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Protein

Leucine-rich repeat serine/threonine-protein kinase 1

Gene

Lrrk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity, Mn2+By similarity

Enzyme regulationi

Binding of GTP stimulates kinase activity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1270 – 12701ATPPROSITE-ProRule annotationBy similarity
Active sitei1386 – 13861Proton acceptorPROSITE-ProRule annotationBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1248 – 12569ATPPROSITE-ProRule annotationBy similarity

GO - Molecular functioni

GO - Biological processi

  • bone resorption Source: MGI
  • negative regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • osteoclast development Source: MGI
  • positive regulation of canonical Wnt signaling pathway Source: MGI
  • positive regulation of intracellular signal transduction Source: MGI
  • positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, GTP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat serine/threonine-protein kinase 1 (EC:2.7.11.1)
Gene namesi
Name:Lrrk1Imported
Synonyms:Kiaa1790
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2142227. Lrrk1.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20142014Leucine-rich repeat serine/threonine-protein kinase 1PRO_0000233378Add
BLAST

Proteomic databases

EPDiQ3UHC2.
MaxQBiQ3UHC2.
PaxDbiQ3UHC2.
PeptideAtlasiQ3UHC2.
PRIDEiQ3UHC2.

PTM databases

iPTMnetiQ3UHC2.
PhosphoSiteiQ3UHC2.

Expressioni

Gene expression databases

BgeeiQ3UHC2.
CleanExiMM_LRRK1.
ExpressionAtlasiQ3UHC2. baseline and differential.
GenevisibleiQ3UHC2. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231403. 2 interactions.
IntActiQ3UHC2. 3 interactions.
MINTiMINT-4111238.
STRINGi10090.ENSMUSP00000015277.

Structurei

3D structure databases

ProteinModelPortaliQ3UHC2.
SMRiQ3UHC2. Positions 61-213, 240-626, 639-827, 1211-1547.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati86 – 11631ANK 1Sequence analysisAdd
BLAST
Repeati119 – 14830ANK 2Sequence analysisAdd
BLAST
Repeati152 – 18231ANK 3Sequence analysisAdd
BLAST
Repeati193 – 22230ANK 4Sequence analysisAdd
BLAST
Repeati279 – 30022LRR 1Add
BLAST
Repeati303 – 32422LRR 2Add
BLAST
Repeati330 – 35122LRR 3Add
BLAST
Repeati353 – 37422LRR 4Sequence analysisAdd
BLAST
Repeati381 – 40222LRR 5Add
BLAST
Repeati405 – 42622LRR 6Add
BLAST
Repeati427 – 44721LRR 7Add
BLAST
Repeati451 – 47222LRR 8Add
BLAST
Repeati474 – 49522LRR 9Add
BLAST
Repeati498 – 51922LRR 10Sequence analysisAdd
BLAST
Repeati549 – 57022LRR 11Add
BLAST
Repeati572 – 59423LRR 12Sequence analysisAdd
BLAST
Repeati596 – 61722LRR 13Add
BLAST
Domaini632 – 826195RocPROSITE-ProRule annotationAdd
BLAST
Domaini1242 – 1525284Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.Sequence analysis
Contains 13 LRR (leucine-rich) repeats.Sequence analysis
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 Roc domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0192. Eukaryota.
KOG0619. Eukaryota.
COG1100. LUCA.
COG4886. LUCA.
GeneTreeiENSGT00530000063477.
HOVERGENiHBG081936.
InParanoidiQ3UHC2.
KOiK08843.
OMAiFEEENAT.
OrthoDBiEOG761BST.
PhylomeDBiQ3UHC2.
TreeFamiTF313679.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.40.50.300. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR032171. COR.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR011044. Quino_amine_DH_bsu.
IPR020859. ROC_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF16095. COR. 1 hit.
PF13855. LRR_8. 1 hit.
PF00069. Pkinase. 1 hit.
PF08477. Roc. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
SM00369. LRR_TYP. 8 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50969. SSF50969. 2 hits.
SSF52058. SSF52058. 2 hits.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS51450. LRR. 11 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS51424. ROC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 12 Publications (identifier: Q3UHC2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGTSQRPPS MYWCVGTEGL AVCPGPAMET HNGAEDMGSK LSLPGGSSTV
60 70 80 90 100
QCPSMEEIHT AYKQRNLSRA RDLLRGVCEE SESSQEKGQL LSIAAAHGDL
110 120 130 140 150
ETVQFLLTEK RVELPTEPTD DNPAVVAAHF GHAEVVRELL ESLPGPCTPQ
160 170 180 190 200
RLLNWMLALA CQRGHLEVVK LLVLTHGADP ENYAVRKNEF PVIVRLPLYA
210 220 230 240 250
AIKAGNEDIA IFLLRHGAYF CSYILLDSPE PSKHLLRKYF IEASALPSSY
260 270 280 290 300
PGKIALRVKW SHLKLPWVDL DWLLDISCQI TELDLSANCL PSLPSIIPWG
310 320 330 340 350
LINLKKLNLS NNQLGELPCV QSSDEIICSR LLEIDISSNK LSHLPPGFLH
360 370 380 390 400
LSKLQKLTAS KNYLERLFEE ENATNWIGLR KLQELDLADN RLTELPVQFM
410 420 430 440 450
HSFKSLTSLN VSRNNLKSFP DPWSCPLKCC KASKNALESL PDKMAVFWKS
460 470 480 490 500
HLRDADFSEN SLKEVPLGLF QLDALMFLRL QGNQLLSLPP QEKWTCTQLK
510 520 530 540 550
TLDLSRNQLG KNEDGLKTKR ISLFTTRGRQ RSGTETASML EFPAFLSESL
560 570 580 590 600
EVLCLNDNHL DAVPPSVCLL KNLSELYLGN NPGLRELPPE LGQLGNLWQL
610 620 630 640 650
DIEDLNISNV PAEVRKEGPK ATLSFLRAQL RKAEKCKLMK MILVGPPRQG
660 670 680 690 700
KSTLLEILQT GKAPQLAHSE ATIRTTKWEL QRPAGSKAKV ESVEFNVWDI
710 720 730 740 750
GGPASMATVN QCFFTDKALY VVVWNLALGE EAVANLQFWL LNIEAKAPNA
760 770 780 790 800
VVLVVGTHLD LIEAKFRVER IATLRAYVLA LCRSPSGSRA TGFPDITFKH
810 820 830 840 850
LHEISCKNLE GQEGLRQLIF HVTCNMKDVG STIGCQKLAG RLIPRSYISL
860 870 880 890 900
QEAVLAEQQR RSLGDQVQYL TDRQLDQLVE QTPGNDIKDY EDLQSAISFL
910 920 930 940 950
IETGTLLHFP DTSHGLRNLY FLDPIWLSEC LQRIFNIKGS RSVAKNGVIQ
960 970 980 990 1000
AEDLRMLLVG TGFTQQTEEQ YFQFLAKFEI ALPVANDSYL LPHLLPSKPG
1010 1020 1030 1040 1050
LDTHSMRHPM ANTIQRVFKM SFVPVGFWQR FIARMLISLA EMDLQLFENK
1060 1070 1080 1090 1100
KNTKSRNRKV TIYSFTGSQR NRCSTFRVRR NQTIYWQEGL LVTFDGGYLS
1110 1120 1130 1140 1150
VESSDVNWKK KKSGGIKIIC QSEMRDFSAM AFITDHVNSL IDQWFPALTA
1160 1170 1180 1190 1200
TESDGTPLME QYVPCPVCEA SWAQHADPNE RSESVQYFDM EDCVLTAIER
1210 1220 1230 1240 1250
DFISCPRHPD LPVPLQELVP ELFMTDFPAR LFLENSKLEH TEGENSILGQ
1260 1270 1280 1290 1300
GGSGTVIYQA RYQGQPVAVK RFHIKKFKNS ANAPADTMLR HLRAMDAMKN
1310 1320 1330 1340 1350
FSDFRQEASM LHALQHPCIV SLIGISIHPL CFALELAPLG SLNTVLSENA
1360 1370 1380 1390 1400
KDSSFMPLGH MLTQKIAYQI ASGLAYLHKK NIIFCDLKSD NILVWSLSAK
1410 1420 1430 1440 1450
EHINIKLSDY GISRQSFHEG ALGVEGTPGY QAPEIRPRIV YDEKVDMFSY
1460 1470 1480 1490 1500
GMVLYELLSG QRPALGHHQL QIVKKLSKGI RPVLGQPEEV QFHRLQALMM
1510 1520 1530 1540 1550
ECWDTKPEKR PLALSVVSQM KDPTFATFMY MLPCGKQSAF FSSQSQEYTV
1560 1570 1580 1590 1600
VFWDGKEESR NYTVVNTEKG LLEVQRMTCP GMKLSCQLKV QSSVWIATED
1610 1620 1630 1640 1650
QKIYIYSLKG MCPLSVPQQA LDTPAVVTCF LAVPVIKKNS FLVLAGLADG
1660 1670 1680 1690 1700
LVAVFPVARG TPKESCSYLC SHTANRSKFC IPDEDARQNP YPVKAMEVVN
1710 1720 1730 1740 1750
SGSEVWYSNG PGLLVIDCTI LDISRRLEPY AAPSMVTSLV CSSDCRGEEM
1760 1770 1780 1790 1800
VWCLDDKANC LVMYHSATYQ LCARYFCGDP NPLRDTFSVQ PSVLETPGSH
1810 1820 1830 1840 1850
KTTSKGPVEE CIADVSIMYS EELGTQILTH QDSLTDYCSM SSYSSSPPHQ
1860 1870 1880 1890 1900
DPRSPSSLPS SLTSYSSVPF SANYEDSDRL QEPSVTSDRT EHDLSPMDGE
1910 1920 1930 1940 1950
TFSQHLQAVK VLAVKDLIWV PRHGGDIIVI GLEKDSGAQR GRVIAVLKAR
1960 1970 1980 1990 2000
ELNRHGVLVD AAVVAKDTVV CSFANENTEW CLAVWRGWGA REFDIFYQSY
2010
EELGRLEACT RKRR
Note: No experimental confirmation available.Curated
Length:2,014
Mass (Da):225,470
Last modified:October 11, 2005 - v1
Checksum:iEE33100F581779D0
GO
Isoform 21 Publication (identifier: Q3UHC2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1610: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:404
Mass (Da):44,456
Checksum:i2CC2B9DB95B439EA
GO
Isoform 31 Publication (identifier: Q3UHC2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.
     1153-1979: Missing.
     1999-2014: SYEELGRLEACTRKRR → LPHQLFQCAFLCQL

Note: No experimental confirmation available.Curated
Show »
Length:1,149
Mass (Da):129,636
Checksum:iF07799A22B7421EB
GO

Sequence cautioni

The sequence AAH27199.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC36341.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC39743.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661N → D in BAC34581 (PubMed:16141072).Curated
Sequence conflicti950 – 9501Q → R (PubMed:14621295).Curated
Sequence conflicti1539 – 15391A → T in BAE32558 (PubMed:16141072).Curated
Sequence conflicti1539 – 15391A → T (PubMed:14621295).Curated
Sequence conflicti1751 – 17511V → L in AAH27199 (PubMed:15489334).Curated
Sequence conflicti1806 – 18061G → E in BAE32558 (PubMed:16141072).Curated
Sequence conflicti1806 – 18061G → E in AAH80819 (PubMed:15489334).Curated
Sequence conflicti1806 – 18061G → E (PubMed:14621295).Curated
Sequence conflicti1903 – 19031S → N in BAE32558 (PubMed:16141072).Curated
Sequence conflicti1903 – 19031S → N in AAH80819 (PubMed:15489334).Curated
Sequence conflicti1903 – 19031S → N (PubMed:14621295).Curated
Sequence conflicti1931 – 19311G → S in BAE32558 (PubMed:16141072).Curated
Sequence conflicti1931 – 19311G → S in AAH80819 (PubMed:15489334).Curated
Sequence conflicti1931 – 19311G → S (PubMed:14621295).Curated
Sequence conflicti1972 – 19721S → G in BAE32558 (PubMed:16141072).Curated
Sequence conflicti1972 – 19721S → G in AAH27199 (PubMed:15489334).Curated
Sequence conflicti1972 – 19721S → G in AAH80819 (PubMed:15489334).Curated
Sequence conflicti1972 – 19721S → G (PubMed:14621295).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 16101610Missing in isoform 2. 1 PublicationVSP_052014Add
BLAST
Alternative sequencei1 – 3636Missing in isoform 3. 1 PublicationVSP_052013Add
BLAST
Alternative sequencei1153 – 1979827Missing in isoform 3. 1 PublicationVSP_052015Add
BLAST
Alternative sequencei1999 – 201416SYEEL…TRKRR → LPHQLFQCAFLCQL in isoform 3. 1 PublicationVSP_052016Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK051264 mRNA. Translation: BAC34581.1.
AK076432 mRNA. Translation: BAC36341.1. Different initiation.
AK081849 mRNA. Translation: BAC38349.1.
AK086795 mRNA. Translation: BAC39743.1. Different initiation.
AK147469 mRNA. Translation: BAE27935.1.
AK154395 mRNA. Translation: BAE32558.1.
BC027199 mRNA. Translation: AAH27199.1. Different initiation.
BC066159 mRNA. Translation: AAH66159.1.
BC072664 mRNA. Translation: AAH72664.1.
BC080819 mRNA. Translation: AAH80819.1.
AK129441 mRNA. Translation: BAC98251.1.
CCDSiCCDS21344.1. [Q3UHC2-1]
RefSeqiNP_666303.3. NM_146191.3. [Q3UHC2-1]
UniGeneiMm.33284.

Genome annotation databases

EnsembliENSMUST00000015277; ENSMUSP00000015277; ENSMUSG00000015133. [Q3UHC2-1]
GeneIDi233328.
KEGGimmu:233328.
UCSCiuc009hhc.1. mouse. [Q3UHC2-2]
uc009hhd.1. mouse. [Q3UHC2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK051264 mRNA. Translation: BAC34581.1.
AK076432 mRNA. Translation: BAC36341.1. Different initiation.
AK081849 mRNA. Translation: BAC38349.1.
AK086795 mRNA. Translation: BAC39743.1. Different initiation.
AK147469 mRNA. Translation: BAE27935.1.
AK154395 mRNA. Translation: BAE32558.1.
BC027199 mRNA. Translation: AAH27199.1. Different initiation.
BC066159 mRNA. Translation: AAH66159.1.
BC072664 mRNA. Translation: AAH72664.1.
BC080819 mRNA. Translation: AAH80819.1.
AK129441 mRNA. Translation: BAC98251.1.
CCDSiCCDS21344.1. [Q3UHC2-1]
RefSeqiNP_666303.3. NM_146191.3. [Q3UHC2-1]
UniGeneiMm.33284.

3D structure databases

ProteinModelPortaliQ3UHC2.
SMRiQ3UHC2. Positions 61-213, 240-626, 639-827, 1211-1547.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231403. 2 interactions.
IntActiQ3UHC2. 3 interactions.
MINTiMINT-4111238.
STRINGi10090.ENSMUSP00000015277.

PTM databases

iPTMnetiQ3UHC2.
PhosphoSiteiQ3UHC2.

Proteomic databases

EPDiQ3UHC2.
MaxQBiQ3UHC2.
PaxDbiQ3UHC2.
PeptideAtlasiQ3UHC2.
PRIDEiQ3UHC2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015277; ENSMUSP00000015277; ENSMUSG00000015133. [Q3UHC2-1]
GeneIDi233328.
KEGGimmu:233328.
UCSCiuc009hhc.1. mouse. [Q3UHC2-2]
uc009hhd.1. mouse. [Q3UHC2-1]

Organism-specific databases

CTDi79705.
MGIiMGI:2142227. Lrrk1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0192. Eukaryota.
KOG0619. Eukaryota.
COG1100. LUCA.
COG4886. LUCA.
GeneTreeiENSGT00530000063477.
HOVERGENiHBG081936.
InParanoidiQ3UHC2.
KOiK08843.
OMAiFEEENAT.
OrthoDBiEOG761BST.
PhylomeDBiQ3UHC2.
TreeFamiTF313679.

Miscellaneous databases

PROiQ3UHC2.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UHC2.
CleanExiMM_LRRK1.
ExpressionAtlasiQ3UHC2. baseline and differential.
GenevisibleiQ3UHC2. MM.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.40.50.300. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR032171. COR.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR011044. Quino_amine_DH_bsu.
IPR020859. ROC_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF16095. COR. 1 hit.
PF13855. LRR_8. 1 hit.
PF00069. Pkinase. 1 hit.
PF08477. Roc. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
SM00369. LRR_TYP. 8 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50969. SSF50969. 2 hits.
SSF52058. SSF52058. 2 hits.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS51450. LRR. 11 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS51424. ROC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6JImported and NODImported.
    Tissue: Dendritic cellImported, Fetal headImported, HeadImported, LungImported and Spinal ganglionImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1632-2014 (ISOFORMS 1/2).
    Strain: C57BL/6JImported and FVB/NImported.
    Tissue: BrainImported, ColonImported, JawImported and KidneyImported.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 117-2014 (ISOFORM 1).
    Tissue: Embryonic tailImported.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Pancreas and Spleen.

Entry informationi

Entry nameiLRRK1_MOUSE
AccessioniPrimary (citable) accession number: Q3UHC2
Secondary accession number(s): Q3U476
, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 11, 2005
Last modified: July 6, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.