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Q3UH66

- WNK2_MOUSE

UniProt

Q3UH66 - WNK2_MOUSE

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Protein
Serine/threonine-protein kinase WNK2
Gene
Wnk2, Kiaa1760
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium By similarity.

Enzyme regulationi

Activation requires autophosphorylation of Ser-356. Phosphorylation of Ser-352 also promotes increased activity By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei207 – 2071ATP By similarity
Active sitei323 – 3231Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi201 – 2099ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. protein phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_196640. Stimuli-sensing channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase WNK2 (EC:2.7.11.1)
Alternative name(s):
Protein kinase lysine-deficient 2
Protein kinase with no lysine 2
Gene namesi
Name:Wnk2
Synonyms:Kiaa1760
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1922857. Wnk2.

Subcellular locationi

Cytoplasm By similarity. Cell membrane By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21492149Serine/threonine-protein kinase WNK2
PRO_0000278774Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei45 – 451Phosphoserine By similarity
Modified residuei352 – 3521Phosphoserine; by autocatalysis By similarity
Modified residuei356 – 3561Phosphoserine; by autocatalysis By similarity
Modified residuei560 – 5601Phosphoserine By similarity
Modified residuei1098 – 10981Phosphoserine By similarity
Modified residuei1210 – 12101Phosphoserine By similarity
Modified residuei1507 – 15071Phosphoserine By similarity
Modified residuei1566 – 15661Phosphoserine1 Publication
Modified residuei1594 – 15941Phosphoserine By similarity
Modified residuei1725 – 17251Phosphoserine By similarity
Modified residuei1726 – 17261Phosphoserine By similarity
Modified residuei1770 – 17701Phosphoserine1 Publication
Modified residuei1797 – 17971Phosphoserine1 Publication
Modified residuei1962 – 19621Phosphoserine By similarity

Post-translational modificationi

Autophosphorylated By similarity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3UH66.
PaxDbiQ3UH66.
PRIDEiQ3UH66.

PTM databases

PhosphoSiteiQ3UH66.

Expressioni

Tissue specificityi

Brain and heart.1 Publication

Gene expression databases

ArrayExpressiQ3UH66.
BgeeiQ3UH66.
CleanExiMM_WNK2.
GenevestigatoriQ3UH66.

Interactioni

Subunit structurei

Forms a complex with the phosphorylated form of STK39 in the brain.

Structurei

3D structure databases

ProteinModelPortaliQ3UH66.
SMRiQ3UH66. Positions 184-545.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini195 – 453259Protein kinase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi172 – 1776Poly-Glu
Compositional biasi645 – 1080436Pro-rich
Add
BLAST
Compositional biasi1430 – 149667Pro-rich
Add
BLAST
Compositional biasi1594 – 15974Poly-Ser

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00550000074385.
HOGENOMiHOG000139922.
HOVERGENiHBG050345.
KOiK08867.
OrthoDBiEOG7KDF8Z.
PhylomeDBiQ3UH66.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR024678. Kinase_OSR1/WNK_CCT.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF12202. OSR1_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3UH66-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDGDGGRRDA PGALMEAGRG TGSAGMAEPR ARAARLGPQR FLRRSVVESD     50
QEEPPGLEAA ETPSAQPPQP LQRRVLLLCK TRRLIAERAR GRPAAPAPAA 100
PAAPPGSPSV PSDPGPERAG TQEPSPDPTT ASAAATQVPD GGPRQEEAPA 150
PTQEDAGTTE AKPEPGRARK DEPEEEEDDE DDLKAVATSL DGRFLKFDIE 200
LGRGSFKTVY KGLDTETWVE VAWCELQDRK LTKLERQRFK EEAEMLKGLQ 250
HPNIVRFYDF WESSAKGKRC IVLVTELMTS GTLKTYLKRF KVMKPKVLRS 300
WCRQILKGLL FLHTRTPPII HRDLKCDNIF ITGPTGSVKI GDLGLATLKR 350
ASFAKSVIGT PEFMAPEMYE EHYDESVDVY AFGMCMLEMA TSEYPYSECQ 400
NAAQIYRKVT CGIKPASFEK VHDPEIKEII GECICKNKEE RYEIKDLLSH 450
AFFAEDTGVR VELAEEDHGR KSTIALRLWV EDPKKLKGKP KDNGAIEFTF 500
DLEKETPDEV AQEMIDSGFF HESDVKIVAK SIRDRVALIQ WRRERIWPAL 550
QSQEPKDSGS PDKARGLPAP LQVQVTYHAQ SGQPGQPEPE EPEADQHLLP 600
PTLPASVTSL ASDSTFDSGQ GSTVYSDSQS SQQSMVLSSL VDTAPTPASC 650
VCSPPVSEGP GLTHSLPTLG AFQQPATVPG LSVGPVPPPA RPPLLQQHFP 700
ESSMSFTPVL PPPSTPVPTG PSQPAPPVQQ PLPMAQPPTL PQVLAPQPMG 750
TVQPVPSHLP PYLAPTSQVV APAQLKPLQM PQPPLQPLAQ VPPQMPQMPV 800
VPPITPLTGL DGLPQTLTDL PAANVAPVPP PQYFSPAVIL PSLTTPLPTS 850
PALPMQAVKL PHPPGTPLAV PCQTIVPNAP AAIPLLAVAP QGVAALSIHP 900
AVAQIPAQPV YPAAFPQMVP GDIPPSPHHT VQSLRATPPQ LASPVPPQPV 950
QPSVIHLPEQ AAPTAASGTQ VLLGHPPSYT ADVAAPVSAV SLPPAVLSPP 1000
LPDTLLPTVP DLLPKVPSSL APTVVAASQS APAQTSSLLL PTNPPLPTGP 1050
AVAGPCPAVQ LMVEVAQEEQ VSQDKPPGPP QSSESFGGSD VTSGRDLSDS 1100
CEGTFGGGRL EGRTARKHHR RSTRARSRQE RASRPRLTIL NVCNTGDKMV 1150
ECQLETHNHK MVTFKFDLDG DAPDEIATYM VEHDFILPAE RETFIEQMKD 1200
VMDKAEDMLS EDTDADHGSD TGTSPPHLGT CGLATGEENR QSQANAPVYQ 1250
QNVLHTGKRW FIICPVAEHP ATDTSESSPP LPLSSLQPEA SQDPAPYPDQ 1300
LSLTDKPSFP AAQQLLSQAG SSNPPGGASA PLAPSSPPVT TVIPAAPATS 1350
TVPESAAGTA MQAGGPGTHQ GPASVHETLQ PLAETRSAQC TAQPLSTGQG 1400
PCTPALEASR CSTGLGEPIS TREVSTQGEP LPASVPEPSP PTGATQSVPG 1450
QPPPPLPITV GAISLAAPQL PSPPLGPTAP PPPPSALESD GEGPPPRVGF 1500
VDNTIKSLDE KLRTLLYQEH VPTSSASAGT PMEASDRDFT LEPLRGDLPS 1550
ALSDKTPSLT QQTQPSLEKS ETAPAGWALA QREQGASSPM TAESSSSNTL 1600
GCDSDAGQVA SDSSTAPSVP QDASGSSVPT HMDPKDQNSS VPREALAAPM 1650
QSGPGSFTVG SPAQLRGARD SGSPHKRPGQ QDNSSPAKTV GRFSVVSTQD 1700
EWTLASPHSL RYSAPPDVYL DEIPSSPEVK LAVRRVQTAS SIEVGVEEPA 1750
SSDSGDERPR RRSQVQKQSS LPGTGGVASD FVKKATAFLH RSSRAGSLGP 1800
ETPSRAGVKV PTISITSFHS QSSYISSDND SEFEDADIKK ELRSLREKHL 1850
KEISELQSQQ KQEIEALYRR LGKPLPPNVG FFHTAPPMGR RRKTSKSKLK 1900
AGKLLNPLVQ QLKVVASSTG HLSDSSRGPP TKDPRGTKAV QTQQPCSVRA 1950
SLSTDICSGL ASDGGGARGQ GWTVYHPTSE RGAYKSSSKP RARFLSGPVS 2000
VSIWSALKRL CLGKEHSSSL YDSPGSSTSS LAPGPEPGPQ PTLHVQAQVN 2050
NSNNKKGTFT DDLHKLVDEW TTKTVGAAQV KPTLNQLKQT QKLHDMEASG 2100
DARATSVPRA AVGASCLAPA PGPLSTTATP GATPALPVPI PDPESEKPD 2149

Note: No experimental confirmation available.

Length:2,149
Mass (Da):227,527
Last modified:February 20, 2007 - v2
Checksum:iA4BBF1D391FE9BEC
GO
Isoform 2 (identifier: Q3UH66-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1921-2004: Missing.

Note: No experimental confirmation available.

Show »
Length:2,065
Mass (Da):218,728
Checksum:iCF4AE4A4DC664F90
GO
Isoform 3 (identifier: Q3UH66-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1935-1935: R → AHASTPP
     2019-2025: SLYDSPG → R

Note: No experimental confirmation available.

Show »
Length:2,149
Mass (Da):227,469
Checksum:i98AD382CFD4CFE45
GO
Isoform 4 (identifier: Q3UH66-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1935-1935: R → AHASTPP
     1971-2024: Missing.

Note: No experimental confirmation available.

Show »
Length:2,101
Mass (Da):222,082
Checksum:i953172919B0CBF8D
GO
Isoform 5 (identifier: Q3UH66-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1935-1935: R → AHASTPP
     2019-2025: SLYDSPG → R
     2142-2149: DPESEKPD → GTVHSSLSGP...STPGPRLHIT

Note: No experimental confirmation available.

Show »
Length:2,213
Mass (Da):234,069
Checksum:i0BE7B0D8B10819E2
GO
Isoform 6 (identifier: Q3UH66-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     731-742: Missing.
     971-1068: Missing.
     1935-1935: R → AHASTPP
     1971-2024: Missing.

Note: No experimental confirmation available.

Show »
Length:1,991
Mass (Da):211,147
Checksum:i1177FFA99C62BFD0
GO
Isoform 7 (identifier: Q3UH66-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     971-1068: Missing.
     1592-1593: AE → E
     1935-1935: R → AHASTPP
     2019-2025: SLYDSPG → R
     2142-2149: DPESEKPD → EACALPTPPCKFLSRPSSGQPTEGRSISGGFHDTCPGGERGDENSLTPSG

Note: No experimental confirmation available.

Show »
Length:2,092
Mass (Da):221,908
Checksum:i581DA7240F2E5FE5
GO

Sequence cautioni

The sequence AAH46464.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence AAH55795.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAE20646.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei731 – 74212Missing in isoform 6.
VSP_023366Add
BLAST
Alternative sequencei971 – 106898Missing in isoform 6 and isoform 7.
VSP_023367Add
BLAST
Alternative sequencei1592 – 15932AE → E in isoform 7.
VSP_023368
Alternative sequencei1921 – 200484Missing in isoform 2.
VSP_023369Add
BLAST
Alternative sequencei1935 – 19351R → AHASTPP in isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7.
VSP_023370
Alternative sequencei1971 – 202454Missing in isoform 4 and isoform 6.
VSP_023371Add
BLAST
Alternative sequencei2019 – 20257SLYDSPG → R in isoform 3, isoform 5 and isoform 7.
VSP_023372
Alternative sequencei2142 – 21498DPESEKPD → GTVHSSLSGPPCTLPLCQYG GLLPDPVSWGPWVASGNPEG SWGSQSPTQVPVFPVFLRPP VISTPGPRLHIT in isoform 5.
VSP_023373
Alternative sequencei2142 – 21498DPESEKPD → EACALPTPPCKFLSRPSSGQ PTEGRSISGGFHDTCPGGER GDENSLTPSG in isoform 7.
VSP_023374

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti761 – 79434PYLAP…QVPPQ → RRYLWPIFCSPQGWGTRPWT RPVHACLQGLLARE in BAC98249. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CAAA01187366 Genomic DNA. No translation available.
AC140284 Genomic DNA. No translation available.
AK044381 mRNA. Translation: BAE20646.1. Different initiation.
AK147550 mRNA. Translation: BAE27991.1.
BC046464 mRNA. Translation: AAH46464.1. Different initiation.
BC055795 mRNA. Translation: AAH55795.1. Different initiation.
BC060187 mRNA. Translation: AAH60187.1.
AK129439 mRNA. Translation: BAC98249.1.
CCDSiCCDS70454.1. [Q3UH66-5]
CCDS70455.1. [Q3UH66-3]
RefSeqiNP_001277240.1. NM_001290311.1.
NP_001277242.1. NM_001290313.1.
NP_083637.2. NM_029361.4.
UniGeneiMm.342723.

Genome annotation databases

EnsembliENSMUST00000160087; ENSMUSP00000124614; ENSMUSG00000037989.
GeneIDi75607.
KEGGimmu:75607.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CAAA01187366 Genomic DNA. No translation available.
AC140284 Genomic DNA. No translation available.
AK044381 mRNA. Translation: BAE20646.1 . Different initiation.
AK147550 mRNA. Translation: BAE27991.1 .
BC046464 mRNA. Translation: AAH46464.1 . Different initiation.
BC055795 mRNA. Translation: AAH55795.1 . Different initiation.
BC060187 mRNA. Translation: AAH60187.1 .
AK129439 mRNA. Translation: BAC98249.1 .
CCDSi CCDS70454.1. [Q3UH66-5 ]
CCDS70455.1. [Q3UH66-3 ]
RefSeqi NP_001277240.1. NM_001290311.1.
NP_001277242.1. NM_001290313.1.
NP_083637.2. NM_029361.4.
UniGenei Mm.342723.

3D structure databases

ProteinModelPortali Q3UH66.
SMRi Q3UH66. Positions 184-545.
ModBasei Search...

PTM databases

PhosphoSitei Q3UH66.

Proteomic databases

MaxQBi Q3UH66.
PaxDbi Q3UH66.
PRIDEi Q3UH66.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000160087 ; ENSMUSP00000124614 ; ENSMUSG00000037989 .
GeneIDi 75607.
KEGGi mmu:75607.

Organism-specific databases

CTDi 65268.
MGIi MGI:1922857. Wnk2.
Rougei Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00550000074385.
HOGENOMi HOG000139922.
HOVERGENi HBG050345.
KOi K08867.
OrthoDBi EOG7KDF8Z.
PhylomeDBi Q3UH66.

Enzyme and pathway databases

Reactomei REACT_196640. Stimuli-sensing channels.

Miscellaneous databases

ChiTaRSi WNK2. mouse.
NextBioi 343494.
PROi Q3UH66.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q3UH66.
Bgeei Q3UH66.
CleanExi MM_WNK2.
Genevestigatori Q3UH66.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR024678. Kinase_OSR1/WNK_CCT.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF12202. OSR1_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1506-2149 (ISOFORM 5).
    Strain: C57BL/6J.
    Tissue: Retina.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 443-2149 (ISOFORM 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 801-2149 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1513-2149 (ISOFORM 4).
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain and Salivary gland.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 761-2149 (ISOFORM 7).
    Tissue: Brain.
  5. Cited for: FUNCTION, TISSUE SPECIFICITY, PHOSPHORYLATION AT SER-1566; SER-1770 AND SER-1797, INTERACTION WITH STK39.

Entry informationi

Entry nameiWNK2_MOUSE
AccessioniPrimary (citable) accession number: Q3UH66
Secondary accession number(s): Q3V387
, Q6PAN9, Q6ZPI6, Q7TNS1, Q811F2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: September 3, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi