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Q3UFB7

- NTRK1_MOUSE

UniProt

Q3UFB7 - NTRK1_MOUSE

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Protein

High affinity nerve growth factor receptor

Gene

Ntrk1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.3 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Enzyme regulationi

The pro-survival signaling effect of NTRK1 in neurons requires its endocytosis into signaling early endosomes and its retrograde axonal transport. This is regulated by different proteins including CFL1, RAC1 and SORT1. NTF3 is unable to induce this signaling probably due to the lability of the NTF3-NTRK1 complex in endosomes. SH2D1A inhibits the autophosphorylation of the receptor, and alters the recruitment and activation of downstream effectors and signaling cascades. Regulated by NGFR.3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei499 – 4991Interaction with SHC1By similarity
Binding sitei547 – 5471ATPPROSITE-ProRule annotation
Active sitei653 – 6531Proton acceptorPROSITE-ProRule annotation
Sitei794 – 7941Interaction with PLCG1By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi519 – 5279ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. nerve growth factor binding Source: UniProtKB
  3. nerve growth factor receptor activity Source: UniProtKB
  4. protein homodimerization activity Source: UniProtKB
  5. protein tyrosine kinase activity Source: MGI
  6. transmembrane receptor protein tyrosine kinase activity Source: UniProtKB

GO - Biological processi

  1. aging Source: Ensembl
  2. axon guidance Source: Ensembl
  3. axonogenesis involved in innervation Source: UniProtKB
  4. B cell differentiation Source: MGI
  5. cellular response to growth factor stimulus Source: MGI
  6. cellular response to nerve growth factor stimulus Source: UniProtKB
  7. cellular response to nicotine Source: Ensembl
  8. circadian rhythm Source: UniProtKB
  9. detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
  10. detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
  11. developmental programmed cell death Source: UniProtKB
  12. learning or memory Source: Ensembl
  13. mechanoreceptor differentiation Source: MGI
  14. negative regulation of cell proliferation Source: UniProtKB
  15. negative regulation of neuron apoptotic process Source: UniProtKB
  16. nerve growth factor signaling pathway Source: UniProtKB
  17. nervous system development Source: MGI
  18. neurotrophin TRK receptor signaling pathway Source: UniProtKB
  19. olfactory nerve development Source: Ensembl
  20. peptidyl-tyrosine phosphorylation Source: GOC
  21. positive regulation of angiogenesis Source: Ensembl
  22. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  23. positive regulation of neuron projection development Source: UniProtKB
  24. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  25. positive regulation of programmed cell death Source: UniProtKB
  26. positive regulation of Ras GTPase activity Source: UniProtKB
  27. positive regulation of Ras protein signal transduction Source: UniProtKB
  28. positive regulation of synaptic transmission, glutamatergic Source: Ensembl
  29. protein autophosphorylation Source: UniProtKB
  30. protein phosphorylation Source: MGI
  31. response to activity Source: Ensembl
  32. response to axon injury Source: Ensembl
  33. response to drug Source: Ensembl
  34. response to electrical stimulus Source: Ensembl
  35. response to ethanol Source: Ensembl
  36. response to hydrostatic pressure Source: Ensembl
  37. response to nutrient levels Source: Ensembl
  38. response to radiation Source: Ensembl
  39. Sertoli cell development Source: Ensembl
  40. sympathetic nervous system development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_202778. Retrograde neurotrophin signalling.
REACT_205300. PI3K/AKT activation.
REACT_209347. NGF-independant TRKA activation.
REACT_212952. Signalling to STAT3.
REACT_213333. TRKA activation by NGF.
REACT_234035. ARMS-mediated activation.
REACT_239722. Signalling to RAS.
REACT_252757. Signalling to p38 via RIT and RIN.
REACT_262560. Frs2-mediated activation.
REACT_263607. PLC-gamma1 signalling.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity nerve growth factor receptor (EC:2.7.10.1)
Alternative name(s):
Neurotrophic tyrosine kinase receptor type 1
Gene namesi
Name:Ntrk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:97383. Ntrk1.

Subcellular locationi

Cell membrane By similarity; Single-pass type I membrane protein By similarity. Early endosome membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Late endosome membrane By similarity; Single-pass type I membrane protein By similarity
Note: Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes (By similarity). Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 420387ExtracellularSequence AnalysisAdd
BLAST
Transmembranei421 – 44121HelicalSequence AnalysisAdd
BLAST
Topological domaini442 – 799358CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. axon Source: MGI
  2. cell surface Source: MGI
  3. cytoplasm Source: MGI
  4. cytoplasmic vesicle Source: Ensembl
  5. dendrite Source: Ensembl
  6. early endosome Source: UniProtKB
  7. integral component of plasma membrane Source: UniProtKB
  8. late endosome Source: UniProtKB
  9. neuronal cell body Source: Ensembl
  10. plasma membrane Source: UniProtKB
  11. protein complex Source: UniProtKB
  12. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice die early after birth due to severe sensory and sympathetic neuropathies characterized by extensive neuronal cell loss in trigeminal, sympathetic and dorsal root ganglia, as well as a decrease in the cholinergic basal forebrain projections to the hippocampus and cortex. There are for instance 35% fewer cells by E17.5 in the superior cervical ganglion, a major component of the sympathetic system.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence AnalysisAdd
BLAST
Chaini34 – 799766High affinity nerve growth factor receptorPRO_0000278537Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi154 ↔ 193PROSITE-ProRule annotation
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi217 ↔ 267PROSITE-ProRule annotation
Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi320 – 3201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi341 – 3411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi361 – 3611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi404 – 4041N-linked (GlcNAc...)Sequence Analysis
Modified residuei499 – 4991Phosphotyrosine; by autocatalysisBy similarity
Modified residuei679 – 6791Phosphotyrosine; by autocatalysisBy similarity
Modified residuei683 – 6831Phosphotyrosine; by autocatalysisBy similarity
Modified residuei684 – 6841Phosphotyrosine; by autocatalysisBy similarity
Modified residuei794 – 7941Phosphotyrosine; by autocatalysisBy similarity

Post-translational modificationi

Ligand-mediated autophosphorylation. Interaction with SQSTM1 is phosphotyrosine-dependent. Autophosphorylation at Tyr-499 mediates interaction and phosphorylation of SHC1.
N-glycosylated.By similarity
Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the internalization of the receptor.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ3UFB7.
PRIDEiQ3UFB7.

PTM databases

PhosphoSiteiQ3UFB7.

Expressioni

Developmental stagei

First detected at E13.5, a time coinciding with the requirement of sympathetic neurons for NGF.1 Publication

Inductioni

Expression oscillates in a circadian manner in the suprachiasmatic nucleus (SCN) of the brain.1 Publication

Gene expression databases

BgeeiQ3UFB7.
CleanExiMM_NTRK1.
GenevestigatoriQ3UFB7.

Interactioni

Subunit structurei

Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Homodimerization is induced by binding of a NGF dimer. Interacts with SQSTM1; bridges NTRK1 to NGFR. Forms a ternary complex with NGFR and KIDINS220; this complex is affected by the expression levels of KIDINS220 and an increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts (phosphorylated upon activation by NGF) with SHC1; mediates SHC1 phosphorylation and activation. Interacts (phosphorylated upon activation by NGF) with PLCG1; mediates PLCG1 phosphorylation and activation. Interacts (phosphorylated) with SH2B1 and SH2B2. Interacts with GRB2. Interacts with PIK3R1. Interacts with FRS2. Interacts with SORT1; may regulate NTRK1 anterograde axonal transport. Interacts with NRADD (By similarity). Interacts with SH2D1A; regulates NTRK1. Interacts with RAB7A (By similarity). Found in a complex, at least composed of KIDINS220, MAGI2, NTRK1 and RAPGEF2; the complex is mainly formed at late endosomes in a nerve growth factor (NGF)-dependent manner (By similarity). Interacts with RAPGEF2; the interaction is strengthened after NGF stimulation (By similarity).By similarity

Protein-protein interaction databases

BioGridi201868. 7 interactions.
DIPiDIP-60900N.
STRINGi10090.ENSMUSP00000029712.

Structurei

3D structure databases

ProteinModelPortaliQ3UFB7.
SMRiQ3UFB7. Positions 36-391, 504-797.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati90 – 11324LRR 1Add
BLAST
Repeati116 – 13722LRR 2Add
BLAST
Domaini148 – 21972LRRCTAdd
BLAST
Domaini196 – 28590Ig-like C2-type 1Add
BLAST
Domaini205 – 368164Ig-like C2-type 2Add
BLAST
Domaini513 – 784272Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni472 – 49322Interaction with SQSTM1By similarityAdd
BLAST

Domaini

The transmembrane domain mediates interaction with KIDINS220.By similarity
The extracellular domain mediates interaction with NGFR.By similarity

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation
Contains 2 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118818.
HOGENOMiHOG000264255.
HOVERGENiHBG056735.
InParanoidiQ3UFB7.
KOiK03176.
OMAiKNVTCWA.
OrthoDBiEOG7GTT32.
PhylomeDBiQ3UFB7.
TreeFamiTF106465.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR020461. Tyr_kinase_neurotrophic_rcpt_1.
IPR020777. Tyr_kinase_NGF_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR01939. NTKRECEPTOR.
PR01940. NTKRECEPTOR1.
PR00109. TYRKINASE.
SMARTiSM00409. IG. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UFB7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRGQRLGQL GWHRPAAGLG SLMTSLMLAC ASAASCREVC CPVGPSGLRC
60 70 80 90 100
TRAGSLDTLR GLRGAGNLTE LYVENQQHLQ RLEFEDLQGL GELRSLTIVK
110 120 130 140 150
SGLRFVAPDA FRFTPRLSHL NLSSNALESL SWKTVQGLSL QDLTLSGNPL
160 170 180 190 200
HCSCALFWLQ RWEQEGLCGV HTQTLHDSGP GDQFLPLGHN TSCGVPTVKI
210 220 230 240 250
QMPNDSVEVG DDVFLQCQVE GLALQQADWI LTELEGAATV KKFGDLPSLG
260 270 280 290 300
LILVNVTSDL NKKNVTCWAE NDVGRAEVSV QVSVSFPASV HLGLAVEQHH
310 320 330 340 350
WCIPFSVDGQ PAPSLRWLFN GSVLNETSFI FTQFLESALT NETMRHGCLR
360 370 380 390 400
LNQPTHVNNG NYTLLAANPY GQAAASVMAA FMDNPFEFNP EDPIPVSFSP
410 420 430 440 450
VDGNSTSRDP VEKKDETPFG VSVAVGLAVS AALFLSALLL VLNKCGQRSK
460 470 480 490 500
FGINRPAVLA PEDGLAMSLH FMTLGGSSLS PTEGKGSGLQ GHIMENPQYF
510 520 530 540 550
SDTCVHHIKR QDIILKWELG EGAFGKVFLA ECYNLLNDQD KMLVAVKALK
560 570 580 590 600
EASENARQDF QREAELLTML QHQHIVRFFG VCTEGGPLLM VFEYMRHGDL
610 620 630 640 650
NRFLRSHGPD AKLLAGGEDV APGPLGLGQL LAVASQVAAG MVYLASLHFV
660 670 680 690 700
HRDLATRNCL VGQGLVVKIG DFGMSRDIYS TDYYRVGGRT MLPIRWMPPE
710 720 730 740 750
SILYRKFSTE SDVWSFGVVL WEIFTYGKQP WYQLSNTEAI ECITQGRELE
760 770 780 790
RPRACPPDVY AIMRGCWQRE PQQRLSMKDV HARLQALAQA PPSYLDVLG
Length:799
Mass (Da):87,738
Last modified:February 20, 2007 - v2
Checksum:i1A37F76A63564603
GO

Sequence cautioni

The sequence BAE28644.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK081588 mRNA. No translation available.
AK148691 mRNA. Translation: BAE28644.1. Different initiation.
CCDSiCCDS50947.1.
RefSeqiNP_001028296.1. NM_001033124.1.
UniGeneiMm.80682.

Genome annotation databases

EnsembliENSMUST00000029712; ENSMUSP00000029712; ENSMUSG00000028072.
GeneIDi18211.
KEGGimmu:18211.
UCSCiuc008psw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK081588 mRNA. No translation available.
AK148691 mRNA. Translation: BAE28644.1 . Different initiation.
CCDSi CCDS50947.1.
RefSeqi NP_001028296.1. NM_001033124.1.
UniGenei Mm.80682.

3D structure databases

ProteinModelPortali Q3UFB7.
SMRi Q3UFB7. Positions 36-391, 504-797.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201868. 7 interactions.
DIPi DIP-60900N.
STRINGi 10090.ENSMUSP00000029712.

PTM databases

PhosphoSitei Q3UFB7.

Proteomic databases

PaxDbi Q3UFB7.
PRIDEi Q3UFB7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029712 ; ENSMUSP00000029712 ; ENSMUSG00000028072 .
GeneIDi 18211.
KEGGi mmu:18211.
UCSCi uc008psw.1. mouse.

Organism-specific databases

CTDi 4914.
MGIi MGI:97383. Ntrk1.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118818.
HOGENOMi HOG000264255.
HOVERGENi HBG056735.
InParanoidi Q3UFB7.
KOi K03176.
OMAi KNVTCWA.
OrthoDBi EOG7GTT32.
PhylomeDBi Q3UFB7.
TreeFami TF106465.

Enzyme and pathway databases

Reactomei REACT_202778. Retrograde neurotrophin signalling.
REACT_205300. PI3K/AKT activation.
REACT_209347. NGF-independant TRKA activation.
REACT_212952. Signalling to STAT3.
REACT_213333. TRKA activation by NGF.
REACT_234035. ARMS-mediated activation.
REACT_239722. Signalling to RAS.
REACT_252757. Signalling to p38 via RIT and RIN.
REACT_262560. Frs2-mediated activation.
REACT_263607. PLC-gamma1 signalling.

Miscellaneous databases

NextBioi 293598.
PROi Q3UFB7.
SOURCEi Search...

Gene expression databases

Bgeei Q3UFB7.
CleanExi MM_NTRK1.
Genevestigatori Q3UFB7.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR020461. Tyr_kinase_neurotrophic_rcpt_1.
IPR020777. Tyr_kinase_NGF_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view ]
Pfami PF13855. LRR_8. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PRINTSi PR01939. NTKRECEPTOR.
PR01940. NTKRECEPTOR1.
PR00109. TYRKINASE.
SMARTi SM00409. IG. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Sympathetic ganglion.
  2. "Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene."
    Smeyne R.J., Klein R., Schnapp A., Long L.K., Bryant S., Lewin A., Lira S.A., Barbacid M.
    Nature 368:246-249(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION IN DEVELOPMENT OF THE NERVOUS SYSTEM.
  3. "TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo."
    Fagan A.M., Zhang H., Landis S., Smeyne R.J., Silos-Santiago I., Barbacid M.
    J. Neurosci. 16:6208-6218(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN SYMPATHETIC NEURONS SURVIVAL, DEVELOPMENTAL STAGE.
  4. "p75 neurotrophin receptor reduces ligand-induced Trk receptor ubiquitination and delays Trk receptor internalization and degradation."
    Makkerh J.P., Ceni C., Auld D.S., Vaillancourt F., Dorval G., Barker P.A.
    EMBO Rep. 6:936-941(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION, ENZYME REGULATION.
  5. "SLAM-associated protein as a potential negative regulator in Trk signaling."
    Lo K.Y., Chin W.H., Ng Y.P., Cheng A.W., Cheung Z.H., Ip N.Y.
    J. Biol. Chem. 280:41744-41752(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME REGULATION, INTERACTION WITH SH2D1A.
  6. "Recruitment of actin modifiers to TrkA endosomes governs retrograde NGF signaling and survival."
    Harrington A.W., St Hillaire C., Zweifel L.S., Glebova N.O., Philippidou P., Halegoua S., Ginty D.D.
    Cell 146:421-434(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN NGF AND NTF3 SIGNALING, ENZYME REGULATION, SUBCELLULAR LOCATION.
  7. "p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks."
    Baeza-Raja B., Eckel-Mahan K., Zhang L., Vagena E., Tsigelny I.F., Sassone-Corsi P., Ptacek L.J., Akassoglou K.
    J. Neurosci. 33:10221-10234(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiNTRK1_MOUSE
AccessioniPrimary (citable) accession number: Q3UFB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 26, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3