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Q3UE37

- UBE2Z_MOUSE

UniProt

Q3UE37 - UBE2Z_MOUSE

Protein

Ubiquitin-conjugating enzyme E2 Z

Gene

Ube2z

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 2 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the covalent attachment of ubiquitin to other proteins. Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation By similarity.PROSITE-ProRule annotation

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei190 – 1901Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Apoptosis, Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2 Z (EC:6.3.2.19)
    Alternative name(s):
    Uba6-specific E2 conjugating enzyme 1
    Short name:
    Use1
    Ubiquitin carrier protein Z
    Ubiquitin-protein ligase Z
    Gene namesi
    Name:Ube2z
    Synonyms:D11Moh35
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1343160. Ube2z.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 356356Ubiquitin-conjugating enzyme E2 ZPRO_0000280516Add
    BLAST

    Proteomic databases

    MaxQBiQ3UE37.
    PaxDbiQ3UE37.
    PRIDEiQ3UE37.

    PTM databases

    PhosphoSiteiQ3UE37.

    Expressioni

    Gene expression databases

    BgeeiQ3UE37.
    CleanExiMM_UBE2Z.
    GenevestigatoriQ3UE37.

    Interactioni

    Protein-protein interaction databases

    BioGridi234504. 1 interaction.
    IntActiQ3UE37. 1 interaction.
    MINTiMINT-8178502.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3UE37.
    SMRiQ3UE37. Positions 96-334.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5078.
    GeneTreeiENSGT00730000110680.
    HOVERGENiHBG083204.
    InParanoidiA2A6M3.
    KOiK10585.
    OMAiAVMANMS.
    OrthoDBiEOG7MSMP5.
    PhylomeDBiQ3UE37.
    TreeFamiTF354204.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3UE37-1 [UniParc]FASTAAdd to Basket

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    MAESPTEEAA TATAGAGAAG PGSSGVAGVV GVSGSGGGFG PPFLPDVWAA    50
    AAAAGGAGGP GSGLAPLPGL PPSAAAHGAA LLSHWDPTLS SDWDGERTAP 100
    QCLLRIKRDI MSIYKEPPPG MFVVPDTVDM TKIHALITGP FDTPYEGGFF 150
    LFVFRCPPDY PIHPPRVKLM TTGNNTVRFN PNFYRNGKVC LSILGTWTGP 200
    AWSPAQSISS VLISIQSLMT ENPYHNEPGF EQERHPGDSK NYNECIRHET 250
    IRVAVCDMME GKCPCPEPLR GVMEKSFLEY YDFYEVACKD RLHLQGQTMQ 300
    DPFGEKRGHF DYQSLLMRLG LIRQKVLERL HNENAEMDSD SSSSGTETDL 350
    HGSLRV 356
    Length:356
    Mass (Da):38,368
    Last modified:March 20, 2007 - v2
    Checksum:i15FB00E9988B0A6D
    GO

    Sequence cautioni

    The sequence BAC37014.1 differs from that shown. Reason: Frameshift at position 115.
    The sequence AAH54412.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB24097.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71E → D in BAC37014. (PubMed:16141072)Curated
    Sequence conflicti10 – 101A → S in BAC37014. (PubMed:16141072)Curated
    Sequence conflicti16 – 172AG → SW in BAC37014. (PubMed:16141072)Curated
    Sequence conflicti200 – 2001P → H in BAC37014. (PubMed:16141072)Curated
    Sequence conflicti223 – 2231P → R in BAC37014. (PubMed:16141072)Curated
    Sequence conflicti238 – 2381D → E in BAC37014. (PubMed:16141072)Curated
    Sequence conflicti336 – 3361E → G in BAE29074. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005524 mRNA. Translation: BAB24097.1. Different initiation.
    AK077793 mRNA. Translation: BAC37014.1. Frameshift.
    AK149770 mRNA. Translation: BAE29074.1.
    AK153328 mRNA. Translation: BAE31907.1.
    AK168942 mRNA. Translation: BAE40750.1.
    AL603682 Genomic DNA. Translation: CAM18270.1.
    BC054412 mRNA. Translation: AAH54412.1. Different initiation.
    CCDSiCCDS36289.1.
    RefSeqiNP_758504.3. NM_172300.3.
    UniGeneiMm.38802.

    Genome annotation databases

    EnsembliENSMUST00000100528; ENSMUSP00000098097; ENSMUSG00000014349.
    GeneIDi268470.
    KEGGimmu:268470.
    UCSCiuc007lbd.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005524 mRNA. Translation: BAB24097.1 . Different initiation.
    AK077793 mRNA. Translation: BAC37014.1 . Frameshift.
    AK149770 mRNA. Translation: BAE29074.1 .
    AK153328 mRNA. Translation: BAE31907.1 .
    AK168942 mRNA. Translation: BAE40750.1 .
    AL603682 Genomic DNA. Translation: CAM18270.1 .
    BC054412 mRNA. Translation: AAH54412.1 . Different initiation.
    CCDSi CCDS36289.1.
    RefSeqi NP_758504.3. NM_172300.3.
    UniGenei Mm.38802.

    3D structure databases

    ProteinModelPortali Q3UE37.
    SMRi Q3UE37. Positions 96-334.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 234504. 1 interaction.
    IntActi Q3UE37. 1 interaction.
    MINTi MINT-8178502.

    PTM databases

    PhosphoSitei Q3UE37.

    Proteomic databases

    MaxQBi Q3UE37.
    PaxDbi Q3UE37.
    PRIDEi Q3UE37.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000100528 ; ENSMUSP00000098097 ; ENSMUSG00000014349 .
    GeneIDi 268470.
    KEGGi mmu:268470.
    UCSCi uc007lbd.2. mouse.

    Organism-specific databases

    CTDi 65264.
    MGIi MGI:1343160. Ube2z.

    Phylogenomic databases

    eggNOGi COG5078.
    GeneTreei ENSGT00730000110680.
    HOVERGENi HBG083204.
    InParanoidi A2A6M3.
    KOi K10585.
    OMAi AVMANMS.
    OrthoDBi EOG7MSMP5.
    PhylomeDBi Q3UE37.
    TreeFami TF354204.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    ChiTaRSi UBE2Z. mouse.
    NextBioi 392311.
    PROi Q3UE37.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3UE37.
    CleanExi MM_UBE2Z.
    Genevestigatori Q3UE37.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Amnion, Bone marrow, Placenta and Thymus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 70-356.
      Strain: Czech II.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiUBE2Z_MOUSE
    AccessioniPrimary (citable) accession number: Q3UE37
    Secondary accession number(s): A2A6M3
    , Q3TFZ8, Q3U618, Q7TMY6, Q8BVL2, Q9DAU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 82 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3