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Protein

Protein LCHN

Gene

Lchn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LCHN
Gene namesi
Name:Lchn
Synonyms:Kiaa1147
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2444256. E330009J07Rik.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Protein LCHNPRO_0000315222Add
BLAST

Proteomic databases

MaxQBiQ3UHG7.
PaxDbiQ3UHG7.
PeptideAtlasiQ3UHG7.
PRIDEiQ3UHG7.

PTM databases

iPTMnetiQ3UHG7.
PhosphoSiteiQ3UHG7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037172.
CleanExiMM_E330009J07RIK.
ExpressionAtlasiQ3UHG7. baseline and differential.
GenevisibleiQ3UHG7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045103.

Structurei

3D structure databases

ProteinModelPortaliQ3UHG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi276 – 2794Poly-Cys

Sequence similaritiesi

Belongs to the LCHN family.Curated

Phylogenomic databases

eggNOGiKOG4704. Eukaryota.
ENOG410XQBR. LUCA.
GeneTreeiENSGT00590000083189.
HOGENOMiHOG000261648.
HOVERGENiHBG108083.
InParanoidiQ3UHG7.
OMAiFILFFME.
OrthoDBiEOG091G0CRD.
PhylomeDBiQ3UHG7.
TreeFamiTF329174.

Family and domain databases

InterProiIPR018626. DUF2347.
[Graphical view]
PfamiPF09804. DUF2347. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UHG7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVEQGDAAPL LRWAEGPAVS VPQDPALQAG GWVRGGSGEG RVAAEAPRRR
60 70 80 90 100
EPDEPAPPEV LLQPGRLELG DVEEDQVVAV FVVTFDPRSG NMVEWCLPQD
110 120 130 140 150
IDLEGVEFKS MASGSHKVQS DFIYFRKGPF FGLACFANMP VESELERGAR
160 170 180 190 200
MKSVGILSPS YTLLYRYMHF LENQVRHQLE MPGHYSHLAA FYEDKKGVLH
210 220 230 240 250
AGPGRGGSLP PVYWLPSIHR YMYPEMKITH PAGCMSQFIK FFGEQILILW
260 270 280 290 300
KFALLRKRIL IFSPPPVGVV CYRVYCCCCL ANVSLPGIGG TIPESKPFFY
310 320 330 340 350
VNVADIESLE VEVSYVACTT EKIFEEKREL YDVYVDNQNV KTHHDHLQPL
360 370 380 390 400
LKINSADREK YRRLNEQRQM LLYSQEVEGD YSPCEEDLFV LFFLEQNNRI
410 420 430 440 450
FQTLLEVSAS QDKTLTAEHA RGMGLDPQGD RSFLMDLLEA YGIDVMLVID

NPCCP
Length:455
Mass (Da):51,428
Last modified:October 11, 2005 - v1
Checksum:i7CC18AB0A2B970D1
GO
Isoform 2 (identifier: Q3UHG7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     392-455: Missing.

Show »
Length:391
Mass (Da):44,257
Checksum:i460BFBD88ABADE92
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei392 – 45564Missing in isoform 2. 1 PublicationVSP_030494Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122457 mRNA. Translation: BAC65739.1.
AK054277 mRNA. Translation: BAC35714.1.
AK139744 mRNA. Translation: BAE24121.1.
AK147402 mRNA. Translation: BAE27890.1.
CCDSiCCDS20028.1. [Q3UHG7-2]
RefSeqiNP_780737.1. NM_175528.4. [Q3UHG7-2]
UniGeneiMm.333006.

Genome annotation databases

EnsembliENSMUST00000039008; ENSMUSP00000045103; ENSMUSG00000037172. [Q3UHG7-2]
ENSMUST00000101492; ENSMUSP00000099031; ENSMUSG00000037172. [Q3UHG7-1]
GeneIDi243780.
KEGGimmu:243780.
UCSCiuc009bmo.1. mouse. [Q3UHG7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122457 mRNA. Translation: BAC65739.1.
AK054277 mRNA. Translation: BAC35714.1.
AK139744 mRNA. Translation: BAE24121.1.
AK147402 mRNA. Translation: BAE27890.1.
CCDSiCCDS20028.1. [Q3UHG7-2]
RefSeqiNP_780737.1. NM_175528.4. [Q3UHG7-2]
UniGeneiMm.333006.

3D structure databases

ProteinModelPortaliQ3UHG7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045103.

PTM databases

iPTMnetiQ3UHG7.
PhosphoSiteiQ3UHG7.

Proteomic databases

MaxQBiQ3UHG7.
PaxDbiQ3UHG7.
PeptideAtlasiQ3UHG7.
PRIDEiQ3UHG7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039008; ENSMUSP00000045103; ENSMUSG00000037172. [Q3UHG7-2]
ENSMUST00000101492; ENSMUSP00000099031; ENSMUSG00000037172. [Q3UHG7-1]
GeneIDi243780.
KEGGimmu:243780.
UCSCiuc009bmo.1. mouse. [Q3UHG7-1]

Organism-specific databases

MGIiMGI:2444256. E330009J07Rik.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4704. Eukaryota.
ENOG410XQBR. LUCA.
GeneTreeiENSGT00590000083189.
HOGENOMiHOG000261648.
HOVERGENiHBG108083.
InParanoidiQ3UHG7.
OMAiFILFFME.
OrthoDBiEOG091G0CRD.
PhylomeDBiQ3UHG7.
TreeFamiTF329174.

Miscellaneous databases

PROiQ3UHG7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037172.
CleanExiMM_E330009J07RIK.
ExpressionAtlasiQ3UHG7. baseline and differential.
GenevisibleiQ3UHG7. MM.

Family and domain databases

InterProiIPR018626. DUF2347.
[Graphical view]
PfamiPF09804. DUF2347. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLCHN_MOUSE
AccessioniPrimary (citable) accession number: Q3UHG7
Secondary accession number(s): Q3UT59, Q80TI8, Q8C6M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.