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Protein
Submitted name:

Bromodomain-containing protein 4

Gene

Brd4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Bromodomain-containing protein 4Imported
Gene namesi
Name:Brd4Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1888520. Brd4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSMUSG00000024002.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113070.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini75 – 14773BromoInterPro annotationAdd
BLAST
Domaini370 – 44273BromoInterPro annotationAdd
BLAST
Domaini602 – 68483NETInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili539 – 56931Sequence analysisAdd
BLAST
Coiled coili1268 – 133972Sequence analysisAdd
BLAST

Keywords - Domaini

BromodomainSAAS annotation, Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1474. Eukaryota.
COG5076. LUCA.
GeneTreeiENSGT00760000119206.
HOGENOMiHOG000231200.
HOVERGENiHBG004896.
KOiK11722.
OMAiQPQSMLD.
OrthoDBiEOG091G01QC.

Family and domain databases

Gene3Di1.20.920.10. 2 hits.
InterProiIPR031354. BRD4_CDT.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR027353. NET_dom.
[Graphical view]
PfamiPF17035. BET. 1 hit.
PF17105. BRD4_CDT. 1 hit.
PF00439. Bromodomain. 2 hits.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 2 hits.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 2 hits.
PS51525. NET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UH70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTESGPGTR LRNLPVMGDG LETSQMSTTQ AQAQPQPANA ASTNPPPPET
60 70 80 90 100
SNPNKPKRQT NQLQYLLRVV LKTLWKHQFA WPFQQPVDAV KLNLPDYYKI
110 120 130 140 150
IKTPMDMGTI KKRLENNYYW NAQECIQDFN TMFTNCYIYN KPGDDIVLMA
160 170 180 190 200
EALEKLFLQK INELPTEETE IMIVQAKGRG RGRKETGRAA KPGVSTVPNT
210 220 230 240 250
TQASTSPQTQ TPQQNPPPPV QATTHPFPAV TPDLIAQPPV MTMVPPQPLQ
260 270 280 290 300
TPSPVPPQPP PPPAPVPQPV QSHPPIIATT PQPVKTKKGV KRKADTTTPT
310 320 330 340 350
TIDPIHEPPS LAPEPKTAKL GPRRESSRPV KPPKKDVPDS QQHPGPEKSS
360 370 380 390 400
KISEQLKCCS GILKEMFAKK HAAYAWPFYK PVDVEALGLH DYCDIIKHPM
410 420 430 440 450
DMSTIKSKLE SREYRDAQEF GADVRLMFSN CYKYNPPDHE VVAMARKLQD
460 470 480 490 500
VFEMRFAKMP DEPEEPVVTV SSPAVPPPTK VVAPPSSSDS SSDSSSDSDS
510 520 530 540 550
STDDSEEERA QRLAELQEQL KAVHEQLAAL SQPQQNKPKK KEKDKKEKKK
560 570 580 590 600
EKHKKKEEVE ENKKSKTKEL PPKKTKKNNS SNSNVSKKEP VPTKTKPPPT
610 620 630 640 650
YESEEEDKCK PMSYEEKRQL SLDINKLPGE KLGRVVHIIQ SREPSLKNSN
660 670 680 690 700
PDEIEIDFET LKPSTLRELE RYVTSCLRKK RKPQAEKVDV IAGSSKMKGF
710 720 730 740 750
SSSESESTSE SSSSDSEDSE TEMAPKSKKK GHTGRDQKKH HHHHHPQMQP
760 770 780 790 800
APAPVPQQPP PPPQQPPPPP PPQQQQQQPP PPPPPPSMPQ QTAPAMKSSP
810 820 830 840 850
PPFITAQVPV LEPQLPGSVF DPIGHFTQPI LHLPQPELPP HLPQPPEHST
860 870 880 890 900
PPHLNQHAVV SPPALHNALP QQPSRPSNRA AALPPKPTRP PAVSPALAQP
910 920 930 940 950
PLLPQPPMAQ PPQVLLEDEE PPAPPLTSMQ MQLYLQQLQK VQPPTPLLPS
960 970 980 990 1000
VKVQSQPPPP LPPPPHPSVQ QQQLQPQPPP PPPPQPQPPP QQQHQPPPRP
1010 1020 1030 1040 1050
VHLPSMPFSA HIQQPPPPPG QQPTHPPPGQ QPPPPQPAKP QQVIQHHPSP
1060 1070 1080 1090 1100
RHHKSDPYSA GHLREAPSPL MIHSPQMPQF QSLTHQSPPQ QNVQPKKQVK
1110 1120 1130 1140 1150
GRAEPQPPGP VMGQGQGCPP ASPAAVPMLS QELRPPSVVQ PQPLVVVKEE
1160 1170 1180 1190 1200
KIHSPIIRSE PFSTSLRPEP PKHPENIKAP VHLPQRPEMK PVDIGRPVIR
1210 1220 1230 1240 1250
PPEQSAPPPG APDKDKQKQE PKTPVAPKKD LKIKNMGSWA SLVQKHPTTP
1260 1270 1280 1290 1300
SSTAKSSSDS FEHFRRAARE KEEREKALKA QAEHAEKEKE RLRQERMRSR
1310 1320 1330 1340 1350
EDEDALEQAR RAHEEARRRQ EQQQQQQQQR QEQQQQQQQA AAVAAASAPQ
1360 1370 1380 1390 1400
AQSSQPQSML DQQRELARKR EQERRRREAM AATIDMNFQS DLLSIFEENL

F
Length:1,401
Mass (Da):156,051
Last modified:October 11, 2005 - v1
Checksum:iCCBD767AA9F3EBED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT033751 Genomic DNA. No translation available.
CT033755 Genomic DNA. No translation available.
AK147545 mRNA. Translation: BAE27987.1.
RefSeqiNP_001273559.1. NM_001286630.1.
NP_065254.3. NM_020508.4.
XP_006524746.1. XM_006524683.2.
XP_006524747.1. XM_006524684.2.
XP_006524748.1. XM_006524685.1.
XP_006524749.1. XM_006524686.1.
XP_006524750.1. XM_006524687.2.
UniGeneiMm.253518.

Genome annotation databases

EnsembliENSMUST00000003726; ENSMUSP00000003726; ENSMUSG00000024002.
GeneIDi57261.
KEGGimmu:57261.
UCSCiuc008bwb.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT033751 Genomic DNA. No translation available.
CT033755 Genomic DNA. No translation available.
AK147545 mRNA. Translation: BAE27987.1.
RefSeqiNP_001273559.1. NM_001286630.1.
NP_065254.3. NM_020508.4.
XP_006524746.1. XM_006524683.2.
XP_006524747.1. XM_006524684.2.
XP_006524748.1. XM_006524685.1.
XP_006524749.1. XM_006524686.1.
XP_006524750.1. XM_006524687.2.
UniGeneiMm.253518.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113070.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003726; ENSMUSP00000003726; ENSMUSG00000024002.
GeneIDi57261.
KEGGimmu:57261.
UCSCiuc008bwb.3. mouse.

Organism-specific databases

CTDi23476.
MGIiMGI:1888520. Brd4.

Phylogenomic databases

eggNOGiKOG1474. Eukaryota.
COG5076. LUCA.
GeneTreeiENSGT00760000119206.
HOGENOMiHOG000231200.
HOVERGENiHBG004896.
KOiK11722.
OMAiQPQSMLD.
OrthoDBiEOG091G01QC.

Miscellaneous databases

ChiTaRSiBrd4. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024002.

Family and domain databases

Gene3Di1.20.920.10. 2 hits.
InterProiIPR031354. BRD4_CDT.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR027353. NET_dom.
[Graphical view]
PfamiPF17035. BET. 1 hit.
PF17105. BRD4_CDT. 1 hit.
PF00439. Bromodomain. 2 hits.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 2 hits.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 2 hits.
PS51525. NET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ3UH70_MOUSE
AccessioniPrimary (citable) accession number: Q3UH70
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.