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Protein

Mesoderm induction early response protein 3

Gene

Mier3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Mesoderm induction early response protein 3
Short name:
Mi-er3
Gene namesi
Name:Mier3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2442317 Mier3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003136821 – 551Mesoderm induction early response protein 3Add BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei52PhosphoserineBy similarity1
Modified residuei53PhosphoserineBy similarity1
Modified residuei114PhosphoserineCombined sources1
Modified residuei156PhosphoserineCombined sources1
Modified residuei163PhosphothreonineCombined sources1
Modified residuei165PhosphoserineCombined sources1
Modified residuei168PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3UHF3
PaxDbiQ3UHF3
PRIDEiQ3UHF3

PTM databases

iPTMnetiQ3UHF3
PhosphoSitePlusiQ3UHF3

Expressioni

Gene expression databases

BgeeiENSMUSG00000032727
ExpressionAtlasiQ3UHF3 baseline and differential
GenevisibleiQ3UHF3 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104895

Structurei

3D structure databases

ProteinModelPortaliQ3UHF3
SMRiQ3UHF3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini174 – 273ELM2PROSITE-ProRule annotationAdd BLAST100
Domaini278 – 330SANTPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG4329 Eukaryota
ENOG410Y9DJ LUCA
GeneTreeiENSGT00510000046482
HOGENOMiHOG000015798
HOVERGENiHBG052923
InParanoidiQ3UHF3
OMAiFAQQTKF
OrthoDBiEOG091G0BKH
PhylomeDBiQ3UHF3
TreeFamiTF106453

Family and domain databases

InterProiView protein in InterPro
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR031156 MIER3
IPR001005 SANT/Myb
IPR017884 SANT_dom
PANTHERiPTHR10865:SF22 PTHR10865:SF22, 1 hit
PfamiView protein in Pfam
PF01448 ELM2, 1 hit
PF00249 Myb_DNA-binding, 1 hit
SMARTiView protein in SMART
SM01189 ELM2, 1 hit
SM00717 SANT, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51156 ELM2, 1 hit
PS51293 SANT, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UHF3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEASFGSSS PVGSLSSEDH DFDPTAEMLV HDYDDERTLE EEELMDDGKN
60 70 80 90 100
FSSEIEDLEK EGNMPLEDLL AFYGYESTIP AVANSSANSS PSELADELPD
110 120 130 140 150
MTLDKEEIAK DLLSGDDEET QSSADDLTPS VTSHETSEFF PRPLRSNTTC
160 170 180 190 200
DGDKESEIED VETDSGNSPE DLRREIMIGL EYQAEIPPYL GEYNGDDEKA
210 220 230 240 250
YENEDQLLWH PGVLLESKVK EYLVETSLRT GNEKVLDRIS SGTHTRDNEQ
260 270 280 290 300
ALYELLKCNH NIKEAIERYC CNGKASQEGM TAWTEEECRS FEHALMLHGK
310 320 330 340 350
DFHLIQKDKV RSRTVAECVA FYYMWKKSER YDYFAQQTKF GKKRYNHHPG
360 370 380 390 400
VTDYMDRLVD ETESLGGTVS SSALTCNRPE PVPDQPLNIL SSFTASDLTA
410 420 430 440 450
LTNSVATVCN PTAVNCLDDS FPPLANTPRG HVNHVPVVTE ELLTLPSNGE
460 470 480 490 500
SDCFNLFETG FYHSELNPMC SEESERPAKR LKMGIAVPES FMNEVSVNNL
510 520 530 540 550
GVDFENHTHH ITSAKMAVSV ADFGSLSANE TNGFINAHSL HQHQHAALHS

E
Length:551
Mass (Da):61,521
Last modified:January 15, 2008 - v2
Checksum:iE4354B466C6903FA
GO
Isoform 2 (identifier: Q3UHF3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.
     278-278: Missing.

Show »
Length:523
Mass (Da):58,652
Checksum:iC8F4AA19F8ED6F9D
GO

Sequence cautioni

The sequence AAI03781 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52S → G in AAI03781 (PubMed:15489334).Curated1
Sequence conflicti107E → K in BAE27904 (PubMed:16141072).Curated1
Sequence conflicti310V → L in BAC39070 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0301041 – 27Missing in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_030105278Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030747 mRNA Translation: BAC27115.1
AK083929 mRNA Translation: BAC39070.1
AK147427 mRNA Translation: BAE27904.1
AK147788 mRNA Translation: BAE28138.1
BC103780 mRNA Translation: AAI03781.1 Different initiation.
CCDSiCCDS26770.2 [Q3UHF3-1]
RefSeqiNP_766181.2, NM_172593.3 [Q3UHF3-1]
XP_006517680.1, XM_006517617.1 [Q3UHF3-2]
UniGeneiMm.31012

Genome annotation databases

EnsembliENSMUST00000047412; ENSMUSP00000036809; ENSMUSG00000032727 [Q3UHF3-2]
ENSMUST00000109272; ENSMUSP00000104895; ENSMUSG00000032727 [Q3UHF3-1]
GeneIDi218613
KEGGimmu:218613
UCSCiuc007rvy.1 mouse [Q3UHF3-1]
uc007rvz.1 mouse [Q3UHF3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMIER3_MOUSE
AccessioniPrimary (citable) accession number: Q3UHF3
Secondary accession number(s): Q3SYJ7
, Q3UGR9, Q8BND7, Q8BSS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health