Q3UHC7 (DAB2P_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Disabled homolog 2-interacting protein
Short name=DAB2-interacting protein

Gene names

Name:	Dab2ip
Synonyms:	Kiaa1743

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1189 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Functions as a Ras GTPase-activating protein. Through its interaction with MAP3K5 disrupts the association of MAP3K5 with the inhibitory 14-3-3 complex. Mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. May act as a tumor suppressor gene By similarity.
Subunit structure	Interacts with MAP3K5, preferentially with its 'Ser-966' dephosphorylated form. On plasma membrane, exists in an inactive form complexed with TNFR1. In response to TNF, dissociates from TNFR1 complex, tranlocates to cytoplasm and forms part of an intracellular signaling complex comprising TRADD, RALBP1, TRAF2 and MAP3K5. Binding to MAP3K5 is induced by TNF. Interacts with DAB1 and DAB2. Part of a cytoplasmic complex made of HIPK1, DAB2IP and MAP3K5 in response to TNF. This complex formation promotes MAP3K5-JNK activation and subsequent apoptosis By similarity.
Subcellular location	Cytoplasm. Cell membrane; Peripheral membrane protein Potential.
Tissue specificity	Highly expressed in the brain, salivary gland, and testis; moderate expression in kidney and heart. Low expression in the lung, seminal vesicle, ventral prostate, epididymis, liver, and bladder. Very low expression in the coagulation gland and skeleton muscles. Lowest expression seen in spleen. Ref.1
Domain	C2 and GAP domains constitutively bind to MAP3K5 and facilitate the release of 14-3-3 from MAP3K5. The C2 domain is critical for MAP3K5 binding By similarity.
Sequence similarities	Contains 1 C2 domain. Contains 1 PH domain. Contains 1 Ras-GAP domain.
Sequence caution	The sequence AAQ77379.1 differs from that shown. Reason: Erroneous initiation. The sequence AAQ77380.1 differs from that shown. Reason: Erroneous initiation. The sequence AAQ77381.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Membrane
Coding sequence diversity	Alternative splicing
Disease	Tumor suppressor
Domain	Coiled coil
Molecular function	GTPase activation
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular protein catabolic process Inferred from sequence or structural similarity. Source: UniProtKB cellular response to epidermal growth factor stimulus Inferred from electronic annotation. Source: Compara cellular response to tumor necrosis factor Inferred from mutant phenotype PubMed 18281285PubMed 19903888. Source: BHF-UCL intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Inferred from mutant phenotype PubMed 18281285. Source: BHF-UCL negative regulation of I-kappaB kinase/NF-kappaB cascade Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of Ras protein signal transduction Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of catenin import into nucleus Inferred from mutant phenotype PubMed 20080667. Source: BHF-UCL negative regulation of cell growth Inferred from electronic annotation. Source: Compara negative regulation of epidermal growth factor receptor signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of fibroblast proliferation Inferred from mutant phenotype PubMed 20154697. Source: BHF-UCL negative regulation of protein serine/threonine kinase activity Inferred from mutant phenotype PubMed 19903888. Source: BHF-UCL positive regulation of JNK cascade Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of JUN kinase activity Inferred from mutant phenotype PubMed 18281285. Source: BHF-UCL positive regulation of apoptotic process Inferred from mutant phenotype PubMed 19903888. Source: BHF-UCL positive regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome intrinsic to internal side of plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	Ras GTPase activator activity Inferred from Biological aspect of Ancestor. Source: RefGenome phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Dab1	P97318	3	EBI-6306507,EBI-81680

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q3UHC7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q3UHC7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-124: Missing.

Isoform 3 (identifier: Q3UHC7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     990-1040: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1189	1189	Disabled homolog 2-interacting protein		PRO_0000252408
Regions
	Domain	101 – 202	102	PH
	Domain	200 – 295	96	C2
	Domain	371 – 563	193	Ras-GAP
	Coiled coil	1025 – 1159	135	Potential
	Compositional bias	8 – 52	45	Arg-rich
	Compositional bias	112 – 117	6	Poly-Ala
	Compositional bias	867 – 870	4	Poly-Ala
	Compositional bias	903 – 948	46	Pro-rich
Amino acid modifications
	Modified residue	702	1	Phosphoserine Ref.6
	Modified residue	978	1	Phosphoserine Ref.7
Natural variations
	Alternative sequence	1 – 124	124	Missing in isoform 2.		VSP_020956
	Alternative sequence	990 – 1040	51	Missing in isoform 3.		VSP_020957

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: E3AF3FDA71FF96C3	FASTA	1,189	131,726
	10 20 30 40 50 60 MSAGGNARKS TGRPSYYYRL LRRPRLQRQR SRSRSRTRPA RESPQERPGS RRSLPGSMSE 70 80 90 100 110 120 KNPSMEPSAS TPFRVTGFLS RRLKGSIKRT KSQPKLDRNH SFRHILPGFR SAAAAAADNE 130 140 150 160 170 180 RSHLMPRLKE SRSHESLLSP SSAVEALDLS MEEEVIIKPV HSSILGQDYC FEVTTSSGSK 190 200 210 220 230 240 CFSCRSAAER DKWMENLRRA VHPNKDNSRR VEHILKLWVI EAKDLPAKKK YLCELCLDDV 250 260 270 280 290 300 LYARTTSKLK TDNVFWGEHF EFHNLPPLRT VTVHLYRETD KKKKKERNSY LGLVSLPAAS 310 320 330 340 350 360 VAGRQFVEKW YPVVTPNPKG GKGPGPMIRI KARYQTVSIL PMEMYKEFAE HITNHYLGLC 370 380 390 400 410 420 AALEPILSAK TKEEMASALV HILQSTGKVK DFLTDLMMSE VDRCGDNEHL IFRENTLATK 430 440 450 460 470 480 AIEEYLKLVG QKYLQDALGE FIKALYESDE NCEVDPSKCS SADLPEHQGN LKMCCELAFC 490 500 510 520 530 540 KIINSYCVFP RELKEVFASW RQECSSRGRP DISERLISAS LFLRFLCPAI MSPSLFNLLQ 550 560 570 580 590 600 EYPDDRTART LTLIAKVTQN LANFAKFGSK EEYMSFMNQF LEHEWTNMQR FLLEISNPET 610 620 630 640 650 660 LSNTAGFEGY IDLGRELSSL HSLLWEAVSQ LDQSVVSKLG PLPRILRDVH TALSTPGSGQ 670 680 690 700 710 720 LPGTNDLAST PGSGSSSVSA GLQKMVIEND LSGLIDFTRL PSPTPENKDL FFVTRSSGVQ 730 740 750 760 770 780 PSPARSSSYS EANEPDLQMA NGSKSLSMVD LQDARTLDGE AGSPVGPDAL PADGQVPATQ 790 800 810 820 830 840 LLAGWPARAA PVSLAGLATV RRAVPTPTTP GTSEGAPGRP QLLAPLSFQN PVYQMAAGLP 850 860 870 880 890 900 LSPRGLGDSG SEGHSSLSSH SNSEELAAAA KLGSFSTAAE ELARRPGELA RRQMSLTEKG 910 920 930 940 950 960 GQPTVPRQNS AGPQRRIDQP PPPPPPPPPA PRGRTPPTLL STLQYPRPSS GTLASASPDW 970 980 990 1000 1010 1020 AGPGTRLRQQ SSSSKGDSPE LKPRAMHKQG PSPVSPNALD RTAAWLLTMN AQLLEDEGLG 1030 1040 1050 1060 1070 1080 PDPPHRDRLR SKEELSQAEK DLAVLQDKLR ISTKKLEEYE TLFKCQEETT QKLVLEYQAR 1090 1100 1110 1120 1130 1140 LEEGEERLRR QQEDKDIQMK GIISRLMSVE EELKKDHAEM QAAVDSKQKI IDAQEKRIAS 1150 1160 1170 1180 LDAANARLMS ALTQLKERYS MQARNGVSPT NPTKLQITEN GEFRNSSNC
	Isoform 2 [UniParc]. Checksum: D5F64197BB7C5755	FASTA	1,065	117,655
	10 20 30 40 50 60 MPRLKESRSH ESLLSPSSAV EALDLSMEEE VIIKPVHSSI LGQDYCFEVT TSSGSKCFSC 70 80 90 100 110 120 RSAAERDKWM ENLRRAVHPN KDNSRRVEHI LKLWVIEAKD LPAKKKYLCE LCLDDVLYAR 130 140 150 160 170 180 TTSKLKTDNV FWGEHFEFHN LPPLRTVTVH LYRETDKKKK KERNSYLGLV SLPAASVAGR 190 200 210 220 230 240 QFVEKWYPVV TPNPKGGKGP GPMIRIKARY QTVSILPMEM YKEFAEHITN HYLGLCAALE 250 260 270 280 290 300 PILSAKTKEE MASALVHILQ STGKVKDFLT DLMMSEVDRC GDNEHLIFRE NTLATKAIEE 310 320 330 340 350 360 YLKLVGQKYL QDALGEFIKA LYESDENCEV DPSKCSSADL PEHQGNLKMC CELAFCKIIN 370 380 390 400 410 420 SYCVFPRELK EVFASWRQEC SSRGRPDISE RLISASLFLR FLCPAIMSPS LFNLLQEYPD 430 440 450 460 470 480 DRTARTLTLI AKVTQNLANF AKFGSKEEYM SFMNQFLEHE WTNMQRFLLE ISNPETLSNT 490 500 510 520 530 540 AGFEGYIDLG RELSSLHSLL WEAVSQLDQS VVSKLGPLPR ILRDVHTALS TPGSGQLPGT 550 560 570 580 590 600 NDLASTPGSG SSSVSAGLQK MVIENDLSGL IDFTRLPSPT PENKDLFFVT RSSGVQPSPA 610 620 630 640 650 660 RSSSYSEANE PDLQMANGSK SLSMVDLQDA RTLDGEAGSP VGPDALPADG QVPATQLLAG 670 680 690 700 710 720 WPARAAPVSL AGLATVRRAV PTPTTPGTSE GAPGRPQLLA PLSFQNPVYQ MAAGLPLSPR 730 740 750 760 770 780 GLGDSGSEGH SSLSSHSNSE ELAAAAKLGS FSTAAEELAR RPGELARRQM SLTEKGGQPT 790 800 810 820 830 840 VPRQNSAGPQ RRIDQPPPPP PPPPPAPRGR TPPTLLSTLQ YPRPSSGTLA SASPDWAGPG 850 860 870 880 890 900 TRLRQQSSSS KGDSPELKPR AMHKQGPSPV SPNALDRTAA WLLTMNAQLL EDEGLGPDPP 910 920 930 940 950 960 HRDRLRSKEE LSQAEKDLAV LQDKLRISTK KLEEYETLFK CQEETTQKLV LEYQARLEEG 970 980 990 1000 1010 1020 EERLRRQQED KDIQMKGIIS RLMSVEEELK KDHAEMQAAV DSKQKIIDAQ EKRIASLDAA 1030 1040 1050 1060 NARLMSALTQ LKERYSMQAR NGVSPTNPTK LQITENGEFR NSSNC
	Isoform 3 [UniParc]. Checksum: E77E300B7C3E2A55	FASTA	1,138	126,136
	10 20 30 40 50 60 MSAGGNARKS TGRPSYYYRL LRRPRLQRQR SRSRSRTRPA RESPQERPGS RRSLPGSMSE 70 80 90 100 110 120 KNPSMEPSAS TPFRVTGFLS RRLKGSIKRT KSQPKLDRNH SFRHILPGFR SAAAAAADNE 130 140 150 160 170 180 RSHLMPRLKE SRSHESLLSP SSAVEALDLS MEEEVIIKPV HSSILGQDYC FEVTTSSGSK 190 200 210 220 230 240 CFSCRSAAER DKWMENLRRA VHPNKDNSRR VEHILKLWVI EAKDLPAKKK YLCELCLDDV 250 260 270 280 290 300 LYARTTSKLK TDNVFWGEHF EFHNLPPLRT VTVHLYRETD KKKKKERNSY LGLVSLPAAS 310 320 330 340 350 360 VAGRQFVEKW YPVVTPNPKG GKGPGPMIRI KARYQTVSIL PMEMYKEFAE HITNHYLGLC 370 380 390 400 410 420 AALEPILSAK TKEEMASALV HILQSTGKVK DFLTDLMMSE VDRCGDNEHL IFRENTLATK 430 440 450 460 470 480 AIEEYLKLVG QKYLQDALGE FIKALYESDE NCEVDPSKCS SADLPEHQGN LKMCCELAFC 490 500 510 520 530 540 KIINSYCVFP RELKEVFASW RQECSSRGRP DISERLISAS LFLRFLCPAI MSPSLFNLLQ 550 560 570 580 590 600 EYPDDRTART LTLIAKVTQN LANFAKFGSK EEYMSFMNQF LEHEWTNMQR FLLEISNPET 610 620 630 640 650 660 LSNTAGFEGY IDLGRELSSL HSLLWEAVSQ LDQSVVSKLG PLPRILRDVH TALSTPGSGQ 670 680 690 700 710 720 LPGTNDLAST PGSGSSSVSA GLQKMVIEND LSGLIDFTRL PSPTPENKDL FFVTRSSGVQ 730 740 750 760 770 780 PSPARSSSYS EANEPDLQMA NGSKSLSMVD LQDARTLDGE AGSPVGPDAL PADGQVPATQ 790 800 810 820 830 840 LLAGWPARAA PVSLAGLATV RRAVPTPTTP GTSEGAPGRP QLLAPLSFQN PVYQMAAGLP 850 860 870 880 890 900 LSPRGLGDSG SEGHSSLSSH SNSEELAAAA KLGSFSTAAE ELARRPGELA RRQMSLTEKG 910 920 930 940 950 960 GQPTVPRQNS AGPQRRIDQP PPPPPPPPPA PRGRTPPTLL STLQYPRPSS GTLASASPDW 970 980 990 1000 1010 1020 AGPGTRLRQQ SSSSKGDSPE LKPRAMHKQD LAVLQDKLRI STKKLEEYET LFKCQEETTQ 1030 1040 1050 1060 1070 1080 KLVLEYQARL EEGEERLRRQ QEDKDIQMKG IISRLMSVEE ELKKDHAEMQ AAVDSKQKII 1090 1100 1110 1120 1130 DAQEKRIASL DAANARLMSA LTQLKERYSM QARNGVSPTN PTKLQITENG EFRNSSNC

References

[1]	"Cloning of mouse Dab2ip gene, a novel member of the RasGTPase-activating protein family and characterization of its regulatory region in prostate." Chen H., Karam J.A., Schultz R., Zhang Z., Duncan C., Hsieh J.-T. DNA Cell Biol. 25:232-245(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), ALTERNATIVE SPLICING, TISSUE SPECIFICITY. Strain: 129S6/SvEvTac. Tissue: Spleen.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: C57BL/6. Tissue: Brain and Heart.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[5]	"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H. DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 328-1189 (ISOFORM 3). Tissue: Brain.
[6]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-702, MASS SPECTROMETRY. Tissue: Brain cortex.
[7]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-978, MASS SPECTROMETRY. Tissue: Melanoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY305656 mRNA. Translation: AAQ77379.1. Different initiation. AY305657 mRNA. Translation: AAQ77380.1. Different initiation. AY305658 mRNA. Translation: AAQ77381.1. Different initiation. AK147464 mRNA. Translation: BAE27930.1. AK147593 mRNA. Translation: BAE28013.1. AK164475 mRNA. Translation: BAE37801.1. AL929241 Genomic DNA. Translation: CAX15340.1. AL929241 Genomic DNA. Translation: CAM25773.2. AL929241 Genomic DNA. Translation: CAM25777.1. BC118530 mRNA. Translation: AAI18531.1. AK122548 mRNA. Translation: BAC65830.1.
IPI	IPI00420622. IPI00753148. IPI00755543.
RefSeq	NP_001001602.2. NM_001001602.2. NP_001107596.1. NM_001114124.1.
UniGene	Mm.29629.
3D structure databases
HSSP	HSSP built from PDB template 1NF1 based on UniProtKB P21359.
ProteinModelPortal	Q3UHC7.
SMR	Q3UHC7. Positions 329-662.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q3UHC7. 1 interaction.
MINT	MINT-136025.
PTM databases
PhosphoSite	Q3UHC7.
Proteomic databases
PaxDb	Q3UHC7.
PRIDE	Q3UHC7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000091010; ENSMUSP00000088532; ENSMUSG00000026883. ENSMUST00000112983; ENSMUSP00000108607; ENSMUSG00000026883. ENSMUST00000112992; ENSMUSP00000108616; ENSMUSG00000026883.
GeneID	69601.
KEGG	mmu:69601.
UCSC	uc008jkr.2. mouse. uc008jks.2. mouse. uc008jkv.2. mouse.
Organism-specific databases
CTD	153090.
MGI	MGI:1916851. Dab2ip.
Rouge	Search...
Phylogenomic databases
eggNOG	NOG245428.
GeneTree	ENSGT00600000084217.
HOVERGEN	HBG006492.
InParanoid	A2AUW9.
OMA	CAALEPI.
OrthoDB	EOG473PQJ.
Gene expression databases
ArrayExpress	Q3UHC7.
Bgee	Q3UHC7.
Genevestigator	Q3UHC7.
GermOnline	ENSMUSG00000026883. Mus musculus.
Family and domain databases
Gene3D	1.10.506.10. 1 hit. 2.30.29.30. 1 hit.
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR021887. DUF3498. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. IPR001936. RasGAP. IPR023152. RasGAP_CS. IPR008936. Rho_GTPase_activation_prot. [Graphical view]
Pfam	PF00168. C2. 1 hit. PF12004. DUF3498. 1 hit. PF00616. RasGAP. 1 hit. [Graphical view]
SMART	SM00239. C2. 1 hit. SM00233. PH. 1 hit. SM00323. RasGAP. 1 hit. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 1 hit. SSF48350. Rho_GAP. 1 hit.
PROSITE	PS50004. C2. False negative. PS50003. PH_DOMAIN. 1 hit. PS00509. RAS_GTPASE_ACTIV_1. 1 hit. PS50018. RAS_GTPASE_ACTIV_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	329884.
SOURCE	Search...

Entry information

Entry name

DAB2P_MOUSE

Accession

Primary (citable) accession number: Q3UHC7
Secondary accession number(s): A2AUW9 , A2AUX2, B7ZD28, Q3TPD5, Q3UH44, Q6JTV1, Q80T97

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	October 11, 2005
Last modified:	May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program