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Protein
Submitted name:

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Gene

Pik3cd

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinasePROSITE-ProRule annotationSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformImported
Gene namesi
Name:Pik3cdImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1098211 Pik3cd

Subcellular locationi

PTM / Processingi

Proteomic databases

MaxQBiQ3UDT3

Expressioni

Gene expression databases

BgeeiENSMUSG00000039936

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6EYZX-ray2.20A1-1044[»]
SMRiQ3UDT3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 105PI3K-ABDInterPro annotationAdd BLAST90
Domaini187 – 278PI3K-RBDInterPro annotationAdd BLAST92
Domaini319 – 476C2 PI3K-typeInterPro annotationAdd BLAST158
Domaini497 – 674PIK helicalInterPro annotationAdd BLAST178
Domaini774 – 1024PI3K/PI4KInterPro annotationAdd BLAST251

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0904 Eukaryota
COG5032 LUCA
GeneTreeiENSGT00760000119110
HOVERGENiHBG052721

Family and domain databases

CDDicd05174 PI3Kc_IA_delta, 1 hit
Gene3Di1.10.1070.11, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR035892 C2_domain_sf
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003113 PI3K_adapt-bd_dom
IPR002420 PI3K_C2_dom
IPR000341 PI3K_Ras-bd_dom
IPR008290 PI3K_Vps34
IPR037703 PI3Kdelta_dom
IPR015433 PI_Kinase
IPR001263 PInositide-3_kin_accessory_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10048 PTHR10048, 1 hit
PfamiView protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
PF00792 PI3K_C2, 1 hit
PF02192 PI3K_p85B, 1 hit
PF00794 PI3K_rbd, 1 hit
PF00613 PI3Ka, 1 hit
PIRSFiPIRSF000587 PI3K_Vps34, 3 hits
SMARTiView protein in SMART
SM00142 PI3K_C2, 1 hit
SM00143 PI3K_p85B, 1 hit
SM00144 PI3K_rbd, 1 hit
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF54236 SSF54236, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51544 PI3K_ABD, 1 hit
PS51547 PI3K_C2, 1 hit
PS51546 PI3K_RBD, 1 hit
PS51545 PIK_HELICAL, 1 hit

Sequencei

Sequence statusi: Complete.

Q3UDT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPGVDCPME FWTKEESQSV VVDFLLPTGV YLNFPVSRNA NLSTIKQVLW
60 70 80 90 100
HRAQYEPLFH MLSDPEAYVF TCVNQTAEQQ ELEDEQRRLC DIQPFLPVLR
110 120 130 140 150
LVAREGDRVK KLINSQISLL IGKGLHEFDS LRDPEVNDFR TKMRQFCEEA
160 170 180 190 200
AAHRQQLGWV EWLQYSFPLQ LEPSARGWRA GLLRVSNRAL LVNVKFEGSE
210 220 230 240 250
ESFTFQVSTK DMPLALMACA LRKKATVFRQ PLVEQPEEYA LQVNGRHEYL
260 270 280 290 300
YGNYPLCHFQ YICSCLHSGL TPHLTMVHSS SILAMRDEQS NPAPQVQKPR
310 320 330 340 350
AKPPPIPAKK PSSVSLWSLE QPFSIELIEG RKVNADERMK LVVQAGLFHG
360 370 380 390 400
NEMLCKTVSS SEVNVCSEPV WKQRLEFDIS VCDLPRMARL CFALYAVVEK
410 420 430 440 450
AKKARSTKKK SKKADCPIAW ANLMLFDYKD QLKTGERCLY MWPSVPDEKG
460 470 480 490 500
ELLNPAGTVR GNPNTESAAA LVIYLPEVAP HPVYFPALEK ILELGRHGER
510 520 530 540 550
GRITEEEQLQ LREILERRGS GELYEHEKDL VWKMRHEVQE HFPEALARLL
560 570 580 590 600
LVTKWNKHED VAQMLYLLCS WPELPVLSAL ELLDFSFPDC YVGSFAIKSL
610 620 630 640 650
RKLTDDELFQ YLLQLVQVLK YESYLDCELT KFLLGRALAN RKIGHFLFWH
660 670 680 690 700
LRSEMHVPSV ALRFGLIMEA YCRGSTHHMK VLMKQGEALS KLKALNDFVK
710 720 730 740 750
VSSQKTTKPQ TKEMMHMCMR QETYMEALSH LQSPLDPSTL LEEVCVEQCT
760 770 780 790 800
FMDSKMKPLW IMYSSEEAGS AGNVGIIFKN GDDLRQDMLT LQMIQLMDVL
810 820 830 840 850
WKQEGLDLRM TPYGCLPTGD RTGLIEVVLH SDTIANIQLN KSNMAATAAF
860 870 880 890 900
NKDALLNWLK SKNPGEALDR AIEEFTLSCA GYCVATYVLG IGDRHSDNIM
910 920 930 940 950
IRESGQLFHI DFGHFLGNFK TKFGINRERV PFILTYDFVH VIQQGKTNNS
960 970 980 990 1000
EKFERFRGYC ERAYTILRRH GLLFLHLFAL MRAAGLPELS CSKDIQYLKD
1010 1020 1030 1040
SLALGKTEEE ALKHFRVKFN EALRESWKTK VNWLAHNVSK DNRQ
Length:1,044
Mass (Da):119,841
Last modified:October 11, 2005 - v1
Checksum:i58F806CC1E72874C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL607078 Genomic DNA No translation available.
AL626808 Genomic DNA No translation available.
AK149935 mRNA Translation: BAE29178.1
RefSeqiNP_001025008.2, NM_001029837.2
NP_032866.2, NM_008840.3
XP_006538714.1, XM_006538651.2
UniGeneiMm.229108

Genome annotation databases

EnsembliENSMUST00000105688; ENSMUSP00000101313; ENSMUSG00000039936
GeneIDi18707
UCSCiuc008vwt.2 mouse

Similar proteinsi

Entry informationi

Entry nameiQ3UDT3_MOUSE
AccessioniPrimary (citable) accession number: Q3UDT3
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 25, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health