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Protein

Box C/D snoRNA protein 1

Gene

Znhit6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri211 – 24535HIT-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Box C/D snoRNA protein 1
Alternative name(s):
Zinc finger HIT domain-containing protein 6
Gene namesi
Name:Znhit6
Synonyms:Bcd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1916996. Znhit6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460Box C/D snoRNA protein 1PRO_0000280240Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei39 – 391PhosphoserineCombined sources
Cross-linki130 – 130Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki137 – 137Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki154 – 154Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki191 – 191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki449 – 449Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ3UFB2.
MaxQBiQ3UFB2.
PaxDbiQ3UFB2.
PRIDEiQ3UFB2.

PTM databases

iPTMnetiQ3UFB2.
PhosphoSiteiQ3UFB2.

Expressioni

Gene expression databases

BgeeiQ3UFB2.
ExpressionAtlasiQ3UFB2. baseline and differential.
GenevisibleiQ3UFB2. MM.

Interactioni

Subunit structurei

Interacts with FBL, SNU13, NOP58, NUFIP1, RUVBL1, RUVBL2 and TAF9.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096136.

Structurei

3D structure databases

ProteinModelPortaliQ3UFB2.
SMRiQ3UFB2. Positions 204-252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi93 – 193101Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the BCD1 family.Curated
Contains 1 HIT-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri211 – 24535HIT-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2858. Eukaryota.
ENOG4111QF2. LUCA.
GeneTreeiENSGT00390000017201.
HOGENOMiHOG000054208.
HOVERGENiHBG102997.
InParanoidiQ3UFB2.
OMAiCKRKLAM.
OrthoDBiEOG7HXCRK.
TreeFamiTF323923.

Family and domain databases

InterProiIPR007529. Znf_HIT.
[Graphical view]
PfamiPF04438. zf-HIT. 1 hit.
[Graphical view]
PROSITEiPS51083. ZF_HIT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UFB2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESAAEKEGT PGGGSQRVAE GARPRPAAGG EGARDLDGSP EAGDGEERNG
60 70 80 90 100
LAGTKTTEDA EEIKMDLAVV KQEVVDWSDL DSGVADSQWV KQEVEGGPEV
110 120 130 140 150
KDEKGVLEVK QEADSSLVVK EEEVDEPEVK EEKVKVKEEV TDWEEVKEED
160 170 180 190 200
LTIKQELFVG QNVKEEQVMD AAPIKEEGSL KSEAMEDAKV KEEPQMNPRV
210 220 230 240 250
GSKRKLALSR CETCGTEEAK YRCPRCMRFS CSLPCVKKHK ADLTCSGVRD
260 270 280 290 300
KTAYVSLQQF TEMNLLSDYR FLEDVARTAD KVSRDTFLKR PKRKKYLFFM
310 320 330 340 350
KNRARKQGIY LRLLPNGFSK RKENSTVFDH RKQQFCWHVK LQFPQSQAEY
360 370 380 390 400
IEKRVPDDKT INEILKPYID PEESDPVIRQ RLKAYAQSQT GVQILMRVEN
410 420 430 440 450
MQQNMIRYHE LDPYKSLSDN LKDKVIIEYP TLHVVLRGSS NDKQLLQVKS
460
ESAQKLGNGN
Length:460
Mass (Da):52,213
Last modified:July 27, 2011 - v2
Checksum:i9771F853FB9FFD43
GO
Isoform 2 (identifier: Q3UFB2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-168: Missing.

Note: No experimental confirmation available.
Show »
Length:292
Mass (Da):34,009
Checksum:iFA36BFBB3549D773
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti366 – 3661K → E in BAE28649 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 168168Missing in isoform 2. 1 PublicationVSP_023573Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148729 mRNA. Translation: BAE28649.1.
AK168844 mRNA. Translation: BAE40667.1.
CH466532 Genomic DNA. Translation: EDL12001.1.
BC147498 mRNA. Translation: AAI47499.1.
BC150966 mRNA. Translation: AAI50967.1.
BC150967 mRNA. Translation: AAI50968.1.
BC151198 mRNA. Translation: AAI51199.1.
CCDSiCCDS38662.1. [Q3UFB2-1]
RefSeqiNP_001074563.1. NM_001081094.1. [Q3UFB2-1]
XP_006501501.1. XM_006501438.1. [Q3UFB2-2]
XP_006501502.1. XM_006501439.1. [Q3UFB2-2]
UniGeneiMm.24586.

Genome annotation databases

EnsembliENSMUST00000098534; ENSMUSP00000096136; ENSMUSG00000074182. [Q3UFB2-1]
ENSMUST00000199033; ENSMUSP00000143306; ENSMUSG00000074182. [Q3UFB2-2]
GeneIDi229937.
KEGGimmu:229937.
UCSCiuc008rqo.1. mouse. [Q3UFB2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148729 mRNA. Translation: BAE28649.1.
AK168844 mRNA. Translation: BAE40667.1.
CH466532 Genomic DNA. Translation: EDL12001.1.
BC147498 mRNA. Translation: AAI47499.1.
BC150966 mRNA. Translation: AAI50967.1.
BC150967 mRNA. Translation: AAI50968.1.
BC151198 mRNA. Translation: AAI51199.1.
CCDSiCCDS38662.1. [Q3UFB2-1]
RefSeqiNP_001074563.1. NM_001081094.1. [Q3UFB2-1]
XP_006501501.1. XM_006501438.1. [Q3UFB2-2]
XP_006501502.1. XM_006501439.1. [Q3UFB2-2]
UniGeneiMm.24586.

3D structure databases

ProteinModelPortaliQ3UFB2.
SMRiQ3UFB2. Positions 204-252.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096136.

PTM databases

iPTMnetiQ3UFB2.
PhosphoSiteiQ3UFB2.

Proteomic databases

EPDiQ3UFB2.
MaxQBiQ3UFB2.
PaxDbiQ3UFB2.
PRIDEiQ3UFB2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098534; ENSMUSP00000096136; ENSMUSG00000074182. [Q3UFB2-1]
ENSMUST00000199033; ENSMUSP00000143306; ENSMUSG00000074182. [Q3UFB2-2]
GeneIDi229937.
KEGGimmu:229937.
UCSCiuc008rqo.1. mouse. [Q3UFB2-1]

Organism-specific databases

CTDi54680.
MGIiMGI:1916996. Znhit6.

Phylogenomic databases

eggNOGiKOG2858. Eukaryota.
ENOG4111QF2. LUCA.
GeneTreeiENSGT00390000017201.
HOGENOMiHOG000054208.
HOVERGENiHBG102997.
InParanoidiQ3UFB2.
OMAiCKRKLAM.
OrthoDBiEOG7HXCRK.
TreeFamiTF323923.

Miscellaneous databases

ChiTaRSiZnhit6. mouse.
NextBioi379747.
PROiQ3UFB2.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UFB2.
ExpressionAtlasiQ3UFB2. baseline and differential.
GenevisibleiQ3UFB2. MM.

Family and domain databases

InterProiIPR007529. Znf_HIT.
[Graphical view]
PfamiPF04438. zf-HIT. 1 hit.
[Graphical view]
PROSITEiPS51083. ZF_HIT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Liver and Sympathetic ganglion.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Lung and Spleen.

Entry informationi

Entry nameiBCD1_MOUSE
AccessioniPrimary (citable) accession number: Q3UFB2
Secondary accession number(s): B2RW16, Q3TG81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 27, 2011
Last modified: March 16, 2016
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.