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Protein
Submitted name:

Prosaposin, isoform CRA_e

Gene

Psap

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Prosaposin, isoform CRA_eImported
Gene namesi
Name:PsapImported
ORF Names:mCG_61290Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97783. Psap.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_501084341117 – 557Sequence analysisAdd BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi63 ↔ 138UniRule annotation
Disulfide bondi66 ↔ 132UniRule annotation
Disulfide bondi94 ↔ 106UniRule annotation
Disulfide bondi197 ↔ 273UniRule annotation
Disulfide bondi200 ↔ 267UniRule annotation
Disulfide bondi229 ↔ 240UniRule annotation
Disulfide bondi317 ↔ 390UniRule annotation
Disulfide bondi320 ↔ 384UniRule annotation
Disulfide bondi348 ↔ 359UniRule annotation
Disulfide bondi442 ↔ 515UniRule annotation
Disulfide bondi445 ↔ 509UniRule annotation
Disulfide bondi473 ↔ 484UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000004207.
ExpressionAtlasiQ3UFE8. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ3UFE8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 58Saposin A-typeInterPro annotationAdd BLAST41
Domaini59 – 142Saposin B-typeInterPro annotationAdd BLAST84
Domaini193 – 277Saposin B-typeInterPro annotationAdd BLAST85
Domaini313 – 394Saposin B-typeInterPro annotationAdd BLAST82
Domaini438 – 519Saposin B-typeInterPro annotationAdd BLAST82
Domaini521 – 557Saposin A-typeInterPro annotationAdd BLAST37

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1340. Eukaryota.
ENOG410XSI5. LUCA.
HOVERGENiHBG002617.
KOiK12382.
OMAiHCQQNVW.

Family and domain databases

Gene3Di1.10.225.10. 4 hits.
InterProiView protein in InterPro
IPR003119. SAP_A.
IPR007856. SapB_1.
IPR008138. SapB_2.
IPR008373. Saposin.
IPR011001. Saposin-like.
IPR021165. Saposin_chordata.
IPR008139. SaposinB_dom.
PfamiView protein in Pfam
PF02199. SapA. 2 hits.
PF05184. SapB_1. 4 hits.
PF03489. SapB_2. 4 hits.
PIRSFiPIRSF002431. Saposin. 1 hit.
PRINTSiPR01797. SAPOSIN.
SMARTiView protein in SMART
SM00162. SAPA. 2 hits.
SM00741. SapB. 4 hits.
SUPFAMiSSF47862. SSF47862. 3 hits.
PROSITEiView protein in PROSITE
PS51110. SAP_A. 2 hits.
PS50015. SAP_B. 4 hits.

Sequencei

Sequence statusi: Complete.

Q3UFE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYALALFASL LATALTSPVQ DPKTCSGGSA VLCRDVKTAV DCGAVKHCQQ
60 70 80 90 100
MVWSKPTAKS LPCDICKTVV TEAGNLLKDN ATQEEILHYL EKTCEWIHDS
110 120 130 140 150
SLSASCKEVV DSYLPVILDM IKGEMSNPGE VCSALNLCQS LQEYLAEQNQ
160 170 180 190 200
KQLESNKIPE VDMARVVAPF MSNIPLLLYP QDHPRSQPQP KANEDVCQDC
210 220 230 240 250
MKLVSDVQTA VKTNSSFIQG FVDHVKEDCD RLGPGVSDIC KNYVDQYSEV
260 270 280 290 300
CVQMLMHMQD QQPKEICVLA GFCNEVKRVP MKTLVPATET IKNILPALEM
310 320 330 340 350
MDPYEQNLVQ AHNVILCQTC QFVMNKFSEL IVNNATEELL VKGLSNACAL
360 370 380 390 400
LPDPARTKCQ EVVGTFGPSL LDIFIHEVNP SSLCGVIGLC AARPELVEAL
410 420 430 440 450
EQPAPAIVSA LLKEPTPPKQ PAQPKQSALP AHVPPQKNGG FCEVCKKLVL
460 470 480 490 500
YLEHNLEKNS TKEEILAALE KGCSFLPDPY QKQCDDFVAE YEPLLLEILV
510 520 530 540 550
EVMDPGFVCS KIGVCPSAYK LLLGTEKCVW GPSYWCQNME TAARCNAVDH

CKRHVWN
Length:557
Mass (Da):61,422
Last modified:October 11, 2005 - v1
Checksum:i134593E20499E35E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148545 mRNA. Translation: BAE28613.1.
CH466553 Genomic DNA. Translation: EDL32178.1.
RefSeqiNP_035309.3. NM_011179.3.
UniGeneiMm.277498.
Mm.29978.

Genome annotation databases

GeneIDi19156.
KEGGimmu:19156.

Similar proteinsi

Entry informationi

Entry nameiQ3UFE8_MOUSE
AccessioniPrimary (citable) accession number: Q3UFE8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: October 25, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)