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Q3UEI1 (PDE4C_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C

EC=3.1.4.53
Gene names
Name:Pde4c
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length686 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes By similarity.

Catalytic activity

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.

Cofactor

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Enzyme regulation

Inhibited by rolipram By similarity.

Pathway

Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.

Subunit structure

Part of a complex containing AKAP5, ADCY5, ADCY6 and PKD2.

Subcellular location

Cell projectioncilium Ref.3.

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.

Ontologies

Keywords
   Cellular componentCell projection
Cilium
   Coding sequence diversityAlternative splicing
   LigandcAMP
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcAMP catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

signal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular_componentprimary cilium

Inferred from direct assay Ref.3. Source: UniProtKB

   Molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity

Inferred from electronic annotation. Source: InterPro

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q3UEI1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q3UEI1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     537-570: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 686686cAMP-specific 3',5'-cyclic phosphodiesterase 4C
PRO_0000198812

Regions

Nucleotide binding389 – 3935cAMP By similarity
Compositional bias659 – 66810Poly-Glu

Sites

Active site3891Proton donor By similarity
Metal binding3931Divalent metal cation 1 By similarity
Metal binding4291Divalent metal cation 1 By similarity
Metal binding4301Divalent metal cation 1 By similarity
Metal binding4301Divalent metal cation 2 By similarity
Metal binding5471Divalent metal cation 1 By similarity
Binding site4301cAMP By similarity
Binding site5471cAMP By similarity
Binding site5981cAMP By similarity
Site5501Binds AMP, but not cAMP By similarity

Natural variations

Alternative sequence537 – 57034Missing in isoform 2.
VSP_016663

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 4B510001564A2A08

FASTA68676,090
        10         20         30         40         50         60 
MRRSGTALSF LWTERVREPV DSGVAPVSPL GGGVILRRFS GTLLLPPLSS RLGSSGEAES 

        70         80         90        100        110        120 
AAHVVFTIGT QGTQRNLGSA QSSFDLENGL PGGKGLLDAQ SGPSLGRALQ PPVHHVQRRE 

       130        140        150        160        170        180 
SFLYRSDSDH EPSPKAVSRT SSAASDLHGE DMIVTPFAQV LASLRTVRNN VAALAHGPGS 

       190        200        210        220        230        240 
ATRQVLLGTP PHSSQQAAPT EDSGLQLVQE TLEELDWCLE QLETLQTRRS VGEMASNKFK 

       250        260        270        280        290        300 
RMLNRELSYL SETSRSGNQV SEYISQTFLD QQAEVELPQP PTEDDPWPMA QITELRRSSH 

       310        320        330        340        350        360 
TSLPTAAIPR FGVQTDQEEQ LAKELEDTNK WGLDVFKVAE LSGNRPLTAV IFSVFQERDL 

       370        380        390        400        410        420 
LKTFQIPADT LLAYLLTLEG HYHSDVAYHN SMHAADVVQS AHVLLGTPAL EAVFTDLEVL 

       430        440        450        460        470        480 
AAIFACAIHD VDHPGVSNQF LINTNSELAL MYNDSSVLEN HHLAVGFKLL QGENCDIFRN 

       490        500        510        520        530        540 
LSTKQRLSLR RMVIDMVLAT DMSKHMSLLA DLKTMVETKK VTSLGVLLLD NYSDRIQVLQ 

       550        560        570        580        590        600 
SLVHCADLSN PAKPLPLYRQ WTERIMAEFF QQGDRERESG LDISPMCDKH TASMEKSQVG 

       610        620        630        640        650        660 
FIDYIAQPLW ETWADLVHPD AQELLDTLED NREWYQSRIP CSPPHTMGSD RFKFELTLEE 

       670        680 
AEEEEEEEDE GQCTALNRES SELPST 

« Hide

Isoform 2 [UniParc].

Checksum: 75B22BC077830AA9
Show »

FASTA65272,106

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: FVB/N.
Tissue: Kidney.
[3]"Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases."
Choi Y.H., Suzuki A., Hajarnis S., Ma Z., Chapin H.C., Caplan M.J., Pontoglio M., Somlo S., Igarashi P.
Proc. Natl. Acad. Sci. U.S.A. 108:10679-10684(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INTERACTION WITH AKAP5; ADCY5; ADCY6 AND PKD2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK149514 mRNA. Translation: BAE28930.1.
BC030873 mRNA. Translation: AAH30873.1.
CCDSCCDS22378.1. [Q3UEI1-2]
RefSeqNP_963901.1. NM_201607.2. [Q3UEI1-2]
UniGeneMm.255180.

3D structure databases

ProteinModelPortalQ3UEI1.
SMRQ3UEI1. Positions 317-640.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ3UEI1. 1 interaction.
STRING10090.ENSMUSP00000105722.

Chemistry

BindingDBQ3UEI1.
ChEMBLCHEMBL2111373.

PTM databases

PhosphoSiteQ3UEI1.

Proteomic databases

MaxQBQ3UEI1.
PaxDbQ3UEI1.
PRIDEQ3UEI1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000034307; ENSMUSP00000034307; ENSMUSG00000031842. [Q3UEI1-2]
ENSMUST00000110095; ENSMUSP00000105722; ENSMUSG00000031842. [Q3UEI1-1]
GeneID110385.
KEGGmmu:110385.
UCSCuc009mbg.1. mouse. [Q3UEI1-2]
uc009mbh.1. mouse. [Q3UEI1-1]

Organism-specific databases

CTD5143.
MGIMGI:99556. Pde4c.

Phylogenomic databases

eggNOGNOG122287.
GeneTreeENSGT00740000115148.
HOGENOMHOG000236297.
HOVERGENHBG108239.
InParanoidQ3UEI1.
KOK01120.
OMAGENCDIF.
OrthoDBEOG7HQNBC.
PhylomeDBQ3UEI1.
TreeFamTF314638.

Enzyme and pathway databases

UniPathwayUPA00762; UER00747.

Gene expression databases

BgeeQ3UEI1.
CleanExMM_PDE4C.
GenevestigatorQ3UEI1.

Family and domain databases

Gene3D1.10.1300.10. 1 hit.
InterProIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamPF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSPR00387. PDIESTERASE1.
SMARTSM00471. HDc. 1 hit.
[Graphical view]
PROSITEPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPDE4C. mouse.
NextBio363905.
PROQ3UEI1.
SOURCESearch...

Entry information

Entry namePDE4C_MOUSE
AccessionPrimary (citable) accession number: Q3UEI1
Secondary accession number(s): Q8K0P4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 11, 2005
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot