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Protein

cAMP-specific 3',5'-cyclic phosphodiesterase 4C

Gene

Pde4c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.By similarity

Caution

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Enzyme regulationi

Inhibited by rolipram.By similarity

Pathwayi: 3',5'-cyclic AMP degradation

This protein is involved in step 1 of the subpathway that synthesizes AMP from 3',5'-cyclic AMP.
Proteins known to be involved in this subpathway in this organism are:
  1. cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Pde4a), High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (Pde8b), cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Pde4c), High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (Pde8a), High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Pde7a), cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Pde4d), cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Pde10a), cAMP-specific 3',5'-cyclic phosphodiesterase 7B (Pde7b)
This subpathway is part of the pathway 3',5'-cyclic AMP degradation, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from 3',5'-cyclic AMP, the pathway 3',5'-cyclic AMP degradation and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei389Proton donorBy similarity1
Metal bindingi393Divalent metal cation 1By similarity1
Metal bindingi429Divalent metal cation 1By similarity1
Metal bindingi430Divalent metal cation 1By similarity1
Metal bindingi430Divalent metal cation 2By similarity1
Binding sitei430cAMPBy similarity1
Metal bindingi547Divalent metal cation 1By similarity1
Binding sitei547cAMPBy similarity1
Sitei550Binds AMP, but not cAMPBy similarity1
Binding sitei598cAMPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi389 – 393cAMPBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandcAMP, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-180024 DARPP-32 events
R-MMU-418555 G alpha (s) signalling events
UniPathwayiUPA00762; UER00747

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC:3.1.4.53)
Gene namesi
Name:Pde4c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:99556 Pde4c

Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2111373

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988121 – 686cAMP-specific 3',5'-cyclic phosphodiesterase 4CAdd BLAST686

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1
Modified residuei28PhosphoserineCombined sources1
Modified residuei40PhosphoserineCombined sources1
Modified residuei83PhosphoserineCombined sources1
Modified residuei642PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3UEI1
PaxDbiQ3UEI1
PRIDEiQ3UEI1

PTM databases

iPTMnetiQ3UEI1
PhosphoSitePlusiQ3UEI1

Expressioni

Gene expression databases

BgeeiENSMUSG00000031842
CleanExiMM_PDE4C
ExpressionAtlasiQ3UEI1 baseline and differential

Interactioni

Subunit structurei

Part of a complex containing AKAP5, ADCY5, ADCY6 and PKD2.

Protein-protein interaction databases

IntActiQ3UEI1 1 interactor.
STRINGi10090.ENSMUSP00000034307

Structurei

3D structure databases

ProteinModelPortaliQ3UEI1
SMRiQ3UEI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini313 – 642PDEasePROSITE-ProRule annotationAdd BLAST330

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi659 – 668Poly-Glu10

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3689 Eukaryota
ENOG410XRI7 LUCA
GeneTreeiENSGT00760000118889
HOGENOMiHOG000236297
HOVERGENiHBG108239
InParanoidiQ3UEI1
KOiK13293
OMAiMCKTSLA
OrthoDBiEOG091G06CD
PhylomeDBiQ3UEI1
TreeFamiTF314638

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.101 hit
InterProiView protein in InterPro
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
PfamiView protein in Pfam
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UEI1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRSGTALSF LWTERVREPV DSGVAPVSPL GGGVILRRFS GTLLLPPLSS
60 70 80 90 100
RLGSSGEAES AAHVVFTIGT QGTQRNLGSA QSSFDLENGL PGGKGLLDAQ
110 120 130 140 150
SGPSLGRALQ PPVHHVQRRE SFLYRSDSDH EPSPKAVSRT SSAASDLHGE
160 170 180 190 200
DMIVTPFAQV LASLRTVRNN VAALAHGPGS ATRQVLLGTP PHSSQQAAPT
210 220 230 240 250
EDSGLQLVQE TLEELDWCLE QLETLQTRRS VGEMASNKFK RMLNRELSYL
260 270 280 290 300
SETSRSGNQV SEYISQTFLD QQAEVELPQP PTEDDPWPMA QITELRRSSH
310 320 330 340 350
TSLPTAAIPR FGVQTDQEEQ LAKELEDTNK WGLDVFKVAE LSGNRPLTAV
360 370 380 390 400
IFSVFQERDL LKTFQIPADT LLAYLLTLEG HYHSDVAYHN SMHAADVVQS
410 420 430 440 450
AHVLLGTPAL EAVFTDLEVL AAIFACAIHD VDHPGVSNQF LINTNSELAL
460 470 480 490 500
MYNDSSVLEN HHLAVGFKLL QGENCDIFRN LSTKQRLSLR RMVIDMVLAT
510 520 530 540 550
DMSKHMSLLA DLKTMVETKK VTSLGVLLLD NYSDRIQVLQ SLVHCADLSN
560 570 580 590 600
PAKPLPLYRQ WTERIMAEFF QQGDRERESG LDISPMCDKH TASMEKSQVG
610 620 630 640 650
FIDYIAQPLW ETWADLVHPD AQELLDTLED NREWYQSRIP CSPPHTMGSD
660 670 680
RFKFELTLEE AEEEEEEEDE GQCTALNRES SELPST
Length:686
Mass (Da):76,090
Last modified:October 11, 2005 - v1
Checksum:i4B510001564A2A08
GO
Isoform 2 (identifier: Q3UEI1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     537-570: Missing.

Note: No experimental confirmation available.
Show »
Length:652
Mass (Da):72,106
Checksum:i75B22BC077830AA9
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016663537 – 570Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK149514 mRNA Translation: BAE28930.1
BC030873 mRNA Translation: AAH30873.1
CCDSiCCDS22378.1 [Q3UEI1-2]
CCDS80891.1 [Q3UEI1-1]
RefSeqiNP_001297394.1, NM_001310465.1 [Q3UEI1-1]
NP_963901.1, NM_201607.2 [Q3UEI1-2]
UniGeneiMm.255180

Genome annotation databases

EnsembliENSMUST00000034307; ENSMUSP00000034307; ENSMUSG00000031842 [Q3UEI1-2]
ENSMUST00000110095; ENSMUSP00000105722; ENSMUSG00000031842 [Q3UEI1-1]
ENSMUST00000213630; ENSMUSP00000150748; ENSMUSG00000111773 [Q3UEI1-2]
ENSMUST00000217521; ENSMUSP00000150796; ENSMUSG00000111773 [Q3UEI1-1]
GeneIDi110385
KEGGimmu:110385
UCSCiuc009mbg.1 mouse [Q3UEI1-2]
uc009mbh.1 mouse [Q3UEI1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPDE4C_MOUSE
AccessioniPrimary (citable) accession number: Q3UEI1
Secondary accession number(s): Q8K0P4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome