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Protein

Mesoderm induction early response protein 3

Gene

Mier3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Mesoderm induction early response protein 3
Short name:
Mi-er3
Gene namesi
Name:Mier3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2442317. Mier3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Mesoderm induction early response protein 3PRO_0000313682Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei52 – 521PhosphoserineBy similarity
Modified residuei53 – 531PhosphoserineBy similarity
Modified residuei114 – 1141PhosphoserineCombined sources
Modified residuei156 – 1561PhosphoserineCombined sources
Modified residuei163 – 1631PhosphothreonineCombined sources
Modified residuei165 – 1651PhosphoserineCombined sources
Modified residuei168 – 1681PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3UHF3.
PaxDbiQ3UHF3.
PRIDEiQ3UHF3.

PTM databases

iPTMnetiQ3UHF3.
PhosphoSiteiQ3UHF3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032727.
ExpressionAtlasiQ3UHF3. baseline and differential.
GenevisibleiQ3UHF3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104895.

Structurei

3D structure databases

ProteinModelPortaliQ3UHF3.
SMRiQ3UHF3. Positions 175-331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini174 – 273100ELM2PROSITE-ProRule annotationAdd
BLAST
Domaini278 – 33053SANTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ELM2 domain.PROSITE-ProRule annotation
Contains 1 SANT domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4329. Eukaryota.
ENOG410Y9DJ. LUCA.
GeneTreeiENSGT00510000046482.
HOGENOMiHOG000015798.
HOVERGENiHBG052923.
InParanoidiQ3UHF3.
OMAiKFGKKRY.
OrthoDBiEOG091G0BKH.
PhylomeDBiQ3UHF3.
TreeFamiTF106453.

Family and domain databases

InterProiIPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR031156. MIER3.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PANTHERiPTHR10865:SF22. PTHR10865:SF22. 1 hit.
PfamiPF01448. ELM2. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM01189. ELM2. 1 hit.
SM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UHF3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEASFGSSS PVGSLSSEDH DFDPTAEMLV HDYDDERTLE EEELMDDGKN
60 70 80 90 100
FSSEIEDLEK EGNMPLEDLL AFYGYESTIP AVANSSANSS PSELADELPD
110 120 130 140 150
MTLDKEEIAK DLLSGDDEET QSSADDLTPS VTSHETSEFF PRPLRSNTTC
160 170 180 190 200
DGDKESEIED VETDSGNSPE DLRREIMIGL EYQAEIPPYL GEYNGDDEKA
210 220 230 240 250
YENEDQLLWH PGVLLESKVK EYLVETSLRT GNEKVLDRIS SGTHTRDNEQ
260 270 280 290 300
ALYELLKCNH NIKEAIERYC CNGKASQEGM TAWTEEECRS FEHALMLHGK
310 320 330 340 350
DFHLIQKDKV RSRTVAECVA FYYMWKKSER YDYFAQQTKF GKKRYNHHPG
360 370 380 390 400
VTDYMDRLVD ETESLGGTVS SSALTCNRPE PVPDQPLNIL SSFTASDLTA
410 420 430 440 450
LTNSVATVCN PTAVNCLDDS FPPLANTPRG HVNHVPVVTE ELLTLPSNGE
460 470 480 490 500
SDCFNLFETG FYHSELNPMC SEESERPAKR LKMGIAVPES FMNEVSVNNL
510 520 530 540 550
GVDFENHTHH ITSAKMAVSV ADFGSLSANE TNGFINAHSL HQHQHAALHS

E
Length:551
Mass (Da):61,521
Last modified:January 15, 2008 - v2
Checksum:iE4354B466C6903FA
GO
Isoform 2 (identifier: Q3UHF3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.
     278-278: Missing.

Show »
Length:523
Mass (Da):58,652
Checksum:iC8F4AA19F8ED6F9D
GO

Sequence cautioni

The sequence AAI03781 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 521S → G in AAI03781 (PubMed:15489334).Curated
Sequence conflicti107 – 1071E → K in BAE27904 (PubMed:16141072).Curated
Sequence conflicti310 – 3101V → L in BAC39070 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2727Missing in isoform 2. 1 PublicationVSP_030104Add
BLAST
Alternative sequencei278 – 2781Missing in isoform 2. 1 PublicationVSP_030105

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030747 mRNA. Translation: BAC27115.1.
AK083929 mRNA. Translation: BAC39070.1.
AK147427 mRNA. Translation: BAE27904.1.
AK147788 mRNA. Translation: BAE28138.1.
BC103780 mRNA. Translation: AAI03781.1. Different initiation.
CCDSiCCDS26770.2. [Q3UHF3-1]
RefSeqiNP_766181.2. NM_172593.3. [Q3UHF3-1]
XP_006517680.1. XM_006517617.1. [Q3UHF3-2]
UniGeneiMm.31012.

Genome annotation databases

EnsembliENSMUST00000047412; ENSMUSP00000036809; ENSMUSG00000032727. [Q3UHF3-2]
ENSMUST00000109272; ENSMUSP00000104895; ENSMUSG00000032727. [Q3UHF3-1]
GeneIDi218613.
KEGGimmu:218613.
UCSCiuc007rvy.1. mouse. [Q3UHF3-1]
uc007rvz.1. mouse. [Q3UHF3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030747 mRNA. Translation: BAC27115.1.
AK083929 mRNA. Translation: BAC39070.1.
AK147427 mRNA. Translation: BAE27904.1.
AK147788 mRNA. Translation: BAE28138.1.
BC103780 mRNA. Translation: AAI03781.1. Different initiation.
CCDSiCCDS26770.2. [Q3UHF3-1]
RefSeqiNP_766181.2. NM_172593.3. [Q3UHF3-1]
XP_006517680.1. XM_006517617.1. [Q3UHF3-2]
UniGeneiMm.31012.

3D structure databases

ProteinModelPortaliQ3UHF3.
SMRiQ3UHF3. Positions 175-331.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104895.

PTM databases

iPTMnetiQ3UHF3.
PhosphoSiteiQ3UHF3.

Proteomic databases

MaxQBiQ3UHF3.
PaxDbiQ3UHF3.
PRIDEiQ3UHF3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047412; ENSMUSP00000036809; ENSMUSG00000032727. [Q3UHF3-2]
ENSMUST00000109272; ENSMUSP00000104895; ENSMUSG00000032727. [Q3UHF3-1]
GeneIDi218613.
KEGGimmu:218613.
UCSCiuc007rvy.1. mouse. [Q3UHF3-1]
uc007rvz.1. mouse. [Q3UHF3-2]

Organism-specific databases

CTDi166968.
MGIiMGI:2442317. Mier3.

Phylogenomic databases

eggNOGiKOG4329. Eukaryota.
ENOG410Y9DJ. LUCA.
GeneTreeiENSGT00510000046482.
HOGENOMiHOG000015798.
HOVERGENiHBG052923.
InParanoidiQ3UHF3.
OMAiKFGKKRY.
OrthoDBiEOG091G0BKH.
PhylomeDBiQ3UHF3.
TreeFamiTF106453.

Miscellaneous databases

PROiQ3UHF3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032727.
ExpressionAtlasiQ3UHF3. baseline and differential.
GenevisibleiQ3UHF3. MM.

Family and domain databases

InterProiIPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR031156. MIER3.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PANTHERiPTHR10865:SF22. PTHR10865:SF22. 1 hit.
PfamiPF01448. ELM2. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM01189. ELM2. 1 hit.
SM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMIER3_MOUSE
AccessioniPrimary (citable) accession number: Q3UHF3
Secondary accession number(s): Q3SYJ7
, Q3UGR9, Q8BND7, Q8BSS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: September 7, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.