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Protein

WD repeat-containing protein 19

Gene

Wdr19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport (By similarity). Involved in cilia function and/or assembly (PubMed:16957054). Associates with the BBSome complex to mediate ciliary transport (PubMed:22922713).By similarity2 Publications

GO - Biological processi

  • cell morphogenesis Source: MGI
  • ciliary receptor clustering involved in smoothened signaling pathway Source: MGI
  • cilium assembly Source: MGI
  • cilium morphogenesis Source: MGI
  • digestive system development Source: MGI
  • ear morphogenesis Source: MGI
  • embryonic camera-type eye development Source: MGI
  • embryonic cranial skeleton morphogenesis Source: MGI
  • embryonic limb morphogenesis Source: MGI
  • gonad development Source: MGI
  • intraciliary retrograde transport Source: MGI
  • in utero embryonic development Source: MGI
  • myotome development Source: MGI
  • neurological system process Source: MGI
  • protein localization to cilium Source: MGI
  • smoothened signaling pathway Source: MGI
  • smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-MMU-5610787. Hedgehog 'off' state.
R-MMU-5620924. Intraflagellar transport.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 19
Gene namesi
Name:Wdr19
Synonyms:Kiaa1638
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2443231. Wdr19.

Subcellular locationi

GO - Cellular componenti

  • cilium Source: MGI
  • cytoplasm Source: UniProtKB-KW
  • cytoskeleton Source: UniProtKB-KW
  • intraciliary transport particle A Source: UniProtKB
  • motile cilium Source: UniProtKB
  • nonmotile primary cilium Source: UniProtKB
  • nucleoplasm Source: MGI
  • photoreceptor connecting cilium Source: UniProtKB
  • photoreceptor outer segment Source: UniProtKB-SubCell
  • plasma membrane Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi341 – 3411G → R: Reduced interaction with BBS1. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13411341WD repeat-containing protein 19PRO_0000233157Add
BLAST

Proteomic databases

MaxQBiQ3UGF1.
PaxDbiQ3UGF1.
PeptideAtlasiQ3UGF1.
PRIDEiQ3UGF1.

PTM databases

iPTMnetiQ3UGF1.
PhosphoSiteiQ3UGF1.

Expressioni

Tissue specificityi

Tissue-specific expression of isoforms (PubMed:12906858). Expressed in the prostate, testis, epididymis, submaxillary and salivary glands (PubMed:12906858). Expressed in ependymal cells lining brain ventricles (at protein level) (PubMed:16957054).2 Publications

Gene expression databases

BgeeiQ3UGF1.
CleanExiMM_WDR19.
ExpressionAtlasiQ3UGF1. baseline and differential.

Interactioni

Subunit structurei

Component of the IFT complex A (IFT-A) (By similarity). Interacts with BBS1 (PubMed:22922713).By similarity1 Publication

Protein-protein interaction databases

DIPiDIP-61859N.
STRINGi10090.ENSMUSP00000038098.

Structurei

3D structure databases

ProteinModelPortaliQ3UGF1.
SMRiQ3UGF1. Positions 278-304, 894-920.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 5141WD 1Add
BLAST
Repeati52 – 9241WD 2Add
BLAST
Repeati95 – 13440WD 3Add
BLAST
Repeati137 – 17539WD 4Add
BLAST
Repeati273 – 31139WD 5Add
BLAST
Repeati317 – 35640WD 6Add
BLAST
Repeati736 – 76934TPR 1Add
BLAST
Repeati775 – 80834TPR 2Add
BLAST
Repeati840 – 87334TPR 3Add
BLAST
Repeati895 – 92834TPR 4Add
BLAST
Repeati951 – 98434TPR 5Add
BLAST
Repeati1020 – 105334TPR 6Add
BLAST

Sequence similaritiesi

Contains 6 TPR repeats.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2247. Eukaryota.
ENOG410XR20. LUCA.
GeneTreeiENSGT00590000083165.
HOGENOMiHOG000230828.
HOVERGENiHBG094157.
InParanoidiQ3UGF1.
KOiK19671.
OMAiCLHSDYA.
OrthoDBiEOG7FNC6X.
PhylomeDBiQ3UGF1.
TreeFamiTF314758.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
2.130.10.10. 3 hits.
InterProiIPR011990. TPR-like_helical_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UGF1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRVFSLLEK SWLGAPIQFA WQKSSGNYLA VTGADYIVKI FDRHGQKRSE
60 70 80 90 100
ISLPGNCVTM DWDKDGDILA VIAEKSSCIY LWDANTNKTS QLDNGMRDQM
110 120 130 140 150
SFLLWSKIGS FLAVGTIKGN LLIYNHQTSR KIPVLGKHTK KITCGCWNSE
160 170 180 190 200
NLLALGGEDK MITVSNQEGD TIRQTPVKSE PSDIKFSMSK TDERISSAEN
210 220 230 240 250
TISAVVGKKM LFLFHLNEPD NPVDLEFQQA YGNIVCYSWY GDGYIMIGFS
260 270 280 290 300
RGTFLAISTH FPEVGQEIFK ARDHKDNLTS VALSQTLNKA ATCGDNCIKI
310 320 330 340 350
HDLTELRDMY AIINLDDENK GLGTLSWTDD GQLLALSTQR GSLHVFLTKL
360 370 380 390 400
PILGDACHTR IAYLTSLLEV TVANLIEGEP PITVSVDVEP TFVAVGLYHL
410 420 430 440 450
AVGMNNRAWF YVLGENVVKK LKDVEYLGTV ASICLHSDYA AALFEGKIQL
460 470 480 490 500
HLIENEMLDA QEERETRLFP AVDDKCRILC HALTSDFLIY GTDTGIIHYF
510 520 530 540 550
FIEDWQFVND YRHPVGVKKL FPDPNGTRLV FIDEKSDGFV YCPVNDATYE
560 570 580 590 600
IPDFSPTIKG VLWENWPMDK GVFIAYDDDK VYTYAFHKDT IQGSKVILAG
610 620 630 640 650
STKLPFSHKP LLLYNGELTC QTQSGKINSI YLSTHSFLGS MKDTEPTDLR
660 670 680 690 700
QMLTQTLLLK RFSDAWDICK MLNDRTSWSE LAKACLHHME VEFAIRVSRT
710 720 730 740 750
MGDVGTVMSL EQIKGIEDYN LLAGHLAMFT NDFNLAQDLY LASNCPVAAL
760 770 780 790 800
EMRRDLQHWD SALQLAKRLA PDQIPFISKE YAIQLEFTGD YVNALAHYEK
810 820 830 840 850
GITGDNKEHD EVCLAGVAQM SIRMGDIRRG ANQALKHPSR VLKRDCGAIL
860 870 880 890 900
ENMKQFSEAA QLYEKGQYYD RAASVYIRCK NWAKVGELLP HVSSPKIHLQ
910 920 930 940 950
YAKAKEADGR YKEAVVAYEN AKQWNSVIRI YLDHLNNPEK AVSIVRETQS
960 970 980 990 1000
LDGAKMVARF FLQLGDYGSA IQFLVLSKCN NEAFTLAQQH NKMEIYADII
1010 1020 1030 1040 1050
GAEDTTNEDY QSIALYFEGE KRHFQAGKFF LLCGQYSRAL KHFLKCPSSE
1060 1070 1080 1090 1100
DNVAIEMAIE TVGQAKDELL TNQLIDHLMG ESDGMPKDAK YLFRLYMALK
1110 1120 1130 1140 1150
QYREAARTAI IIAREEQSAG NYRNAHDVLF SMYAELKAQK IKIPSEMATN
1160 1170 1180 1190 1200
LMILHSYILV KIHVKSGDHM KGARMLIRVA NNISKFPSHI VPILTSTVIE
1210 1220 1230 1240 1250
CHRAGLKNSA FSFAAMLMRP EYRNKIDAKY KKKIEAMVRR PDTSETEEAT
1260 1270 1280 1290 1300
TPCPFCQFLL PECELLCPGC KNNIPYCIAT GRHMLKDDWT MCPHCGFPAL
1310 1320 1330 1340
YSEFKILLNS ESTCPMCSER LNSSQLKKIT DCSQYLRTEM E
Length:1,341
Mass (Da):151,457
Last modified:October 11, 2005 - v1
Checksum:iD0658DA05745B7CF
GO
Isoform 2 (identifier: Q3UGF1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.

Note: No experimental confirmation available.
Show »
Length:1,282
Mass (Da):144,831
Checksum:iE95F28F0C4BD4EB9
GO
Isoform 3 (identifier: Q3UGF1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1002-1021: AEDTTNEDYQSIALYFEGEK → KCCYLPYFLINMCYHRNPDS
     1022-1341: Missing.

Note: No experimental confirmation available.
Show »
Length:1,021
Mass (Da):115,148
Checksum:i1A5B35363A851C2E
GO

Sequence cautioni

The sequence AAH46432.1 differs from that shown. Reason: Frameshift at position 1201. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1231 – 12322KK → RE in AAK38746 (PubMed:12906858).Curated
Sequence conflicti1257 – 12571Q → K in AAK38746 (PubMed:12906858).Curated
Sequence conflicti1261 – 12611P → S in AAK38746 (PubMed:12906858).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5959Missing in isoform 2. 1 PublicationVSP_018075Add
BLAST
Alternative sequencei1002 – 102120AEDTT…FEGEK → KCCYLPYFLINMCYHRNPDS in isoform 3. 1 PublicationVSP_018076Add
BLAST
Alternative sequencei1022 – 1341320Missing in isoform 3. 1 PublicationVSP_018077Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029258 mRNA. Translation: AAK38746.1.
AK052303 mRNA. Translation: BAC34929.1.
AK147970 mRNA. Translation: BAE28258.1.
AK129413 Transcribed RNA. Translation: BAC98223.2.
BC046432 mRNA. Translation: AAH46432.1. Sequence problems.
CCDSiCCDS51509.1. [Q3UGF1-1]
RefSeqiNP_700440.2. NM_153391.2. [Q3UGF1-1]
XP_011239015.1. XM_011240713.1. [Q3UGF1-1]
UniGeneiMm.127550.

Genome annotation databases

EnsembliENSMUST00000041892; ENSMUSP00000038098; ENSMUSG00000037890. [Q3UGF1-1]
ENSMUST00000203653; ENSMUSP00000144866; ENSMUSG00000037890. [Q3UGF1-1]
GeneIDi213081.
KEGGimmu:213081.
UCSCiuc008xne.1. mouse. [Q3UGF1-1]
uc008xnf.1. mouse. [Q3UGF1-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029258 mRNA. Translation: AAK38746.1.
AK052303 mRNA. Translation: BAC34929.1.
AK147970 mRNA. Translation: BAE28258.1.
AK129413 Transcribed RNA. Translation: BAC98223.2.
BC046432 mRNA. Translation: AAH46432.1. Sequence problems.
CCDSiCCDS51509.1. [Q3UGF1-1]
RefSeqiNP_700440.2. NM_153391.2. [Q3UGF1-1]
XP_011239015.1. XM_011240713.1. [Q3UGF1-1]
UniGeneiMm.127550.

3D structure databases

ProteinModelPortaliQ3UGF1.
SMRiQ3UGF1. Positions 278-304, 894-920.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61859N.
STRINGi10090.ENSMUSP00000038098.

PTM databases

iPTMnetiQ3UGF1.
PhosphoSiteiQ3UGF1.

Proteomic databases

MaxQBiQ3UGF1.
PaxDbiQ3UGF1.
PeptideAtlasiQ3UGF1.
PRIDEiQ3UGF1.

Protocols and materials databases

DNASUi213081.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041892; ENSMUSP00000038098; ENSMUSG00000037890. [Q3UGF1-1]
ENSMUST00000203653; ENSMUSP00000144866; ENSMUSG00000037890. [Q3UGF1-1]
GeneIDi213081.
KEGGimmu:213081.
UCSCiuc008xne.1. mouse. [Q3UGF1-1]
uc008xnf.1. mouse. [Q3UGF1-3]

Organism-specific databases

CTDi57728.
MGIiMGI:2443231. Wdr19.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2247. Eukaryota.
ENOG410XR20. LUCA.
GeneTreeiENSGT00590000083165.
HOGENOMiHOG000230828.
HOVERGENiHBG094157.
InParanoidiQ3UGF1.
KOiK19671.
OMAiCLHSDYA.
OrthoDBiEOG7FNC6X.
PhylomeDBiQ3UGF1.
TreeFamiTF314758.

Enzyme and pathway databases

ReactomeiR-MMU-5610787. Hedgehog 'off' state.
R-MMU-5620924. Intraflagellar transport.

Miscellaneous databases

ChiTaRSiWdr19. mouse.
PROiQ3UGF1.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UGF1.
CleanExiMM_WDR19.
ExpressionAtlasiQ3UGF1. baseline and differential.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
2.130.10.10. 3 hits.
InterProiIPR011990. TPR-like_helical_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of human and mouse WDR19,a novel WD-repeat protein exhibiting androgen-regulated expression in prostate epithelium."
    Lin B., White J.T., Utleg A.G., Wang S., Ferguson C., True L.D., Vessella R., Hood L., Nelson P.S.
    Genomics 82:331-342(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: BALB/cJ.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Heart and Melanocyte.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 335-1239 (ISOFORM 3).
    Tissue: Brain.
  4. Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 581-1341.
    Strain: NMRI.
    Tissue: Mammary tumor.
  6. "Caenorhabditis elegans DYF-2, an orthologue of human WDR19, is a component of the intraflagellar transport machinery in sensory cilia."
    Efimenko E., Blacque O.E., Ou G., Haycraft C.J., Yoder B.K., Scholey J.M., Leroux M.R., Swoboda P.
    Mol. Biol. Cell 17:4801-4811(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  7. "Essential role of nephrocystin in photoreceptor intraflagellar transport in mouse."
    Jiang S.T., Chiou Y.Y., Wang E., Chien Y.L., Ho H.H., Tsai F.J., Lin C.Y., Tsai S.P., Li H.
    Hum. Mol. Genet. 18:1566-1577(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.
  9. "The BBSome controls IFT assembly and turnaround in cilia."
    Wei Q., Zhang Y., Li Y., Zhang Q., Ling K., Hu J.
    Nat. Cell Biol. 14:950-957(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH BBS1, MUTAGENESIS OF GLY-341.

Entry informationi

Entry nameiWDR19_MOUSE
AccessioniPrimary (citable) accession number: Q3UGF1
Secondary accession number(s): Q6ZPK8
, Q80VQ6, Q8C794, Q8K3R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 11, 2005
Last modified: July 6, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.