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Q3UEW8

- Q3UEW8_MOUSE

UniProt

Q3UEW8 - Q3UEW8_MOUSE

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Protein
Submitted name:

Putative uncharacterized protein

Gene

Pdpk1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. 3-phosphoinositide-dependent protein kinase activity Source: MGI
  2. ATP binding Source: UniProtKB-KW
  3. phospholipase activator activity Source: Ensembl

GO - Biological processi

  1. activation of protein kinase B activity Source: Ensembl
  2. calcium-mediated signaling Source: Ensembl
  3. cell migration Source: Ensembl
  4. cellular response to epidermal growth factor stimulus Source: Ensembl
  5. cellular response to insulin stimulus Source: Ensembl
  6. epidermal growth factor receptor signaling pathway Source: Ensembl
  7. extrinsic apoptotic signaling pathway Source: Ensembl
  8. focal adhesion assembly Source: Ensembl
  9. hyperosmotic response Source: MGI
  10. negative regulation of protein kinase activity Source: Ensembl
  11. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  12. peptidyl-threonine phosphorylation Source: Ensembl
  13. positive regulation of establishment of protein localization to plasma membrane Source: Ensembl
  14. positive regulation of phospholipase activity Source: Ensembl
  15. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
  16. regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  17. signal transduction Source: MGI
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Pdpk1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1338068. Pdpk1.

Subcellular locationi

GO - Cellular componenti

  1. cell projection Source: Ensembl
  2. cytoplasm Source: MGI
  3. cytoplasmic membrane-bounded vesicle Source: MGI
  4. cytosol Source: Ensembl
  5. plasma membrane Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ3UEW8.
ExpressionAtlasiQ3UEW8. baseline and differential.
GenevestigatoriQ3UEW8.

Structurei

3D structure databases

ProteinModelPortaliQ3UEW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000233026.
HOVERGENiHBG098357.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3UEW8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARTTSQLYD AVPIQSSVVL CSCPSPSMVR SQTEPGSSPG IPSGVSRQGS
60 70 80 90 100
TMDGTTAEAR PSTNPLQQHP AQLPPQPRKK RPEDFKFGKI LGEGSFSTVV
110 120 130 140 150
LARELATSRE YAIKILEKRH IIKENKVPYV TRERDVMSRL DHPFFVKLYF
160 170 180 190 200
TFQDDEKLYF GLSYAKNGEL LKYIRKIGSF DETCTRFYTA EIVSALEYLH
210 220 230 240 250
GKGIIHRDLK PENILLNEDM HIQITDFGTA KVLSPESKQA RANSFVGTAQ
260 270 280 290 300
YVSPELLTEK SACKSSDLWA LGCIIYQLVA GLPPFRAGNE YLIFQKIIKL
310 320 330 340 350
EYHFPEKFFP KARDLVEKLL VLDATKRLGC EEMEGYGPLK AHPFFETITW
360 370 380 390 400
ENLHQQTPPK LTAYLPAMSE DDEDCYGNYD NLLSQFGFMQ VSSSSSSHSL
410 420 430
STVETSLPQR SGSNIEQYIH DLDTNSFELD LQFS
Length:434
Mass (Da):48,960
Last modified:October 11, 2005 - v1
Checksum:i161630FB56FC793F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei434 – 4341Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK149289 mRNA. Translation: BAE28793.1.
UniGeneiMm.10504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK149289 mRNA. Translation: BAE28793.1 .
UniGenei Mm.10504.

3D structure databases

ProteinModelPortali Q3UEW8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1338068. Pdpk1.

Phylogenomic databases

HOGENOMi HOG000233026.
HOVERGENi HBG098357.

Miscellaneous databases

ChiTaRSi PDPK1. mouse.
SOURCEi Search...

Gene expression databases

Bgeei Q3UEW8.
ExpressionAtlasi Q3UEW8. baseline and differential.
Genevestigatori Q3UEW8.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: RetinaImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: RetinaImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: RetinaImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: RetinaImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: RetinaImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: RetinaImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: RetinaImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: RetinaImported.

Entry informationi

Entry nameiQ3UEW8_MOUSE
AccessioniPrimary (citable) accession number: Q3UEW8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)