Reviewed,
UniProtKB/Swiss-Prot Q3UFY7 (5NT3L_MOUSE)
Last modified
June 16, 2009.
Version 37.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cytosolic 5'-nucleotidase III-like protein Short name=cN-III-like protein EC=3.1.3.5 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 292 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Can act both as nucleotidase and as phosphotransferase By similarity. |
| Catalytic activity | A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. |
| Subcellular location | Cytoplasm Potential. |
| Sequence similarities | Belongs to the pyrimidine 5'-nucleotidase family. |
| Sequence caution | The sequence BAB24814.1 differs from that shown. Reason: Frameshift at position 10. The sequence CAM23034.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAM23036.1 differs from that shown. Reason: Erroneous gene model prediction. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Nucleotide metabolism |
| Cellular component | Cytoplasm |
| Coding sequence diversity | Alternative splicing |
| Ligand | Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Hydrolase Transferase |
| Gene Ontology (GO) | |
| Biological process | nucleotide metabolic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | 5'-nucleotidase activity Inferred from electronic annotation. Source: EC magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW nucleotide bindingInferred from electronic annotation. Source: UniProtKB-KW transferase activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q3UFY7-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q3UFY7-2) The sequence of this isoform differs from the canonical sequence as follows: 249-253: VEERR → LPEAQ 254-292: Missing. | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform 3 (identifier: Q3UFY7-3) The sequence of this isoform differs from the canonical sequence as follows: 69-77: LTELFHHYY → CGETCNPRG 78-292: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 292 | 292 | Cytosolic 5'-nucleotidase III-like protein | PRO_0000328949 | |||||
Regions | |||||||||
| Region | 148 – 149 | 2 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Active site | 33 | 1 | Nucleophile By similarity | ||||||
| Active site | 35 | 1 | Proton donor By similarity | ||||||
| Metal binding | 33 | 1 | Magnesium By similarity | ||||||
| Metal binding | 35 | 1 | Magnesium; via carbonyl oxygen By similarity | ||||||
| Metal binding | 222 | 1 | Magnesium By similarity | ||||||
| Binding site | 197 | 1 | Substrate By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 69 – 77 | 9 | LTELFHHYY → CGETCNPRG in isoform 3. | VSP_032851 | |||||
| Alternative sequence | 78 – 292 | 215 | Missing in isoform 3. | VSP_032852 | |||||
| Alternative sequence | 249 – 253 | 5 | VEERR → LPEAQ in isoform 2. | VSP_032853 | |||||
| Alternative sequence | 254 – 292 | 39 | Missing in isoform 2. | VSP_032854 | |||||
Experimental info | |||||||||
| Sequence conflict | 150 | 1 | G → R in BAB24814. Ref.1 | ||||||
| Sequence conflict | 177 | 1 | D → H in BAB24814. Ref.1 | ||||||
| Sequence conflict | 181 | 1 | D → H in BAB24814. Ref.1 | ||||||
Sequences
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References
| [1] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). Strain: C57BL/6J. Tissue: Testis and Thymus. |
| [2] | The mouse genome sequencing consortium Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: FVB/N. Tissue: Kidney. |
Cross-references
Sequence databases | |
|---|---|
| AK006972 mRNA. Translation: BAB24814.1. Frameshift. AK082816 mRNA. Translation: BAC38632.1. Different initiation. AK148222 mRNA. Translation: BAE28422.1. Different initiation. AK162770 mRNA. Translation: BAE37053.1. Different initiation. AK166393 mRNA. Translation: BAE38749.1. Different initiation. AL590968 Genomic DNA. Translation: CAM23034.1. Sequence problems. AL590968 Genomic DNA. Translation: CAM23035.1. AL590968 Genomic DNA. Translation: CAM23036.1. Sequence problems. BC015307 mRNA. Translation: AAH15307.1. Different initiation. | |
| IPI | IPI00308345. IPI00649681. IPI00652301. |
| RefSeq | NP_001096120.1. NP_080837.3. |
| UniGene | Mm.28738 |
3D structure databases | |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q3UFY7. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000017176. Mus musculus. [Contig view] |
| GeneID | 68106. |
| KEGG | mmu:68106. |
Organism-specific databases | |
| MGI | MGI:1915356. Nt5c3l. |
Phylogenomic databases | |
| HOGENOM | Q3UFY7. |
| HOVERGEN | Q3UFY7. |
Enzyme and pathway databases | |
| BRENDA | 3.1.3.5. 244. |
Gene expression databases | |
| ArrayExpress | Q3UFY7. |
| Bgee | Q3UFY7. |
Family and domain databases | |
| InterPro | IPR006434. HAD-SF_hydro_IE. IPR018012. HAD-SF_hydro_IE_pln. [Graphical view] |
| Pfam | PF05822. UMPH-1. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01544. HAD-SF-IE. 1 hit. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 326426. |
| SOURCE | Search... |
Entry information
| Entry name | 5NT3L_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q3UFY7 Secondary accession number(s): A2A4I2 Q9D9F9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


