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Protein
Submitted name:

Putative uncharacterized protein

Gene

Atp1a1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ADP binding Source: Ensembl
  2. chaperone binding Source: MGI
  3. phosphatase activity Source: MGI
  4. potassium ion binding Source: Ensembl
  5. sodium:potassium-exchanging ATPase activity Source: MGI
  6. sodium ion binding Source: Ensembl
  7. steroid hormone binding Source: MGI

GO - Biological processi

  1. cellular potassium ion homeostasis Source: MGI
  2. cellular response to mechanical stimulus Source: Ensembl
  3. cellular response to steroid hormone stimulus Source: MGI
  4. cellular sodium ion homeostasis Source: MGI
  5. dephosphorylation Source: GOC
  6. membrane hyperpolarization Source: Ensembl
  7. membrane repolarization Source: MGI
  8. negative regulation of glucocorticoid biosynthetic process Source: MGI
  9. negative regulation of heart contraction Source: MGI
  10. positive regulation of heart contraction Source: MGI
  11. positive regulation of striated muscle contraction Source: MGI
  12. potassium ion import Source: MGI
  13. regulation of blood pressure Source: MGI
  14. regulation of cardiac muscle cell contraction Source: Ensembl
  15. regulation of sodium ion transport Source: Ensembl
  16. regulation of the force of heart contraction Source: MGI
  17. response to drug Source: MGI
  18. response to glycoside Source: Ensembl
  19. sodium ion export from cell Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Atp1a1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88105. Atp1a1.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: MGI
  2. basolateral plasma membrane Source: MGI
  3. caveola Source: Ensembl
  4. endoplasmic reticulum Source: Ensembl
  5. endosome Source: Ensembl
  6. extracellular vesicular exosome Source: MGI
  7. Golgi apparatus Source: Ensembl
  8. membrane Source: MGI
  9. neuronal postsynaptic density Source: MGI
  10. plasma membrane Source: MGI
  11. protein complex Source: MGI
  12. sarcolemma Source: MGI
  13. sodium:potassium-exchanging ATPase complex Source: MGI
  14. vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ3UF49.

Expressioni

Gene expression databases

BgeeiQ3UF49.
ExpressionAtlasiQ3UF49. baseline and differential.
GenevestigatoriQ3UF49.

Structurei

3D structure databases

ProteinModelPortaliQ3UF49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG004298.

Family and domain databases

Gene3Di1.20.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR023298. ATPase_P-typ_TM_dom.
IPR023214. HAD-like_dom.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q3UF49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GDHPITAKAI AKGVGIISEG NETVEDIAAR LNIPVNQVNP RDAKACVVHG
60 70 80 90 100
SDLKDMTSEE LDDILRYHTE IVFARTSPQQ KLIIVEGCQR QGAIVAVTGD
110 120 130 140 150
GVNDSPALKK ADIGVAMGIV GSDVSKQAAD MILLDDNFAS IVTGVEEGRL
160 170 180 190 200
IFDNLKKSIA YTLTSNIPEI TPFLIFIIAN IPLPLGTVTI LCIDLGTDMV
210 220 230 240 250
PAISLAYEQA ESDIMKRQPR NPKTDKLVNE RLISMAYGQI GMIQALGGFF
260 270 280 290 300
TYFVILAENG FLPFHLLGIR ETWDDRWVND VEDSYGQQWT YEQRKIVEFT
310 320 330 340 350
CHTAFFVSIV VVQWADLVIC KTRRNSVFQQ GMKNKILIFG LFEETALAAF
360 370 380 390 400
LSYCPGMGAA LRMYPLKPTW WFCAFPYSLL IFVYDEVRKL IIRRRPGGWV

EKETYY
Length:406
Mass (Da):45,361
Last modified:October 10, 2005 - v1
Checksum:iD0D8A6024BCB012C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148989 mRNA. Translation: BAE28712.1.
UniGeneiMm.280103.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148989 mRNA. Translation: BAE28712.1.
UniGeneiMm.280103.

3D structure databases

ProteinModelPortaliQ3UF49.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ3UF49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:88105. Atp1a1.

Phylogenomic databases

HOVERGENiHBG004298.

Miscellaneous databases

ChiTaRSiAtp1a1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UF49.
ExpressionAtlasiQ3UF49. baseline and differential.
GenevestigatoriQ3UF49.

Family and domain databases

Gene3Di1.20.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR023298. ATPase_P-typ_TM_dom.
IPR023214. HAD-like_dom.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Sympathetic ganglionImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Sympathetic ganglionImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Sympathetic ganglionImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2000)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Sympathetic ganglionImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Sympathetic ganglionImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Sympathetic ganglionImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2004)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Sympathetic ganglionImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Sympathetic ganglionImported.

Entry informationi

Entry nameiQ3UF49_MOUSE
AccessioniPrimary (citable) accession number: Q3UF49
Entry historyi
Integrated into UniProtKB/TrEMBL: October 10, 2005
Last sequence update: October 10, 2005
Last modified: March 3, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.