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Protein

Nucleolar MIF4G domain-containing protein 1

Gene

Nom1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in targeting PPP1CA to the nucleolus.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar MIF4G domain-containing protein 1
Alternative name(s):
SGD1 homolog
Gene namesi
Name:Nom1
Synonyms:Gm1040
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1861749. Nom1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002868241 – 854Nucleolar MIF4G domain-containing protein 1Add BLAST854

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineBy similarity1
Modified residuei311PhosphoserineBy similarity1
Modified residuei314PhosphoserineCombined sources1
Modified residuei315PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3UFM5.
MaxQBiQ3UFM5.
PaxDbiQ3UFM5.
PeptideAtlasiQ3UFM5.
PRIDEiQ3UFM5.

PTM databases

iPTMnetiQ3UFM5.
PhosphoSitePlusiQ3UFM5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000001569.
CleanExiMM_GM1040.

Interactioni

Subunit structurei

May interact with EIF4A1, EIF4A2 and EIF4A3. Interacts with PPP1CA and PPP1CC (By similarity).By similarity

Protein-protein interaction databases

BioGridi241474. 1 interactor.
STRINGi10090.ENSMUSP00000001611.

Structurei

3D structure databases

ProteinModelPortaliQ3UFM5.
SMRiQ3UFM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini356 – 553MIF4GPROSITE-ProRule annotationAdd BLAST198
Domaini648 – 764MIPROSITE-ProRule annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 275Necessary for nucleolar localization and for targeting PPP1CA to the nucleolusBy similarityAdd BLAST274

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi301 – 304Required for efficient binding to PPP1CA and for targeting PPP1CA to the nucleolusBy similarity4

Sequence similaritiesi

Belongs to the CWC22 family.Curated
Contains 1 MI domain.PROSITE-ProRule annotation
Contains 1 MIF4G domain.Curated

Phylogenomic databases

eggNOGiKOG2141. Eukaryota.
ENOG410XNNQ. LUCA.
GeneTreeiENSGT00550000075087.
HOGENOMiHOG000044155.
HOVERGENiHBG098839.
InParanoidiQ3UFM5.
KOiK17583.
OMAiHQEREIV.
OrthoDBiEOG091G03TZ.
TreeFamiTF312808.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR003891. Initiation_fac_eIF4g_MI.
IPR016021. MIF4-like.
IPR003890. MIF4G-like_typ-3.
[Graphical view]
PfamiPF02847. MA3. 1 hit.
PF02854. MIF4G. 1 hit.
[Graphical view]
SMARTiSM00544. MA3. 1 hit.
SM00543. MIF4G. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS51366. MI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UFM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRNVPEVNG VYRHGACELW CRAMAHALLK RSGVRRGLGG REGPLKRLRL
60 70 80 90 100
AVEDFVRTTS ESEACESRSA VARSRPGGRK SRKELRKEKR HLRKARRLQR
110 120 130 140 150
TVGSGSGDQG GNVGLNDGPE TRRPPTEVRP TPAKATATPA KASAPSTNTK
160 170 180 190 200
ASAAQPKAKA KGAPGKPGPA TATARKRALL AANEEEDREI RKLERCLGLH
210 220 230 240 250
KRKKKGDGSS VPLSFARDGL DYILGALECG SGGGLYESSE EEEEEKLETG
260 270 280 290 300
QTVLESDLES NSKESEEDPD WQVLQEDQED VNSKRRGEAE SGTRGNKGTK
310 320 330 340 350
KVRFAEVVEK SRSSSEDDIE QQESHSVESG EKYIPPRLRN EEVIDVHKKE
360 370 380 390 400
ELDRLKKHVK GLINRLSEPN MASISGQLEE LYMAHSRKDM NDTLTTALMD
410 420 430 440 450
ACVTASAMPS RLMMEHVFLV SILHHTVGIE VGACFLEAVV KKFDAIYRDG
460 470 480 490 500
GEGKELDNLF TMIAHLYNFH VVQSILIFDI LKKLVGTFTE KDIELILLML
510 520 530 540 550
KNVGFALRKD DALSLKELIT EAQTQASGAG NKFQDQNRVR FMLETMLALK
560 570 580 590 600
NNDLRKIPGY NPEPVEKLKK LQRTLVRNAG SGSETRLRIS WDGILNAEQT
610 620 630 640 650
GRWWIVGSAW SGTPMIDNSH HIQLQKPLAG MASSKMLELA RKQRMNTDVR
660 670 680 690 700
RIIFCTLMTS EDFLDAFEKL LKLGLKDQQE REIVHILMDC CLQEKTYNPF
710 720 730 740 750
YAFLASKFCD YERRFQMTFQ FSIWDKFRDL ENLPDTKFSN LVHLLAHLLR
760 770 780 790 800
TKSLPLSVLK VVEFSELDKP RVHFLRRVLT ALLMETEDDD LAVIFSRVSD
810 820 830 840 850
NPKLGMLREG LKLFIGHFLL KHTQAHQSAE EASLLREKAG LASKSLQGKA

ILRM
Length:854
Mass (Da):95,960
Last modified:July 27, 2011 - v2
Checksum:i0A9BC99B9F521475
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti309E → D in BAE28535 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148406 mRNA. Translation: BAE28535.1.
AC171500 Genomic DNA. No translation available.
CCDSiCCDS19149.1.
RefSeqiNP_001028629.2. NM_001033457.2.
UniGeneiMm.262815.

Genome annotation databases

EnsembliENSMUST00000001611; ENSMUSP00000001611; ENSMUSG00000001569.
GeneIDi433864.
KEGGimmu:433864.
UCSCiuc008wuj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148406 mRNA. Translation: BAE28535.1.
AC171500 Genomic DNA. No translation available.
CCDSiCCDS19149.1.
RefSeqiNP_001028629.2. NM_001033457.2.
UniGeneiMm.262815.

3D structure databases

ProteinModelPortaliQ3UFM5.
SMRiQ3UFM5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi241474. 1 interactor.
STRINGi10090.ENSMUSP00000001611.

PTM databases

iPTMnetiQ3UFM5.
PhosphoSitePlusiQ3UFM5.

Proteomic databases

EPDiQ3UFM5.
MaxQBiQ3UFM5.
PaxDbiQ3UFM5.
PeptideAtlasiQ3UFM5.
PRIDEiQ3UFM5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001611; ENSMUSP00000001611; ENSMUSG00000001569.
GeneIDi433864.
KEGGimmu:433864.
UCSCiuc008wuj.1. mouse.

Organism-specific databases

CTDi64434.
MGIiMGI:1861749. Nom1.

Phylogenomic databases

eggNOGiKOG2141. Eukaryota.
ENOG410XNNQ. LUCA.
GeneTreeiENSGT00550000075087.
HOGENOMiHOG000044155.
HOVERGENiHBG098839.
InParanoidiQ3UFM5.
KOiK17583.
OMAiHQEREIV.
OrthoDBiEOG091G03TZ.
TreeFamiTF312808.

Miscellaneous databases

PROiQ3UFM5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001569.
CleanExiMM_GM1040.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR003891. Initiation_fac_eIF4g_MI.
IPR016021. MIF4-like.
IPR003890. MIF4G-like_typ-3.
[Graphical view]
PfamiPF02847. MA3. 1 hit.
PF02854. MIF4G. 1 hit.
[Graphical view]
SMARTiSM00544. MA3. 1 hit.
SM00543. MIF4G. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS51366. MI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNOM1_MOUSE
AccessioniPrimary (citable) accession number: Q3UFM5
Secondary accession number(s): E9QPB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.