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Q3UH66

- WNK2_MOUSE

UniProt

Q3UH66 - WNK2_MOUSE

Protein

Serine/threonine-protein kinase WNK2

Gene

Wnk2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.1 Publication

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Activation requires autophosphorylation of Ser-356. Phosphorylation of Ser-352 also promotes increased activity By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei207 – 2071ATPPROSITE-ProRule annotation
    Active sitei323 – 3231Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi201 – 2099ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. protein phosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_196640. Stimuli-sensing channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase WNK2 (EC:2.7.11.1)
    Alternative name(s):
    Protein kinase lysine-deficient 2
    Protein kinase with no lysine 2
    Gene namesi
    Name:Wnk2
    Synonyms:Kiaa1760
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1922857. Wnk2.

    Subcellular locationi

    Cytoplasm By similarity. Cell membrane By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 21492149Serine/threonine-protein kinase WNK2PRO_0000278774Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei45 – 451PhosphoserineBy similarity
    Modified residuei352 – 3521Phosphoserine; by autocatalysisBy similarity
    Modified residuei356 – 3561Phosphoserine; by autocatalysisBy similarity
    Modified residuei560 – 5601PhosphoserineBy similarity
    Modified residuei1098 – 10981PhosphoserineBy similarity
    Modified residuei1210 – 12101PhosphoserineBy similarity
    Modified residuei1507 – 15071PhosphoserineBy similarity
    Modified residuei1566 – 15661Phosphoserine1 Publication
    Modified residuei1594 – 15941PhosphoserineBy similarity
    Modified residuei1725 – 17251PhosphoserineBy similarity
    Modified residuei1726 – 17261PhosphoserineBy similarity
    Modified residuei1770 – 17701Phosphoserine1 Publication
    Modified residuei1797 – 17971Phosphoserine1 Publication
    Modified residuei1962 – 19621PhosphoserineBy similarity

    Post-translational modificationi

    Autophosphorylated.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ3UH66.
    PaxDbiQ3UH66.
    PRIDEiQ3UH66.

    PTM databases

    PhosphoSiteiQ3UH66.

    Expressioni

    Tissue specificityi

    Brain and heart.1 Publication

    Gene expression databases

    ArrayExpressiQ3UH66.
    BgeeiQ3UH66.
    CleanExiMM_WNK2.
    GenevestigatoriQ3UH66.

    Interactioni

    Subunit structurei

    Forms a complex with the phosphorylated form of STK39 in the brain.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3UH66.
    SMRiQ3UH66. Positions 184-545.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini195 – 453259Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi172 – 1776Poly-Glu
    Compositional biasi645 – 1080436Pro-richAdd
    BLAST
    Compositional biasi1430 – 149667Pro-richAdd
    BLAST
    Compositional biasi1594 – 15974Poly-Ser

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00550000074385.
    HOGENOMiHOG000139922.
    HOVERGENiHBG050345.
    KOiK08867.
    OrthoDBiEOG7KDF8Z.
    PhylomeDBiQ3UH66.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR024678. Kinase_OSR1/WNK_CCT.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF12202. OSR1_C. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q3UH66-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDGDGGRRDA PGALMEAGRG TGSAGMAEPR ARAARLGPQR FLRRSVVESD     50
    QEEPPGLEAA ETPSAQPPQP LQRRVLLLCK TRRLIAERAR GRPAAPAPAA 100
    PAAPPGSPSV PSDPGPERAG TQEPSPDPTT ASAAATQVPD GGPRQEEAPA 150
    PTQEDAGTTE AKPEPGRARK DEPEEEEDDE DDLKAVATSL DGRFLKFDIE 200
    LGRGSFKTVY KGLDTETWVE VAWCELQDRK LTKLERQRFK EEAEMLKGLQ 250
    HPNIVRFYDF WESSAKGKRC IVLVTELMTS GTLKTYLKRF KVMKPKVLRS 300
    WCRQILKGLL FLHTRTPPII HRDLKCDNIF ITGPTGSVKI GDLGLATLKR 350
    ASFAKSVIGT PEFMAPEMYE EHYDESVDVY AFGMCMLEMA TSEYPYSECQ 400
    NAAQIYRKVT CGIKPASFEK VHDPEIKEII GECICKNKEE RYEIKDLLSH 450
    AFFAEDTGVR VELAEEDHGR KSTIALRLWV EDPKKLKGKP KDNGAIEFTF 500
    DLEKETPDEV AQEMIDSGFF HESDVKIVAK SIRDRVALIQ WRRERIWPAL 550
    QSQEPKDSGS PDKARGLPAP LQVQVTYHAQ SGQPGQPEPE EPEADQHLLP 600
    PTLPASVTSL ASDSTFDSGQ GSTVYSDSQS SQQSMVLSSL VDTAPTPASC 650
    VCSPPVSEGP GLTHSLPTLG AFQQPATVPG LSVGPVPPPA RPPLLQQHFP 700
    ESSMSFTPVL PPPSTPVPTG PSQPAPPVQQ PLPMAQPPTL PQVLAPQPMG 750
    TVQPVPSHLP PYLAPTSQVV APAQLKPLQM PQPPLQPLAQ VPPQMPQMPV 800
    VPPITPLTGL DGLPQTLTDL PAANVAPVPP PQYFSPAVIL PSLTTPLPTS 850
    PALPMQAVKL PHPPGTPLAV PCQTIVPNAP AAIPLLAVAP QGVAALSIHP 900
    AVAQIPAQPV YPAAFPQMVP GDIPPSPHHT VQSLRATPPQ LASPVPPQPV 950
    QPSVIHLPEQ AAPTAASGTQ VLLGHPPSYT ADVAAPVSAV SLPPAVLSPP 1000
    LPDTLLPTVP DLLPKVPSSL APTVVAASQS APAQTSSLLL PTNPPLPTGP 1050
    AVAGPCPAVQ LMVEVAQEEQ VSQDKPPGPP QSSESFGGSD VTSGRDLSDS 1100
    CEGTFGGGRL EGRTARKHHR RSTRARSRQE RASRPRLTIL NVCNTGDKMV 1150
    ECQLETHNHK MVTFKFDLDG DAPDEIATYM VEHDFILPAE RETFIEQMKD 1200
    VMDKAEDMLS EDTDADHGSD TGTSPPHLGT CGLATGEENR QSQANAPVYQ 1250
    QNVLHTGKRW FIICPVAEHP ATDTSESSPP LPLSSLQPEA SQDPAPYPDQ 1300
    LSLTDKPSFP AAQQLLSQAG SSNPPGGASA PLAPSSPPVT TVIPAAPATS 1350
    TVPESAAGTA MQAGGPGTHQ GPASVHETLQ PLAETRSAQC TAQPLSTGQG 1400
    PCTPALEASR CSTGLGEPIS TREVSTQGEP LPASVPEPSP PTGATQSVPG 1450
    QPPPPLPITV GAISLAAPQL PSPPLGPTAP PPPPSALESD GEGPPPRVGF 1500
    VDNTIKSLDE KLRTLLYQEH VPTSSASAGT PMEASDRDFT LEPLRGDLPS 1550
    ALSDKTPSLT QQTQPSLEKS ETAPAGWALA QREQGASSPM TAESSSSNTL 1600
    GCDSDAGQVA SDSSTAPSVP QDASGSSVPT HMDPKDQNSS VPREALAAPM 1650
    QSGPGSFTVG SPAQLRGARD SGSPHKRPGQ QDNSSPAKTV GRFSVVSTQD 1700
    EWTLASPHSL RYSAPPDVYL DEIPSSPEVK LAVRRVQTAS SIEVGVEEPA 1750
    SSDSGDERPR RRSQVQKQSS LPGTGGVASD FVKKATAFLH RSSRAGSLGP 1800
    ETPSRAGVKV PTISITSFHS QSSYISSDND SEFEDADIKK ELRSLREKHL 1850
    KEISELQSQQ KQEIEALYRR LGKPLPPNVG FFHTAPPMGR RRKTSKSKLK 1900
    AGKLLNPLVQ QLKVVASSTG HLSDSSRGPP TKDPRGTKAV QTQQPCSVRA 1950
    SLSTDICSGL ASDGGGARGQ GWTVYHPTSE RGAYKSSSKP RARFLSGPVS 2000
    VSIWSALKRL CLGKEHSSSL YDSPGSSTSS LAPGPEPGPQ PTLHVQAQVN 2050
    NSNNKKGTFT DDLHKLVDEW TTKTVGAAQV KPTLNQLKQT QKLHDMEASG 2100
    DARATSVPRA AVGASCLAPA PGPLSTTATP GATPALPVPI PDPESEKPD 2149

    Note: No experimental confirmation available.

    Length:2,149
    Mass (Da):227,527
    Last modified:February 20, 2007 - v2
    Checksum:iA4BBF1D391FE9BEC
    GO
    Isoform 2 (identifier: Q3UH66-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1921-2004: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:2,065
    Mass (Da):218,728
    Checksum:iCF4AE4A4DC664F90
    GO
    Isoform 3 (identifier: Q3UH66-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1935-1935: R → AHASTPP
         2019-2025: SLYDSPG → R

    Note: No experimental confirmation available.

    Show »
    Length:2,149
    Mass (Da):227,469
    Checksum:i98AD382CFD4CFE45
    GO
    Isoform 4 (identifier: Q3UH66-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1935-1935: R → AHASTPP
         1971-2024: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:2,101
    Mass (Da):222,082
    Checksum:i953172919B0CBF8D
    GO
    Isoform 5 (identifier: Q3UH66-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1935-1935: R → AHASTPP
         2019-2025: SLYDSPG → R
         2142-2149: DPESEKPD → GTVHSSLSGP...STPGPRLHIT

    Note: No experimental confirmation available.

    Show »
    Length:2,213
    Mass (Da):234,069
    Checksum:i0BE7B0D8B10819E2
    GO
    Isoform 6 (identifier: Q3UH66-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         731-742: Missing.
         971-1068: Missing.
         1935-1935: R → AHASTPP
         1971-2024: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,991
    Mass (Da):211,147
    Checksum:i1177FFA99C62BFD0
    GO
    Isoform 7 (identifier: Q3UH66-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         971-1068: Missing.
         1592-1593: AE → E
         1935-1935: R → AHASTPP
         2019-2025: SLYDSPG → R
         2142-2149: DPESEKPD → EACALPTPPCKFLSRPSSGQPTEGRSISGGFHDTCPGGERGDENSLTPSG

    Note: No experimental confirmation available.

    Show »
    Length:2,092
    Mass (Da):221,908
    Checksum:i581DA7240F2E5FE5
    GO

    Sequence cautioni

    The sequence AAH46464.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAH55795.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAE20646.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti761 – 79434PYLAP…QVPPQ → RRYLWPIFCSPQGWGTRPWT RPVHACLQGLLARE in BAC98249. (PubMed:14621295)CuratedAdd
    BLAST

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei731 – 74212Missing in isoform 6. 1 PublicationVSP_023366Add
    BLAST
    Alternative sequencei971 – 106898Missing in isoform 6 and isoform 7. 2 PublicationsVSP_023367Add
    BLAST
    Alternative sequencei1592 – 15932AE → E in isoform 7. 1 PublicationVSP_023368
    Alternative sequencei1921 – 200484Missing in isoform 2. 1 PublicationVSP_023369Add
    BLAST
    Alternative sequencei1935 – 19351R → AHASTPP in isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7. 3 PublicationsVSP_023370
    Alternative sequencei1971 – 202454Missing in isoform 4 and isoform 6. 1 PublicationVSP_023371Add
    BLAST
    Alternative sequencei2019 – 20257SLYDSPG → R in isoform 3, isoform 5 and isoform 7. 3 PublicationsVSP_023372
    Alternative sequencei2142 – 21498DPESEKPD → GTVHSSLSGPPCTLPLCQYG GLLPDPVSWGPWVASGNPEG SWGSQSPTQVPVFPVFLRPP VISTPGPRLHIT in isoform 5. 1 PublicationVSP_023373
    Alternative sequencei2142 – 21498DPESEKPD → EACALPTPPCKFLSRPSSGQ PTEGRSISGGFHDTCPGGER GDENSLTPSG in isoform 7. 1 PublicationVSP_023374

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CAAA01187366 Genomic DNA. No translation available.
    AC140284 Genomic DNA. No translation available.
    AK044381 mRNA. Translation: BAE20646.1. Different initiation.
    AK147550 mRNA. Translation: BAE27991.1.
    BC046464 mRNA. Translation: AAH46464.1. Different initiation.
    BC055795 mRNA. Translation: AAH55795.1. Different initiation.
    BC060187 mRNA. Translation: AAH60187.1.
    AK129439 mRNA. Translation: BAC98249.1.
    CCDSiCCDS70454.1. [Q3UH66-5]
    CCDS70455.1. [Q3UH66-3]
    RefSeqiNP_001277240.1. NM_001290311.1.
    NP_001277242.1. NM_001290313.1.
    NP_083637.2. NM_029361.4.
    UniGeneiMm.342723.

    Genome annotation databases

    EnsembliENSMUST00000160087; ENSMUSP00000124614; ENSMUSG00000037989.
    GeneIDi75607.
    KEGGimmu:75607.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CAAA01187366 Genomic DNA. No translation available.
    AC140284 Genomic DNA. No translation available.
    AK044381 mRNA. Translation: BAE20646.1 . Different initiation.
    AK147550 mRNA. Translation: BAE27991.1 .
    BC046464 mRNA. Translation: AAH46464.1 . Different initiation.
    BC055795 mRNA. Translation: AAH55795.1 . Different initiation.
    BC060187 mRNA. Translation: AAH60187.1 .
    AK129439 mRNA. Translation: BAC98249.1 .
    CCDSi CCDS70454.1. [Q3UH66-5 ]
    CCDS70455.1. [Q3UH66-3 ]
    RefSeqi NP_001277240.1. NM_001290311.1.
    NP_001277242.1. NM_001290313.1.
    NP_083637.2. NM_029361.4.
    UniGenei Mm.342723.

    3D structure databases

    ProteinModelPortali Q3UH66.
    SMRi Q3UH66. Positions 184-545.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q3UH66.

    Proteomic databases

    MaxQBi Q3UH66.
    PaxDbi Q3UH66.
    PRIDEi Q3UH66.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000160087 ; ENSMUSP00000124614 ; ENSMUSG00000037989 .
    GeneIDi 75607.
    KEGGi mmu:75607.

    Organism-specific databases

    CTDi 65268.
    MGIi MGI:1922857. Wnk2.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00550000074385.
    HOGENOMi HOG000139922.
    HOVERGENi HBG050345.
    KOi K08867.
    OrthoDBi EOG7KDF8Z.
    PhylomeDBi Q3UH66.

    Enzyme and pathway databases

    Reactomei REACT_196640. Stimuli-sensing channels.

    Miscellaneous databases

    ChiTaRSi WNK2. mouse.
    NextBioi 343494.
    PROi Q3UH66.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3UH66.
    Bgeei Q3UH66.
    CleanExi MM_WNK2.
    Genevestigatori Q3UH66.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR024678. Kinase_OSR1/WNK_CCT.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF12202. OSR1_C. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1506-2149 (ISOFORM 5).
      Strain: C57BL/6J.
      Tissue: Retina.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 443-2149 (ISOFORM 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 801-2149 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1513-2149 (ISOFORM 4).
      Strain: C57BL/6 and FVB/N.
      Tissue: Brain and Salivary gland.
    4. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 761-2149 (ISOFORM 7).
      Tissue: Brain.
    5. Cited for: FUNCTION, TISSUE SPECIFICITY, PHOSPHORYLATION AT SER-1566; SER-1770 AND SER-1797, INTERACTION WITH STK39.

    Entry informationi

    Entry nameiWNK2_MOUSE
    AccessioniPrimary (citable) accession number: Q3UH66
    Secondary accession number(s): Q3V387
    , Q6PAN9, Q6ZPI6, Q7TNS1, Q811F2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3