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Protein

Mitochondrial ribonuclease P protein 1

Gene

Trmt10c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial ribonuclease P protein 1 (EC:2.1.1.-)
Short name:
Mitochondrial RNase P protein 1
Alternative name(s):
RNA (guanine-9-)-methyltransferase domain-containing protein 1
tRNA methyltransferase 10 homolog C
Gene namesi
Name:Trmt10c
Synonyms:Mrpp1, Rg9mtd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1196261. Trmt10c.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial nucleoid Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
  • nucleoplasm Source: MGI

Keywords - Cellular componenti

Mitochondrion, Mitochondrion nucleoid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 35MitochondrionSequence analysisAdd BLAST35
ChainiPRO_000031131036 – 414Mitochondrial ribonuclease P protein 1Add BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei79PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3UFY8.
MaxQBiQ3UFY8.
PaxDbiQ3UFY8.
PeptideAtlasiQ3UFY8.
PRIDEiQ3UFY8.

PTM databases

iPTMnetiQ3UFY8.
PhosphoSitePlusiQ3UFY8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000044763.
GenevisibleiQ3UFY8. MM.

Interactioni

Subunit structurei

Interacts with MRPP2/HSD17B10 and MRPP3/KIAA0391. Interacts with GRSF1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058954.

Structurei

3D structure databases

ProteinModelPortaliQ3UFY8.
SMRiQ3UFY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 378SAM-dependent MTase TRM10-typePROSITE-ProRule annotationAdd BLAST193

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili133 – 171Sequence analysisAdd BLAST39

Sequence similaritiesi

Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

eggNOGiKOG2967. Eukaryota.
ENOG4111JE4. LUCA.
GeneTreeiENSGT00530000063169.
HOGENOMiHOG000088648.
HOVERGENiHBG108146.
InParanoidiQ3UFY8.
KOiK17654.
OMAiKTLMECV.
OrthoDBiEOG091G09AL.
PhylomeDBiQ3UFY8.
TreeFamiTF319795.

Family and domain databases

InterProiView protein in InterPro
IPR025812. MRPP1.
IPR028564. MT_TRM10-typ.
IPR007356. tRNA_m1G_MeTrfase_euk.
IPR016009. tRNA_MeTrfase_TRMD/TRM10.
PANTHERiPTHR13563. PTHR13563. 1 hit.
PTHR13563:SF18. PTHR13563:SF18. 1 hit.
PfamiView protein in Pfam
PF01746. tRNA_m1G_MT. 1 hit.
PROSITEiView protein in PROSITE
PS51675. SAM_MT_TRM10. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UFY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVTVRFLRP FARCLVPYTF HRKRSHLYSG VLQRYMSSKA PSLSCHNKDS
60 70 80 90 100
ASPPEQLELD GWKATMKSSI QEDGVSEVSD KDEDSLASTR ELIEMWRLLG
110 120 130 140 150
KEVPEHITEE DLKTLMECAS KSAKKKYLRY LYGKEKAKKA KQVKKEMKAE
160 170 180 190 200
AREEAKRARL LETTAEEQQQ DFMFLRLWDR QINIALGWKG VQAMQFGQPL
210 220 230 240 250
VFDMAYDNYM KPSELQNTVS QLLESEGWNR RNVDPFHIYF CNLKIDSAYH
260 270 280 290 300
RELVKRYREK WDKLLLTATE KSPVDLFPKD SIIYLTADSP NVMTTFKHDK
310 320 330 340 350
IYIIGSFVDK NTQTGTSLAK AKRLNIATEC LPLDKYLQWE IGNKNLTLDQ
360 370 380 390 400
MIRILLCLKN TGNWEEALKF VPRRKHTGYL EVSEQSQELV RKLKKTKTLN
410
SFRKGSLNVR TWKR
Length:414
Mass (Da):48,386
Last modified:November 13, 2007 - v2
Checksum:iA48979421D1E7038
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40A → T in BAE28421 (PubMed:16141072).Curated1
Sequence conflicti111D → E in BAE28421 (PubMed:16141072).Curated1
Sequence conflicti137A → V in BAE28421 (PubMed:16141072).Curated1
Sequence conflicti226E → G in BAE28421 (PubMed:16141072).Curated1
Sequence conflicti326I → L in BAE28421 (PubMed:16141072).Curated1
Sequence conflicti363N → S in AAI06132 (PubMed:15489334).Curated1
Sequence conflicti363N → S in AAH23147 (PubMed:15489334).Curated1
Sequence conflicti408N → S in BAE28421 (PubMed:16141072).Curated1
Sequence conflicti409V → A in BAE28421 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005047 mRNA. Translation: BAB23773.1.
AK087991 mRNA. Translation: BAC40080.1.
AK135426 mRNA. Translation: BAE22529.1.
AK148219 mRNA. Translation: BAE28421.1.
AK166781 mRNA. Translation: BAE39015.1.
BC023147 mRNA. Translation: AAH23147.1.
BC106131 mRNA. Translation: AAI06132.1.
CCDSiCCDS28220.1.
RefSeqiNP_083368.1. NM_029092.3.
UniGeneiMm.288742.

Genome annotation databases

EnsembliENSMUST00000059052; ENSMUSP00000058954; ENSMUSG00000044763.
GeneIDi52575.
KEGGimmu:52575.
UCSCiuc007zmd.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMRRP1_MOUSE
AccessioniPrimary (citable) accession number: Q3UFY8
Secondary accession number(s): Q8R588, Q9DBC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: May 10, 2017
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families