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Protein
Submitted name:

Putative uncharacterized protein

Gene

Hdac6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. alpha-tubulin binding Source: MGI
  2. beta-catenin binding Source: MGI
  3. beta-tubulin binding Source: MGI
  4. core promoter binding Source: MGI
  5. dynein complex binding Source: MGI
  6. histone deacetylase activity Source: MGI
  7. histone deacetylase binding Source: MGI
  8. Hsp90 protein binding Source: MGI
  9. microtubule binding Source: MGI
  10. polyubiquitin binding Source: MGI
  11. tau protein binding Source: MGI
  12. tubulin deacetylase activity Source: MGI
  13. ubiquitin binding Source: MGI
  14. ubiquitin protein ligase binding Source: MGI

GO - Biological processi

  1. aggresome assembly Source: MGI
  2. cellular response to hydrogen peroxide Source: MGI
  3. cellular response to misfolded protein Source: MGI
  4. cellular response to topologically incorrect protein Source: MGI
  5. histone deacetylation Source: MGI
  6. Hsp90 deacetylation Source: MGI
  7. intracellular protein transport Source: MGI
  8. lysosome localization Source: MGI
  9. macroautophagy Source: MGI
  10. misfolded or incompletely synthesized protein catabolic process Source: MGI
  11. negative regulation of microtubule depolymerization Source: MGI
  12. negative regulation of protein complex disassembly Source: MGI
  13. negative regulation of proteolysis Source: MGI
  14. peptidyl-lysine deacetylation Source: MGI
  15. polyubiquitinated misfolded protein transport Source: MGI
  16. positive regulation of chaperone-mediated protein complex assembly Source: MGI
  17. positive regulation of epithelial cell migration Source: MGI
  18. positive regulation of hydrogen peroxide-mediated programmed cell death Source: MGI
  19. positive regulation of receptor biosynthetic process Source: MGI
  20. positive regulation of signal transduction Source: MGI
  21. protein complex disassembly Source: MGI
  22. protein deacetylation Source: MGI
  23. protein polyubiquitination Source: MGI
  24. regulation of establishment of protein localization Source: MGI
  25. regulation of fat cell differentiation Source: MGI
  26. regulation of gene expression, epigenetic Source: MGI
  27. regulation of receptor activity Source: MGI
  28. response to growth factor Source: MGI
  29. response to misfolded protein Source: MGI
  30. response to organic substance Source: MGI
  31. response to toxic substance Source: MGI
  32. tubulin deacetylation Source: MGI
  33. ubiquitin-dependent protein catabolic process Source: MGI
  34. ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Hdac6Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1333752. Hdac6.

Subcellular locationi

GO - Cellular componenti

  1. aggresome Source: MGI
  2. caveola Source: MGI
  3. cell leading edge Source: MGI
  4. cytoplasm Source: MGI
  5. dynein complex Source: Ensembl
  6. histone deacetylase complex Source: MGI
  7. inclusion body Source: MGI
  8. microtubule Source: MGI
  9. microtubule associated complex Source: MGI
  10. nucleoplasm Source: MGI
  11. nucleus Source: MGI
  12. perinuclear region of cytoplasm Source: MGI
  13. protein complex Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ3UG37. baseline and differential.
GenevestigatoriQ3UG37.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ3UG37.
SMRiQ3UG37. Positions 84-438, 479-834.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000004769.
HOVERGENiHBG051894.
KOiK11407.

Family and domain databases

Gene3Di3.40.800.20. 2 hits.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 2 hits.
[Graphical view]
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Fragment.

Q3UG37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTGQDSST RQRKSRHNPQ SPLQESSATL KRGGKKCAVP HSSPNLAEVK
60 70 80 90 100
KKGKMKKLSQ PAEEDLVVGL QGLDLNPETR VPVGTGLVFD EQLNDFHCLW
110 120 130 140 150
DDSFPESPER LHAIREQLIL EGLLGRCVSF QARFAEKEEL MLVHSLEYID
160 170 180 190 200
LMETTQYMNE GELRVLAETY DSVYLHPNSY SCACLATGSV LRLVDALMGA
210 220 230 240 250
EIRNGMAVIR PPGHHAQHNL MDGYCMFNHL AVAARYAQKK HRIQRVLIVD
260 270 280 290 300
WDVHHGQGTQ FIFDQDPSVL YFSIHRYEHG RFWPHLKASN WSTIGFGQGQ
310 320 330 340 350
GYTINVPWNQ TGMRDADYIA AFLHILLPVA SEFQPQLVLV AAGFDALHGD
360 370 380 390 400
PKGEMAATPA GFAHLTHLLM GLAGGKLILS LEGGYNLRAL AKGVSASLHT
410 420 430 440 450
LLGDPCPMLE SCVVPCASAQ TSIYCTLEAL EPFWEVLERS VETQEEDEVE
460 470 480 490 500
EAVLEEEEEE GGWEATALPM DTWPLLQNRT GLVYDEKMMS HCNLWDNHHP
510 520 530 540 550
ETPQRILRIM CHLEEVGLAA RCLILPARPA LDSELLTCHS AEYVEHLRTT
560 570 580 590 600
EKMKTRDLHR EGANFDSIYI CPSTFACAKL ATGAACRLVE AVLSGEVLNG
610 620 630 640 650
IAVVRPPGHH AEPNAACGFC FFNSVAVAAR HAQIIAGRAL RILIVDWDVH
660 670 680 690 700
HGNGTQHIFE DDPSVLYVSL HRYDRGTFFP MGDEGASSQV GRDAGIGFTV
710 720 730 740 750
NVPWNGPRMG DADYLAAWHR LVLPIAYEFN PELVLISAGF DAAQGDPLGG
760 770 780 790 800
CQVTPEGYAH LTHLLMGLAG GRIILILEGG YNLASISESM AACTHSLLGD
810 820 830 840 850
PPPQLTLLRP PQSGALVSIS EVIQVHRKYW RSLRLMKMED KEECSSSRLV
860 870 880 890 900
IKKLPPTASP VSAKEMTTPK GKVPEESVRK TIAALPGKES TLGQAKSKMA
910 920 930 940 950
KAVLAQGQSS EQAAKGTTLD LATSKETVGG ATTDLWASAA APENFPNQTT
960 970 980 990 1000
SVEALGETEP TPPASHTNKQ TTGASPLQGV TAQQSLQLGV LSTLELSREA

EEAHDSEEG
Length:1,009
Mass (Da):110,243
Last modified:October 11, 2005 - v1
Checksum:iF91A3A0E0DA8E91F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1009 – 10091Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148144 mRNA. Translation: BAE28372.1.
RefSeqiNP_034543.3. NM_010413.3.
UniGeneiMm.29854.

Genome annotation databases

GeneIDi15185.
KEGGimmu:15185.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148144 mRNA. Translation: BAE28372.1.
RefSeqiNP_034543.3. NM_010413.3.
UniGeneiMm.29854.

3D structure databases

ProteinModelPortaliQ3UG37.
SMRiQ3UG37. Positions 84-438, 479-834.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ3UG37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi15185.
KEGGimmu:15185.

Organism-specific databases

CTDi10013.
MGIiMGI:1333752. Hdac6.

Phylogenomic databases

HOGENOMiHOG000004769.
HOVERGENiHBG051894.
KOiK11407.

Miscellaneous databases

NextBioi287707.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiQ3UG37. baseline and differential.
GenevestigatoriQ3UG37.

Family and domain databases

Gene3Di3.40.800.20. 2 hits.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 2 hits.
[Graphical view]
PRINTSiPR01270. HDASUPER.
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ3UG37_MOUSE
AccessioniPrimary (citable) accession number: Q3UG37
Secondary accession number(s): F6Q3W9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: March 4, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.