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Q3UF49 (Q3UF49_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Atp1a1 MGI 88105
OrganismMus musculus (Mouse) EMBL BAE28712.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length406 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix SAAS SAAS006068
   Molecular functionHydrolase SAAS SAAS001757
Gene Ontology (GO)
   Biological_processcellular response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

dephosphorylation

Inferred from mutant phenotype PubMed 10360172. Source: GOC

membrane hyperpolarization

Inferred from electronic annotation. Source: Ensembl

negative regulation of glucocorticoid biosynthetic process

Inferred from mutant phenotype PubMed 17234593. Source: MGI

negative regulation of heart contraction

Inferred from mutant phenotype PubMed 15485817. Source: MGI

positive regulation of heart contraction

Inferred from mutant phenotype PubMed 10360172. Source: MGI

positive regulation of striated muscle contraction

Inferred from mutant phenotype PubMed 11507009. Source: MGI

potassium ion import

Inferred from electronic annotation. Source: Ensembl

regulation of blood pressure

Inferred from genetic interaction PubMed 16243970. Source: MGI

regulation of cardiac muscle cell contraction

Inferred from electronic annotation. Source: Ensembl

regulation of sodium ion transport

Inferred from electronic annotation. Source: Ensembl

regulation of the force of heart contraction

Inferred from mutant phenotype PubMed 10360172PubMed 15485817. Source: MGI

response to drug

Inferred from mutant phenotype PubMed 17234593. Source: MGI

sodium ion transmembrane transport

Inferred from mutant phenotype PubMed 10360172PubMed 15485817. Source: GOC

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: Ensembl

apical plasma membrane

Inferred from direct assay PubMed 21705333. Source: MGI

basolateral plasma membrane

Inferred from direct assay PubMed 8144700. Source: MGI

caveola

Inferred from electronic annotation. Source: Ensembl

endoplasmic reticulum

Inferred from electronic annotation. Source: Ensembl

endosome

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from direct assay PubMed 10468580PubMed 10837135. Source: MGI

sarcolemma

Inferred from direct assay PubMed 15485817. Source: MGI

sodium:potassium-exchanging ATPase complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionADP binding

Inferred from electronic annotation. Source: Ensembl

ATP binding

Inferred from electronic annotation. Source: Ensembl

phosphatase activity

Inferred from mutant phenotype PubMed 10360172. Source: MGI

potassium ion binding

Inferred from electronic annotation. Source: Ensembl

sodium ion binding

Inferred from electronic annotation. Source: Ensembl

sodium:potassium-exchanging ATPase activity

Inferred from mutant phenotype PubMed 10360172PubMed 15485817. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL BAE28712.1

Sequences

Sequence LengthMass (Da)Tools
Q3UF49 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: D0D8A6024BCB012C

FASTA40645,361
        10         20         30         40         50         60 
GDHPITAKAI AKGVGIISEG NETVEDIAAR LNIPVNQVNP RDAKACVVHG SDLKDMTSEE 

        70         80         90        100        110        120 
LDDILRYHTE IVFARTSPQQ KLIIVEGCQR QGAIVAVTGD GVNDSPALKK ADIGVAMGIV 

       130        140        150        160        170        180 
GSDVSKQAAD MILLDDNFAS IVTGVEEGRL IFDNLKKSIA YTLTSNIPEI TPFLIFIIAN 

       190        200        210        220        230        240 
IPLPLGTVTI LCIDLGTDMV PAISLAYEQA ESDIMKRQPR NPKTDKLVNE RLISMAYGQI 

       250        260        270        280        290        300 
GMIQALGGFF TYFVILAENG FLPFHLLGIR ETWDDRWVND VEDSYGQQWT YEQRKIVEFT 

       310        320        330        340        350        360 
CHTAFFVSIV VVQWADLVIC KTRRNSVFQQ GMKNKILIFG LFEETALAAF LSYCPGMGAA 

       370        380        390        400 
LRMYPLKPTW WFCAFPYSLL IFVYDEVRKL IIRRRPGGWV EKETYY 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE28712.1.
Tissue: Sympathetic ganglion EMBL BAE28712.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE28712.1.
Tissue: Sympathetic ganglion EMBL BAE28712.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE28712.1.
Tissue: Sympathetic ganglion EMBL BAE28712.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE28712.1.
Tissue: Sympathetic ganglion EMBL BAE28712.1.
[5]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE28712.1.
Tissue: Sympathetic ganglion EMBL BAE28712.1.
[6]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE28712.1.
Tissue: Sympathetic ganglion EMBL BAE28712.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE28712.1.
Tissue: Sympathetic ganglion EMBL BAE28712.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE28712.1.
Tissue: Sympathetic ganglion EMBL BAE28712.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK148989 mRNA. Translation: BAE28712.1.
UniGeneMm.280103.

3D structure databases

ProteinModelPortalQ3UF49.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ3UF49.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:88105. Atp1a1.

Phylogenomic databases

HOVERGENHBG004298.
InParanoidQ3UF49.

Gene expression databases

ArrayExpressQ3UF49.
BgeeQ3UF49.
GenevestigatorQ3UF49.

Family and domain databases

Gene3D1.20.1110.10. 1 hit.
InterProIPR006068. ATPase_P-typ_cation-transptr_C.
IPR023298. ATPase_P-typ_TM_dom.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamPF00689. Cation_ATPase_C. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
SUPFAMSSF56784. SSF56784. 1 hit.
TIGRFAMsTIGR01494. ATPase_P-type. 1 hit.
ProtoNetSearch...

Other

ChiTaRSATP1A1. mouse.
SOURCESearch...

Entry information

Entry nameQ3UF49_MOUSE
AccessionPrimary (citable) accession number: Q3UF49
Entry history
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)