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Protein

Spatacsin

Gene

Spg11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • axo-dendritic transport Source: MGI
  • axon extension Source: MGI
  • axonogenesis Source: MGI
  • regulation of synaptic plasticity Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Spatacsin
Alternative name(s):
Spastic paraplegia 11 protein homolog
Gene namesi
Name:Spg11
Synonyms:Kiaa1840
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2444989. Spg11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 12391239ExtracellularSequence analysisAdd
BLAST
Transmembranei1240 – 126021HelicalSequence analysisAdd
BLAST
Topological domaini1261 – 1457197CytoplasmicSequence analysisAdd
BLAST
Transmembranei1458 – 147821HelicalSequence analysisAdd
BLAST
Topological domaini1479 – 2430952ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • axon Source: MGI
  • cytoplasm Source: MGI
  • cytoplasmic vesicle Source: MGI
  • cytosol Source: UniProtKB-SubCell
  • dendrite Source: MGI
  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • lysosomal membrane Source: MGI
  • nucleolus Source: MGI
  • plasma membrane Source: MGI
  • synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 24302430SpatacsinPRO_0000287468Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi1038 – 10381N-linked (GlcNAc...)Sequence analysis
Modified residuei1942 – 19421PhosphoserineCombined sources
Modified residuei1943 – 19431PhosphoserineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ3UHA3.
MaxQBiQ3UHA3.
PaxDbiQ3UHA3.
PRIDEiQ3UHA3.

PTM databases

iPTMnetiQ3UHA3.
PhosphoSiteiQ3UHA3.

Expressioni

Tissue specificityi

Ubiquitously expressed at low level.1 Publication

Gene expression databases

BgeeiQ3UHA3.
CleanExiMM_SPG11.
GenevisibleiQ3UHA3. MM.

Interactioni

Subunit structurei

Interacts with AP5Z1, AP5B1, AP5S1 and ZFYVE26.By similarity

Protein-protein interaction databases

IntActiQ3UHA3. 1 interaction.
STRINGi10090.ENSMUSP00000037543.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1884. Eukaryota.
ENOG410XR4T. LUCA.
GeneTreeiENSGT00390000016791.
HOVERGENiHBG080456.
InParanoidiQ3UHA3.
KOiK19026.
OMAiEKQIWLC.
OrthoDBiEOG7B05C5.
TreeFamiTF325171.

Family and domain databases

InterProiIPR028103. Spatacsin.
IPR028107. Spatacsin_C_dom.
[Graphical view]
PANTHERiPTHR13650. PTHR13650. 1 hit.
PfamiPF14649. Spatacsin_C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UHA3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAQPGPGSA ASPGCAGAME RVLPMLLVRI PAEETAQLGP RAQLHRELEA
60 70 80 90 100
LGSLTAAGSL QVLSLAPGSR GGSSCCLPGP FRQFLWEESQ NSTSRDRPKL
110 120 130 140 150
LVAREDYELL VYEFDLRDGR CDAALLHGCC GRTLQKLTED QGVSISFKSL
160 170 180 190 200
RILSFHNNTS LLLINRCLIL RVVFPGKEPG VPVLDCLSLP LPAQAADMII
210 220 230 240 250
DAQLCERFLF VLSTVGLIYI FNTMDGTQVA QVDLALLRED SEQLEPASVS
260 270 280 290 300
SFTSLRVSQD LDVLVLVSSA STAVALNLHL YFRQHPGHLL CEGTLEDLPI
310 320 330 340 350
EGPPGIDEDD LVNSAHNMKL SKVSFQVDRS WRAQLLSLNE SVRGSEPEVS
360 370 380 390 400
CCAPWFQSAL RLESLESADH TPTVPTHVFI PGDVPRGRCA FPQKEHVKSS
410 420 430 440 450
DPGRPWKTMH LSEHEQPTEL TCLSVTGFTA LFTWAVGATS CTIGLWDLET
460 470 480 490 500
QSMQCFSLSQ KCTPVDIGGD QQLCLALTDD GLSLILFGLT QEEFLNRLMI
510 520 530 540 550
HGSASTVDSL CHLNGWGRCS IPIHALEAGI ENRQLDTVDF FLKSKENLLT
560 570 580 590 600
PSSQSPAPDQ QHPFSSHLYL RQVEEMSPAL DLLCSAIRES DSETQSKHFA
610 620 630 640 650
EQLLHLTLSF LNKQIRELCV HTEELDEHFQ KGVAILTSYI NELRTFMIKF
660 670 680 690 700
PWKPGDAIDE SDVNEGVVTV KEDRVWEELS FEEVIADAIL NNRIPEAQTF
710 720 730 740 750
FRISGHSAQR LEELVRIGLD LAFDSLKKNN VEEASRLLRN MGFSVEDELL
760 770 780 790 800
KICFYTTDKN IRDFLVEILK EKECFSEKER RTVDFVHQLE ALYSGHFQEN
810 820 830 840 850
AQTQAFPRYW IKEQDCFKHK SVLDTFLKYD KKDEFHKQDH RIALNWAHRW
860 870 880 890 900
DLQTQECILL RRLSPEEYKA RSPEALWRHL TARHDCSSIS LWMEEFQTQE
910 920 930 940 950
TESPQQSKWP PLSADIIEQG TCCHSHMRNE ILDKLARSGI FLASELEDFE
960 970 980 990 1000
RLLLRLSRIG GVMQDSLPVQ SYKSRAGCDF HSRFILYCLE HGLQHLLYTY
1010 1020 1030 1040 1050
LDYYKLSPGN CPFLEKKELH EAHPWLEFLV QCRQVSSNLT DPKLIFQASL
1060 1070 1080 1090 1100
ANAQILIPTN QASVSSMLLE GHTLLALATT MYAPGGVSQV IQNEDSENCL
1110 1120 1130 1140 1150
KKVDPQLLKV ALTPYPKLKA ALFPQYTAPS ILPSDITLYH LIQSLPPFDP
1160 1170 1180 1190 1200
SRLFVWQSAN TLAIGDTGSQ LPHFSSPDLV SKYAVLERLN YAYYLHHGRP
1210 1220 1230 1240 1250
SFAFGTFLVQ ELIKSKTPKQ LIQQVGKEAY TLGLSSFTNP SVGAACVCFL
1260 1270 1280 1290 1300
ELLGLSSLKL RVDLKMANVI LGSKRRDEDA RSSFIRESLA EKLSKLADGD
1310 1320 1330 1340 1350
RAATEELLVL LEEGVWDSIE QQGFSRLSSE SSSQWALVLQ FCMLHDRKLS
1360 1370 1380 1390 1400
VSYLRECAKA NDWLQFLVHS QLHNYHPAEV ESLLQYFSPV LQSHLKLASE
1410 1420 1430 1440 1450
KLSSGSISRD DSCLQELQKN KGETSNFFEI LHRCSDESTS WSWLLAEAVR
1460 1470 1480 1490 1500
HRAPILSVLA SCVQGASVVS CLCVWIVTSV EDKVAAEAMG HIQISVEDHH
1510 1520 1530 1540 1550
WSLKDLSIIW RTVLTRRKSH TLIRGFQLFI KDSPLLLIME MYELCMFFKN
1560 1570 1580 1590 1600
YEKAKVKLLE FQKSLETLDT VAARVLPIIP ASWMKDQVCF LLKLMPQQCE
1610 1620 1630 1640 1650
TQYELGKLLQ LFVGTEQLFS DGPDVQKLCL LSQVLKDTPI AISPAVISSY
1660 1670 1680 1690 1700
STENFQRECR SILEKLKADG QFAVARRVAE LAALPVDSLL IEQLTQEMQT
1710 1720 1730 1740 1750
LTHTPQWSLK QERLGFWKKC HEIFKKNSIS KRAASSFFSS QAPEVSEHPA
1760 1770 1780 1790 1800
EQGSLEERHL LLTLAGHWLA QEEPVPVEEL EGLEKQIWIC RVAQHTCGGA
1810 1820 1830 1840 1850
EEEAKPSLSQ HKLAAAELSF DSLASELSFS KLAALNTSKY LGLNDLPSKT
1860 1870 1880 1890 1900
TCENRLKHKE QESLNTLIGQ LLDGGCVHEA SRVCQYFRFY SQDLVLVLHC
1910 1920 1930 1940 1950
RALASAEATM EDLHSEIRAL LSSAAQPEDL ESPSVPLRKA HSSSSLDSQS
1960 1970 1980 1990 2000
FVMVPPTDEV AQNLHTLISK CLHGKNYCRQ VLCLYELAKD LGCSYGDVAA
2010 2020 2030 2040 2050
RDSEAMLRAI LASQRPDRCR QAQVFINTQG LEADTVAELV AEEVTRELLT
2060 2070 2080 2090 2100
PSEGTGEKQP FNPAEESQTF LQLTALCQDR TLVGMKLLDK IPSVPHGELS
2110 2120 2130 2140 2150
CTTELLILAH HCFTFTCHME GITRVLQAAR MLTDNHLAPN EEYGLVVRLL
2160 2170 2180 2190 2200
TGIGRYNEMT YIFDLLHQKH YFEVLMRKKL DPTGTLKTAL LDYIKRCRPG
2210 2220 2230 2240 2250
DSEKHNMIAL CFSMCREIGE NHEAAACIQL KLIESQPWEE SLKDGAQLKQ
2260 2270 2280 2290 2300
LLLKALTLML DAAESYAKDS CVRQALHCNR LTKLITLQIH FLNSGQNTML
2310 2320 2330 2340 2350
INLGHQKLMD CIMTLPRFYQ ASIVAEAYDF VPDWAEVLYQ QVILKGDFSY
2360 2370 2380 2390 2400
LEEFKQQKLL RPNIFEDISK KYKQHQPTDR VTENLKKLLS YCEDIYLYYK
2410 2420 2430
LAYEHKFFEI VNMLLKDPQT GCCLKDMLAG
Length:2,430
Mass (Da):273,934
Last modified:July 27, 2011 - v3
Checksum:iB8D7CD876C1338BD
GO
Isoform 2 (identifier: Q3UHA3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     479-496: DDGLSLILFGLTQEEFLN → GEQAVSDGRTLRRGVTAL
     497-2430: Missing.

Note: No experimental confirmation available.
Show »
Length:496
Mass (Da):53,888
Checksum:iC6EF0587324932B8
GO

Sequence cautioni

The sequence AAH19404.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC30307.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti579 – 5791A → S in BAE27954 (PubMed:16141072).Curated
Sequence conflicti853 – 8531Q → K in BAC98263 (PubMed:14621295).Curated
Sequence conflicti929 – 9291N → H in BAC98263 (PubMed:14621295).Curated
Sequence conflicti1426 – 14261N → D in BAC98263 (PubMed:14621295).Curated
Sequence conflicti1715 – 17151G → D in BAC98263 (PubMed:14621295).Curated
Sequence conflicti2192 – 21921D → G in BAE27954 (PubMed:16141072).Curated
Sequence conflicti2266 – 22661Y → C in BAE27954 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei479 – 49618DDGLS…EEFLN → GEQAVSDGRTLRRGVTAL in isoform 2. 1 PublicationVSP_025485Add
BLAST
Alternative sequencei497 – 24301934Missing in isoform 2. 1 PublicationVSP_025486Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039286 mRNA. Translation: BAC30307.1. Different initiation.
AK049236 mRNA. Translation: BAC33628.1.
AK049617 mRNA. Translation: BAC33842.1.
AK083468 mRNA. Translation: BAC38926.1.
AK147500 mRNA. Translation: BAE27954.1.
AL845457 Genomic DNA. Translation: CAM21781.1.
AK129453 mRNA. Translation: BAC98263.1.
BC019404 mRNA. Translation: AAH19404.1. Different initiation.
CCDSiCCDS50687.1. [Q3UHA3-1]
RefSeqiNP_663506.2. NM_145531.2. [Q3UHA3-1]
UniGeneiMm.222303.

Genome annotation databases

EnsembliENSMUST00000036450; ENSMUSP00000037543; ENSMUSG00000033396. [Q3UHA3-1]
GeneIDi214585.
KEGGimmu:214585.
UCSCiuc008mac.2. mouse. [Q3UHA3-1]
uc008mad.2. mouse. [Q3UHA3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039286 mRNA. Translation: BAC30307.1. Different initiation.
AK049236 mRNA. Translation: BAC33628.1.
AK049617 mRNA. Translation: BAC33842.1.
AK083468 mRNA. Translation: BAC38926.1.
AK147500 mRNA. Translation: BAE27954.1.
AL845457 Genomic DNA. Translation: CAM21781.1.
AK129453 mRNA. Translation: BAC98263.1.
BC019404 mRNA. Translation: AAH19404.1. Different initiation.
CCDSiCCDS50687.1. [Q3UHA3-1]
RefSeqiNP_663506.2. NM_145531.2. [Q3UHA3-1]
UniGeneiMm.222303.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3UHA3. 1 interaction.
STRINGi10090.ENSMUSP00000037543.

PTM databases

iPTMnetiQ3UHA3.
PhosphoSiteiQ3UHA3.

Proteomic databases

EPDiQ3UHA3.
MaxQBiQ3UHA3.
PaxDbiQ3UHA3.
PRIDEiQ3UHA3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036450; ENSMUSP00000037543; ENSMUSG00000033396. [Q3UHA3-1]
GeneIDi214585.
KEGGimmu:214585.
UCSCiuc008mac.2. mouse. [Q3UHA3-1]
uc008mad.2. mouse. [Q3UHA3-2]

Organism-specific databases

CTDi80208.
MGIiMGI:2444989. Spg11.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1884. Eukaryota.
ENOG410XR4T. LUCA.
GeneTreeiENSGT00390000016791.
HOVERGENiHBG080456.
InParanoidiQ3UHA3.
KOiK19026.
OMAiEKQIWLC.
OrthoDBiEOG7B05C5.
TreeFamiTF325171.

Miscellaneous databases

ChiTaRSiSpg11. mouse.
NextBioi374376.
PROiQ3UHA3.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UHA3.
CleanExiMM_SPG11.
GenevisibleiQ3UHA3. MM.

Family and domain databases

InterProiIPR028103. Spatacsin.
IPR028107. Spatacsin_C_dom.
[Graphical view]
PANTHERiPTHR13650. PTHR13650. 1 hit.
PfamiPF14649. Spatacsin_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Spinal cord.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 851-2430 (ISOFORM 1).
    Tissue: Embryonic tail.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1932-2430 (ISOFORM 1).
    Strain: FVB/N-3.
    Tissue: Mammary tumor.
  5. Cited for: TISSUE SPECIFICITY.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1942 AND SER-1943, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiSPTCS_MOUSE
AccessioniPrimary (citable) accession number: Q3UHA3
Secondary accession number(s): A2ARM0
, Q6ZPH3, Q8BHQ1, Q8C7R3, Q8C7U2, Q8CA88, Q8VEA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 27, 2011
Last modified: April 13, 2016
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.