Q3UF49 (Q3UF49_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein EMBL BAE28712.1

Gene names

Name:

Atp1a1 MGI 88105

Organism

Mus musculus (Mouse) EMBL BAE28712.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	406 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Biological process	Ion transport SAAS SAAS006069 Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS006068
Ligand	ATP-binding SAAS SAAS006068 Nucleotide-binding
Molecular function	Hydrolase SAAS SAAS006068
PTM	Phosphoprotein SAAS SAAS006068
Gene Ontology (GO)
Biological_process	cellular response to mechanical stimulus Inferred from electronic annotation. Source: Compara membrane hyperpolarization Inferred from electronic annotation. Source: Compara negative regulation of glucocorticoid biosynthetic process Inferred from mutant phenotype PubMed 17234593. Source: MGI negative regulation of heart contraction Inferred from mutant phenotype PubMed 15485817. Source: MGI positive regulation of heart contraction Inferred from mutant phenotype PubMed 10360172. Source: MGI positive regulation of striated muscle contraction Inferred from mutant phenotype PubMed 11507009. Source: MGI potassium ion import Inferred from electronic annotation. Source: Compara regulation of blood pressure Inferred from genetic interaction PubMed 16243970. Source: MGI regulation of cardiac muscle cell contraction Inferred from electronic annotation. Source: Compara regulation of sodium ion transport Inferred from electronic annotation. Source: Compara regulation of the force of heart contraction Inferred from mutant phenotype PubMed 10360172PubMed 15485817. Source: MGI response to drug Inferred from mutant phenotype PubMed 17234593. Source: MGI
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: Compara basolateral plasma membrane Inferred from direct assay PubMed 8144700. Source: MGI caveola Inferred from electronic annotation. Source: Compara endoplasmic reticulum Inferred from electronic annotation. Source: Compara endosome Inferred from electronic annotation. Source: Compara sarcolemma Inferred from direct assay PubMed 15485817. Source: MGI sodium:potassium-exchanging ATPase complex Inferred from electronic annotation. Source: Compara
Molecular_function	4-nitrophenylphosphatase activity Inferred from mutant phenotype PubMed 10360172. Source: MGI ADP binding Inferred from electronic annotation. Source: Compara ATP binding Inferred from electronic annotation. Source: UniProtKB-KW potassium ion binding Inferred from electronic annotation. Source: Compara sodium ion binding Inferred from electronic annotation. Source: Compara sodium:potassium-exchanging ATPase activity Inferred from mutant phenotype PubMed 10360172PubMed 15485817. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAE28712.1

Sequences

	Sequence		Length	Mass (Da)
	Q3UF49 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: D0D8A6024BCB012C	FASTA	406	45,361
	10 20 30 40 50 60 GDHPITAKAI AKGVGIISEG NETVEDIAAR LNIPVNQVNP RDAKACVVHG SDLKDMTSEE 70 80 90 100 110 120 LDDILRYHTE IVFARTSPQQ KLIIVEGCQR QGAIVAVTGD GVNDSPALKK ADIGVAMGIV 130 140 150 160 170 180 GSDVSKQAAD MILLDDNFAS IVTGVEEGRL IFDNLKKSIA YTLTSNIPEI TPFLIFIIAN 190 200 210 220 230 240 IPLPLGTVTI LCIDLGTDMV PAISLAYEQA ESDIMKRQPR NPKTDKLVNE RLISMAYGQI 250 260 270 280 290 300 GMIQALGGFF TYFVILAENG FLPFHLLGIR ETWDDRWVND VEDSYGQQWT YEQRKIVEFT 310 320 330 340 350 360 CHTAFFVSIV VVQWADLVIC KTRRNSVFQQ GMKNKILIFG LFEETALAAF LSYCPGMGAA 370 380 390 400 LRMYPLKPTW WFCAFPYSLL IFVYDEVRKL IIRRRPGGWV EKETYY

References

[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE28712.1. Tissue: Sympathetic ganglion EMBL BAE28712.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE28712.1. Tissue: Sympathetic ganglion EMBL BAE28712.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE28712.1. Tissue: Sympathetic ganglion EMBL BAE28712.1.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE28712.1. Tissue: Sympathetic ganglion EMBL BAE28712.1.
[5]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE28712.1. Tissue: Sympathetic ganglion EMBL BAE28712.1.
[6]	Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE28712.1. Tissue: Sympathetic ganglion EMBL BAE28712.1.
[7]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE28712.1. Tissue: Sympathetic ganglion EMBL BAE28712.1.
[8]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE28712.1. Tissue: Sympathetic ganglion EMBL BAE28712.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK148989 mRNA. Translation: BAE28712.1.
IPI	IPI00311682.
UniGene	Mm.280103.
3D structure databases
ProteinModelPortal	Q3UF49.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3UF49.
Proteomic databases
PRIDE	Q3UF49.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:88105. Atp1a1.
Phylogenomic databases
HOVERGEN	HBG004298.
InParanoid	Q3UF49.
Gene expression databases
ArrayExpress	Q3UF49.
Bgee	Q3UF49.
Genevestigator	Q3UF49.
Family and domain databases
Gene3D	1.20.1110.10. 1 hit.
InterPro	IPR006068. ATPase_P-typ_cation-transptr_C. IPR023298. ATPase_P-typ_TM_dom. IPR001757. Cation_transp_P_typ_ATPase. IPR023214. HAD-like_dom. [Graphical view]
PANTHER	PTHR24093. PTHR24093. 1 hit.
Pfam	PF00689. Cation_ATPase_C. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE.
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01494. ATPase_P-type. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	ATP1A1. mouse.
SOURCE	Search...

Entry information

Entry name

Q3UF49_MOUSE

Accession

Primary (citable) accession number: Q3UF49

Entry history

Integrated into UniProtKB/TrEMBL:	October 11, 2005
Last sequence update:	October 11, 2005
Last modified:	May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)