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Q3UEW6 (Q3UEW6_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase receptor PIRNR PIRNR000615

EC=2.7.10.1 PIRNR PIRNR000615
Gene names
Name:Flt3 MGI 95559 Ensembl ENSMUSP00000039041
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1000 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS008266 RuleBase RU000311 PIRNR PIRNR000615

Subcellular location

Membrane; Single-pass type I membrane protein By similarity RuleBase RU000311.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. RuleBase RU000311 PIRNR PIRNR000615

Contains protein kinase domain. SAAS SAAS008266

Ontologies

Keywords
   Cellular componentMembrane
   DomainImmunoglobulin domain SAAS SAAS008266 RuleBase RU000311
Transmembrane
Transmembrane helix SAAS SAAS008266
   LigandATP-binding SAAS SAAS008266 PIRNR PIRNR000615
Nucleotide-binding
   Molecular functionKinase
Receptor SAAS SAAS008266 RuleBase RU000311 PIRNR PIRNR000615
Transferase
Tyrosine-protein kinase SAAS SAAS008266 PIRNR PIRNR000615
   PTMDisulfide bond SAAS SAAS013151
Phosphoprotein SAAS SAAS008266 RuleBase RU003595
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhemopoiesis

Inferred from sequence orthology PubMed 7507245. Source: MGI

lymphocyte differentiation

Inferred from direct assay PubMed 12387740. Source: MGI

lymphoid progenitor cell differentiation

Inferred from genetic interaction PubMed 7621074. Source: MGI

myeloid progenitor cell differentiation

Inferred from mutant phenotype PubMed 18245664. Source: MGI

negative regulation of B cell differentiation

Inferred from direct assay PubMed 16618805. Source: MGI

negative regulation of cell proliferation

Inferred from mutant phenotype PubMed 7919361. Source: MGI

peptidyl-tyrosine phosphorylation

Inferred from direct assay PubMed 8384358. Source: GOC

positive regulation of protein phosphorylation

Inferred from genetic interaction PubMed 20360400. Source: MGI

pro-B cell differentiation

Inferred from mutant phenotype PubMed 7621074. Source: MGI

pro-T cell differentiation

Inferred from mutant phenotype PubMed 7621074. Source: MGI

protein autophosphorylation

Inferred from direct assay PubMed 8183574PubMed 8384358. Source: MGI

transmembrane receptor protein tyrosine kinase signaling pathway

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcell surface

Inferred from direct assay PubMed 7630197PubMed 9620281. Source: MGI

external side of plasma membrane

Inferred from direct assay PubMed 23528453. Source: MGI

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphatidylinositol 3-kinase binding

Inferred from direct assay PubMed 8183574. Source: MGI

protein tyrosine kinase activity

Inferred from direct assay PubMed 8384358. Source: MGI

transmembrane receptor protein tyrosine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q3UEW6 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 9CDDEFB16F2E3042

FASTA1,000113,409
        10         20         30         40         50         60 
MRALAQRSDR RLLLLVVLSV MILETVTNQD LPVIKCVLIS HENNGSSAGK PSSYRMVRGS 

        70         80         90        100        110        120 
PEDLQCAPRR QSEGTVYEAA TVEVAESGSI TLQVQLATPG DLSCLWVFKH SSLGCQPHFD 

       130        140        150        160        170        180 
LQNRGIVSMA ILNVTETQAG EYLLHIQSEA ANYTVLFTVN VRDTQLYVLR RPYFRKMENQ 

       190        200        210        220        230        240 
DALLCISEGV PEPTVEWVLC SSHRESCKEE GPAVVRKEEK VLHELFGTDI RCCARNALGR 

       250        260        270        280        290        300 
ECTKLFTIDL NQAPQSTLPQ LFLKVGEPLW IRCKAIHVNH GFGLTWELED KALEEGSYFE 

       310        320        330        340        350        360 
MSTYSTNRTM IRILLAFVSS VGRNDTGYYT CSSSKHPSQS ALVTILEKGF INATSSQEEY 

       370        380        390        400        410        420 
EIDPYEKFCF SVRFKAYPRI RCTWIFSQAS FPCEQRGLED GYSISKFCDH KNKPGEYIFY 

       430        440        450        460        470        480 
AENDDAQFTK MFTLNIRKKP QVLANASASQ ASCSSDGYPL PSWTWKKCSD KSPNCTEEIP 

       490        500        510        520        530        540 
EGVWNKKANR KVFGQWVSSS TLNMSEAGKG LLVKCCAYNS MGTSCETIFL NSPGPFPFIQ 

       550        560        570        580        590        600 
DNISFYATIG LCLPFIVVLI VLICHKYKKQ FRYESQLQMI QVTGPLDNEY FYVDFRDYEY 

       610        620        630        640        650        660 
DLKWEFPREN LEFGKVLGSG AFGRVMNATA YGISKTGVSI QVAVKMLKEK ADSCEKEALM 

       670        680        690        700        710        720 
SELKMMTHLG HHDNIVNLLG ACTLSGPVYL IFEYCCYGDL LNYLRSKREK FHRTWTEIFK 

       730        740        750        760        770        780 
EHNFSFYPTF QAHSNSSMPG SREVQLHPPL DQLSGFNGNL IHSEDEIEYE NQKRLAEEEE 

       790        800        810        820        830        840 
EDLNVLTFED LLCFAYQVAK GMEFLEFKSC VHRDLAARNV LVTHGKVVKI CDFGLARDIL 

       850        860        870        880        890        900 
SDSSYVVRGN ARLPVKWMAP ESLFEGIYTI KSDVWSYGIL LWEIFSLGVN PYPGIPVDAN 

       910        920        930        940        950        960 
FYKLIQSGFK MEQPFYATEG IYFVMQSCWA FDSRKRPSFP NLTSFLGCQL AEAEEAMYQN 

       970        980        990       1000 
MGGNVPEHPS IYQNRRPLSR EAGSEPPSPQ AQVKIHGERS 

« Hide

References

« Hide 'large scale' references
[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE28795.1.
Tissue: Retina EMBL BAE28795.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE28795.1.
Tissue: Retina EMBL BAE28795.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE28795.1.
Tissue: Retina EMBL BAE28795.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE28795.1.
Tissue: Retina EMBL BAE28795.1.
[5]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE28795.1.
Tissue: Retina EMBL BAE28795.1.
[6]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE28795.1.
Tissue: Retina EMBL BAE28795.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE28795.1.
Tissue: Retina EMBL BAE28795.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE28795.1.
Tissue: Retina EMBL BAE28795.1.
[9]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000039041.
[10]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000039041.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC127549 Genomic DNA. No translation available.
AC134441 Genomic DNA. No translation available.
AK149292 mRNA. Translation: BAE28795.1.
RefSeqNP_034359.2. NM_010229.2.
UniGeneMm.194.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

DNASU14255.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000049324; ENSMUSP00000039041; ENSMUSG00000042817.
GeneID14255.
KEGGmmu:14255.
UCSCuc009aob.2. mouse.

Organism-specific databases

CTD2322.
MGIMGI:95559. Flt3.

Phylogenomic databases

GeneTreeENSGT00720000108490.
HOGENOMHOG000112616.
HOVERGENHBG005735.
InParanoidQ3UEW6.
KOK05092.
OMAGPIYLIF.
OrthoDBEOG7H792D.
TreeFamTF325768.

Gene expression databases

GenevestigatorQ3UEW6.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016243. Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824. Tyr_kinase_rcpt_3_CS.
[Graphical view]
PfamPF00047. ig. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFPIRSF000615. TyrPK_CSF1-R. 1 hit.
SMARTSM00409. IG. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio285583.
SOURCESearch...

Entry information

Entry nameQ3UEW6_MOUSE
AccessionPrimary (citable) accession number: Q3UEW6
Entry history
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)