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Protein

Protein LCHN

Gene

Lchn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LCHN
Gene namesi
Name:Lchn
Synonyms:Kiaa1147
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2444256. E330009J07Rik.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003152222 – 455Protein LCHNAdd BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylvalineBy similarity1
Modified residuei41Omega-N-methylarginineBy similarity1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

MaxQBiQ3UHG7.
PaxDbiQ3UHG7.
PeptideAtlasiQ3UHG7.
PRIDEiQ3UHG7.

PTM databases

iPTMnetiQ3UHG7.
PhosphoSitePlusiQ3UHG7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037172.
CleanExiMM_E330009J07RIK.
ExpressionAtlasiQ3UHG7. baseline and differential.
GenevisibleiQ3UHG7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045103.

Structurei

3D structure databases

ProteinModelPortaliQ3UHG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 187uDENNPROSITE-ProRule annotationAdd BLAST173
Domaini214 – 362cDENNPROSITE-ProRule annotationAdd BLAST149
Domaini364 – 455dDENNPROSITE-ProRule annotationAdd BLAST92

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi276 – 279Poly-Cys4

Sequence similaritiesi

Belongs to the LCHN family.Curated

Phylogenomic databases

eggNOGiKOG4704. Eukaryota.
ENOG410XQBR. LUCA.
GeneTreeiENSGT00590000083189.
HOGENOMiHOG000261648.
HOVERGENiHBG108083.
InParanoidiQ3UHG7.
OMAiFILFFME.
OrthoDBiEOG091G0CRD.
PhylomeDBiQ3UHG7.
TreeFamiTF329174.

Family and domain databases

InterProiView protein in InterPro
IPR018626. DUF2347.
PfamiView protein in Pfam
PF09804. DUF2347. 1 hit.
PROSITEiView protein in PROSITE
PS50211. DENN. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UHG7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVEQGDAAPL LRWAEGPAVS VPQDPALQAG GWVRGGSGEG RVAAEAPRRR
60 70 80 90 100
EPDEPAPPEV LLQPGRLELG DVEEDQVVAV FVVTFDPRSG NMVEWCLPQD
110 120 130 140 150
IDLEGVEFKS MASGSHKVQS DFIYFRKGPF FGLACFANMP VESELERGAR
160 170 180 190 200
MKSVGILSPS YTLLYRYMHF LENQVRHQLE MPGHYSHLAA FYEDKKGVLH
210 220 230 240 250
AGPGRGGSLP PVYWLPSIHR YMYPEMKITH PAGCMSQFIK FFGEQILILW
260 270 280 290 300
KFALLRKRIL IFSPPPVGVV CYRVYCCCCL ANVSLPGIGG TIPESKPFFY
310 320 330 340 350
VNVADIESLE VEVSYVACTT EKIFEEKREL YDVYVDNQNV KTHHDHLQPL
360 370 380 390 400
LKINSADREK YRRLNEQRQM LLYSQEVEGD YSPCEEDLFV LFFLEQNNRI
410 420 430 440 450
FQTLLEVSAS QDKTLTAEHA RGMGLDPQGD RSFLMDLLEA YGIDVMLVID

NPCCP
Length:455
Mass (Da):51,428
Last modified:October 11, 2005 - v1
Checksum:i7CC18AB0A2B970D1
GO
Isoform 2 (identifier: Q3UHG7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     392-455: Missing.

Show »
Length:391
Mass (Da):44,257
Checksum:i460BFBD88ABADE92
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030494392 – 455Missing in isoform 2. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122457 mRNA. Translation: BAC65739.1.
AK054277 mRNA. Translation: BAC35714.1.
AK139744 mRNA. Translation: BAE24121.1.
AK147402 mRNA. Translation: BAE27890.1.
CCDSiCCDS20028.1. [Q3UHG7-2]
RefSeqiNP_780737.1. NM_175528.4. [Q3UHG7-2]
UniGeneiMm.333006.

Genome annotation databases

EnsembliENSMUST00000039008; ENSMUSP00000045103; ENSMUSG00000037172. [Q3UHG7-2]
ENSMUST00000101492; ENSMUSP00000099031; ENSMUSG00000037172. [Q3UHG7-1]
GeneIDi243780.
KEGGimmu:243780.
UCSCiuc009bmo.1. mouse. [Q3UHG7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLCHN_MOUSE
AccessioniPrimary (citable) accession number: Q3UHG7
Secondary accession number(s): Q3UT59, Q80TI8, Q8C6M2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2005
Last modified: September 27, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families