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Protein

Microtubule-associated tumor suppressor candidate 2 homolog

Gene

Mtus2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated tumor suppressor candidate 2 homolog
Alternative name(s):
Cardiac zipper protein
Microtubule plus-end tracking protein TIP150
Short name:
Tracking protein of 150 kDa
Gene namesi
Name:Mtus2
Synonyms:Cazip, Kiaa0774, Tip150
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1915388. Mtus2.

Subcellular locationi

  • Cytoplasmcytoskeleton

  • Note: Associated with the microtubule network at the growing distal tip (the plus-end) of microtubules.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13531353Microtubule-associated tumor suppressor candidate 2 homologPRO_0000280112Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei364 – 3641PhosphoserineCombined sources
Modified residuei365 – 3651PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3UHD3.
MaxQBiQ3UHD3.
PaxDbiQ3UHD3.
PeptideAtlasiQ3UHD3.
PRIDEiQ3UHD3.

PTM databases

iPTMnetiQ3UHD3.
PhosphoSiteiQ3UHD3.

Expressioni

Tissue specificityi

Expressed in heart from early embryonic development onwards. Later during embryonic development, expressed in brain and nervous system, in limb buds and in the epithelium lining the bronchia of the lung. Detected in adult brain, heart and eye, but not detected in other adult tissues examined.1 Publication

Gene expression databases

BgeeiQ3UHD3.
CleanExiMM_C130038G02RIK.
ExpressionAtlasiQ3UHD3. baseline and differential.
GenevisibleiQ3UHD3. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with KIF2C and MAPRE1; the interaction is direct and probably targets MTUS2 and KIF2C to microtubules (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082694.

Structurei

3D structure databases

ProteinModelPortaliQ3UHD3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni626 – 964339Mediates interaction with MAPRE1By similarityAdd
BLAST
Regioni786 – 1134349Localization to the growing distal tip of microtubulesBy similarityAdd
BLAST
Regioni786 – 87489Sufficient for interaction with KIF2CBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili976 – 1319344Sequence analysisAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the MTUS1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJWE. Eukaryota.
ENOG411103Z. LUCA.
GeneTreeiENSGT00390000006245.
HOGENOMiHOG000013016.
InParanoidiQ3UHD3.
OMAiVATQHFF.
OrthoDBiEOG7J70DT.
PhylomeDBiQ3UHD3.
TreeFamiTF333416.

Family and domain databases

InterProiIPR033339. MTUS2.
[Graphical view]
PANTHERiPTHR24200:SF8. PTHR24200:SF8. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UHD3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVPLAPKKS CFGQLRDHRE GAKNNNESIL RTGDTNANQI MLEVSSSCDE
60 70 80 90 100
AKSRDLDDEL GNSNLSRPQY HSHFQKEPLH LQGFGKGSQA GSTSQRESQA
110 120 130 140 150
SLTVHRQLSE EHAVKRGALQ APQCVQGPSL SSWRNAVGQA SPEASAKKDA
160 170 180 190 200
EIPRHIPKDK LAKTLDNEEL KRASSCSAAA GSVPPTDLQP VQLDTLGPQD
210 220 230 240 250
HVPARGEGPQ RTPASHSPGK GFSPGEGTSE GNSVYLPKPS TSEAKGSSPS
260 270 280 290 300
DTKMEGPHGL DVYNERITHA ELTPSSASAS KENPGLRHPE VCLGQGTGKS
310 320 330 340 350
KVELKSVQPR NEEGLTSAQA QGPGCHEERS MSPVERQELL EKAYREATSQ
360 370 380 390 400
GNSSHRQLGV RRGSSLEEMT GVSAGVEGSQ QATPTLSAAP AGEAGTRLTG
410 420 430 440 450
KMSAGVGRMA RETASGQTAP DVGQAAPVRR DPTESVPSEV SGEERRLGSG
460 470 480 490 500
NSGSTKLLAS GPSAGGSRTD TSGLLSPRGS NLEARKGKEM VAENRNLLEN
510 520 530 540 550
AAQTDNTPAG VDSAFSTPAP LLHPETTVNS SHHPTPPGSS SQELGVFSGD
560 570 580 590 600
TGSPSVASPP TDGGQVLNTS PKVPDRTTCS SGIPKPPTHP KDTPSSQEAR
610 620 630 640 650
EKLETEKMEE RAEAKPILMP KPKHVRPKII TYIRRNPQAL SQGDASLVPV
660 670 680 690 700
GLPYAPPTCG MPLPQEEKAA SRDLQPSANM YEKLKPDLQK PRVFPSGLMV
710 720 730 740 750
SGIKPPAHHF SQMSEKFLQE VADHPGKEEF CSPPYTHYEV PPTFYRSAML
760 770 780 790 800
LKPQLGLGAM SRLPSTKSRI LIASQRSSAS AIHPPGSLTT AASFYGSDPS
810 820 830 840 850
DLKKASNSNA AKASLPKSGL RPPGYSRLPA AKLAAFGFVR SSSISAVPSS
860 870 880 890 900
QSLDSVQPEQ SRPVTRSTFG NEEQAPLKQA LPSKDTPKGA GRAAPASSSN
910 920 930 940 950
ATTPRRSLLP APKSTSTPAG AKKELQKDPE AKKPAVSSPK RTASAATKPH
960 970 980 990 1000
SPGYPKQRTS APRNEFPPKP DLQAREAERQ LAQRLRDRCE WQARQLGLAR
1010 1020 1030 1040 1050
RELKKAIQGF DALAVSTKHF FGKSERALAK EKELSIELAN IRDEVAFNTA
1060 1070 1080 1090 1100
KCEKLQKEKE TLERRFEEEL RRLGWQQQAE VQELQERLQQ QFQAESARLQ
1110 1120 1130 1140 1150
AEHQDQLLRM RCQHQEQVED ITASHEAALL EMENNHTVAI TILQDDHDHK
1160 1170 1180 1190 1200
VQELMSTHEF EKKELEENFE KLRLTLQDQV DTLTFQSQSL RDRARRFEEA
1210 1220 1230 1240 1250
LRKTTEEQLE IALAPYQHLE EDMQSLKQVL EMKNQQIHLQ EKKIIELEKL
1260 1270 1280 1290 1300
VEKNIILEER IQVLQQQNED LKARIDQNTV VTRQLSEENA NLQEYVEKET
1310 1320 1330 1340 1350
QEKKRLSRTN EELLWKLQTG DPTSPIKLSP TSPVYRGSSS GPSSPARVST

TPR
Length:1,353
Mass (Da):147,356
Last modified:October 11, 2005 - v1
Checksum:iBFBFF33BA1A91B43
GO
Isoform 3 (identifier: Q3UHD3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1005: Missing.
     1006-1023: AIQGFDALAVSTKHFFGK → MGHHCCKPYICLQCLDKT

Note: No experimental confirmation available.
Show »
Length:348
Mass (Da):40,942
Checksum:iED1CA0DC5B567F35
GO
Isoform 4 (identifier: Q3UHD3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1201: Missing.
     1202-1210: RKTTEEQLE → MSLRTWARH

Note: No experimental confirmation available.
Show »
Length:152
Mass (Da):17,656
Checksum:i177DDBBBA7EE950E
GO

Sequence cautioni

The sequence BAC41447.2 differs from that shown.Aberrant splicing.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 12011201Missing in isoform 4. 1 PublicationVSP_023544Add
BLAST
Alternative sequencei1 – 10051005Missing in isoform 3. 1 PublicationVSP_023545Add
BLAST
Alternative sequencei1006 – 102318AIQGF…HFFGK → MGHHCCKPYICLQCLDKT in isoform 3. 1 PublicationVSP_023546Add
BLAST
Alternative sequencei1202 – 12109RKTTEEQLE → MSLRTWARH in isoform 4. 1 PublicationVSP_023548

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019985 mRNA. Translation: BAB31952.1.
AK147457 mRNA. Translation: BAE27924.1.
BC055016 mRNA. Translation: AAH55016.1.
BC150942 mRNA. Translation: AAI50943.1.
AB093263 Unassigned RNA. Translation: BAC41447.2. Sequence problems.
CCDSiCCDS19881.1. [Q3UHD3-1]
RefSeqiNP_084196.4. NM_029920.7.
XP_006504953.1. XM_006504890.2. [Q3UHD3-1]
UniGeneiMm.244177.

Genome annotation databases

EnsembliENSMUST00000085554; ENSMUSP00000082690; ENSMUSG00000029651. [Q3UHD3-4]
ENSMUST00000085558; ENSMUSP00000082694; ENSMUSG00000029651. [Q3UHD3-1]
ENSMUST00000110515; ENSMUSP00000106144; ENSMUSG00000029651. [Q3UHD3-3]
GeneIDi77521.
KEGGimmu:77521.
UCSCiuc009aon.2. mouse. [Q3UHD3-1]
uc009aop.2. mouse. [Q3UHD3-3]
uc009aoq.2. mouse. [Q3UHD3-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019985 mRNA. Translation: BAB31952.1.
AK147457 mRNA. Translation: BAE27924.1.
BC055016 mRNA. Translation: AAH55016.1.
BC150942 mRNA. Translation: AAI50943.1.
AB093263 Unassigned RNA. Translation: BAC41447.2. Sequence problems.
CCDSiCCDS19881.1. [Q3UHD3-1]
RefSeqiNP_084196.4. NM_029920.7.
XP_006504953.1. XM_006504890.2. [Q3UHD3-1]
UniGeneiMm.244177.

3D structure databases

ProteinModelPortaliQ3UHD3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082694.

PTM databases

iPTMnetiQ3UHD3.
PhosphoSiteiQ3UHD3.

Proteomic databases

EPDiQ3UHD3.
MaxQBiQ3UHD3.
PaxDbiQ3UHD3.
PeptideAtlasiQ3UHD3.
PRIDEiQ3UHD3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085554; ENSMUSP00000082690; ENSMUSG00000029651. [Q3UHD3-4]
ENSMUST00000085558; ENSMUSP00000082694; ENSMUSG00000029651. [Q3UHD3-1]
ENSMUST00000110515; ENSMUSP00000106144; ENSMUSG00000029651. [Q3UHD3-3]
GeneIDi77521.
KEGGimmu:77521.
UCSCiuc009aon.2. mouse. [Q3UHD3-1]
uc009aop.2. mouse. [Q3UHD3-3]
uc009aoq.2. mouse. [Q3UHD3-4]

Organism-specific databases

CTDi23281.
MGIiMGI:1915388. Mtus2.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IJWE. Eukaryota.
ENOG411103Z. LUCA.
GeneTreeiENSGT00390000006245.
HOGENOMiHOG000013016.
InParanoidiQ3UHD3.
OMAiVATQHFF.
OrthoDBiEOG7J70DT.
PhylomeDBiQ3UHD3.
TreeFamiTF333416.

Miscellaneous databases

ChiTaRSiMtus2. mouse.
PROiQ3UHD3.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UHD3.
CleanExiMM_C130038G02RIK.
ExpressionAtlasiQ3UHD3. baseline and differential.
GenevisibleiQ3UHD3. MM.

Family and domain databases

InterProiIPR033339. MTUS2.
[Graphical view]
PANTHERiPTHR24200:SF8. PTHR24200:SF8. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
    Strain: C57BL/6J.
    Tissue: Embryo and Placenta.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Brain and Eye.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
    DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 201-1117 AND 1155-1353 (ISOFORM 1).
  4. "CAZIP, a novel protein expressed in the developing heart and nervous system."
    Du Puy L., Beqqali A., Monshouwer-Kloots J., Haagsman H.P., Roelen B.A., Passier R.
    Dev. Dyn. 238:2903-2911(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-364 AND SER-365, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Heart.

Entry informationi

Entry nameiMTUS2_MOUSE
AccessioniPrimary (citable) accession number: Q3UHD3
Secondary accession number(s): B9EKJ2
, Q7TPP7, Q8CHD2, Q9CY74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: October 11, 2005
Last modified: July 6, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.