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Q3UEW8

- Q3UEW8_MOUSE

UniProt

Q3UEW8 - Q3UEW8_MOUSE

Protein
Submitted name:

Putative uncharacterized protein

Gene

Pdpk1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. 3-phosphoinositide-dependent protein kinase activity Source: MGI
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. activation of protein kinase B activity Source: Ensembl
    2. cellular response to insulin stimulus Source: Ensembl
    3. extrinsic apoptotic signaling pathway Source: Ensembl
    4. focal adhesion assembly Source: Ensembl
    5. hyperosmotic response Source: MGI
    6. intracellular signal transduction Source: Ensembl
    7. negative regulation of protein kinase activity Source: Ensembl
    8. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    9. peptidyl-threonine phosphorylation Source: Ensembl
    10. positive regulation of establishment of protein localization to plasma membrane Source: Ensembl
    11. regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    12. signal transduction Source: MGI

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative uncharacterized proteinImported
    Gene namesi
    Name:Pdpk1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1338068. Pdpk1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytoplasmic membrane-bounded vesicle Source: MGI
    3. cytosol Source: Ensembl
    4. plasma membrane Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiQ3UEW8.
    BgeeiQ3UEW8.
    GenevestigatoriQ3UEW8.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3UEW8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000233026.
    HOVERGENiHBG098357.
    InParanoidiQ3UEW8.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q3UEW8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARTTSQLYD AVPIQSSVVL CSCPSPSMVR SQTEPGSSPG IPSGVSRQGS    50
    TMDGTTAEAR PSTNPLQQHP AQLPPQPRKK RPEDFKFGKI LGEGSFSTVV 100
    LARELATSRE YAIKILEKRH IIKENKVPYV TRERDVMSRL DHPFFVKLYF 150
    TFQDDEKLYF GLSYAKNGEL LKYIRKIGSF DETCTRFYTA EIVSALEYLH 200
    GKGIIHRDLK PENILLNEDM HIQITDFGTA KVLSPESKQA RANSFVGTAQ 250
    YVSPELLTEK SACKSSDLWA LGCIIYQLVA GLPPFRAGNE YLIFQKIIKL 300
    EYHFPEKFFP KARDLVEKLL VLDATKRLGC EEMEGYGPLK AHPFFETITW 350
    ENLHQQTPPK LTAYLPAMSE DDEDCYGNYD NLLSQFGFMQ VSSSSSSHSL 400
    STVETSLPQR SGSNIEQYIH DLDTNSFELD LQFS 434
    Length:434
    Mass (Da):48,960
    Last modified:October 11, 2005 - v1
    Checksum:i161630FB56FC793F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei434 – 4341Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK149289 mRNA. Translation: BAE28793.1.
    UniGeneiMm.10504.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK149289 mRNA. Translation: BAE28793.1 .
    UniGenei Mm.10504.

    3D structure databases

    ProteinModelPortali Q3UEW8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1338068. Pdpk1.

    Phylogenomic databases

    HOGENOMi HOG000233026.
    HOVERGENi HBG098357.
    InParanoidi Q3UEW8.

    Miscellaneous databases

    ChiTaRSi PDPK1. mouse.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3UEW8.
    Bgeei Q3UEW8.
    Genevestigatori Q3UEW8.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: RetinaImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: RetinaImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: RetinaImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: RetinaImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: RetinaImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: RetinaImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: RetinaImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: RetinaImported.

    Entry informationi

    Entry nameiQ3UEW8_MOUSE
    AccessioniPrimary (citable) accession number: Q3UEW8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)