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Protein

Pyruvate kinase

Gene

Pklr

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (Gapdh), Glyceraldehyde-3-phosphate dehydrogenase (Gapdh), Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Glyceraldehyde-3-phosphate dehydrogenase (Gapdh), Glyceraldehyde-3-phosphate dehydrogenase (Gapdhs), Glyceraldehyde-3-phosphate dehydrogenase (Gm10358), Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (Gapdhs), Glyceraldehyde-3-phosphate dehydrogenase (Gapdhs), Glyceraldehyde-3-phosphate dehydrogenase (Gm3839)
  2. Phosphoglycerate kinase (Pgk1), Phosphoglycerate kinase 2 (Pgk2), Phosphoglycerate kinase 1 (Pgk1), Phosphoglycerate kinase (Pgk1)
  3. no protein annotated in this organism
  4. Gamma-enolase (Eno2), Alpha-enolase (Eno1), Beta-enolase (Eno3), Enolase 4 (Eno4)
  5. Pyruvate kinase (Pklr), Pyruvate kinase (Pklr), Pyruvate kinase PKLR (Pklr), Pyruvate kinase (Pklr), Pyruvate kinase (Pklr), Pyruvate kinase (Pklr), Pyruvate kinase PKM (Pkm)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

Keywordsi

Molecular functionKinaseUniRule annotation, Transferase
Biological processGlycolysisUniRule annotation
LigandMagnesiumUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Name:PklrImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97604. Pklr.

PTM / Processingi

Proteomic databases

PaxDbiQ3UEI4.
PRIDEiQ3UEI4.

Expressioni

Gene expression databases

GenevisibleiQ3UEI4. MM.

Structurei

3D structure databases

ProteinModelPortaliQ3UEI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 409PKInterPro annotationAdd BLAST352
Domaini426 – 543PK_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2323. Eukaryota.
COG0469. LUCA.
HOGENOMiHOG000021559.
HOVERGENiHBG000941.
KOiK12406.

Family and domain databases

CDDicd00288. Pyruvate_Kinase. 1 hit.
Gene3Di3.40.1380.20. 1 hit.
InterProiView protein in InterPro
IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiView protein in Pfam
PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiView protein in PROSITE
PS00110. PYRUVATE_KINASE. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q3UEI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GSSMEGPAGY LRRASVAQLT QELGTAFFQQ QQLPAAMADT FLEHLCLLDI
60 70 80 90 100
DSEPVAARST SIIATIGPAS RSVDRLKEMI KAGMNIARLN FSHGSHEYHA
110 120 130 140 150
ESIANIREAA ESFATSPLSY RPVAIALDTK GPEIRTGVLQ GGPESEVEIV
160 170 180 190 200
KGSQVLVTVD PKFRTRGDAK TVWVDYHNIT QVVAVGGRIY IDDGLISLVV
210 220 230 240 250
RKIGPEGLVT EVEHGGFLGN RKGVNLPNAE VDLPGLSEQD LLDLRFGVEH
260 270 280 290 300
NVDIIFASFV RKASDVVAVR DALGPEGRGI KIISKIENHE GVKKFDEILE
310 320 330 340 350
VSDGIMVARG DLGIEIPAEK VFLAQKMMIG RCNLAGKPVV CATQMLESMI
360 370 380 390 400
TKARPTRAET SDVANAVLDG ADCIMLSGET AKGSFPVEAV KMQHAIAREA
410 420 430 440 450
EAAVYHRQLF EELRRAAPLS RDPTEVTAIG AVEASFKCCA AAIIVLTKTG
460 470 480 490 500
RSAQLLSRYR PRAAVIAVTR SAQAARQVHL SRGVFPLLYR EPPEAVWADD
510 520 530 540
VDRRVQFGIE SGKLRGFLRV GDLVIVVTGW RPGSGYTNIM RVLTIS
Length:546
Mass (Da):59,052
Last modified:October 11, 2005 - v1
Checksum:i7F0BE99BB6E036C1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK149508 mRNA. Translation: BAE28927.1.
RefSeqiNP_001093249.1. NM_001099779.1.
NP_038659.2. NM_013631.2.
UniGeneiMm.383180.

Genome annotation databases

GeneIDi18770.
KEGGimmu:18770.

Similar proteinsi

Entry informationi

Entry nameiQ3UEI4_MOUSE
AccessioniPrimary (citable) accession number: Q3UEI4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: August 30, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)