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Protein

Mas-related G-protein coupled receptor member X2

Gene

Mrgprx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • mast cell activation Source: UniProtKB
  • mast cell degranulation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member X2
Alternative name(s):
Mas-related G-protein coupled receptor member B10
Gene namesi
Name:Mrgprx2
Synonyms:Mrgprb10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3588270. Mrgprx2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545ExtracellularSequence analysisAdd
BLAST
Transmembranei46 – 6621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini67 – 759CytoplasmicSequence analysis
Transmembranei76 – 9621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini97 – 10711ExtracellularSequence analysisAdd
BLAST
Transmembranei108 – 12821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini129 – 15527CytoplasmicSequence analysisAdd
BLAST
Transmembranei156 – 17621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini177 – 19519ExtracellularSequence analysisAdd
BLAST
Transmembranei196 – 21621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini217 – 23923CytoplasmicSequence analysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini261 – 27515ExtracellularSequence analysisAdd
BLAST
Transmembranei276 – 29621Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini297 – 34751CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Mas-related G-protein coupled receptor member X2PRO_0000303886Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Glycosylationi16 – 161N-linked (GlcNAc...)Sequence analysis
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence analysis
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence analysis
Glycosylationi31 – 311N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3UG50.
PRIDEiQ3UG50.

Expressioni

Gene expression databases

CleanExiMM_MRGPRX2.
ExpressionAtlasiQ3UG50. differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000127022.

Structurei

3D structure databases

ProteinModelPortaliQ3UG50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9NM. Eukaryota.
ENOG4111AUB. LUCA.
GeneTreeiENSGT00550000074531.
HOVERGENiHBG003592.
InParanoidiQ3UG50.
KOiK08396.
OMAiFQIGYCF.
OrthoDBiEOG091G0CSX.
TreeFamiTF336336.

Family and domain databases

InterProiIPR019430. 7TM_GPCR_serpentine_rcpt_Srx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF10328. 7TM_GPCR_Srx. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UG50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEERNISGRD LRVDSNITYW GTNITAVNES NHTGMSFCEV VSCTMVFLSL
60 70 80 90 100
IVALVGLVGN ATVLWFLGFQ MRRNAFSVYI LNLAGADFLF ICFQIGYCFH
110 120 130 140 150
MILDIDSIPI EIDLFYLVVL NFPYFCGLSI LSAISIERCL SVMWPIWYHC
160 170 180 190 200
QRPRHTSAVI CTLLWVLSLV CSLLEGKECG FLYYTSDPGW CKTFDLITAT
210 220 230 240 250
WLIVLFVALL GSSLALVITI FWGLHKIPVT RLYVAIVFTV LVFLLFGLPY
260 270 280 290 300
GIYWFLLVWI EKFYYVLPCS IYPVTVFLSC VNSSAKPIIY CLVGSIRHHR
310 320 330 340 350
FQRKTLKLFL QRAMQDTPEE EECGEMGSSG RSREIKTIWK GLRAALIRHK

EL
Length:352
Mass (Da):40,304
Last modified:July 27, 2011 - v2
Checksum:i8202537C926465F8
GO

Sequence cautioni

The sequence CDG86230 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti203 – 2031I → V in BAE28359 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HG426112 Genomic DNA. Translation: CDG86230.1. Sequence problems.
AK148121 mRNA. Translation: BAE28359.1.
AC115742 Genomic DNA. No translation available.
CCDSiCCDS52258.1.
RefSeqiNP_001030040.2. NM_001034868.3.
UniGeneiMm.333873.

Genome annotation databases

EnsembliENSMUST00000098433; ENSMUSP00000127022; ENSMUSG00000074109.
GeneIDi243978.
KEGGimmu:243978.
UCSCiuc009har.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HG426112 Genomic DNA. Translation: CDG86230.1. Sequence problems.
AK148121 mRNA. Translation: BAE28359.1.
AC115742 Genomic DNA. No translation available.
CCDSiCCDS52258.1.
RefSeqiNP_001030040.2. NM_001034868.3.
UniGeneiMm.333873.

3D structure databases

ProteinModelPortaliQ3UG50.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000127022.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ3UG50.
PRIDEiQ3UG50.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098433; ENSMUSP00000127022; ENSMUSG00000074109.
GeneIDi243978.
KEGGimmu:243978.
UCSCiuc009har.2. mouse.

Organism-specific databases

CTDi117194.
MGIiMGI:3588270. Mrgprx2.

Phylogenomic databases

eggNOGiENOG410J9NM. Eukaryota.
ENOG4111AUB. LUCA.
GeneTreeiENSGT00550000074531.
HOVERGENiHBG003592.
InParanoidiQ3UG50.
KOiK08396.
OMAiFQIGYCF.
OrthoDBiEOG091G0CSX.
TreeFamiTF336336.

Miscellaneous databases

PROiQ3UG50.
SOURCEiSearch...

Gene expression databases

CleanExiMM_MRGPRX2.
ExpressionAtlasiQ3UG50. differential.

Family and domain databases

InterProiIPR019430. 7TM_GPCR_serpentine_rcpt_Srx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF10328. 7TM_GPCR_Srx. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRGX2_MOUSE
AccessioniPrimary (citable) accession number: Q3UG50
Secondary accession number(s): E9PV62, W8W3J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

In spite of its official gene name, this protein may not be the functional ortholog of human MRGPRX2.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.