Q3UH66 (WNK2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase WNK2
EC=2.7.11.1

Alternative name(s):
Protein kinase lysine-deficient 2
Protein kinase with no lysine 2

Gene names

Name:	Wnk2
Synonyms:	Kiaa1760

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2149 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity. Ref.5
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Cofactor	Magnesium By similarity.
Enzyme regulation	Activation requires autophosphorylation of Ser-356. Phosphorylation of Ser-352 also promotes increased activity By similarity.
Subunit structure	Forms a complex with the phosphorylated form of STK39 in the brain.
Subcellular location	Cytoplasm By similarity. Cell membrane By similarity.
Tissue specificity	Brain and heart. Ref.5
Post-translational modification	Autophosphorylated By similarity. Ref.5
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily. Contains 1 protein kinase domain.
Caution	Cys-224 is present instead of the conserved Lys which is expected to be an active site residue. Lys-207 appears to fulfill the required catalytic function.
Sequence caution	The sequence AAH46464.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence AAH55795.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAE20646.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Membrane
Coding sequence diversity	Alternative splicing
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein phosphorylation Inferred from direct assay Ref.5. Source: UniProtKB
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q3UH66-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q3UH66-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1921-2004: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q3UH66-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1935-1935: R → AHASTPP
     2019-2025: SLYDSPG → R

Note: No experimental confirmation available.

Isoform 4 (identifier: Q3UH66-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1935-1935: R → AHASTPP
     1971-2024: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q3UH66-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1935-1935: R → AHASTPP
     2019-2025: SLYDSPG → R
     2142-2149: DPESEKPD → GTVHSSLSGP...STPGPRLHIT

Note: No experimental confirmation available.

Isoform 6 (identifier: Q3UH66-6)

The sequence of this isoform differs from the canonical sequence as follows:
     731-742: Missing.
     971-1068: Missing.
     1935-1935: R → AHASTPP
     1971-2024: Missing.

Note: No experimental confirmation available.

Isoform 7 (identifier: Q3UH66-7)

The sequence of this isoform differs from the canonical sequence as follows:
     971-1068: Missing.
     1592-1593: AE → E
     1935-1935: R → AHASTPP
     2019-2025: SLYDSPG → R
     2142-2149: DPESEKPD → EACALPTPPCKFLSRPSSGQPTEGRSISGGFHDTCPGGERGDENSLTPSG

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2149	2149	Serine/threonine-protein kinase WNK2		PRO_0000278774
Regions
	Domain	195 – 453	259	Protein kinase
	Nucleotide binding	201 – 209	9	ATP By similarity
	Compositional bias	172 – 177	6	Poly-Glu
	Compositional bias	645 – 1080	436	Pro-rich
	Compositional bias	1430 – 1496	67	Pro-rich
	Compositional bias	1594 – 1597	4	Poly-Ser
Sites
	Active site	323	1	Proton acceptor By similarity
	Binding site	207	1	ATP By similarity
Amino acid modifications
	Modified residue	45	1	Phosphoserine By similarity
	Modified residue	352	1	Phosphoserine; by autocatalysis By similarity
	Modified residue	356	1	Phosphoserine; by autocatalysis By similarity
	Modified residue	560	1	Phosphoserine By similarity
	Modified residue	1098	1	Phosphoserine By similarity
	Modified residue	1210	1	Phosphoserine By similarity
	Modified residue	1507	1	Phosphoserine By similarity
	Modified residue	1566	1	Phosphoserine Ref.5
	Modified residue	1594	1	Phosphoserine By similarity
	Modified residue	1725	1	Phosphoserine By similarity
	Modified residue	1726	1	Phosphoserine By similarity
	Modified residue	1770	1	Phosphoserine Ref.5
	Modified residue	1797	1	Phosphoserine Ref.5
	Modified residue	1962	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	731 – 742	12	Missing in isoform 6.		VSP_023366
	Alternative sequence	971 – 1068	98	Missing in isoform 6 and isoform 7.		VSP_023367
	Alternative sequence	1592 – 1593	2	AE → E in isoform 7.		VSP_023368
	Alternative sequence	1921 – 2004	84	Missing in isoform 2.		VSP_023369
	Alternative sequence	1935	1	R → AHASTPP in isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7.		VSP_023370
	Alternative sequence	1971 – 2024	54	Missing in isoform 4 and isoform 6.		VSP_023371
	Alternative sequence	2019 – 2025	7	SLYDSPG → R in isoform 3, isoform 5 and isoform 7.		VSP_023372
	Alternative sequence	2142 – 2149	8	DPESEKPD → GTVHSSLSGPPCTLPLCQYG GLLPDPVSWGPWVASGNPEG SWGSQSPTQVPVFPVFLRPP VISTPGPRLHIT in isoform 5.		VSP_023373
	Alternative sequence	2142 – 2149	8	DPESEKPD → EACALPTPPCKFLSRPSSGQ PTEGRSISGGFHDTCPGGER GDENSLTPSG in isoform 7.		VSP_023374
Experimental info
	Sequence conflict	761 – 794	34	PYLAP…QVPPQ → RRYLWPIFCSPQGWGTRPWT RPVHACLQGLLARE in BAC98249. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 20, 2007. Version 2. Checksum: A4BBF1D391FE9BEC	FASTA	2,149	227,527
	10 20 30 40 50 60 MDGDGGRRDA PGALMEAGRG TGSAGMAEPR ARAARLGPQR FLRRSVVESD QEEPPGLEAA 70 80 90 100 110 120 ETPSAQPPQP LQRRVLLLCK TRRLIAERAR GRPAAPAPAA PAAPPGSPSV PSDPGPERAG 130 140 150 160 170 180 TQEPSPDPTT ASAAATQVPD GGPRQEEAPA PTQEDAGTTE AKPEPGRARK DEPEEEEDDE 190 200 210 220 230 240 DDLKAVATSL DGRFLKFDIE LGRGSFKTVY KGLDTETWVE VAWCELQDRK LTKLERQRFK 250 260 270 280 290 300 EEAEMLKGLQ HPNIVRFYDF WESSAKGKRC IVLVTELMTS GTLKTYLKRF KVMKPKVLRS 310 320 330 340 350 360 WCRQILKGLL FLHTRTPPII HRDLKCDNIF ITGPTGSVKI GDLGLATLKR ASFAKSVIGT 370 380 390 400 410 420 PEFMAPEMYE EHYDESVDVY AFGMCMLEMA TSEYPYSECQ NAAQIYRKVT CGIKPASFEK 430 440 450 460 470 480 VHDPEIKEII GECICKNKEE RYEIKDLLSH AFFAEDTGVR VELAEEDHGR KSTIALRLWV 490 500 510 520 530 540 EDPKKLKGKP KDNGAIEFTF DLEKETPDEV AQEMIDSGFF HESDVKIVAK SIRDRVALIQ 550 560 570 580 590 600 WRRERIWPAL QSQEPKDSGS PDKARGLPAP LQVQVTYHAQ SGQPGQPEPE EPEADQHLLP 610 620 630 640 650 660 PTLPASVTSL ASDSTFDSGQ GSTVYSDSQS SQQSMVLSSL VDTAPTPASC VCSPPVSEGP 670 680 690 700 710 720 GLTHSLPTLG AFQQPATVPG LSVGPVPPPA RPPLLQQHFP ESSMSFTPVL PPPSTPVPTG 730 740 750 760 770 780 PSQPAPPVQQ PLPMAQPPTL PQVLAPQPMG TVQPVPSHLP PYLAPTSQVV APAQLKPLQM 790 800 810 820 830 840 PQPPLQPLAQ VPPQMPQMPV VPPITPLTGL DGLPQTLTDL PAANVAPVPP PQYFSPAVIL 850 860 870 880 890 900 PSLTTPLPTS PALPMQAVKL PHPPGTPLAV PCQTIVPNAP AAIPLLAVAP QGVAALSIHP 910 920 930 940 950 960 AVAQIPAQPV YPAAFPQMVP GDIPPSPHHT VQSLRATPPQ LASPVPPQPV QPSVIHLPEQ 970 980 990 1000 1010 1020 AAPTAASGTQ VLLGHPPSYT ADVAAPVSAV SLPPAVLSPP LPDTLLPTVP DLLPKVPSSL 1030 1040 1050 1060 1070 1080 APTVVAASQS APAQTSSLLL PTNPPLPTGP AVAGPCPAVQ LMVEVAQEEQ VSQDKPPGPP 1090 1100 1110 1120 1130 1140 QSSESFGGSD VTSGRDLSDS CEGTFGGGRL EGRTARKHHR RSTRARSRQE RASRPRLTIL 1150 1160 1170 1180 1190 1200 NVCNTGDKMV ECQLETHNHK MVTFKFDLDG DAPDEIATYM VEHDFILPAE RETFIEQMKD 1210 1220 1230 1240 1250 1260 VMDKAEDMLS EDTDADHGSD TGTSPPHLGT CGLATGEENR QSQANAPVYQ QNVLHTGKRW 1270 1280 1290 1300 1310 1320 FIICPVAEHP ATDTSESSPP LPLSSLQPEA SQDPAPYPDQ LSLTDKPSFP AAQQLLSQAG 1330 1340 1350 1360 1370 1380 SSNPPGGASA PLAPSSPPVT TVIPAAPATS TVPESAAGTA MQAGGPGTHQ GPASVHETLQ 1390 1400 1410 1420 1430 1440 PLAETRSAQC TAQPLSTGQG PCTPALEASR CSTGLGEPIS TREVSTQGEP LPASVPEPSP 1450 1460 1470 1480 1490 1500 PTGATQSVPG QPPPPLPITV GAISLAAPQL PSPPLGPTAP PPPPSALESD GEGPPPRVGF 1510 1520 1530 1540 1550 1560 VDNTIKSLDE KLRTLLYQEH VPTSSASAGT PMEASDRDFT LEPLRGDLPS ALSDKTPSLT 1570 1580 1590 1600 1610 1620 QQTQPSLEKS ETAPAGWALA QREQGASSPM TAESSSSNTL GCDSDAGQVA SDSSTAPSVP 1630 1640 1650 1660 1670 1680 QDASGSSVPT HMDPKDQNSS VPREALAAPM QSGPGSFTVG SPAQLRGARD SGSPHKRPGQ 1690 1700 1710 1720 1730 1740 QDNSSPAKTV GRFSVVSTQD EWTLASPHSL RYSAPPDVYL DEIPSSPEVK LAVRRVQTAS 1750 1760 1770 1780 1790 1800 SIEVGVEEPA SSDSGDERPR RRSQVQKQSS LPGTGGVASD FVKKATAFLH RSSRAGSLGP 1810 1820 1830 1840 1850 1860 ETPSRAGVKV PTISITSFHS QSSYISSDND SEFEDADIKK ELRSLREKHL KEISELQSQQ 1870 1880 1890 1900 1910 1920 KQEIEALYRR LGKPLPPNVG FFHTAPPMGR RRKTSKSKLK AGKLLNPLVQ QLKVVASSTG 1930 1940 1950 1960 1970 1980 HLSDSSRGPP TKDPRGTKAV QTQQPCSVRA SLSTDICSGL ASDGGGARGQ GWTVYHPTSE 1990 2000 2010 2020 2030 2040 RGAYKSSSKP RARFLSGPVS VSIWSALKRL CLGKEHSSSL YDSPGSSTSS LAPGPEPGPQ 2050 2060 2070 2080 2090 2100 PTLHVQAQVN NSNNKKGTFT DDLHKLVDEW TTKTVGAAQV KPTLNQLKQT QKLHDMEASG 2110 2120 2130 2140 DARATSVPRA AVGASCLAPA PGPLSTTATP GATPALPVPI PDPESEKPD
	Isoform 2 [UniParc]. Checksum: CF4AE4A4DC664F90	FASTA	2,065	218,728
	10 20 30 40 50 60 MDGDGGRRDA PGALMEAGRG TGSAGMAEPR ARAARLGPQR FLRRSVVESD QEEPPGLEAA 70 80 90 100 110 120 ETPSAQPPQP LQRRVLLLCK TRRLIAERAR GRPAAPAPAA PAAPPGSPSV PSDPGPERAG 130 140 150 160 170 180 TQEPSPDPTT ASAAATQVPD GGPRQEEAPA PTQEDAGTTE AKPEPGRARK DEPEEEEDDE 190 200 210 220 230 240 DDLKAVATSL DGRFLKFDIE LGRGSFKTVY KGLDTETWVE VAWCELQDRK LTKLERQRFK 250 260 270 280 290 300 EEAEMLKGLQ HPNIVRFYDF WESSAKGKRC IVLVTELMTS GTLKTYLKRF KVMKPKVLRS 310 320 330 340 350 360 WCRQILKGLL FLHTRTPPII HRDLKCDNIF ITGPTGSVKI GDLGLATLKR ASFAKSVIGT 370 380 390 400 410 420 PEFMAPEMYE EHYDESVDVY AFGMCMLEMA TSEYPYSECQ NAAQIYRKVT CGIKPASFEK 430 440 450 460 470 480 VHDPEIKEII GECICKNKEE RYEIKDLLSH AFFAEDTGVR VELAEEDHGR KSTIALRLWV 490 500 510 520 530 540 EDPKKLKGKP KDNGAIEFTF DLEKETPDEV AQEMIDSGFF HESDVKIVAK SIRDRVALIQ 550 560 570 580 590 600 WRRERIWPAL QSQEPKDSGS PDKARGLPAP LQVQVTYHAQ SGQPGQPEPE EPEADQHLLP 610 620 630 640 650 660 PTLPASVTSL ASDSTFDSGQ GSTVYSDSQS SQQSMVLSSL VDTAPTPASC VCSPPVSEGP 670 680 690 700 710 720 GLTHSLPTLG AFQQPATVPG LSVGPVPPPA RPPLLQQHFP ESSMSFTPVL PPPSTPVPTG 730 740 750 760 770 780 PSQPAPPVQQ PLPMAQPPTL PQVLAPQPMG TVQPVPSHLP PYLAPTSQVV APAQLKPLQM 790 800 810 820 830 840 PQPPLQPLAQ VPPQMPQMPV VPPITPLTGL DGLPQTLTDL PAANVAPVPP PQYFSPAVIL 850 860 870 880 890 900 PSLTTPLPTS PALPMQAVKL PHPPGTPLAV PCQTIVPNAP AAIPLLAVAP QGVAALSIHP 910 920 930 940 950 960 AVAQIPAQPV YPAAFPQMVP GDIPPSPHHT VQSLRATPPQ LASPVPPQPV QPSVIHLPEQ 970 980 990 1000 1010 1020 AAPTAASGTQ VLLGHPPSYT ADVAAPVSAV SLPPAVLSPP LPDTLLPTVP DLLPKVPSSL 1030 1040 1050 1060 1070 1080 APTVVAASQS APAQTSSLLL PTNPPLPTGP AVAGPCPAVQ LMVEVAQEEQ VSQDKPPGPP 1090 1100 1110 1120 1130 1140 QSSESFGGSD VTSGRDLSDS CEGTFGGGRL EGRTARKHHR RSTRARSRQE RASRPRLTIL 1150 1160 1170 1180 1190 1200 NVCNTGDKMV ECQLETHNHK MVTFKFDLDG DAPDEIATYM VEHDFILPAE RETFIEQMKD 1210 1220 1230 1240 1250 1260 VMDKAEDMLS EDTDADHGSD TGTSPPHLGT CGLATGEENR QSQANAPVYQ QNVLHTGKRW 1270 1280 1290 1300 1310 1320 FIICPVAEHP ATDTSESSPP LPLSSLQPEA SQDPAPYPDQ LSLTDKPSFP AAQQLLSQAG 1330 1340 1350 1360 1370 1380 SSNPPGGASA PLAPSSPPVT TVIPAAPATS TVPESAAGTA MQAGGPGTHQ GPASVHETLQ 1390 1400 1410 1420 1430 1440 PLAETRSAQC TAQPLSTGQG PCTPALEASR CSTGLGEPIS TREVSTQGEP LPASVPEPSP 1450 1460 1470 1480 1490 1500 PTGATQSVPG QPPPPLPITV GAISLAAPQL PSPPLGPTAP PPPPSALESD GEGPPPRVGF 1510 1520 1530 1540 1550 1560 VDNTIKSLDE KLRTLLYQEH VPTSSASAGT PMEASDRDFT LEPLRGDLPS ALSDKTPSLT 1570 1580 1590 1600 1610 1620 QQTQPSLEKS ETAPAGWALA QREQGASSPM TAESSSSNTL GCDSDAGQVA SDSSTAPSVP 1630 1640 1650 1660 1670 1680 QDASGSSVPT HMDPKDQNSS VPREALAAPM QSGPGSFTVG SPAQLRGARD SGSPHKRPGQ 1690 1700 1710 1720 1730 1740 QDNSSPAKTV GRFSVVSTQD EWTLASPHSL RYSAPPDVYL DEIPSSPEVK LAVRRVQTAS 1750 1760 1770 1780 1790 1800 SIEVGVEEPA SSDSGDERPR RRSQVQKQSS LPGTGGVASD FVKKATAFLH RSSRAGSLGP 1810 1820 1830 1840 1850 1860 ETPSRAGVKV PTISITSFHS QSSYISSDND SEFEDADIKK ELRSLREKHL KEISELQSQQ 1870 1880 1890 1900 1910 1920 KQEIEALYRR LGKPLPPNVG FFHTAPPMGR RRKTSKSKLK AGKLLNPLVQ QLKVVASSTG 1930 1940 1950 1960 1970 1980 SALKRLCLGK EHSSSLYDSP GSSTSSLAPG PEPGPQPTLH VQAQVNNSNN KKGTFTDDLH 1990 2000 2010 2020 2030 2040 KLVDEWTTKT VGAAQVKPTL NQLKQTQKLH DMEASGDARA TSVPRAAVGA SCLAPAPGPL 2050 2060 STTATPGATP ALPVPIPDPE SEKPD
	Isoform 3 [UniParc]. Checksum: 98AD382CFD4CFE45	FASTA	2,149	227,469
	10 20 30 40 50 60 MDGDGGRRDA PGALMEAGRG TGSAGMAEPR ARAARLGPQR FLRRSVVESD QEEPPGLEAA 70 80 90 100 110 120 ETPSAQPPQP LQRRVLLLCK TRRLIAERAR GRPAAPAPAA PAAPPGSPSV PSDPGPERAG 130 140 150 160 170 180 TQEPSPDPTT ASAAATQVPD GGPRQEEAPA PTQEDAGTTE AKPEPGRARK DEPEEEEDDE 190 200 210 220 230 240 DDLKAVATSL DGRFLKFDIE LGRGSFKTVY KGLDTETWVE VAWCELQDRK LTKLERQRFK 250 260 270 280 290 300 EEAEMLKGLQ HPNIVRFYDF WESSAKGKRC IVLVTELMTS GTLKTYLKRF KVMKPKVLRS 310 320 330 340 350 360 WCRQILKGLL FLHTRTPPII HRDLKCDNIF ITGPTGSVKI GDLGLATLKR ASFAKSVIGT 370 380 390 400 410 420 PEFMAPEMYE EHYDESVDVY AFGMCMLEMA TSEYPYSECQ NAAQIYRKVT CGIKPASFEK 430 440 450 460 470 480 VHDPEIKEII GECICKNKEE RYEIKDLLSH AFFAEDTGVR VELAEEDHGR KSTIALRLWV 490 500 510 520 530 540 EDPKKLKGKP KDNGAIEFTF DLEKETPDEV AQEMIDSGFF HESDVKIVAK SIRDRVALIQ 550 560 570 580 590 600 WRRERIWPAL QSQEPKDSGS PDKARGLPAP LQVQVTYHAQ SGQPGQPEPE EPEADQHLLP 610 620 630 640 650 660 PTLPASVTSL ASDSTFDSGQ GSTVYSDSQS SQQSMVLSSL VDTAPTPASC VCSPPVSEGP 670 680 690 700 710 720 GLTHSLPTLG AFQQPATVPG LSVGPVPPPA RPPLLQQHFP ESSMSFTPVL PPPSTPVPTG 730 740 750 760 770 780 PSQPAPPVQQ PLPMAQPPTL PQVLAPQPMG TVQPVPSHLP PYLAPTSQVV APAQLKPLQM 790 800 810 820 830 840 PQPPLQPLAQ VPPQMPQMPV VPPITPLTGL DGLPQTLTDL PAANVAPVPP PQYFSPAVIL 850 860 870 880 890 900 PSLTTPLPTS PALPMQAVKL PHPPGTPLAV PCQTIVPNAP AAIPLLAVAP QGVAALSIHP 910 920 930 940 950 960 AVAQIPAQPV YPAAFPQMVP GDIPPSPHHT VQSLRATPPQ LASPVPPQPV QPSVIHLPEQ 970 980 990 1000 1010 1020 AAPTAASGTQ VLLGHPPSYT ADVAAPVSAV SLPPAVLSPP LPDTLLPTVP DLLPKVPSSL 1030 1040 1050 1060 1070 1080 APTVVAASQS APAQTSSLLL PTNPPLPTGP AVAGPCPAVQ LMVEVAQEEQ VSQDKPPGPP 1090 1100 1110 1120 1130 1140 QSSESFGGSD VTSGRDLSDS CEGTFGGGRL EGRTARKHHR RSTRARSRQE RASRPRLTIL 1150 1160 1170 1180 1190 1200 NVCNTGDKMV ECQLETHNHK MVTFKFDLDG DAPDEIATYM VEHDFILPAE RETFIEQMKD 1210 1220 1230 1240 1250 1260 VMDKAEDMLS EDTDADHGSD TGTSPPHLGT CGLATGEENR QSQANAPVYQ QNVLHTGKRW 1270 1280 1290 1300 1310 1320 FIICPVAEHP ATDTSESSPP LPLSSLQPEA SQDPAPYPDQ LSLTDKPSFP AAQQLLSQAG 1330 1340 1350 1360 1370 1380 SSNPPGGASA PLAPSSPPVT TVIPAAPATS TVPESAAGTA MQAGGPGTHQ GPASVHETLQ 1390 1400 1410 1420 1430 1440 PLAETRSAQC TAQPLSTGQG PCTPALEASR CSTGLGEPIS TREVSTQGEP LPASVPEPSP 1450 1460 1470 1480 1490 1500 PTGATQSVPG QPPPPLPITV GAISLAAPQL PSPPLGPTAP PPPPSALESD GEGPPPRVGF 1510 1520 1530 1540 1550 1560 VDNTIKSLDE KLRTLLYQEH VPTSSASAGT PMEASDRDFT LEPLRGDLPS ALSDKTPSLT 1570 1580 1590 1600 1610 1620 QQTQPSLEKS ETAPAGWALA QREQGASSPM TAESSSSNTL GCDSDAGQVA SDSSTAPSVP 1630 1640 1650 1660 1670 1680 QDASGSSVPT HMDPKDQNSS VPREALAAPM QSGPGSFTVG SPAQLRGARD SGSPHKRPGQ 1690 1700 1710 1720 1730 1740 QDNSSPAKTV GRFSVVSTQD EWTLASPHSL RYSAPPDVYL DEIPSSPEVK LAVRRVQTAS 1750 1760 1770 1780 1790 1800 SIEVGVEEPA SSDSGDERPR RRSQVQKQSS LPGTGGVASD FVKKATAFLH RSSRAGSLGP 1810 1820 1830 1840 1850 1860 ETPSRAGVKV PTISITSFHS QSSYISSDND SEFEDADIKK ELRSLREKHL KEISELQSQQ 1870 1880 1890 1900 1910 1920 KQEIEALYRR LGKPLPPNVG FFHTAPPMGR RRKTSKSKLK AGKLLNPLVQ QLKVVASSTG 1930 1940 1950 1960 1970 1980 HLSDSSRGPP TKDPAHASTP PGTKAVQTQQ PCSVRASLST DICSGLASDG GGARGQGWTV 1990 2000 2010 2020 2030 2040 YHPTSERGAY KSSSKPRARF LSGPVSVSIW SALKRLCLGK EHSSRSSTSS LAPGPEPGPQ 2050 2060 2070 2080 2090 2100 PTLHVQAQVN NSNNKKGTFT DDLHKLVDEW TTKTVGAAQV KPTLNQLKQT QKLHDMEASG 2110 2120 2130 2140 DARATSVPRA AVGASCLAPA PGPLSTTATP GATPALPVPI PDPESEKPD
	Isoform 4 [UniParc]. Checksum: 953172919B0CBF8D	FASTA	2,101	222,082
	10 20 30 40 50 60 MDGDGGRRDA PGALMEAGRG TGSAGMAEPR ARAARLGPQR FLRRSVVESD QEEPPGLEAA 70 80 90 100 110 120 ETPSAQPPQP LQRRVLLLCK TRRLIAERAR GRPAAPAPAA PAAPPGSPSV PSDPGPERAG 130 140 150 160 170 180 TQEPSPDPTT ASAAATQVPD GGPRQEEAPA PTQEDAGTTE AKPEPGRARK DEPEEEEDDE 190 200 210 220 230 240 DDLKAVATSL DGRFLKFDIE LGRGSFKTVY KGLDTETWVE VAWCELQDRK LTKLERQRFK 250 260 270 280 290 300 EEAEMLKGLQ HPNIVRFYDF WESSAKGKRC IVLVTELMTS GTLKTYLKRF KVMKPKVLRS 310 320 330 340 350 360 WCRQILKGLL FLHTRTPPII HRDLKCDNIF ITGPTGSVKI GDLGLATLKR ASFAKSVIGT 370 380 390 400 410 420 PEFMAPEMYE EHYDESVDVY AFGMCMLEMA TSEYPYSECQ NAAQIYRKVT CGIKPASFEK 430 440 450 460 470 480 VHDPEIKEII GECICKNKEE RYEIKDLLSH AFFAEDTGVR VELAEEDHGR KSTIALRLWV 490 500 510 520 530 540 EDPKKLKGKP KDNGAIEFTF DLEKETPDEV AQEMIDSGFF HESDVKIVAK SIRDRVALIQ 550 560 570 580 590 600 WRRERIWPAL QSQEPKDSGS PDKARGLPAP LQVQVTYHAQ SGQPGQPEPE EPEADQHLLP 610 620 630 640 650 660 PTLPASVTSL ASDSTFDSGQ GSTVYSDSQS SQQSMVLSSL VDTAPTPASC VCSPPVSEGP 670 680 690 700 710 720 GLTHSLPTLG AFQQPATVPG LSVGPVPPPA RPPLLQQHFP ESSMSFTPVL PPPSTPVPTG 730 740 750 760 770 780 PSQPAPPVQQ PLPMAQPPTL PQVLAPQPMG TVQPVPSHLP PYLAPTSQVV APAQLKPLQM 790 800 810 820 830 840 PQPPLQPLAQ VPPQMPQMPV VPPITPLTGL DGLPQTLTDL PAANVAPVPP PQYFSPAVIL 850 860 870 880 890 900 PSLTTPLPTS PALPMQAVKL PHPPGTPLAV PCQTIVPNAP AAIPLLAVAP QGVAALSIHP 910 920 930 940 950 960 AVAQIPAQPV YPAAFPQMVP GDIPPSPHHT VQSLRATPPQ LASPVPPQPV QPSVIHLPEQ 970 980 990 1000 1010 1020 AAPTAASGTQ VLLGHPPSYT ADVAAPVSAV SLPPAVLSPP LPDTLLPTVP DLLPKVPSSL 1030 1040 1050 1060 1070 1080 APTVVAASQS APAQTSSLLL PTNPPLPTGP AVAGPCPAVQ LMVEVAQEEQ VSQDKPPGPP 1090 1100 1110 1120 1130 1140 QSSESFGGSD VTSGRDLSDS CEGTFGGGRL EGRTARKHHR RSTRARSRQE RASRPRLTIL 1150 1160 1170 1180 1190 1200 NVCNTGDKMV ECQLETHNHK MVTFKFDLDG DAPDEIATYM VEHDFILPAE RETFIEQMKD 1210 1220 1230 1240 1250 1260 VMDKAEDMLS EDTDADHGSD TGTSPPHLGT CGLATGEENR QSQANAPVYQ QNVLHTGKRW 1270 1280 1290 1300 1310 1320 FIICPVAEHP ATDTSESSPP LPLSSLQPEA SQDPAPYPDQ LSLTDKPSFP AAQQLLSQAG 1330 1340 1350 1360 1370 1380 SSNPPGGASA PLAPSSPPVT TVIPAAPATS TVPESAAGTA MQAGGPGTHQ GPASVHETLQ 1390 1400 1410 1420 1430 1440 PLAETRSAQC TAQPLSTGQG PCTPALEASR CSTGLGEPIS TREVSTQGEP LPASVPEPSP 1450 1460 1470 1480 1490 1500 PTGATQSVPG QPPPPLPITV GAISLAAPQL PSPPLGPTAP PPPPSALESD GEGPPPRVGF 1510 1520 1530 1540 1550 1560 VDNTIKSLDE KLRTLLYQEH VPTSSASAGT PMEASDRDFT LEPLRGDLPS ALSDKTPSLT 1570 1580 1590 1600 1610 1620 QQTQPSLEKS ETAPAGWALA QREQGASSPM TAESSSSNTL GCDSDAGQVA SDSSTAPSVP 1630 1640 1650 1660 1670 1680 QDASGSSVPT HMDPKDQNSS VPREALAAPM QSGPGSFTVG SPAQLRGARD SGSPHKRPGQ 1690 1700 1710 1720 1730 1740 QDNSSPAKTV GRFSVVSTQD EWTLASPHSL RYSAPPDVYL DEIPSSPEVK LAVRRVQTAS 1750 1760 1770 1780 1790 1800 SIEVGVEEPA SSDSGDERPR RRSQVQKQSS LPGTGGVASD FVKKATAFLH RSSRAGSLGP 1810 1820 1830 1840 1850 1860 ETPSRAGVKV PTISITSFHS QSSYISSDND SEFEDADIKK ELRSLREKHL KEISELQSQQ 1870 1880 1890 1900 1910 1920 KQEIEALYRR LGKPLPPNVG FFHTAPPMGR RRKTSKSKLK AGKLLNPLVQ QLKVVASSTG 1930 1940 1950 1960 1970 1980 HLSDSSRGPP TKDPAHASTP PGTKAVQTQQ PCSVRASLST DICSGLASDG GGARGQGSST 1990 2000 2010 2020 2030 2040 SSLAPGPEPG PQPTLHVQAQ VNNSNNKKGT FTDDLHKLVD EWTTKTVGAA QVKPTLNQLK 2050 2060 2070 2080 2090 2100 QTQKLHDMEA SGDARATSVP RAAVGASCLA PAPGPLSTTA TPGATPALPV PIPDPESEKP D
	Isoform 5 [UniParc]. Checksum: 0BE7B0D8B10819E2	FASTA	2,213	234,069
	10 20 30 40 50 60 MDGDGGRRDA PGALMEAGRG TGSAGMAEPR ARAARLGPQR FLRRSVVESD QEEPPGLEAA 70 80 90 100 110 120 ETPSAQPPQP LQRRVLLLCK TRRLIAERAR GRPAAPAPAA PAAPPGSPSV PSDPGPERAG 130 140 150 160 170 180 TQEPSPDPTT ASAAATQVPD GGPRQEEAPA PTQEDAGTTE AKPEPGRARK DEPEEEEDDE 190 200 210 220 230 240 DDLKAVATSL DGRFLKFDIE LGRGSFKTVY KGLDTETWVE VAWCELQDRK LTKLERQRFK 250 260 270 280 290 300 EEAEMLKGLQ HPNIVRFYDF WESSAKGKRC IVLVTELMTS GTLKTYLKRF KVMKPKVLRS 310 320 330 340 350 360 WCRQILKGLL FLHTRTPPII HRDLKCDNIF ITGPTGSVKI GDLGLATLKR ASFAKSVIGT 370 380 390 400 410 420 PEFMAPEMYE EHYDESVDVY AFGMCMLEMA TSEYPYSECQ NAAQIYRKVT CGIKPASFEK 430 440 450 460 470 480 VHDPEIKEII GECICKNKEE RYEIKDLLSH AFFAEDTGVR VELAEEDHGR KSTIALRLWV 490 500 510 520 530 540 EDPKKLKGKP KDNGAIEFTF DLEKETPDEV AQEMIDSGFF HESDVKIVAK SIRDRVALIQ 550 560 570 580 590 600 WRRERIWPAL QSQEPKDSGS PDKARGLPAP LQVQVTYHAQ SGQPGQPEPE EPEADQHLLP 610 620 630 640 650 660 PTLPASVTSL ASDSTFDSGQ GSTVYSDSQS SQQSMVLSSL VDTAPTPASC VCSPPVSEGP 670 680 690 700 710 720 GLTHSLPTLG AFQQPATVPG LSVGPVPPPA RPPLLQQHFP ESSMSFTPVL PPPSTPVPTG 730 740 750 760 770 780 PSQPAPPVQQ PLPMAQPPTL PQVLAPQPMG TVQPVPSHLP PYLAPTSQVV APAQLKPLQM 790 800 810 820 830 840 PQPPLQPLAQ VPPQMPQMPV VPPITPLTGL DGLPQTLTDL PAANVAPVPP PQYFSPAVIL 850 860 870 880 890 900 PSLTTPLPTS PALPMQAVKL PHPPGTPLAV PCQTIVPNAP AAIPLLAVAP QGVAALSIHP 910 920 930 940 950 960 AVAQIPAQPV YPAAFPQMVP GDIPPSPHHT VQSLRATPPQ LASPVPPQPV QPSVIHLPEQ 970 980 990 1000 1010 1020 AAPTAASGTQ VLLGHPPSYT ADVAAPVSAV SLPPAVLSPP LPDTLLPTVP DLLPKVPSSL 1030 1040 1050 1060 1070 1080 APTVVAASQS APAQTSSLLL PTNPPLPTGP AVAGPCPAVQ LMVEVAQEEQ VSQDKPPGPP 1090 1100 1110 1120 1130 1140 QSSESFGGSD VTSGRDLSDS CEGTFGGGRL EGRTARKHHR RSTRARSRQE RASRPRLTIL 1150 1160 1170 1180 1190 1200 NVCNTGDKMV ECQLETHNHK MVTFKFDLDG DAPDEIATYM VEHDFILPAE RETFIEQMKD 1210 1220 1230 1240 1250 1260 VMDKAEDMLS EDTDADHGSD TGTSPPHLGT CGLATGEENR QSQANAPVYQ QNVLHTGKRW 1270 1280 1290 1300 1310 1320 FIICPVAEHP ATDTSESSPP LPLSSLQPEA SQDPAPYPDQ LSLTDKPSFP AAQQLLSQAG 1330 1340 1350 1360 1370 1380 SSNPPGGASA PLAPSSPPVT TVIPAAPATS TVPESAAGTA MQAGGPGTHQ GPASVHETLQ 1390 1400 1410 1420 1430 1440 PLAETRSAQC TAQPLSTGQG PCTPALEASR CSTGLGEPIS TREVSTQGEP LPASVPEPSP 1450 1460 1470 1480 1490 1500 PTGATQSVPG QPPPPLPITV GAISLAAPQL PSPPLGPTAP PPPPSALESD GEGPPPRVGF 1510 1520 1530 1540 1550 1560 VDNTIKSLDE KLRTLLYQEH VPTSSASAGT PMEASDRDFT LEPLRGDLPS ALSDKTPSLT 1570 1580 1590 1600 1610 1620 QQTQPSLEKS ETAPAGWALA QREQGASSPM TAESSSSNTL GCDSDAGQVA SDSSTAPSVP 1630 1640 1650 1660 1670 1680 QDASGSSVPT HMDPKDQNSS VPREALAAPM QSGPGSFTVG SPAQLRGARD SGSPHKRPGQ 1690 1700 1710 1720 1730 1740 QDNSSPAKTV GRFSVVSTQD EWTLASPHSL RYSAPPDVYL DEIPSSPEVK LAVRRVQTAS 1750 1760 1770 1780 1790 1800 SIEVGVEEPA SSDSGDERPR RRSQVQKQSS LPGTGGVASD FVKKATAFLH RSSRAGSLGP 1810 1820 1830 1840 1850 1860 ETPSRAGVKV PTISITSFHS QSSYISSDND SEFEDADIKK ELRSLREKHL KEISELQSQQ 1870 1880 1890 1900 1910 1920 KQEIEALYRR LGKPLPPNVG FFHTAPPMGR RRKTSKSKLK AGKLLNPLVQ QLKVVASSTG 1930 1940 1950 1960 1970 1980 HLSDSSRGPP TKDPAHASTP PGTKAVQTQQ PCSVRASLST DICSGLASDG GGARGQGWTV 1990 2000 2010 2020 2030 2040 YHPTSERGAY KSSSKPRARF LSGPVSVSIW SALKRLCLGK EHSSRSSTSS LAPGPEPGPQ 2050 2060 2070 2080 2090 2100 PTLHVQAQVN NSNNKKGTFT DDLHKLVDEW TTKTVGAAQV KPTLNQLKQT QKLHDMEASG 2110 2120 2130 2140 2150 2160 DARATSVPRA AVGASCLAPA PGPLSTTATP GATPALPVPI PGTVHSSLSG PPCTLPLCQY 2170 2180 2190 2200 2210 GGLLPDPVSW GPWVASGNPE GSWGSQSPTQ VPVFPVFLRP PVISTPGPRL HIT
	Isoform 6 [UniParc]. Checksum: 1177FFA99C62BFD0	FASTA	1,991	211,147
	10 20 30 40 50 60 MDGDGGRRDA PGALMEAGRG TGSAGMAEPR ARAARLGPQR FLRRSVVESD QEEPPGLEAA 70 80 90 100 110 120 ETPSAQPPQP LQRRVLLLCK TRRLIAERAR GRPAAPAPAA PAAPPGSPSV PSDPGPERAG 130 140 150 160 170 180 TQEPSPDPTT ASAAATQVPD GGPRQEEAPA PTQEDAGTTE AKPEPGRARK DEPEEEEDDE 190 200 210 220 230 240 DDLKAVATSL DGRFLKFDIE LGRGSFKTVY KGLDTETWVE VAWCELQDRK LTKLERQRFK 250 260 270 280 290 300 EEAEMLKGLQ HPNIVRFYDF WESSAKGKRC IVLVTELMTS GTLKTYLKRF KVMKPKVLRS 310 320 330 340 350 360 WCRQILKGLL FLHTRTPPII HRDLKCDNIF ITGPTGSVKI GDLGLATLKR ASFAKSVIGT 370 380 390 400 410 420 PEFMAPEMYE EHYDESVDVY AFGMCMLEMA TSEYPYSECQ NAAQIYRKVT CGIKPASFEK 430 440 450 460 470 480 VHDPEIKEII GECICKNKEE RYEIKDLLSH AFFAEDTGVR VELAEEDHGR KSTIALRLWV 490 500 510 520 530 540 EDPKKLKGKP KDNGAIEFTF DLEKETPDEV AQEMIDSGFF HESDVKIVAK SIRDRVALIQ 550 560 570 580 590 600 WRRERIWPAL QSQEPKDSGS PDKARGLPAP LQVQVTYHAQ SGQPGQPEPE EPEADQHLLP 610 620 630 640 650 660 PTLPASVTSL ASDSTFDSGQ GSTVYSDSQS SQQSMVLSSL VDTAPTPASC VCSPPVSEGP 670 680 690 700 710 720 GLTHSLPTLG AFQQPATVPG LSVGPVPPPA RPPLLQQHFP ESSMSFTPVL PPPSTPVPTG 730 740 750 760 770 780 PSQPAPPVQQ VLAPQPMGTV QPVPSHLPPY LAPTSQVVAP AQLKPLQMPQ PPLQPLAQVP 790 800 810 820 830 840 PQMPQMPVVP PITPLTGLDG LPQTLTDLPA ANVAPVPPPQ YFSPAVILPS LTTPLPTSPA 850 860 870 880 890 900 LPMQAVKLPH PPGTPLAVPC QTIVPNAPAA IPLLAVAPQG VAALSIHPAV AQIPAQPVYP 910 920 930 940 950 960 AAFPQMVPGD IPPSPHHTVQ SLRATPPQLA SPVPPQPVQP SVIHLPEQAA PTAASGTQEQ 970 980 990 1000 1010 1020 VSQDKPPGPP QSSESFGGSD VTSGRDLSDS CEGTFGGGRL EGRTARKHHR RSTRARSRQE 1030 1040 1050 1060 1070 1080 RASRPRLTIL NVCNTGDKMV ECQLETHNHK MVTFKFDLDG DAPDEIATYM VEHDFILPAE 1090 1100 1110 1120 1130 1140 RETFIEQMKD VMDKAEDMLS EDTDADHGSD TGTSPPHLGT CGLATGEENR QSQANAPVYQ 1150 1160 1170 1180 1190 1200 QNVLHTGKRW FIICPVAEHP ATDTSESSPP LPLSSLQPEA SQDPAPYPDQ LSLTDKPSFP 1210 1220 1230 1240 1250 1260 AAQQLLSQAG SSNPPGGASA PLAPSSPPVT TVIPAAPATS TVPESAAGTA MQAGGPGTHQ 1270 1280 1290 1300 1310 1320 GPASVHETLQ PLAETRSAQC TAQPLSTGQG PCTPALEASR CSTGLGEPIS TREVSTQGEP 1330 1340 1350 1360 1370 1380 LPASVPEPSP PTGATQSVPG QPPPPLPITV GAISLAAPQL PSPPLGPTAP PPPPSALESD 1390 1400 1410 1420 1430 1440 GEGPPPRVGF VDNTIKSLDE KLRTLLYQEH VPTSSASAGT PMEASDRDFT LEPLRGDLPS 1450 1460 1470 1480 1490 1500 ALSDKTPSLT QQTQPSLEKS ETAPAGWALA QREQGASSPM TAESSSSNTL GCDSDAGQVA 1510 1520 1530 1540 1550 1560 SDSSTAPSVP QDASGSSVPT HMDPKDQNSS VPREALAAPM QSGPGSFTVG SPAQLRGARD 1570 1580 1590 1600 1610 1620 SGSPHKRPGQ QDNSSPAKTV GRFSVVSTQD EWTLASPHSL RYSAPPDVYL DEIPSSPEVK 1630 1640 1650 1660 1670 1680 LAVRRVQTAS SIEVGVEEPA SSDSGDERPR RRSQVQKQSS LPGTGGVASD FVKKATAFLH 1690 1700 1710 1720 1730 1740 RSSRAGSLGP ETPSRAGVKV PTISITSFHS QSSYISSDND SEFEDADIKK ELRSLREKHL 1750 1760 1770 1780 1790 1800 KEISELQSQQ KQEIEALYRR LGKPLPPNVG FFHTAPPMGR RRKTSKSKLK AGKLLNPLVQ 1810 1820 1830 1840 1850 1860 QLKVVASSTG HLSDSSRGPP TKDPAHASTP PGTKAVQTQQ PCSVRASLST DICSGLASDG 1870 1880 1890 1900 1910 1920 GGARGQGSST SSLAPGPEPG PQPTLHVQAQ VNNSNNKKGT FTDDLHKLVD EWTTKTVGAA 1930 1940 1950 1960 1970 1980 QVKPTLNQLK QTQKLHDMEA SGDARATSVP RAAVGASCLA PAPGPLSTTA TPGATPALPV 1990 PIPDPESEKP D
	Isoform 7 [UniParc]. Checksum: 581DA7240F2E5FE5	FASTA	2,092	221,908
	10 20 30 40 50 60 MDGDGGRRDA PGALMEAGRG TGSAGMAEPR ARAARLGPQR FLRRSVVESD QEEPPGLEAA 70 80 90 100 110 120 ETPSAQPPQP LQRRVLLLCK TRRLIAERAR GRPAAPAPAA PAAPPGSPSV PSDPGPERAG 130 140 150 160 170 180 TQEPSPDPTT ASAAATQVPD GGPRQEEAPA PTQEDAGTTE AKPEPGRARK DEPEEEEDDE 190 200 210 220 230 240 DDLKAVATSL DGRFLKFDIE LGRGSFKTVY KGLDTETWVE VAWCELQDRK LTKLERQRFK 250 260 270 280 290 300 EEAEMLKGLQ HPNIVRFYDF WESSAKGKRC IVLVTELMTS GTLKTYLKRF KVMKPKVLRS 310 320 330 340 350 360 WCRQILKGLL FLHTRTPPII HRDLKCDNIF ITGPTGSVKI GDLGLATLKR ASFAKSVIGT 370 380 390 400 410 420 PEFMAPEMYE EHYDESVDVY AFGMCMLEMA TSEYPYSECQ NAAQIYRKVT CGIKPASFEK 430 440 450 460 470 480 VHDPEIKEII GECICKNKEE RYEIKDLLSH AFFAEDTGVR VELAEEDHGR KSTIALRLWV 490 500 510 520 530 540 EDPKKLKGKP KDNGAIEFTF DLEKETPDEV AQEMIDSGFF HESDVKIVAK SIRDRVALIQ 550 560 570 580 590 600 WRRERIWPAL QSQEPKDSGS PDKARGLPAP LQVQVTYHAQ SGQPGQPEPE EPEADQHLLP 610 620 630 640 650 660 PTLPASVTSL ASDSTFDSGQ GSTVYSDSQS SQQSMVLSSL VDTAPTPASC VCSPPVSEGP 670 680 690 700 710 720 GLTHSLPTLG AFQQPATVPG LSVGPVPPPA RPPLLQQHFP ESSMSFTPVL PPPSTPVPTG 730 740 750 760 770 780 PSQPAPPVQQ PLPMAQPPTL PQVLAPQPMG TVQPVPSHLP PYLAPTSQVV APAQLKPLQM 790 800 810 820 830 840 PQPPLQPLAQ VPPQMPQMPV VPPITPLTGL DGLPQTLTDL PAANVAPVPP PQYFSPAVIL 850 860 870 880 890 900 PSLTTPLPTS PALPMQAVKL PHPPGTPLAV PCQTIVPNAP AAIPLLAVAP QGVAALSIHP 910 920 930 940 950 960 AVAQIPAQPV YPAAFPQMVP GDIPPSPHHT VQSLRATPPQ LASPVPPQPV QPSVIHLPEQ 970 980 990 1000 1010 1020 AAPTAASGTQ EQVSQDKPPG PPQSSESFGG SDVTSGRDLS DSCEGTFGGG RLEGRTARKH 1030 1040 1050 1060 1070 1080 HRRSTRARSR QERASRPRLT ILNVCNTGDK MVECQLETHN HKMVTFKFDL DGDAPDEIAT 1090 1100 1110 1120 1130 1140 YMVEHDFILP AERETFIEQM KDVMDKAEDM LSEDTDADHG SDTGTSPPHL GTCGLATGEE 1150 1160 1170 1180 1190 1200 NRQSQANAPV YQQNVLHTGK RWFIICPVAE HPATDTSESS PPLPLSSLQP EASQDPAPYP 1210 1220 1230 1240 1250 1260 DQLSLTDKPS FPAAQQLLSQ AGSSNPPGGA SAPLAPSSPP VTTVIPAAPA TSTVPESAAG 1270 1280 1290 1300 1310 1320 TAMQAGGPGT HQGPASVHET LQPLAETRSA QCTAQPLSTG QGPCTPALEA SRCSTGLGEP 1330 1340 1350 1360 1370 1380 ISTREVSTQG EPLPASVPEP SPPTGATQSV PGQPPPPLPI TVGAISLAAP QLPSPPLGPT 1390 1400 1410 1420 1430 1440 APPPPPSALE SDGEGPPPRV GFVDNTIKSL DEKLRTLLYQ EHVPTSSASA GTPMEASDRD 1450 1460 1470 1480 1490 1500 FTLEPLRGDL PSALSDKTPS LTQQTQPSLE KSETAPAGWA LAQREQGASS PMTESSSSNT 1510 1520 1530 1540 1550 1560 LGCDSDAGQV ASDSSTAPSV PQDASGSSVP THMDPKDQNS SVPREALAAP MQSGPGSFTV 1570 1580 1590 1600 1610 1620 GSPAQLRGAR DSGSPHKRPG QQDNSSPAKT VGRFSVVSTQ DEWTLASPHS LRYSAPPDVY 1630 1640 1650 1660 1670 1680 LDEIPSSPEV KLAVRRVQTA SSIEVGVEEP ASSDSGDERP RRRSQVQKQS SLPGTGGVAS 1690 1700 1710 1720 1730 1740 DFVKKATAFL HRSSRAGSLG PETPSRAGVK VPTISITSFH SQSSYISSDN DSEFEDADIK 1750 1760 1770 1780 1790 1800 KELRSLREKH LKEISELQSQ QKQEIEALYR RLGKPLPPNV GFFHTAPPMG RRRKTSKSKL 1810 1820 1830 1840 1850 1860 KAGKLLNPLV QQLKVVASST GHLSDSSRGP PTKDPAHAST PPGTKAVQTQ QPCSVRASLS 1870 1880 1890 1900 1910 1920 TDICSGLASD GGGARGQGWT VYHPTSERGA YKSSSKPRAR FLSGPVSVSI WSALKRLCLG 1930 1940 1950 1960 1970 1980 KEHSSRSSTS SLAPGPEPGP QPTLHVQAQV NNSNNKKGTF TDDLHKLVDE WTTKTVGAAQ 1990 2000 2010 2020 2030 2040 VKPTLNQLKQ TQKLHDMEAS GDARATSVPR AAVGASCLAP APGPLSTTAT PGATPALPVP 2050 2060 2070 2080 2090 IPEACALPTP PCKFLSRPSS GQPTEGRSIS GGFHDTCPGG ERGDENSLTP SG

References

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[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1506-2149 (ISOFORM 5). Strain: C57BL/6J. Tissue: Retina.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 443-2149 (ISOFORM 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 801-2149 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1513-2149 (ISOFORM 4). Strain: C57BL/6 and FVB/N. Tissue: Brain and Salivary gland.
[4]	"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H. DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 761-2149 (ISOFORM 7). Tissue: Brain.
[5]	"WNK2 is a novel regulator of essential neuronal cation-chloride cotransporters." Rinehart J., Vazquez N., Kahle K.T., Hodson C.A., Ring A.M., Gulcicek E.E., Louvi A., Bobadilla N.A., Gamba G., Lifton R.P. J. Biol. Chem. 286:30171-30180(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, PHOSPHORYLATION AT SER-1566; SER-1770 AND SER-1797, INTERACTION WITH STK39.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CAAA01187366 Genomic DNA. No translation available. AC140284 Genomic DNA. No translation available. AK044381 mRNA. Translation: BAE20646.1. Different initiation. AK147550 mRNA. Translation: BAE27991.1. BC046464 mRNA. Translation: AAH46464.1. Different initiation. BC055795 mRNA. Translation: AAH55795.1. Different initiation. BC060187 mRNA. Translation: AAH60187.1. AK129439 mRNA. Translation: BAC98249.1.
IPI	IPI00355244. IPI00408595. IPI00653345. IPI00828549. IPI00828654. IPI00828738. IPI00828980.
RefSeq	NP_083637.2. NM_029361.3.
UniGene	Mm.342723.
3D structure databases
ProteinModelPortal	Q3UH66.
SMR	Q3UH66. Positions 184-545.
ModBase	Search...
PTM databases
PhosphoSite	Q3UH66.
Proteomic databases
PaxDb	Q3UH66.
PRIDE	Q3UH66.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000160087; ENSMUSP00000124614; ENSMUSG00000037989.
GeneID	75607.
KEGG	mmu:75607.
UCSC	uc007qis.2. mouse. uc007qiv.1. mouse. uc009val.1. mouse.
Organism-specific databases
CTD	65268.
MGI	MGI:1922857. Wnk2.
Rouge	Search...
Phylogenomic databases
eggNOG	COG0515.
GeneTree	ENSGT00550000074385.
HOGENOM	HOG000139922.
HOVERGEN	HBG050345.
KO	K08867.
OrthoDB	EOG4NP72M.
Gene expression databases
ArrayExpress	Q3UH66.
Bgee	Q3UH66.
CleanEx	MM_WNK2.
Genevestigator	Q3UH66.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR024678. Kinase_OSR1/WNK_CCT. IPR000719. Prot_kinase_cat_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF12202. OSR1_C. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	WNK2. mouse.
NextBio	343494.
SOURCE	Search...

Entry information

Entry name

WNK2_MOUSE

Accession

Primary (citable) accession number: Q3UH66
Secondary accession number(s): Q3V387 , Q6PAN9, Q6ZPI6, Q7TNS1, Q811F2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	February 20, 2007
Last modified:	May 1, 2013
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program