAASAPLGG RAGSGSSAEI
60 70 80 90 100
QPLPALHPSG GPHSSCCAAT AAPSLLLLDY DGSVLPFLGG LGGGYQKTLV
110 120 130 140 150
VLTWIPALFI GFSQFSDSFL LDQPDFWCRG AGKGTELAGA TVTGRWGDMG
160 170 180 190 200
NWTSPSATPF STASWGTTSN RSNSSDTPPL PSPPGKGNND SNCDCHAWDY
210 220 230 240 250
GIRTGLIQNV VSKWDLVCDN TWKVHIAKFS LLVGLIFGYL ITGCIADWVG
260 270 280 290 300
RRPVLLFSTI FILIFGLTVA LSVNVTMFST LRFFEGFCLA GIILTLYALR
310 320 330 340 350
IELCPPGKRF IITMVASFVA MAGQFLMPGL AALCRDWQVL QALIICPFLL
360 370 380 390 400
MLLYWSIFPE SLRWLMATQQ FESAKKLILY LTQKNCVSPE SDIKGVMPEL
410 420 430 440 450
EKELSRRPKK VCIVKVVGTR NLWKNIVVLC VNSLTGYGIH HCFARSMMGH
460 470 480 490 500
EVKVPLLENF YADYYTMASI ALASCLAMCL VVKFLGRRGG LLLFMILTAL
510 520 530 540 550
ASLLQLGLLN LIGKYSQHPD SELQLKLAVG MSDSVKDKFS IAFSIVGMFA
560 570 580 590 600
SHAVGSLSVF FCAEITPTVI RCGGLGLVLA SAGFGMLTAP IIELHNQKGY
610 620 630 640 650
FLHHIIFACC TLICIICILL LPESRNQNLP ENIANGEHYT RQPLLPHKKG
660 670 680
EQPLLLTNAE LKDYSGLHDV AAVGDGLPEG ATANGMKTM
Length:689
Mass (Da):74,325
Last modified:October 11, 2005 - v1
Checksum:i928C97B6BF58F02D
GO
Isoform 2 (identifier: Q3UHH2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-276: Missing.
     522-529: Missing.

Show »
Length:405
Mass (Da):44,679
Checksum:iEB20D41C3AD4C53C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti370 – 3701Q → R in AAH53705 (PubMed:15489334).Curated
Sequence conflicti501 – 5011A → V in AAH53705 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 276276Missing in isoform 2. 1 PublicationVSP_028957Add
BLAST
Alternative sequencei522 – 5298Missing in isoform 2. 1 PublicationVSP_028958

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147397 mRNA. Translation: BAE27885.1.
BC053705 mRNA. Translation: AAH53705.1.
CCDSiCCDS26446.1. [Q3UHH2-1]
RefSeqiNP_001028339.1. NM_001033167.3. [Q3UHH2-1]
UniGeneiMm.23932.

Genome annotation databases

EnsembliENSMUST00000040336; ENSMUSP00000042742; ENSMUSG00000038267. [Q3UHH2-1]
GeneIDi73102.
KEGGimmu:73102.
UCSCiuc007qbg.1. mouse. [Q3UHH2-2]
uc007qbh.1. mouse. [Q3UHH2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147397 mRNA. Translation: BAE27885.1.
BC053705 mRNA. Translation: AAH53705.1.
CCDSiCCDS26446.1. [Q3UHH2-1]
RefSeqiNP_001028339.1. NM_001033167.3. [Q3UHH2-1]
UniGeneiMm.23932.

3D structure databases

ProteinModelPortaliQ3UHH2.
SMRiQ3UHH2. Positions 230-378.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042742.

PTM databases

iPTMnetiQ3UHH2.
PhosphoSiteiQ3UHH2.

Proteomic databases

MaxQBiQ3UHH2.
PaxDbiQ3UHH2.
PRIDEiQ3UHH2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040336; ENSMUSP00000042742; ENSMUSG00000038267. [Q3UHH2-1]
GeneIDi73102.
KEGGimmu:73102.
UCSCiuc007qbg.1. mouse. [Q3UHH2-2]
uc007qbh.1. mouse. [Q3UHH2-1]

Organism-specific databases

CTDi63027.
MGIiMGI:1920352. Slc22a23.

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
ENOG410ZZ6M. LUCA.
GeneTreeiENSGT00390000014377.
HOGENOMiHOG000124569.
HOVERGENiHBG108437.
InParanoidiQ3UHH2.
KOiK08215.
OMAiCPPGRRF.
OrthoDBiEOG754HP0.
PhylomeDBiQ3UHH2.
TreeFamiTF335753.

Miscellaneous databases

ChiTaRSiSlc22a23. mouse.
PROiQ3UHH2.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UHH2.
CleanExiMM_SLC22A23.
ExpressionAtlasiQ3UHH2. baseline and differential.
GenevisibleiQ3UHH2. MM.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C3H/He.
    Tissue: Osteoblast.
  3. "Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family."
    Jacobsson J.A., Haitina T., Lindblom J., Fredriksson R.
    Genomics 90:595-609(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiS22AN_MOUSE
AccessioniPrimary (citable) accession number: Q3UHH2
Secondary accession number(s): Q7TPT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 11, 2005
Last modified: June 8, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.