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Q3UHF7

- ZEP2_MOUSE

UniProt

Q3UHF7 - ZEP2_MOUSE

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Protein
Transcription factor HIVEP2
Gene
Hivep2, Mibp1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation By similarity.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri189 – 21123C2H2-type 1
Add
BLAST
Zinc fingeri217 – 23923C2H2-type 2
Add
BLAST
Zinc fingeri1783 – 180523C2H2-type 3
Add
BLAST
Zinc fingeri1811 – 183525C2H2-type 4
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: MGI
  3. sequence-specific DNA binding transcription factor activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. signal transduction Source: MGI
  2. transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor HIVEP2
Alternative name(s):
Human immunodeficiency virus type I enhancer-binding protein 2 homolog
Myc intron-binding protein 1
Short name:
MIBP-1
Gene namesi
Name:Hivep2
Synonyms:Mibp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1338076. Hivep2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 24302430Transcription factor HIVEP2
PRO_0000047372Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki2076 – 2076Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ3UHF7.
PRIDEiQ3UHF7.

PTM databases

PhosphoSiteiQ3UHF7.

Expressioni

Tissue specificityi

Expressed in heart, lung, skeletal muscle and liver. In the brain expressed in cerebral cortex, hippocampus, corpora amygdala and cerebellar cortex.1 Publication

Developmental stagei

At E13.5 and E15.5 expressed in anterior neural tube over primordial frontal cortex, spinal cord, dorsal root glanglia and developing skeletal muscle.1 Publication

Gene expression databases

BgeeiQ3UHF7.
GenevestigatoriQ3UHF7.

Interactioni

Subunit structurei

Interacts with TCF4.1 Publication

Protein-protein interaction databases

BioGridi200314. 1 interaction.
STRINGi10090.ENSMUSP00000015645.

Structurei

3D structure databases

ProteinModelPortaliQ3UHF7.
SMRiQ3UHF7. Positions 188-244, 1782-1838.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati2037 – 204041
Repeati2043 – 204642
Repeati2055 – 205843
Repeati2067 – 207044
Repeati2073 – 207645
Repeati2090 – 209346
Repeati2096 – 209947
Repeati2102 – 210548
Repeati2114 – 211749
Repeati2129 – 2132410

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2037 – 21329610 X 4 AA tandem repeats of S-P-[RGMKC]-[RK]
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi929 – 9357Nuclear localization signal Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi942 – 97433Ser-rich
Add
BLAST
Compositional biasi1499 – 156971Ser-rich
Add
BLAST
Compositional biasi1883 – 190725Asp/Glu-rich (acidic)
Add
BLAST
Compositional biasi2057 – 213276Arg-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG296349.
GeneTreeiENSGT00530000063161.
HOGENOMiHOG000155774.
HOVERGENiHBG007119.
InParanoidiQ3UHF7.
KOiK09239.
OMAiRKKCFLV.
OrthoDBiEOG7V1FPQ.
PhylomeDBiQ3UHF7.
TreeFamiTF331837.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UHF7-1 [UniParc]FASTAAdd to Basket

« Hide

MDTGDTALGQ KATSRSGETD SVSGRWRQEQ SAVLKMSTFS SQEGPRQPQI     50
DPEQIGNAAS AQLFGSGKLA SPGEGLHQVT EKQYPPHRPS PYPCQHSLSF 100
PQHSLSQGMT HSHKPHQSLE GPPWLFPGPL PSVASEDLFP FPMHGHSGGY 150
PRKKISNLNP AYSQYSQKSI EQAEDAHKKE HKPKKPGKYI CPYCSRACAK 200
PSVLKKHIRS HTGERPYPCI PCGFSFKTKS NLYKHRKSHA HAIKAGLVPF 250
TESSVSKLDL EAGFIDVEAE IHSDGEQSTD TDEESSLFAE ASDKVSPGPP 300
VPLDIASRGG YHGSLEESLG GPMKVPILII PKSGIPLASE GSQYLSSEML 350
PNPSLNAKAD DSHTVKQKLA LRLSEKKGQD SEPSLNLLSP HSKGSTDSGY 400
FSRSESAEQQ ISPPNTNAKS YEEIIFGKYC RLSPRNTLSV TPTGQERTAM 450
GRRGIMEPLP HLNTRLEVKM FEDPISQLNP SKGEMDPGQI NMLKTTKFNS 500
ECRQPQAIPS SVRNEGKPYP GNFLGSNPML LEAPVDSSPL IRSNSMPTSS 550
ATNLSVPPSL RGSHSFDERM TGSDDVFYPG TVGIPPQRML RRQAAFELPS 600
VQEGHMESEH PARVSKGLAS PSLKEKKLLP GDRPGYDYDV CRKPYKKWED 650
SETLKQSYLG SFKQGGEYFM DPSVPVQGVP TMFGTTCENR KRRKEKSVGD 700
EEDVPMICGG MGNAPVGMMS SEYDPKLQDG GRSGFAMTAH ESLAHGHSDR 750
LDPARPQLPS RSPSLGSEDL PLAADPDKMT DLGKKPPGNV ISVIQHTNSL 800
SRPNSFERSE STEMVACPQD KTPSPAETCD SEVLEAPVSP EWAPPGDGGE 850
SGSKPTPSQQ VPQHSYHAQP RLVRQHNIQV PEIRVTEEPD KPEKEKEAPT 900
KEPEKPVEEF QWPQRSETLS QLPAEKLPPK KKRLRLADLE HSSGESSFES 950
TGTGLSRSPS QESNLSHSSS FSMSFDREET VKLTAPPKQD ESGKHSEFLT 1000
VPAGSYSLSV PGHHHQKEMR RCSSEQMPCP HPTEVPEIRS KSFDYGNLSH 1050
APVAGTSPST LSPSRERKKC FLVRQASFSG SPEIAQGEAG VDPSVKQEHM 1100
EHLHAGLRAA WSSVLPPLPG DDPGKQVGTC GPLSSGPPLH LTQQQIMHMD 1150
SQESLRNPLI QPTSYMTSKH LPEQPHLFPH QDAVPFSPIQ NALFQFQYPT 1200
VCMVHLPAQQ PPWWQTHFPH PFAPHPQNSY SKPPFQADLH SSYPLEHVAE 1250
HTGKKSADYP HAKEQTYPCY SGTSGLHSKN LPLKFPSDPG SKSTETPTEQ 1300
LLREDFASEN AGPLQSLPGT VVPVRIQTHV PSYGSVMYTS ISQILGQNSP 1350
AIVICKVDEN MTQRTLVTNA AMQGIGLNIA QVLGQHTGLE KYPLWKVPQT 1400
LPLGLESSIP LCLPSTSDNA ASLGGSKRML SPASSLELFM ETKQQKRVKE 1450
EKMYGQIVEE LSAVELTNSD IKKGLSRPQK PQLVRQGCAS EPKDGCFQSR 1500
SSSFSSLSPS SSQDHPSASG PFPPNREILP GSRAPPRRKF SGPSESRESS 1550
DELDMDETSS DMSMSPQSSA LPTGGGQQEE EGKARKLPVS MLVHMASGPG 1600
GNVANSTLLF TDVADFQQIL QFPSLRTTTT VSWCFLNYTK PSFVQQATFK 1650
SSVYASWCIS SCNPNPSGLN TKTTLALLRS KQKITAEIYT LAAMHRPGAG 1700
KLTSSSVWKQ FAQMKPDAPF LFGNKLERKL AGNVLKERGK GEIHGDKDLG 1750
SKQTEPIRIK IFEGGYKSNE DYVYVRGRGR GKYICEECGI RCKKPSMLKK 1800
HIRTHTDVRP YVCKLCNFAF KTKGNLTKHM KSKAHMKKCL ELGVSMTSVD 1850
DTETEEAENM EELHKTSEKH SMSGISTDHQ FSDAEESDGE DGDDNDDDDE 1900
DDDDFDDQGD LTPKTRSRST SPQPPRFSSL PVNVGAVAHG VPSDSSLGHS 1950
SLISYLVTLP SIQVTQLMTP SDSCDDTQMT EYQRLFQSKS TDSEPDKDRL 2000
DIPSSMDEEA MLSSEPSSSP RDFSPSSYRS SPGYDSSPCR DNSPKRYLIP 2050
KGDLSPRRHL SPRRDLSPMR HLSPRKEAAL RREMSQGDAS PRRHLSPRRP 2100
LSPGKDITAR RDLSPRRERR YMTTIRAPSP RRALYPNPPL SMGQYLQTEP 2150
IVLGPPNLRR GIPQVPYFSL YGDQEGAYEH HGSSLFPEGP TDYVFSHLPL 2200
HSQQQVRAPI PMVPVGGIQM VHSLPPALSG LHPPPTLPLP TEGSEEKKGA 2250
PGEAFAKDPY ILSRRHEKQA PQVLQSSGLP SSPSSPRLLM KQSTSEDSLN 2300
STEREQEENI QTCTKAIASL RIATEEAALL GADPPTWVQE SPQKPLESAH 2350
VSIRHFGGPE PGQPCTSAAH PDLHDGEKDT FGTSQTAVAH PTFYSKSSVD 2400
EKRVDFQSSK ELSLSTEEGN EPSPEKNQLH 2430
Length:2,430
Mass (Da):266,705
Last modified:October 11, 2005 - v1
Checksum:i265694210C8A7024
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti572 – 5721G → E in CAA75868. 1 Publication
Sequence conflicti661 – 6611S → P in CAA75868. 1 Publication
Sequence conflicti749 – 7491D → N in CAA75868. 1 Publication
Sequence conflicti762 – 7621S → G in CAA75868. 1 Publication
Sequence conflicti1112 – 11121S → P in CAA75868. 1 Publication
Sequence conflicti1211 – 12111P → S in CAA75868. 1 Publication
Sequence conflicti1223 – 12231A → G in CAA75868. 1 Publication
Sequence conflicti1496 – 14961C → S in CAA75868. 1 Publication
Sequence conflicti2001 – 20011D → E in BAE23294. 1 Publication
Sequence conflicti2091 – 20911P → A in CAA75868. 1 Publication
Sequence conflicti2122 – 21221M → L in CAA75868. 1 Publication
Sequence conflicti2263 – 22631S → C in BAE23336. 1 Publication
Sequence conflicti2294 – 22941T → A in BAE23294. 1 Publication
Sequence conflicti2314 – 23141T → A in CAA75868. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y15907 mRNA. Translation: CAA75868.1.
AK137291 mRNA. Translation: BAE23294.1.
AK137384 mRNA. Translation: BAE23336.1.
AK147244 mRNA. Translation: BAE27792.1.
AK147419 mRNA. Translation: BAE27900.1.
CCDSiCCDS23704.1.
RefSeqiNP_034567.2. NM_010437.2.
XP_006512619.1. XM_006512556.1.
XP_006512620.1. XM_006512557.1.
XP_006512621.1. XM_006512558.1.
XP_006512622.1. XM_006512559.1.
XP_006512623.1. XM_006512560.1.
XP_006512624.1. XM_006512561.1.
XP_006512625.1. XM_006512562.1.
XP_006512626.1. XM_006512563.1.
UniGeneiMm.42157.
Mm.484135.

Genome annotation databases

EnsembliENSMUST00000015645; ENSMUSP00000015645; ENSMUSG00000015501.
GeneIDi15273.
KEGGimmu:15273.
UCSCiuc007elg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y15907 mRNA. Translation: CAA75868.1 .
AK137291 mRNA. Translation: BAE23294.1 .
AK137384 mRNA. Translation: BAE23336.1 .
AK147244 mRNA. Translation: BAE27792.1 .
AK147419 mRNA. Translation: BAE27900.1 .
CCDSi CCDS23704.1.
RefSeqi NP_034567.2. NM_010437.2.
XP_006512619.1. XM_006512556.1.
XP_006512620.1. XM_006512557.1.
XP_006512621.1. XM_006512558.1.
XP_006512622.1. XM_006512559.1.
XP_006512623.1. XM_006512560.1.
XP_006512624.1. XM_006512561.1.
XP_006512625.1. XM_006512562.1.
XP_006512626.1. XM_006512563.1.
UniGenei Mm.42157.
Mm.484135.

3D structure databases

ProteinModelPortali Q3UHF7.
SMRi Q3UHF7. Positions 188-244, 1782-1838.
ModBasei Search...

Protein-protein interaction databases

BioGridi 200314. 1 interaction.
STRINGi 10090.ENSMUSP00000015645.

PTM databases

PhosphoSitei Q3UHF7.

Proteomic databases

PaxDbi Q3UHF7.
PRIDEi Q3UHF7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000015645 ; ENSMUSP00000015645 ; ENSMUSG00000015501 .
GeneIDi 15273.
KEGGi mmu:15273.
UCSCi uc007elg.1. mouse.

Organism-specific databases

CTDi 3097.
MGIi MGI:1338076. Hivep2.

Phylogenomic databases

eggNOGi NOG296349.
GeneTreei ENSGT00530000063161.
HOGENOMi HOG000155774.
HOVERGENi HBG007119.
InParanoidi Q3UHF7.
KOi K09239.
OMAi RKKCFLV.
OrthoDBi EOG7V1FPQ.
PhylomeDBi Q3UHF7.
TreeFami TF331837.

Miscellaneous databases

ChiTaRSi HIVEP2. mouse.
NextBioi 287901.
PROi Q3UHF7.
SOURCEi Search...

Gene expression databases

Bgeei Q3UHF7.
Genevestigatori Q3UHF7.

Family and domain databases

Gene3Di 3.30.160.60. 4 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 4 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain."
    Doerflinger U., Pscherer A., Moser M., Ruemmele P., Schuele R., Buettner R.
    Mol. Cell. Biol. 19:3736-3747(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TCF4, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and C57BL/6J.
    Tissue: Brain, Cerebellum and Urinary bladder.

Entry informationi

Entry nameiZEP2_MOUSE
AccessioniPrimary (citable) accession number: Q3UHF7
Secondary accession number(s): O55140, Q3UVD4, Q3UVH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 11, 2005
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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