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Protein

FERM domain-containing protein 8

Gene

Frmd8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
FERM domain-containing protein 8
Gene namesi
Name:Frmd8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1914707. Frmd8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 466466FERM domain-containing protein 8PRO_0000295779Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei24 – 241PhosphoserineBy similarity
Modified residuei384 – 3841PhosphoserineBy similarity
Modified residuei409 – 4091PhosphoserineBy similarity
Modified residuei420 – 4201PhosphothreonineCombined sources
Modified residuei440 – 4401PhosphoserineBy similarity
Modified residuei447 – 4471PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ3UFK8.
MaxQBiQ3UFK8.
PaxDbiQ3UFK8.
PeptideAtlasiQ3UFK8.
PRIDEiQ3UFK8.

PTM databases

iPTMnetiQ3UFK8.
PhosphoSiteiQ3UFK8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024816.
CleanExiMM_FRMD8.
ExpressionAtlasiQ3UFK8. baseline and differential.
GenevisibleiQ3UFK8. MM.

Interactioni

Protein-protein interaction databases

IntActiQ3UFK8. 1 interaction.
MINTiMINT-4128454.
STRINGi10090.ENSMUSP00000025728.

Structurei

3D structure databases

ProteinModelPortaliQ3UFK8.
SMRiQ3UFK8. Positions 59-323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 377348FERMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4335. Eukaryota.
ENOG410ZV6V. LUCA.
GeneTreeiENSGT00530000063721.
HOGENOMiHOG000285969.
HOVERGENiHBG104171.
InParanoidiQ3UFK8.
OMAiHGEVDKP.
OrthoDBiEOG091G08IJ.
PhylomeDBiQ3UFK8.
TreeFamiTF317921.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
[Graphical view]
PfamiPF00373. FERM_M. 1 hit.
[Graphical view]
SMARTiSM00295. B41. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
PROSITEiPS50057. FERM_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UFK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGAEGNAGQ PGPAERSHRS SVSSVGARAA DVLVYLADDT VVPLAVENLS
60 70 80 90 100
SISAHELHRA VREVLQLPDV ALEAFALWLV SPLLEVQLKP KHQPYKLGRQ
110 120 130 140 150
WPELLLRFTN ASDDDVAMDE PSLQFRRNVF FPRRRELQIH DEEVLRLLYE
160 170 180 190 200
EAKGNVLTAR YPCDLEDCEV LGGLVCRVQL GPYQPGQPAA CTLREKLDSF
210 220 230 240 250
LPAHLCKRGH GLFAAFRGRG AKTGPGEQGL LNAYRQVKEV TGNNSEREAT
260 270 280 290 300
LGSHYRAYLL KCHELPFYGC AFFHGEVDKP AQGFLHRGGR KPVTVAISLE
310 320 330 340 350
GVHVIDNREK HVLLGLRFQE LSWDHTSPEE EEPVLWLEFD GDSEGTPVNK
360 370 380 390 400
LLRIYSKQAE LMSGLIEYCI ELSQAAEPTL SQESASGPHE APSPSPPPTQ
410 420 430 440 450
RPKLRRQGSV VCSRIQHLST IDYVEDGKGI KRVKPKRTTS FFSRQLSSSQ
460
GSYTVVQPTD DSLEQS
Length:466
Mass (Da):51,828
Last modified:July 24, 2007 - v2
Checksum:i8E8F93B96C6C5A4F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti110 – 1101N → D in BAE28552 (PubMed:16141072).Curated
Sequence conflicti110 – 1101N → D in AAH04765 (PubMed:15489334).Curated
Sequence conflicti210 – 2101H → Y in BAC33626 (PubMed:16141072).Curated
Sequence conflicti260 – 2601L → I in BAB27763 (PubMed:16141072).Curated
Sequence conflicti392 – 3921P → R in BAE28552 (PubMed:16141072).Curated
Sequence conflicti399 – 3991T → A in BAC33620 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011659 mRNA. Translation: BAB27763.1.
AK004603 mRNA. Translation: BAB23402.1.
AK083902 mRNA. Translation: BAC39054.1.
AK088639 mRNA. Translation: BAC40471.1.
AK049224 mRNA. Translation: BAC33620.1.
AK049233 mRNA. Translation: BAC33626.1.
AK148434 mRNA. Translation: BAE28552.1.
BC004765 mRNA. Translation: AAH04765.1.
CCDSiCCDS29481.1.
RefSeqiNP_080445.1. NM_026169.4.
XP_006531891.1. XM_006531828.1.
UniGeneiMm.202092.

Genome annotation databases

EnsembliENSMUST00000025728; ENSMUSP00000025728; ENSMUSG00000024816.
GeneIDi67457.
KEGGimmu:67457.
UCSCiuc008gfn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011659 mRNA. Translation: BAB27763.1.
AK004603 mRNA. Translation: BAB23402.1.
AK083902 mRNA. Translation: BAC39054.1.
AK088639 mRNA. Translation: BAC40471.1.
AK049224 mRNA. Translation: BAC33620.1.
AK049233 mRNA. Translation: BAC33626.1.
AK148434 mRNA. Translation: BAE28552.1.
BC004765 mRNA. Translation: AAH04765.1.
CCDSiCCDS29481.1.
RefSeqiNP_080445.1. NM_026169.4.
XP_006531891.1. XM_006531828.1.
UniGeneiMm.202092.

3D structure databases

ProteinModelPortaliQ3UFK8.
SMRiQ3UFK8. Positions 59-323.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3UFK8. 1 interaction.
MINTiMINT-4128454.
STRINGi10090.ENSMUSP00000025728.

PTM databases

iPTMnetiQ3UFK8.
PhosphoSiteiQ3UFK8.

Proteomic databases

EPDiQ3UFK8.
MaxQBiQ3UFK8.
PaxDbiQ3UFK8.
PeptideAtlasiQ3UFK8.
PRIDEiQ3UFK8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025728; ENSMUSP00000025728; ENSMUSG00000024816.
GeneIDi67457.
KEGGimmu:67457.
UCSCiuc008gfn.1. mouse.

Organism-specific databases

CTDi83786.
MGIiMGI:1914707. Frmd8.

Phylogenomic databases

eggNOGiKOG4335. Eukaryota.
ENOG410ZV6V. LUCA.
GeneTreeiENSGT00530000063721.
HOGENOMiHOG000285969.
HOVERGENiHBG104171.
InParanoidiQ3UFK8.
OMAiHGEVDKP.
OrthoDBiEOG091G08IJ.
PhylomeDBiQ3UFK8.
TreeFamiTF317921.

Miscellaneous databases

ChiTaRSiFrmd8. mouse.
PROiQ3UFK8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024816.
CleanExiMM_FRMD8.
ExpressionAtlasiQ3UFK8. baseline and differential.
GenevisibleiQ3UFK8. MM.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
[Graphical view]
PfamiPF00373. FERM_M. 1 hit.
[Graphical view]
SMARTiSM00295. B41. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
PROSITEiPS50057. FERM_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFRMD8_MOUSE
AccessioniPrimary (citable) accession number: Q3UFK8
Secondary accession number(s): Q8C7U3
, Q8C7U5, Q99KB3, Q9CSY6, Q9DC30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: September 7, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.