Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q3UGU3

- Q3UGU3_MOUSE

UniProt

Q3UGU3 - Q3UGU3_MOUSE

Protein

Amidophosphoribosyltransferase

Gene

Ppat

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O.UniRule annotation

    Cofactori

    Binds 1 4Fe-4S cluster per subunit.UniRule annotation
    Binds 1 magnesium ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei12 – 121For GATase activityUniRule annotation
    Metal bindingi280 – 2801Iron-sulfur (4Fe-4S)
    Metal bindingi426 – 4261Iron-sulfur (4Fe-4S)
    Metal bindingi503 – 5031Iron-sulfur (4Fe-4S)
    Metal bindingi506 – 5061Iron-sulfur (4Fe-4S)

    GO - Molecular functioni

    1. amidophosphoribosyltransferase activity Source: UniProtKB-EC
    2. iron-sulfur cluster binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
    2. nucleoside metabolic process Source: InterPro
    3. purine nucleobase biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    GlycosyltransferaseUniRule annotation, Transferase

    Keywords - Biological processi

    Purine biosynthesisUniRule annotation

    Keywords - Ligandi

    Iron, Iron-sulfurUniRule annotation, MagnesiumUniRule annotation, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00074; UER00124.

    Protein family/group databases

    MEROPSiC44.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AmidophosphoribosyltransferaseUniRule annotation (EC:2.4.2.14UniRule annotation)
    Short name:
    ATaseUniRule annotation
    Alternative name(s):
    Glutamine phosphoribosylpyrophosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:PpatImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:2387203. Ppat.

    Expressioni

    Gene expression databases

    GenevestigatoriQ3UGU3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3UGU3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG002589.
    InParanoidiQ3UGU3.
    KOiK00764.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    3.60.20.10. 1 hit.
    InterProiIPR005854. Amd_phspho_trans.
    IPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR029055. Ntn_hydrolases_N.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view]
    PfamiPF00310. GATase_2. 2 hits.
    PF00156. Pribosyltran. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000485. Amd_phspho_trans. 1 hit.
    SUPFAMiSSF53271. SSF53271. 1 hit.
    SSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01134. purF. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3UGU3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELEELGIRE ECGVFGCIAS GDWPTQLDVP HVITLGLVGL QHRGQESAGI    50
    VTSDGSAVPK FRVHKGMGLV NHVFTEDNLK KLYDSNLGIG HTRYATTGKC 100
    ELENCQPFVV ETLHGKIAVA HNGELVNAAR LRKKLLRQGI GLSTSSDSEM 150
    ITQLLAYTPP QEKDDAPDWV ARIKNLMKEA PAAYSLVIMH RDFIYAVRDP 200
    YGNRPLCIGR LMPVSDVNDK EKKSSETEGW VVSSESCSFL SIGARYCHEV 250
    KPGEIVEISR HGIRTLDIIP RSNGDPVAFC IFEYVYFARP DSMFEDQMVY 300
    TVRYRCGQQL AIEAPVEADL VSTVPESATP AALGYATKCG LPYVEVLCKN 350
    RYVGRTFIHP TLRLRQLGVA KKFGVSSDNF KGKRIVLIDD SIVRGNTISP 400
    IIKLLKESGA KEVHIRVASP PIKYPCFMGI NIPTKEELIA NKPEFDCLAE 450
    YLGANSVVYL SVEGLVSSVQ QEIKFKKQKV KKHDIAIQEN GNGLEYFEKT 500
    GHCTACLTGQ YPVELEW 517
    Length:517
    Mass (Da):57,355
    Last modified:October 11, 2005 - v1
    Checksum:iFAA15F6386729DC1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK147750 mRNA. Translation: BAE28114.1.
    RefSeqiNP_742158.1. NM_172146.2.
    UniGeneiMm.202337.

    Genome annotation databases

    GeneIDi231327.
    KEGGimmu:231327.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK147750 mRNA. Translation: BAE28114.1 .
    RefSeqi NP_742158.1. NM_172146.2.
    UniGenei Mm.202337.

    3D structure databases

    ProteinModelPortali Q3UGU3.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C44.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 231327.
    KEGGi mmu:231327.

    Organism-specific databases

    CTDi 5471.
    MGIi MGI:2387203. Ppat.

    Phylogenomic databases

    HOVERGENi HBG002589.
    InParanoidi Q3UGU3.
    KOi K00764.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00124 .

    Miscellaneous databases

    NextBioi 380505.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q3UGU3.

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    3.60.20.10. 1 hit.
    InterProi IPR005854. Amd_phspho_trans.
    IPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR029055. Ntn_hydrolases_N.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view ]
    Pfami PF00310. GATase_2. 2 hits.
    PF00156. Pribosyltran. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000485. Amd_phspho_trans. 1 hit.
    SUPFAMi SSF53271. SSF53271. 1 hit.
    SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01134. purF. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ3UGU3_MOUSE
    AccessioniPrimary (citable) accession number: Q3UGU3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)