Adam9

Functionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	347	Zinc; catalyticPROSITE-ProRule annotation	1
Active siteⁱ	348	PROSITE-ProRule annotation	1
Metal bindingⁱ	351	Zinc; catalyticPROSITE-ProRule annotation	1
Metal bindingⁱ	357	Zinc; catalyticPROSITE-ProRule annotation	1

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
metalloendopeptidase activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

integrin-mediated signaling pathway Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	IntegrinImported
Ligand	Metal-bindingPROSITE-ProRule annotation, ZincPROSITE-ProRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: A disintegrin and metallopeptidase domain 9 (Meltrin gamma), isoform CRA_aImported
Gene namesⁱ	Name:Adam9Imported ORF Names:mCG_14516Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:105376. Adam9.

Subcellular locationⁱ

GO - Cellular component

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	699 – 718	HelicalSequence analysisAdd BLAST		20

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 29	Sequence analysisAdd BLAST		29
ChainⁱPRO_5014104757	30 – 845	Sequence analysisAdd BLAST		816

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	365 ↔ 370	PROSITE-ProRule annotation
Disulfide bondⁱ	473 ↔ 493	PROSITE-ProRule annotation
Disulfide bondⁱ	664 ↔ 673	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	212 – 406	Peptidase M12BInterPro annotationAdd BLAST	195
Domainⁱ	414 – 501	DisintegrinInterPro annotationAdd BLAST	88
Domainⁱ	640 – 674	EGF-likeInterPro annotationAdd BLAST	35

Keywords - Domainⁱ

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG3607. Eukaryota. ENOG410XX2M. LUCA.
HOVERGENⁱ	HBG006978.
KEGG Orthology (KO) More...KOⁱ	K06834.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd04269. ZnMc_adamalysin_II_like. 1 hit.
Gene3Dⁱ	3.40.390.10. 1 hit. 4.10.70.10. 1 hit.
InterProⁱ	View protein in InterPro IPR006586. ADAM_Cys-rich. IPR018358. Disintegrin_CS. IPR001762. Disintegrin_dom. IPR036436. Disintegrin_dom_sf. IPR013032. EGF-like_CS. IPR000742. EGF-like_dom. IPR024079. MetalloPept_cat_dom_sf. IPR001590. Peptidase_M12B. IPR002870. Peptidase_M12B_N. IPR034027. Reprolysin_adamalysin.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08516. ADAM_CR. 1 hit. PF00200. Disintegrin. 1 hit. PF01562. Pep_M12B_propep. 1 hit. PF01421. Reprolysin. 1 hit.
PRINTSⁱ	PR00289. DISINTEGRIN.
SMARTⁱ	View protein in SMART SM00608. ACR. 1 hit. SM00050. DISIN. 1 hit.
SUPFAMⁱ	SSF57552. SSF57552. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50215. ADAM_MEPRO. 1 hit. PS00427. DISINTEGRIN_1. 1 hit. PS50214. DISINTEGRIN_2. 1 hit. PS01186. EGF_2. 1 hit. PS50026. EGF_3. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q3UG15-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGPRALSPLA SLRLRWLLAC GLLGPVLEAG RPDLEQTVHL SSYEIITPWR 
        60         70         80         90        100
LTRERREALG PSSQQISYVI QAQGKQHIIH LERNTDLLPN DFVVYTYDKE 
       110        120        130        140        150
GSLLSDHPNV QSHCHYRGYV EGVQNSAVAV SACFGLRGLL HLENASFGIE 
       160        170        180        190        200
PLHNSSHFEH IFYPMDGIHQ EPLRCGVSNR DTEKEGTQGD EEEHPSVTQL 
       210        220        230        240        250
LRRRRAVLPQ TRYVELFIVV DKERYDMMGR NQTAVREEMI RLANYLDSMY 
       260        270        280        290        300
IMLNIRIVLV GLEIWTDRNP INIIGGAGDV LGNFVQWREK FLITRRRHDS 
       310        320        330        340        350
AQLVLKKGFG GTAGMAFVGT VCSRSHAGGI NVFGQITVET FASIVAHELG 
       360        370        380        390        400
HNLGMNHDDG RECFCGAKSC IMNSGASGSR NFSSCSAEDF EKLTLNKGGS 
       410        420        430        440        450
CLLNIPKPDE AYSAPSCGNK LVDPGEECDC GTAKECEVDP CCEGSTCKLK 
       460        470        480        490        500
SFAECAYGDC CKDCQFLPGG SMCRGKTSEC DVPEYCNGSS QFCPPDVFIQ 
       510        520        530        540        550
NGYPCQNSKA YCYNGMCQYY DAQCQVIFGS KAKAAPRDCF IEVNSKGDRF 
       560        570        580        590        600
GNCGFSGSEY KKCATGNALC GKLQCENVQD MPVFGIVPAI IQTPSRGTKC 
       610        620        630        640        650
WGVDFQLGSD VPDPGMVNEG TKCDAGKICR NFQCVNASVL NYDCDIQGKC 
       660        670        680        690        700
HGHGVCNSNK NCHCEDGWAP PHCDTKGYGG SVDSGPTYNA KSTALRDGLL 
       710        720        730        740        750
VFFFLIVPLV AAAIFLFIKR DELRKTFRKK RSQMSDGRNQ ANVSRQPGDP 
       760        770        780        790        800
SISRPPGGPN VSRPPGGPGV SRPPGGPGVS RPPGGPGVSR PPPGHGNRFP 
       810        820        830        840 
VPTYAAKQPA QFPSRPPPPQ PKISSQGNLI PARPAPAPPL YSSLT

Length:845

Mass (Da):92,049

Last modified:October 11, 2005 - v1

Checksum:ⁱ17562E89D4A61674

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK148174 mRNA. Translation: BAE28394.1. CH466580 Genomic DNA. Translation: EDL32848.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_031430.2. NM_007404.2.
UniGeneⁱ	Mm.28908.

Genome annotation databases

GeneIDⁱ	11502.
KEGGⁱ	mmu:11502.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q3UG15	Q61072 E9PTA4 Q58GH6 UPI000A30D81B E9Q638 Q3U1W3 UPI00067AD8CA UPI0007DA957E A0A1U7QFM4 UPI00038BC976 +1	Mus musculus (Mouse) Rattus norvegicus (Rat) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Microtus ochrogaster (Prairie vole) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) Mesocricetus auratus (Golden hamster)	845	UniRef90_Q61072	Cluster: Disintegrin and metalloproteinase domain-containing protein 9	12

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q3UG15	Q13443 G7MZ55 UPI000274187D G7PD80 A0A2K5EHD1 A0A2K6K9A2 H9G1A5 A0A096MVR7 A0A2K5EH95 UPI0003346137 +370	Homo sapiens (Human) Macaca mulatta (Rhesus macaque) Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Aotus nancymaae (Ma's night monkey) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Papio anubis (Olive baboon) Condylura cristata (Star-nosed mole) Equus caballus (Horse) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) And more	819	UniRef50_Q13443	Cluster: Disintegrin and metalloproteinase domain-containing protein 9	381

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK148174 mRNA. Translation: BAE28394.1. CH466580 Genomic DNA. Translation: EDL32848.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_031430.2. NM_007404.2.
UniGeneⁱ	Mm.28908.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	11502.
KEGGⁱ	mmu:11502.

Organism-specific databases

CTDⁱ	8754.
MGIⁱ	MGI:105376. Adam9.

Phylogenomic databases

eggNOGⁱ	KOG3607. Eukaryota. ENOG410XX2M. LUCA.
HOVERGENⁱ	HBG006978.
KEGG Orthology (KO) More...KOⁱ	K06834.

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd04269. ZnMc_adamalysin_II_like. 1 hit.
Gene3Dⁱ	3.40.390.10. 1 hit. 4.10.70.10. 1 hit.
InterProⁱ	View protein in InterPro IPR006586. ADAM_Cys-rich. IPR018358. Disintegrin_CS. IPR001762. Disintegrin_dom. IPR036436. Disintegrin_dom_sf. IPR013032. EGF-like_CS. IPR000742. EGF-like_dom. IPR024079. MetalloPept_cat_dom_sf. IPR001590. Peptidase_M12B. IPR002870. Peptidase_M12B_N. IPR034027. Reprolysin_adamalysin.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08516. ADAM_CR. 1 hit. PF00200. Disintegrin. 1 hit. PF01562. Pep_M12B_propep. 1 hit. PF01421. Reprolysin. 1 hit.
PRINTSⁱ	PR00289. DISINTEGRIN.
SMARTⁱ	View protein in SMART SM00608. ACR. 1 hit. SM00050. DISIN. 1 hit.
SUPFAMⁱ	SSF57552. SSF57552. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50215. ADAM_MEPRO. 1 hit. PS00427. DISINTEGRIN_1. 1 hit. PS50214. DISINTEGRIN_2. 1 hit. PS01186. EGF_2. 1 hit. PS50026. EGF_3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q3UG15_MOUSE
Accessionⁱ	Q3UG15Primary (citable) accession number: Q3UG15
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 11, 2005
	Last sequence update:	October 11, 2005
	Last modified:	March 28, 2018
	This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3UG15 (Q3UG15_MOUSE)

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A disintegrin and metallopeptidase domain 9 (Meltrin gamma), isoform CRA_a

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ