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Q3UHF7 (ZEP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor HIVEP2
Alternative name(s):
Human immunodeficiency virus type I enhancer-binding protein 2 homolog
Myc intron-binding protein 1
Short name=MIBP-1
Gene names
Name:Hivep2
Synonyms:Mibp1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length2430 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation By similarity. Ref.1

Subunit structure

Interacts with TCF4. Ref.1

Subcellular location

Nucleus.

Tissue specificity

Expressed in heart, lung, skeletal muscle and liver. In the brain expressed in cerebral cortex, hippocampus, corpora amygdala and cerebellar cortex. Ref.1

Developmental stage

At E13.5 and E15.5 expressed in anterior neural tube over primordial frontal cortex, spinal cord, dorsal root glanglia and developing skeletal muscle. Ref.1

Sequence similarities

Contains 4 C2H2-type zinc fingers.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 24302430Transcription factor HIVEP2
PRO_0000047372

Regions

Repeat2037 – 204041
Repeat2043 – 204642
Repeat2055 – 205843
Repeat2067 – 207044
Repeat2073 – 207645
Repeat2090 – 209346
Repeat2096 – 209947
Repeat2102 – 210548
Repeat2114 – 211749
Repeat2129 – 2132410
Zinc finger189 – 21123C2H2-type 1
Zinc finger217 – 23923C2H2-type 2
Zinc finger1783 – 180523C2H2-type 3
Zinc finger1811 – 183525C2H2-type 4
Region2037 – 21329610 X 4 AA tandem repeats of S-P-[RGMKC]-[RK]
Motif929 – 9357Nuclear localization signal Potential
Compositional bias942 – 97433Ser-rich
Compositional bias1499 – 156971Ser-rich
Compositional bias1883 – 190725Asp/Glu-rich (acidic)
Compositional bias2057 – 213276Arg-rich

Amino acid modifications

Cross-link2076Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Experimental info

Sequence conflict5721G → E in CAA75868. Ref.1
Sequence conflict6611S → P in CAA75868. Ref.1
Sequence conflict7491D → N in CAA75868. Ref.1
Sequence conflict7621S → G in CAA75868. Ref.1
Sequence conflict11121S → P in CAA75868. Ref.1
Sequence conflict12111P → S in CAA75868. Ref.1
Sequence conflict12231A → G in CAA75868. Ref.1
Sequence conflict14961C → S in CAA75868. Ref.1
Sequence conflict20011D → E in BAE23294. Ref.2
Sequence conflict20911P → A in CAA75868. Ref.1
Sequence conflict21221M → L in CAA75868. Ref.1
Sequence conflict22631S → C in BAE23336. Ref.2
Sequence conflict22941T → A in BAE23294. Ref.2
Sequence conflict23141T → A in CAA75868. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q3UHF7 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 265694210C8A7024

FASTA2,430266,705
        10         20         30         40         50         60 
MDTGDTALGQ KATSRSGETD SVSGRWRQEQ SAVLKMSTFS SQEGPRQPQI DPEQIGNAAS 

        70         80         90        100        110        120 
AQLFGSGKLA SPGEGLHQVT EKQYPPHRPS PYPCQHSLSF PQHSLSQGMT HSHKPHQSLE 

       130        140        150        160        170        180 
GPPWLFPGPL PSVASEDLFP FPMHGHSGGY PRKKISNLNP AYSQYSQKSI EQAEDAHKKE 

       190        200        210        220        230        240 
HKPKKPGKYI CPYCSRACAK PSVLKKHIRS HTGERPYPCI PCGFSFKTKS NLYKHRKSHA 

       250        260        270        280        290        300 
HAIKAGLVPF TESSVSKLDL EAGFIDVEAE IHSDGEQSTD TDEESSLFAE ASDKVSPGPP 

       310        320        330        340        350        360 
VPLDIASRGG YHGSLEESLG GPMKVPILII PKSGIPLASE GSQYLSSEML PNPSLNAKAD 

       370        380        390        400        410        420 
DSHTVKQKLA LRLSEKKGQD SEPSLNLLSP HSKGSTDSGY FSRSESAEQQ ISPPNTNAKS 

       430        440        450        460        470        480 
YEEIIFGKYC RLSPRNTLSV TPTGQERTAM GRRGIMEPLP HLNTRLEVKM FEDPISQLNP 

       490        500        510        520        530        540 
SKGEMDPGQI NMLKTTKFNS ECRQPQAIPS SVRNEGKPYP GNFLGSNPML LEAPVDSSPL 

       550        560        570        580        590        600 
IRSNSMPTSS ATNLSVPPSL RGSHSFDERM TGSDDVFYPG TVGIPPQRML RRQAAFELPS 

       610        620        630        640        650        660 
VQEGHMESEH PARVSKGLAS PSLKEKKLLP GDRPGYDYDV CRKPYKKWED SETLKQSYLG 

       670        680        690        700        710        720 
SFKQGGEYFM DPSVPVQGVP TMFGTTCENR KRRKEKSVGD EEDVPMICGG MGNAPVGMMS 

       730        740        750        760        770        780 
SEYDPKLQDG GRSGFAMTAH ESLAHGHSDR LDPARPQLPS RSPSLGSEDL PLAADPDKMT 

       790        800        810        820        830        840 
DLGKKPPGNV ISVIQHTNSL SRPNSFERSE STEMVACPQD KTPSPAETCD SEVLEAPVSP 

       850        860        870        880        890        900 
EWAPPGDGGE SGSKPTPSQQ VPQHSYHAQP RLVRQHNIQV PEIRVTEEPD KPEKEKEAPT 

       910        920        930        940        950        960 
KEPEKPVEEF QWPQRSETLS QLPAEKLPPK KKRLRLADLE HSSGESSFES TGTGLSRSPS 

       970        980        990       1000       1010       1020 
QESNLSHSSS FSMSFDREET VKLTAPPKQD ESGKHSEFLT VPAGSYSLSV PGHHHQKEMR 

      1030       1040       1050       1060       1070       1080 
RCSSEQMPCP HPTEVPEIRS KSFDYGNLSH APVAGTSPST LSPSRERKKC FLVRQASFSG 

      1090       1100       1110       1120       1130       1140 
SPEIAQGEAG VDPSVKQEHM EHLHAGLRAA WSSVLPPLPG DDPGKQVGTC GPLSSGPPLH 

      1150       1160       1170       1180       1190       1200 
LTQQQIMHMD SQESLRNPLI QPTSYMTSKH LPEQPHLFPH QDAVPFSPIQ NALFQFQYPT 

      1210       1220       1230       1240       1250       1260 
VCMVHLPAQQ PPWWQTHFPH PFAPHPQNSY SKPPFQADLH SSYPLEHVAE HTGKKSADYP 

      1270       1280       1290       1300       1310       1320 
HAKEQTYPCY SGTSGLHSKN LPLKFPSDPG SKSTETPTEQ LLREDFASEN AGPLQSLPGT 

      1330       1340       1350       1360       1370       1380 
VVPVRIQTHV PSYGSVMYTS ISQILGQNSP AIVICKVDEN MTQRTLVTNA AMQGIGLNIA 

      1390       1400       1410       1420       1430       1440 
QVLGQHTGLE KYPLWKVPQT LPLGLESSIP LCLPSTSDNA ASLGGSKRML SPASSLELFM 

      1450       1460       1470       1480       1490       1500 
ETKQQKRVKE EKMYGQIVEE LSAVELTNSD IKKGLSRPQK PQLVRQGCAS EPKDGCFQSR 

      1510       1520       1530       1540       1550       1560 
SSSFSSLSPS SSQDHPSASG PFPPNREILP GSRAPPRRKF SGPSESRESS DELDMDETSS 

      1570       1580       1590       1600       1610       1620 
DMSMSPQSSA LPTGGGQQEE EGKARKLPVS MLVHMASGPG GNVANSTLLF TDVADFQQIL 

      1630       1640       1650       1660       1670       1680 
QFPSLRTTTT VSWCFLNYTK PSFVQQATFK SSVYASWCIS SCNPNPSGLN TKTTLALLRS 

      1690       1700       1710       1720       1730       1740 
KQKITAEIYT LAAMHRPGAG KLTSSSVWKQ FAQMKPDAPF LFGNKLERKL AGNVLKERGK 

      1750       1760       1770       1780       1790       1800 
GEIHGDKDLG SKQTEPIRIK IFEGGYKSNE DYVYVRGRGR GKYICEECGI RCKKPSMLKK 

      1810       1820       1830       1840       1850       1860 
HIRTHTDVRP YVCKLCNFAF KTKGNLTKHM KSKAHMKKCL ELGVSMTSVD DTETEEAENM 

      1870       1880       1890       1900       1910       1920 
EELHKTSEKH SMSGISTDHQ FSDAEESDGE DGDDNDDDDE DDDDFDDQGD LTPKTRSRST 

      1930       1940       1950       1960       1970       1980 
SPQPPRFSSL PVNVGAVAHG VPSDSSLGHS SLISYLVTLP SIQVTQLMTP SDSCDDTQMT 

      1990       2000       2010       2020       2030       2040 
EYQRLFQSKS TDSEPDKDRL DIPSSMDEEA MLSSEPSSSP RDFSPSSYRS SPGYDSSPCR 

      2050       2060       2070       2080       2090       2100 
DNSPKRYLIP KGDLSPRRHL SPRRDLSPMR HLSPRKEAAL RREMSQGDAS PRRHLSPRRP 

      2110       2120       2130       2140       2150       2160 
LSPGKDITAR RDLSPRRERR YMTTIRAPSP RRALYPNPPL SMGQYLQTEP IVLGPPNLRR 

      2170       2180       2190       2200       2210       2220 
GIPQVPYFSL YGDQEGAYEH HGSSLFPEGP TDYVFSHLPL HSQQQVRAPI PMVPVGGIQM 

      2230       2240       2250       2260       2270       2280 
VHSLPPALSG LHPPPTLPLP TEGSEEKKGA PGEAFAKDPY ILSRRHEKQA PQVLQSSGLP 

      2290       2300       2310       2320       2330       2340 
SSPSSPRLLM KQSTSEDSLN STEREQEENI QTCTKAIASL RIATEEAALL GADPPTWVQE 

      2350       2360       2370       2380       2390       2400 
SPQKPLESAH VSIRHFGGPE PGQPCTSAAH PDLHDGEKDT FGTSQTAVAH PTFYSKSSVD 

      2410       2420       2430 
EKRVDFQSSK ELSLSTEEGN EPSPEKNQLH 

« Hide

References

« Hide 'large scale' references
[1]"Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain."
Doerflinger U., Pscherer A., Moser M., Ruemmele P., Schuele R., Buettner R.
Mol. Cell. Biol. 19:3736-3747(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TCF4, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Tissue: Brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6 and C57BL/6J.
Tissue: Brain, Cerebellum and Urinary bladder.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y15907 mRNA. Translation: CAA75868.1.
AK137291 mRNA. Translation: BAE23294.1.
AK137384 mRNA. Translation: BAE23336.1.
AK147244 mRNA. Translation: BAE27792.1.
AK147419 mRNA. Translation: BAE27900.1.
CCDSCCDS23704.1.
RefSeqNP_034567.2. NM_010437.2.
XP_006512619.1. XM_006512556.1.
XP_006512620.1. XM_006512557.1.
XP_006512621.1. XM_006512558.1.
XP_006512622.1. XM_006512559.1.
XP_006512623.1. XM_006512560.1.
XP_006512624.1. XM_006512561.1.
XP_006512625.1. XM_006512562.1.
XP_006512626.1. XM_006512563.1.
UniGeneMm.42157.
Mm.484135.

3D structure databases

ProteinModelPortalQ3UHF7.
SMRQ3UHF7. Positions 188-244, 1782-1838.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200314. 1 interaction.
STRING10090.ENSMUSP00000015645.

PTM databases

PhosphoSiteQ3UHF7.

Proteomic databases

PaxDbQ3UHF7.
PRIDEQ3UHF7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000015645; ENSMUSP00000015645; ENSMUSG00000015501.
GeneID15273.
KEGGmmu:15273.
UCSCuc007elg.1. mouse.

Organism-specific databases

CTD3097.
MGIMGI:1338076. Hivep2.

Phylogenomic databases

eggNOGNOG296349.
GeneTreeENSGT00530000063161.
HOGENOMHOG000155774.
HOVERGENHBG007119.
InParanoidQ3UHF7.
KOK09239.
OMARKKCFLV.
OrthoDBEOG7V1FPQ.
PhylomeDBQ3UHF7.
TreeFamTF331837.

Gene expression databases

BgeeQ3UHF7.
GenevestigatorQ3UHF7.

Family and domain databases

Gene3D3.30.160.60. 4 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHIVEP2. mouse.
NextBio287901.
PROQ3UHF7.
SOURCESearch...

Entry information

Entry nameZEP2_MOUSE
AccessionPrimary (citable) accession number: Q3UHF7
Secondary accession number(s): O55140, Q3UVD4, Q3UVH5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 11, 2005
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot