Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquitin-conjugating enzyme E2 Z

Gene

Ube2z

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation.PROSITE-ProRule annotation

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei190Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ubiquitin conjugating enzyme activity Source: MGI
  • ubiquitin protein ligase activity Source: GO_Central
  • ubiquitin protein ligase binding Source: GO_Central

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • positive regulation of apoptotic process Source: MGI
  • ubiquitin-dependent protein catabolic process Source: MGI

Keywordsi

Molecular functionTransferase
Biological processApoptosis, Ubl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 Z (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme Z
Uba6-specific E2 conjugating enzyme 1
Short name:
Use1
Ubiquitin carrier protein Z
Ubiquitin-protein ligase Z
Gene namesi
Name:Ube2z
Synonyms:D11Moh35
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1343160 Ube2z

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002805161 – 356Ubiquitin-conjugating enzyme E2 ZAdd BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei339PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3UE37
MaxQBiQ3UE37
PaxDbiQ3UE37
PeptideAtlasiQ3UE37
PRIDEiQ3UE37

PTM databases

iPTMnetiQ3UE37
PhosphoSitePlusiQ3UE37

Expressioni

Gene expression databases

BgeeiENSMUSG00000014349
CleanExiMM_UBE2Z
GenevisibleiQ3UE37 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi234504, 1 interactor
IntActiQ3UE37, 1 interactor
MINTiQ3UE37
STRINGi10090.ENSMUSP00000098097

Structurei

3D structure databases

ProteinModelPortaliQ3UE37
SMRiQ3UE37
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410ITJE Eukaryota
COG5078 LUCA
GeneTreeiENSGT00730000110680
HOVERGENiHBG083204
InParanoidiQ3UE37
KOiK10585
OMAiYYDFYEG
OrthoDBiEOG091G0K0Y
PhylomeDBiQ3UE37
TreeFamiTF354204

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q3UE37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESPTEEAA TATAGAGAAG PGSSGVAGVV GVSGSGGGFG PPFLPDVWAA
60 70 80 90 100
AAAAGGAGGP GSGLAPLPGL PPSAAAHGAA LLSHWDPTLS SDWDGERTAP
110 120 130 140 150
QCLLRIKRDI MSIYKEPPPG MFVVPDTVDM TKIHALITGP FDTPYEGGFF
160 170 180 190 200
LFVFRCPPDY PIHPPRVKLM TTGNNTVRFN PNFYRNGKVC LSILGTWTGP
210 220 230 240 250
AWSPAQSISS VLISIQSLMT ENPYHNEPGF EQERHPGDSK NYNECIRHET
260 270 280 290 300
IRVAVCDMME GKCPCPEPLR GVMEKSFLEY YDFYEVACKD RLHLQGQTMQ
310 320 330 340 350
DPFGEKRGHF DYQSLLMRLG LIRQKVLERL HNENAEMDSD SSSSGTETDL

HGSLRV
Length:356
Mass (Da):38,368
Last modified:March 20, 2007 - v2
Checksum:i15FB00E9988B0A6D
GO

Sequence cautioni

The sequence AAH54412 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB24097 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC37014 differs from that shown. Reason: Frameshift at position 115.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7E → D in BAC37014 (PubMed:16141072).Curated1
Sequence conflicti10A → S in BAC37014 (PubMed:16141072).Curated1
Sequence conflicti16 – 17AG → SW in BAC37014 (PubMed:16141072).Curated2
Sequence conflicti200P → H in BAC37014 (PubMed:16141072).Curated1
Sequence conflicti223P → R in BAC37014 (PubMed:16141072).Curated1
Sequence conflicti238D → E in BAC37014 (PubMed:16141072).Curated1
Sequence conflicti336E → G in BAE29074 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005524 mRNA Translation: BAB24097.1 Different initiation.
AK077793 mRNA Translation: BAC37014.1 Frameshift.
AK149770 mRNA Translation: BAE29074.1
AK153328 mRNA Translation: BAE31907.1
AK168942 mRNA Translation: BAE40750.1
AL603682 Genomic DNA No translation available.
BC054412 mRNA Translation: AAH54412.1 Different initiation.
CCDSiCCDS36289.1
RefSeqiNP_758504.3, NM_172300.3
UniGeneiMm.38802

Genome annotation databases

EnsembliENSMUST00000100528; ENSMUSP00000098097; ENSMUSG00000014349
GeneIDi268470
KEGGimmu:268470
UCSCiuc007lbd.2 mouse

Similar proteinsi

Entry informationi

Entry nameiUBE2Z_MOUSE
AccessioniPrimary (citable) accession number: Q3UE37
Secondary accession number(s): A2A6M3
, Q3TFZ8, Q3U618, Q7TMY6, Q8BVL2, Q9DAU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: May 23, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health