Reviewed, UniProtKB/Swiss-Prot Q3UEI1 (PDE4C_MOUSE)

Names and origin

Protein names

Recommended name:
    cAMP-specific 3',5'-cyclic phosphodiesterase 4C
    EC=3.1.4.17

Gene names

Name:

Pde4c

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	686 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.
Enzyme regulation	Inhibited by rolipram By similarity.
Pathway	Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
Sequence similarities	Belongs to the cyclic nucleotide phosphodiesterase family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Ligand	cAMP
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	signal transduction Inferred from electronic annotation. Source: InterPro
Molecular function	3',5'-cyclic-nucleotide phosphodiesterase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q3UEI1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q3UEI1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     537-570: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 686	686	cAMP-specific 3',5'-cyclic phosphodiesterase 4C		PRO_0000198812
Regions
	Compositional bias	659 – 668	10	Poly-Glu
Amino acid modifications
	Modified residue	166	1	Phosphothreonine By similarity
	Modified residue	299	1	Phosphoserine Ref.3
Natural variations
	Alternative sequence	537 – 570	34	Missing in isoform 2.		VSP_016663

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 4B510001564A2A08	FASTA	686	76,090
	10 20 30 40 50 60 MRRSGTALSF LWTERVREPV DSGVAPVSPL GGGVILRRFS GTLLLPPLSS RLGSSGEAES 70 80 90 100 110 120 AAHVVFTIGT QGTQRNLGSA QSSFDLENGL PGGKGLLDAQ SGPSLGRALQ PPVHHVQRRE 130 140 150 160 170 180 SFLYRSDSDH EPSPKAVSRT SSAASDLHGE DMIVTPFAQV LASLRTVRNN VAALAHGPGS 190 200 210 220 230 240 ATRQVLLGTP PHSSQQAAPT EDSGLQLVQE TLEELDWCLE QLETLQTRRS VGEMASNKFK 250 260 270 280 290 300 RMLNRELSYL SETSRSGNQV SEYISQTFLD QQAEVELPQP PTEDDPWPMA QITELRRSSH 310 320 330 340 350 360 TSLPTAAIPR FGVQTDQEEQ LAKELEDTNK WGLDVFKVAE LSGNRPLTAV IFSVFQERDL 370 380 390 400 410 420 LKTFQIPADT LLAYLLTLEG HYHSDVAYHN SMHAADVVQS AHVLLGTPAL EAVFTDLEVL 430 440 450 460 470 480 AAIFACAIHD VDHPGVSNQF LINTNSELAL MYNDSSVLEN HHLAVGFKLL QGENCDIFRN 490 500 510 520 530 540 LSTKQRLSLR RMVIDMVLAT DMSKHMSLLA DLKTMVETKK VTSLGVLLLD NYSDRIQVLQ 550 560 570 580 590 600 SLVHCADLSN PAKPLPLYRQ WTERIMAEFF QQGDRERESG LDISPMCDKH TASMEKSQVG 610 620 630 640 650 660 FIDYIAQPLW ETWADLVHPD AQELLDTLED NREWYQSRIP CSPPHTMGSD RFKFELTLEE 670 680 AEEEEEEEDE GQCTALNRES SELPST
	Isoform 2. Checksum: 75B22BC077830AA9	FASTA	652	72,106
	10 20 30 40 50 60 MRRSGTALSF LWTERVREPV DSGVAPVSPL GGGVILRRFS GTLLLPPLSS RLGSSGEAES 70 80 90 100 110 120 AAHVVFTIGT QGTQRNLGSA QSSFDLENGL PGGKGLLDAQ SGPSLGRALQ PPVHHVQRRE 130 140 150 160 170 180 SFLYRSDSDH EPSPKAVSRT SSAASDLHGE DMIVTPFAQV LASLRTVRNN VAALAHGPGS 190 200 210 220 230 240 ATRQVLLGTP PHSSQQAAPT EDSGLQLVQE TLEELDWCLE QLETLQTRRS VGEMASNKFK 250 260 270 280 290 300 RMLNRELSYL SETSRSGNQV SEYISQTFLD QQAEVELPQP PTEDDPWPMA QITELRRSSH 310 320 330 340 350 360 TSLPTAAIPR FGVQTDQEEQ LAKELEDTNK WGLDVFKVAE LSGNRPLTAV IFSVFQERDL 370 380 390 400 410 420 LKTFQIPADT LLAYLLTLEG HYHSDVAYHN SMHAADVVQS AHVLLGTPAL EAVFTDLEVL 430 440 450 460 470 480 AAIFACAIHD VDHPGVSNQF LINTNSELAL MYNDSSVLEN HHLAVGFKLL QGENCDIFRN 490 500 510 520 530 540 LSTKQRLSLR RMVIDMVLAT DMSKHMSLLA DLKTMVETKK VTSLGVLLLD NYSDRIQQGD 550 560 570 580 590 600 RERESGLDIS PMCDKHTASM EKSQVGFIDY IAQPLWETWA DLVHPDAQEL LDTLEDNREW 610 620 630 640 650 YQSRIPCSPP HTMGSDRFKF ELTLEEAEEE EEEEDEGQCT ALNRESSELP ST

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6J. Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: FVB/N. Tissue: Kidney.
[3]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed: 17242355] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-299, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK149514 mRNA. Translation: BAE28930.1. BC030873 mRNA. Translation: AAH30873.1.
IPI	IPI00111678. IPI00653801.
RefSeq	NP_963901.1.
UniGene	Mm.255180
3D structure databases
HSSP	HSSP built from PDB template 1OYN based on UniProtKB Q08499.
SMR	Q3UEI1. Positions 308-640.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3UEI1.
PTM databases
PhosphoSite	Q3UEI1.
Proteomic databases
PRIDE	Q3UEI1.
Genome annotation databases
Ensembl	ENSMUST00000034307; ENSMUSP00000034307; ENSMUSG00000031842; Mus musculus. [Genome view] ENSMUST00000110095; ENSMUSP00000105722; ENSMUSG00000031842; Mus musculus. [Genome view]
GeneID	110385.
KEGG	mmu:110385.
UCSC	uc009mbg.1. mouse. uc009mbh.1. mouse.
Organism-specific databases
MGI	MGI:99556. Pde4c.
Phylogenomic databases
HOVERGEN	Q3UEI1.
OMA	AIMFSIF.
Enzyme and pathway databases
BRENDA	3.1.4.17. 244.
Gene expression databases
Bgee	Q3UEI1.
CleanEx	MM_PDE4C.
Genevestigator	Q3UEI1.
Family and domain databases
InterPro	IPR003607. Met-dep_phosphohydro_HD. IPR002073. PDEase. [Graphical view]
Pfam	PF00233. PDEase_I. 1 hit. [Graphical view]
PRINTS	PR00387. PDIESTERASE1.
SMART	SM00471. HDc. 1 hit. [Graphical view]
PROSITE	PS00126. PDEASE_I. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

PDE4C_MOUSE

Accession

Primary (citable) accession number: Q3UEI1
Secondary accession number(s): Q8K0P4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	October 11, 2005
Last modified:	November 3, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)