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Protein
Submitted name:

Receptor-type tyrosine-protein kinase FLT3

Gene

Flt3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-449836. Other interleukin signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Receptor-type tyrosine-protein kinase FLT3Imported
Gene namesi
Name:Flt3Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:95559. Flt3.

Subcellular locationi

  • Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei543 – 564HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_501084342429 – 1000Sequence analysisAdd BLAST972

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000042817.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini254 – 344Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST91
Domaini611 – 946Protein kinaseInterPro annotationAdd BLAST336

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili762 – 789Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Immunoglobulin domainUniRule annotationSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118923.
HOGENOMiHOG000112616.
HOVERGENiHBG005735.
KOiK05092.
OMAiFHRTWTE.
OrthoDBiEOG091G01TL.
TreeFamiTF325768.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiView protein in InterPro
IPR030118. FLT3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR001824. Tyr_kinase_rcpt_3_CS.
PANTHERiPTHR24416:SF395. PTHR24416:SF395. 1 hit.
PfamiView protein in Pfam
PF00047. ig. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 2 hits.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3UEW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALAQRSDR RLLLLVVLSV MILETVTNQD LPVIKCVLIS HENNGSSAGK
60 70 80 90 100
PSSYRMVRGS PEDLQCAPRR QSEGTVYEAA TVEVAESGSI TLQVQLATPG
110 120 130 140 150
DLSCLWVFKH SSLGCQPHFD LQNRGIVSMA ILNVTETQAG EYLLHIQSEA
160 170 180 190 200
ANYTVLFTVN VRDTQLYVLR RPYFRKMENQ DALLCISEGV PEPTVEWVLC
210 220 230 240 250
SSHRESCKEE GPAVVRKEEK VLHELFGTDI RCCARNALGR ECTKLFTIDL
260 270 280 290 300
NQAPQSTLPQ LFLKVGEPLW IRCKAIHVNH GFGLTWELED KALEEGSYFE
310 320 330 340 350
MSTYSTNRTM IRILLAFVSS VGRNDTGYYT CSSSKHPSQS ALVTILEKGF
360 370 380 390 400
INATSSQEEY EIDPYEKFCF SVRFKAYPRI RCTWIFSQAS FPCEQRGLED
410 420 430 440 450
GYSISKFCDH KNKPGEYIFY AENDDAQFTK MFTLNIRKKP QVLANASASQ
460 470 480 490 500
ASCSSDGYPL PSWTWKKCSD KSPNCTEEIP EGVWNKKANR KVFGQWVSSS
510 520 530 540 550
TLNMSEAGKG LLVKCCAYNS MGTSCETIFL NSPGPFPFIQ DNISFYATIG
560 570 580 590 600
LCLPFIVVLI VLICHKYKKQ FRYESQLQMI QVTGPLDNEY FYVDFRDYEY
610 620 630 640 650
DLKWEFPREN LEFGKVLGSG AFGRVMNATA YGISKTGVSI QVAVKMLKEK
660 670 680 690 700
ADSCEKEALM SELKMMTHLG HHDNIVNLLG ACTLSGPVYL IFEYCCYGDL
710 720 730 740 750
LNYLRSKREK FHRTWTEIFK EHNFSFYPTF QAHSNSSMPG SREVQLHPPL
760 770 780 790 800
DQLSGFNGNL IHSEDEIEYE NQKRLAEEEE EDLNVLTFED LLCFAYQVAK
810 820 830 840 850
GMEFLEFKSC VHRDLAARNV LVTHGKVVKI CDFGLARDIL SDSSYVVRGN
860 870 880 890 900
ARLPVKWMAP ESLFEGIYTI KSDVWSYGIL LWEIFSLGVN PYPGIPVDAN
910 920 930 940 950
FYKLIQSGFK MEQPFYATEG IYFVMQSCWA FDSRKRPSFP NLTSFLGCQL
960 970 980 990 1000
AEAEEAMYQN MGGNVPEHPS IYQNRRPLSR EAGSEPPSPQ AQVKIHGERS
Length:1,000
Mass (Da):113,409
Last modified:October 11, 2005 - v1
Checksum:i9CDDEFB16F2E3042
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127549 Genomic DNA. No translation available.
AC134441 Genomic DNA. No translation available.
AK149292 mRNA. Translation: BAE28795.1.
RefSeqiNP_034359.2. NM_010229.2.
UniGeneiMm.194.

Genome annotation databases

EnsembliENSMUST00000049324; ENSMUSP00000039041; ENSMUSG00000042817.
GeneIDi14255.
KEGGimmu:14255.
UCSCiuc009aob.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ3UEW6_MOUSE
AccessioniPrimary (citable) accession number: Q3UEW6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: August 30, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported