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Protein
Submitted name:

Propionyl-Coenzyme A carboxylase, alpha polypeptide, isoform CRA_b

Gene

Pcca

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

biotinSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionLigaseSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, BiotinSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Propionyl-Coenzyme A carboxylase, alpha polypeptide, isoform CRA_bImported
Gene namesi
Name:PccaImported
ORF Names:mCG_123227Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97499. Pcca.

Expressioni

Gene expression databases

BgeeiENSMUSG00000041650.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 505Biotin carboxylationInterPro annotationAdd BLAST448
Domaini177 – 374ATP-graspInterPro annotationAdd BLAST198
Domaini645 – 724Lipoyl-bindingInterPro annotationAdd BLAST80

Phylogenomic databases

eggNOGiKOG0238. Eukaryota.
COG4770. LUCA.
HOVERGENiHBG000555.
KOiK01965.
OMAiDYDPMLA.
OrthoDBiEOG091G06RG.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR005481. BC-like_N.
IPR001882. Biotin_BS.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
PfamiView protein in Pfam
PF02785. Biotin_carb_C. 1 hit.
PF00289. Biotin_carb_N. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
SMARTiView protein in SMART
SM00878. Biotin_carb_C. 1 hit.
SUPFAMiSSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3UGC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGQWVRTVA LLAARRHWRR SSQQQLLGTL KHAPVYSYQC LVVSRSLSSV
60 70 80 90 100
EYEPKEKTFD KILIANRGEI ACRVIKTCKK MGIKTVAIHS DVDASSVHVK
110 120 130 140 150
MADEAVCVGP APTSKSYLNM DAIMEAIKKT RAQAVHPGYG FLSENKEFAK
160 170 180 190 200
RLAAEDVTFI GPDTHAIQAM GDKIESKLLA KRAKVNTIPG FDGVVKDADE
210 220 230 240 250
AVRIAREIGY PVMIKASAGG GGKGMRIAWD DEETRDGFRF SSQEAASSFG
260 270 280 290 300
DDRLLIEKFI DNPRHIEIQV LGDKHGNALW LNERECSIQR RNQKVVEEAP
310 320 330 340 350
SIFLDPETRQ AMGEQAVALA KAVKYSSAGT VEFLVDSQKN FYFLEMNTRL
360 370 380 390 400
QVEHPVTECI TGLDLVQEMI LVAKGYPLRH KQEDIPISGW AVECRVYAED
410 420 430 440 450
PYKSFGLPSI GRLSQYQEPI HLPGVRVDSG IQPGSDISIY YDPMISKLVT
460 470 480 490 500
YGSDRAEALK RMEDALDNYV IRGVTHNIPL LREVIINTRF VKGDISTKFL
510 520 530 540 550
SDVYPDGFKG HTLTLSERNQ LLAIASSVFV ASQLRAQRFQ EHSRVPVIRP
560 570 580 590 600
DVAKWELSVK LHDEDHTVVA SNNGPAFTVE VDGSKLNVTS TWNLASPLLS
610 620 630 640 650
VNVDGTQRTV QCLSREAGGN MSIQFLGTVY KVHILTKLAA ELNKFMLEKV
660 670 680 690 700
PKDTSSTLCS PMPGVVVAVS VKPGDMVAEG QEICVIEAMK MQNSMTAGKM
710 720
GKVKLVHCKA GDTVGEGDLL VELE
Length:724
Mass (Da):79,922
Last modified:October 11, 2005 - v1
Checksum:i249189EDF9F99274
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148002 mRNA. Translation: BAE28281.1.
CH466544 Genomic DNA. Translation: EDL00631.1.
RefSeqiNP_659093.2. NM_144844.2.
UniGeneiMm.23876.

Genome annotation databases

GeneIDi110821.
KEGGimmu:110821.

Similar proteinsi

Entry informationi

Entry nameiQ3UGC8_MOUSE
AccessioniPrimary (citable) accession number: Q3UGC8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: October 25, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)