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Q3UG37

- Q3UG37_MOUSE

UniProt

Q3UG37 - Q3UG37_MOUSE

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Protein
Submitted name:

Histone deacetylase 6

Gene

Hdac6

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. beta-tubulin binding Source: MGI
  2. histone deacetylase activity Source: MGI
  3. tubulin deacetylase activity Source: MGI
  4. ubiquitin binding Source: MGI

GO - Biological processi

  1. aggresome assembly Source: MGI
  2. cellular response to hydrogen peroxide Source: Ensembl
  3. cellular response to misfolded protein Source: MGI
  4. Hsp90 deacetylation Source: MGI
  5. lysosome localization Source: Ensembl
  6. macroautophagy Source: Ensembl
  7. misfolded or incompletely synthesized protein catabolic process Source: Ensembl
  8. negative regulation of microtubule depolymerization Source: MGI
  9. negative regulation of proteolysis Source: Ensembl
  10. peptidyl-lysine deacetylation Source: Ensembl
  11. polyubiquitinated misfolded protein transport Source: Ensembl
  12. positive regulation of chaperone-mediated protein complex assembly Source: Ensembl
  13. positive regulation of epithelial cell migration Source: Ensembl
  14. positive regulation of hydrogen peroxide-mediated programmed cell death Source: Ensembl
  15. positive regulation of receptor biosynthetic process Source: Ensembl
  16. positive regulation of signal transduction Source: Ensembl
  17. protein complex disassembly Source: MGI
  18. protein deacetylation Source: MGI
  19. protein polyubiquitination Source: MGI
  20. regulation of establishment of protein localization Source: MGI
  21. regulation of fat cell differentiation Source: MGI
  22. regulation of receptor activity Source: Ensembl
  23. response to growth factor Source: Ensembl
  24. response to toxic substance Source: Ensembl
  25. tubulin deacetylation Source: MGI
  26. ubiquitin-dependent protein catabolic process Source: MGI
  27. ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Histone deacetylase 6Imported
Gene namesi
Name:Hdac6Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1333752. Hdac6.

Subcellular locationi

GO - Cellular componenti

  1. aggresome Source: Ensembl
  2. caveola Source: Ensembl
  3. cell leading edge Source: Ensembl
  4. cytoplasm Source: MGI
  5. dynein complex Source: Ensembl
  6. histone deacetylase complex Source: Ensembl
  7. microtubule Source: Ensembl
  8. nucleus Source: MGI
  9. perinuclear region of cytoplasm Source: Ensembl
  10. protein complex Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ3UG37. baseline and differential.
GenevestigatoriQ3UG37.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000062809.
HOGENOMiHOG000004769.
HOVERGENiHBG051894.
KOiK11407.

Family and domain databases

Gene3Di3.40.800.20. 2 hits.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 2 hits.
[Graphical view]
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Fragment.

Q3UG37-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSTGQDSST RQRKSRHNPQ SPLQESSATL KRGGKKCAVP HSSPNLAEVK
60 70 80 90 100
KKGKMKKLSQ PAEEDLVVGL QGLDLNPETR VPVGTGLVFD EQLNDFHCLW
110 120 130 140 150
DDSFPESPER LHAIREQLIL EGLLGRCVSF QARFAEKEEL MLVHSLEYID
160 170 180 190 200
LMETTQYMNE GELRVLAETY DSVYLHPNSY SCACLATGSV LRLVDALMGA
210 220 230 240 250
EIRNGMAVIR PPGHHAQHNL MDGYCMFNHL AVAARYAQKK HRIQRVLIVD
260 270 280 290 300
WDVHHGQGTQ FIFDQDPSVL YFSIHRYEHG RFWPHLKASN WSTIGFGQGQ
310 320 330 340 350
GYTINVPWNQ TGMRDADYIA AFLHILLPVA SEFQPQLVLV AAGFDALHGD
360 370 380 390 400
PKGEMAATPA GFAHLTHLLM GLAGGKLILS LEGGYNLRAL AKGVSASLHT
410 420 430 440 450
LLGDPCPMLE SCVVPCASAQ TSIYCTLEAL EPFWEVLERS VETQEEDEVE
460 470 480 490 500
EAVLEEEEEE GGWEATALPM DTWPLLQNRT GLVYDEKMMS HCNLWDNHHP
510 520 530 540 550
ETPQRILRIM CHLEEVGLAA RCLILPARPA LDSELLTCHS AEYVEHLRTT
560 570 580 590 600
EKMKTRDLHR EGANFDSIYI CPSTFACAKL ATGAACRLVE AVLSGEVLNG
610 620 630 640 650
IAVVRPPGHH AEPNAACGFC FFNSVAVAAR HAQIIAGRAL RILIVDWDVH
660 670 680 690 700
HGNGTQHIFE DDPSVLYVSL HRYDRGTFFP MGDEGASSQV GRDAGIGFTV
710 720 730 740 750
NVPWNGPRMG DADYLAAWHR LVLPIAYEFN PELVLISAGF DAAQGDPLGG
760 770 780 790 800
CQVTPEGYAH LTHLLMGLAG GRIILILEGG YNLASISESM AACTHSLLGD
810 820 830 840 850
PPPQLTLLRP PQSGALVSIS EVIQVHRKYW RSLRLMKMED KEECSSSRLV
860 870 880 890 900
IKKLPPTASP VSAKEMTTPK GKVPEESVRK TIAALPGKES TLGQAKSKMA
910 920 930 940 950
KAVLAQGQSS EQAAKGTTLD LATSKETVGG ATTDLWASAA APENFPNQTT
960 970 980 990 1000
SVEALGETEP TPPASHTNKQ TTGASPLQGV TAQQSLQLGV LSTLELSREA

EEAHDSEEG
Length:1,009
Mass (Da):110,243
Last modified:October 11, 2005 - v1
Checksum:iF91A3A0E0DA8E91F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1009 – 10091Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670169 Genomic DNA. No translation available.
AK148144 mRNA. Translation: BAE28372.1.
RefSeqiNP_034543.3. NM_010413.3.
UniGeneiMm.29854.

Genome annotation databases

EnsembliENSMUST00000145675; ENSMUSP00000121653; ENSMUSG00000031161.
GeneIDi15185.
KEGGimmu:15185.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670169 Genomic DNA. No translation available.
AK148144 mRNA. Translation: BAE28372.1 .
RefSeqi NP_034543.3. NM_010413.3.
UniGenei Mm.29854.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000145675 ; ENSMUSP00000121653 ; ENSMUSG00000031161 .
GeneIDi 15185.
KEGGi mmu:15185.

Organism-specific databases

CTDi 10013.
MGIi MGI:1333752. Hdac6.

Phylogenomic databases

GeneTreei ENSGT00530000062809.
HOGENOMi HOG000004769.
HOVERGENi HBG051894.
KOi K11407.

Miscellaneous databases

NextBioi 287707.
SOURCEi Search...

Gene expression databases

ExpressionAtlasi Q3UG37. baseline and differential.
Genevestigatori Q3UG37.

Family and domain databases

Gene3Di 3.40.800.20. 2 hits.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 2 hits.
[Graphical view ]
PRINTSi PR01270. HDASUPER.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  10. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ3UG37_MOUSE
AccessioniPrimary (citable) accession number: Q3UG37
Secondary accession number(s): F6Q3W9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 26, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3