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Q3UEI1

- PDE4C_MOUSE

UniProt

Q3UEI1 - PDE4C_MOUSE

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Protein
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Gene
Pde4c
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes By similarity.

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Enzyme regulationi

Inhibited by rolipram By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei389 – 3891Proton donor By similarity
Metal bindingi393 – 3931Divalent metal cation 1 By similarity
Metal bindingi429 – 4291Divalent metal cation 1 By similarity
Metal bindingi430 – 4301Divalent metal cation 1 By similarity
Metal bindingi430 – 4301Divalent metal cation 2 By similarity
Binding sitei430 – 4301cAMP By similarity
Metal bindingi547 – 5471Divalent metal cation 1 By similarity
Binding sitei547 – 5471cAMP By similarity
Sitei550 – 5501Binds AMP, but not cAMP By similarity
Binding sitei598 – 5981cAMP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi389 – 3935cAMP By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-nucleotide phosphodiesterase activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. cAMP catabolic process Source: UniProtKB-UniPathway
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_203795. DARPP-32 events.
UniPathwayiUPA00762; UER00747.

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC:3.1.4.53)
Gene namesi
Name:Pde4c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:99556. Pde4c.

Subcellular locationi

Cell projectioncilium 1 Publication

GO - Cellular componenti

  1. primary cilium Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 686686cAMP-specific 3',5'-cyclic phosphodiesterase 4C
PRO_0000198812Add
BLAST

Proteomic databases

MaxQBiQ3UEI1.
PaxDbiQ3UEI1.
PRIDEiQ3UEI1.

PTM databases

PhosphoSiteiQ3UEI1.

Expressioni

Gene expression databases

BgeeiQ3UEI1.
CleanExiMM_PDE4C.
GenevestigatoriQ3UEI1.

Interactioni

Subunit structurei

Part of a complex containing AKAP5, ADCY5, ADCY6 and PKD2.

Protein-protein interaction databases

IntActiQ3UEI1. 1 interaction.
STRINGi10090.ENSMUSP00000105722.

Structurei

3D structure databases

ProteinModelPortaliQ3UEI1.
SMRiQ3UEI1. Positions 317-640.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi659 – 66810Poly-Glu

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG122287.
GeneTreeiENSGT00740000115148.
HOGENOMiHOG000236297.
HOVERGENiHBG108239.
InParanoidiQ3UEI1.
KOiK01120.
OMAiGENCDIF.
OrthoDBiEOG7HQNBC.
PhylomeDBiQ3UEI1.
TreeFamiTF314638.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
InterProiIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3UEI1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRRSGTALSF LWTERVREPV DSGVAPVSPL GGGVILRRFS GTLLLPPLSS    50
RLGSSGEAES AAHVVFTIGT QGTQRNLGSA QSSFDLENGL PGGKGLLDAQ 100
SGPSLGRALQ PPVHHVQRRE SFLYRSDSDH EPSPKAVSRT SSAASDLHGE 150
DMIVTPFAQV LASLRTVRNN VAALAHGPGS ATRQVLLGTP PHSSQQAAPT 200
EDSGLQLVQE TLEELDWCLE QLETLQTRRS VGEMASNKFK RMLNRELSYL 250
SETSRSGNQV SEYISQTFLD QQAEVELPQP PTEDDPWPMA QITELRRSSH 300
TSLPTAAIPR FGVQTDQEEQ LAKELEDTNK WGLDVFKVAE LSGNRPLTAV 350
IFSVFQERDL LKTFQIPADT LLAYLLTLEG HYHSDVAYHN SMHAADVVQS 400
AHVLLGTPAL EAVFTDLEVL AAIFACAIHD VDHPGVSNQF LINTNSELAL 450
MYNDSSVLEN HHLAVGFKLL QGENCDIFRN LSTKQRLSLR RMVIDMVLAT 500
DMSKHMSLLA DLKTMVETKK VTSLGVLLLD NYSDRIQVLQ SLVHCADLSN 550
PAKPLPLYRQ WTERIMAEFF QQGDRERESG LDISPMCDKH TASMEKSQVG 600
FIDYIAQPLW ETWADLVHPD AQELLDTLED NREWYQSRIP CSPPHTMGSD 650
RFKFELTLEE AEEEEEEEDE GQCTALNRES SELPST 686
Length:686
Mass (Da):76,090
Last modified:October 11, 2005 - v1
Checksum:i4B510001564A2A08
GO
Isoform 2 (identifier: Q3UEI1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     537-570: Missing.

Note: No experimental confirmation available.

Show »
Length:652
Mass (Da):72,106
Checksum:i75B22BC077830AA9
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei537 – 57034Missing in isoform 2.
VSP_016663Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK149514 mRNA. Translation: BAE28930.1.
BC030873 mRNA. Translation: AAH30873.1.
CCDSiCCDS22378.1. [Q3UEI1-2]
RefSeqiNP_963901.1. NM_201607.2. [Q3UEI1-2]
UniGeneiMm.255180.

Genome annotation databases

EnsembliENSMUST00000034307; ENSMUSP00000034307; ENSMUSG00000031842. [Q3UEI1-2]
ENSMUST00000110095; ENSMUSP00000105722; ENSMUSG00000031842. [Q3UEI1-1]
GeneIDi110385.
KEGGimmu:110385.
UCSCiuc009mbg.1. mouse. [Q3UEI1-2]
uc009mbh.1. mouse. [Q3UEI1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK149514 mRNA. Translation: BAE28930.1 .
BC030873 mRNA. Translation: AAH30873.1 .
CCDSi CCDS22378.1. [Q3UEI1-2 ]
RefSeqi NP_963901.1. NM_201607.2. [Q3UEI1-2 ]
UniGenei Mm.255180.

3D structure databases

ProteinModelPortali Q3UEI1.
SMRi Q3UEI1. Positions 317-640.
ModBasei Search...

Protein-protein interaction databases

IntActi Q3UEI1. 1 interaction.
STRINGi 10090.ENSMUSP00000105722.

Chemistry

BindingDBi Q3UEI1.
ChEMBLi CHEMBL2111373.

PTM databases

PhosphoSitei Q3UEI1.

Proteomic databases

MaxQBi Q3UEI1.
PaxDbi Q3UEI1.
PRIDEi Q3UEI1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034307 ; ENSMUSP00000034307 ; ENSMUSG00000031842 . [Q3UEI1-2 ]
ENSMUST00000110095 ; ENSMUSP00000105722 ; ENSMUSG00000031842 . [Q3UEI1-1 ]
GeneIDi 110385.
KEGGi mmu:110385.
UCSCi uc009mbg.1. mouse. [Q3UEI1-2 ]
uc009mbh.1. mouse. [Q3UEI1-1 ]

Organism-specific databases

CTDi 5143.
MGIi MGI:99556. Pde4c.

Phylogenomic databases

eggNOGi NOG122287.
GeneTreei ENSGT00740000115148.
HOGENOMi HOG000236297.
HOVERGENi HBG108239.
InParanoidi Q3UEI1.
KOi K01120.
OMAi GENCDIF.
OrthoDBi EOG7HQNBC.
PhylomeDBi Q3UEI1.
TreeFami TF314638.

Enzyme and pathway databases

UniPathwayi UPA00762 ; UER00747 .
Reactomei REACT_203795. DARPP-32 events.

Miscellaneous databases

ChiTaRSi PDE4C. mouse.
NextBioi 363905.
PROi Q3UEI1.
SOURCEi Search...

Gene expression databases

Bgeei Q3UEI1.
CleanExi MM_PDE4C.
Genevestigatori Q3UEI1.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
InterProi IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00471. HDc. 1 hit.
[Graphical view ]
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Kidney.
  3. "Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases."
    Choi Y.H., Suzuki A., Hajarnis S., Ma Z., Chapin H.C., Caplan M.J., Pontoglio M., Somlo S., Igarashi P.
    Proc. Natl. Acad. Sci. U.S.A. 108:10679-10684(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH AKAP5; ADCY5; ADCY6 AND PKD2.

Entry informationi

Entry nameiPDE4C_MOUSE
AccessioniPrimary (citable) accession number: Q3UEI1
Secondary accession number(s): Q8K0P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 11, 2005
Last modified: September 3, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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