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Protein

Calcium-transporting ATPase

Gene

Atp2b2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.UniRule annotation

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processCalcium transportUniRule annotation, Ion transport, Transport
LigandATP-bindingUniRule annotationSAAS annotation, Calcium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPaseUniRule annotation (EC:3.6.3.8UniRule annotation)
Gene namesi
Name:Atp2b2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:105368. Atp2b2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei98 – 121HelicalUniRule annotationAdd BLAST24
Transmembranei151 – 170HelicalUniRule annotationAdd BLAST20
Transmembranei357 – 378HelicalUniRule annotationAdd BLAST22
Transmembranei398 – 424HelicalUniRule annotationAdd BLAST27
Transmembranei906 – 924HelicalUniRule annotationAdd BLAST19
Transmembranei982 – 1002HelicalUniRule annotationAdd BLAST21
Transmembranei1014 – 1035HelicalUniRule annotationAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ3UHH0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030302.
GenevisibleiQ3UHH0. MM.

Interactioni

Protein-protein interaction databases

IntActiQ3UHH0. 1 interactor.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 123Cation_ATPase_NInterPro annotationAdd BLAST77

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0204. Eukaryota.
ENOG410XNNC. LUCA.
GeneTreeiENSGT00510000046331.
HOVERGENiHBG061286.
KOiK05850.

Family and domain databases

Gene3Di3.40.1110.10. 2 hits.
InterProiView protein in InterPro
IPR030322. ATP2B2.
IPR022141. ATP_Ca_trans_C.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006408. P-type_ATPase_IIB.
IPR001757. P_typ_ATPase.
PANTHERiPTHR24093:SF370. PTHR24093:SF370. 1 hit.
PfamiView protein in Pfam
PF12424. ATP_Ca_trans_C. 1 hit.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF08282. Hydrolase_3. 1 hit.
SMARTiView protein in SMART
SM00831. Cation_ATPase_N. 1 hit.
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81653. SSF81653. 1 hit.
SSF81660. SSF81660. 1 hit.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3UHH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDMTNSDFY SKNQRNESSH GGEFGCTMEE LRSLMELRGT EAVVKIKETY
60 70 80 90 100
GDTEAICRRL KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW
110 120 130 140 150
EALQDVTLII LEIAAIISLG LSFYHPPGES NEGCATAQGG AEDEGEAEAG
160 170 180 190 200
WIEGAAILLS VICVVLVTAF NDWSKEKQFR GLQSRIEQEQ KFTVVRAGQV
210 220 230 240 250
VQIPVAEIVV GDIAQIKYGD LLPADGLFIQ GNDLKIDESS LTGESDQVRK
260 270 280 290 300
SVDKDPMLLS GTHVMEGSGR MVVTAVGVNS QTGIIFTLLG AGGEEEEKKD
310 320 330 340 350
KKAKQQDGAA AMEMQPLKSA EGGDADDKKK ANMHKKEKSV LQGKLTKLAV
360 370 380 390 400
QIGKAGLVMS AITVIILVLY FTVDTFVVNK KPWLTECTPV YVQYFVKFFI
410 420 430 440 450
IGVTVLVVAV PEGLPLAVTI SLAYSVKKMM KDNNLVRHLD ACETMGNATA
460 470 480 490 500
ICSDKTGTLT TNRMTVVQAY VGDVHYKEIP DPSSINAKTL ELLVNAIAIN
510 520 530 540 550
SAYTTKILPP EKEGALPRQV GNKTECGLLG FVLDLRQDYE PVRSQMPEEK
560 570 580 590 600
LYKVYTFNSV RKSMSTVIKM PDESFRMYSK GASEIVLKKC CKILSGAGEA
610 620 630 640 650
RVFRPRDRDE MVKKVIEPMA CDGLRTICVA YRDFPSSPEP DWDNENDILN
660 670 680 690 700
ELTCICVVGI EDPVPEAIRK CQRAGITVRM VTGDNINTAR AIAIKCGIIH
710 720 730 740 750
PGEDFLCLEG KEFNRRIRNE KGEIEQERID KIWPKLRVLA RSSPTDKHTL
760 770 780 790 800
VKGIIDSTHT EQRQVVAVTG DGTNDGPALK KADVGFAMGI AGTDVAKEAS
810 820 830 840 850
DIILTDDNFS SIVKAVMWGR NVYDSISKFL QFQLTVNVVA VIVAFTGACI
860 870 880 890 900
TQDSPLKAVQ MLWVNLIMDT FASLALATEP PTETLLLRKP YGRNKPLISR
910 920 930 940 950
TMMKNILGHA VYQLTLIFTL LFVGEKMFQI DSGRNAPLHS PPSEHYTIIF
960 970 980 990 1000
NTFVMMQLFN EINARKIHGE RNVFDGIFRN PIFCTIVLGT FAIQIVIVQF
1010 1020 1030 1040 1050
GGKPFSCSPL QLDQWMWCIF IGLGELVWGQ VIATIPTSRL KFLKEAGRLT
1060 1070 1080 1090 1100
QKEEIPEEEL NEDVEEIDHA ERELRRGQIL WFRGLNRIQT QIRVVKAFRS
1110 1120 1130 1140 1150
SLYEGLEKPE SRTSIHNFMA HPEFRIEDSQ PHIPLIDDTD LEEDAALKQN
1160 1170 1180 1190
SSPPSSLNKN NSAIDSGINL TTDTSKSATS SSPGSPIHSL ETSL
Length:1,194
Mass (Da):132,106
Last modified:October 11, 2005 - v1
Checksum:iA26599F258AA50C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117596 Genomic DNA. No translation available.
AC153590 Genomic DNA. No translation available.
AK147399 mRNA. Translation: BAE27887.1.
RefSeqiNP_001031761.1. NM_001036684.3.
UniGeneiMm.321755.
Mm.443564.

Genome annotation databases

EnsembliENSMUST00000205052; ENSMUSP00000145174; ENSMUSG00000030302.
GeneIDi11941.
KEGGimmu:11941.
UCSCiuc012eqi.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ3UHH0_MOUSE
AccessioniPrimary (citable) accession number: Q3UHH0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: September 27, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported