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Protein

Tubulin--tyrosine ligase-like protein 12

Gene

Ttll12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei463 – 4631ATPBy similarity
Binding sitei465 – 4651ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi445 – 4484ATP bindingBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin--tyrosine ligase-like protein 12
Gene namesi
Name:Ttll12Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:3039573. Ttll12.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 639639Tubulin--tyrosine ligase-like protein 12PRO_0000326166Add
BLAST

Proteomic databases

EPDiQ3UDE2.
MaxQBiQ3UDE2.
PaxDbiQ3UDE2.
PRIDEiQ3UDE2.

PTM databases

iPTMnetiQ3UDE2.
PhosphoSiteiQ3UDE2.

Expressioni

Tissue specificityi

Widely expressed with highest levels in brain, kidney, liver, lung, muscle and testis.1 Publication

Gene expression databases

BgeeiQ3UDE2.
CleanExiMM_TTLL12.
ExpressionAtlasiQ3UDE2. baseline and differential.
GenevisibleiQ3UDE2. MM.

Interactioni

Protein-protein interaction databases

BioGridi230183. 17 interactions.
IntActiQ3UDE2. 17 interactions.
MINTiMINT-8178494.
STRINGi10090.ENSMUSP00000016901.

Structurei

3D structure databases

ProteinModelPortaliQ3UDE2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini295 – 639345TTLPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 TTL domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2155. Eukaryota.
ENOG410XQ0A. LUCA.
GeneTreeiENSGT00390000006760.
HOGENOMiHOG000006517.
HOVERGENiHBG055617.
InParanoidiQ3UDE2.
KOiK16609.
OMAiPKIAQKY.
OrthoDBiEOG7KDF98.
PhylomeDBiQ3UDE2.
TreeFamiTF313037.

Family and domain databases

InterProiIPR004344. TTL/TTLL_fam.
IPR027749. TTLL12.
[Graphical view]
PANTHERiPTHR12241:SF13. PTHR12241:SF13. 1 hit.
PfamiPF03133. TTL. 1 hit.
[Graphical view]
PROSITEiPS51221. TTL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UDE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIQSGPQPG SPGRAERLNA RLLDEFVSLH GPTLRASGVP ERLWGRLLHK
60 70 80 90 100
LEHEVFDAGE MFGIMQVEEV EEAEDEAARE AQRKQPNPGG ELCYKVIVTS
110 120 130 140 150
ESGVRADDPN SIFLIDHAWT CRVEHARKQL QQVPGLLHRM ANLMGIEFHG
160 170 180 190 200
EVPSPEVVAL VLEEMWKFNQ TYQLAHGTAE EKVPVWYIMD EFGSRIQHSD
210 220 230 240 250
MPSFATAPFF YMPQQVAYTL LWPLRDLDTG EEVTRDFAYG EADPLIRKCM
260 270 280 290 300
LLPWAPADML DLSFSTPEPP AKYYQAILEE NKEKLPLAIS PVARPQGHVF
310 320 330 340 350
RVHCDVQQVL GHLTHPRFTF TDSEADADIF FHFSHFKDYM KLSQESPQVL
360 370 380 390 400
LNQFPCENLL TVKDCLASIA RRAGGPEGPP WLPRTFNLRT ELPQFVSYFQ
410 420 430 440 450
HRERRGEDNH WICKPWNLAR SLDTHVTNNL HSIIRHREST PKVVSKYIES
460 470 480 490 500
PVLFLREDVG NVKFDIRYIV LLRSVRPLRL FAYDVFWLRF SNRPFALDDL
510 520 530 540 550
DDYEKHFTVM NYDPDVVLKQ VHYNEFIPQF EKQYPEFPWS DVQAEIFKAF
560 570 580 590 600
TELFQVACAK PPPMGLCDYP SSRAMYAIDL MLNWDNHPDG KRVMQPQILE
610 620 630
VNFNPDCERA CRYHPSFFND VFSTLFLDET DNCHVTRII
Length:639
Mass (Da):74,043
Last modified:October 11, 2005 - v1
Checksum:i584D72AA05BCA837
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651M → K in AAH55368 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM690756 mRNA. Translation: CAM84333.1.
AK150116 mRNA. Translation: BAE29319.1.
AL583887 Genomic DNA. Translation: CAO77935.1.
BC055368 mRNA. Translation: AAH55368.1.
CCDSiCCDS27706.1.
RefSeqiNP_898838.2. NM_183017.2.
UniGeneiMm.46778.

Genome annotation databases

EnsembliENSMUST00000016901; ENSMUSP00000016901; ENSMUSG00000016757.
GeneIDi223723.
KEGGimmu:223723.
UCSCiuc007xbh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM690756 mRNA. Translation: CAM84333.1.
AK150116 mRNA. Translation: BAE29319.1.
AL583887 Genomic DNA. Translation: CAO77935.1.
BC055368 mRNA. Translation: AAH55368.1.
CCDSiCCDS27706.1.
RefSeqiNP_898838.2. NM_183017.2.
UniGeneiMm.46778.

3D structure databases

ProteinModelPortaliQ3UDE2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230183. 17 interactions.
IntActiQ3UDE2. 17 interactions.
MINTiMINT-8178494.
STRINGi10090.ENSMUSP00000016901.

PTM databases

iPTMnetiQ3UDE2.
PhosphoSiteiQ3UDE2.

Proteomic databases

EPDiQ3UDE2.
MaxQBiQ3UDE2.
PaxDbiQ3UDE2.
PRIDEiQ3UDE2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000016901; ENSMUSP00000016901; ENSMUSG00000016757.
GeneIDi223723.
KEGGimmu:223723.
UCSCiuc007xbh.2. mouse.

Organism-specific databases

CTDi23170.
MGIiMGI:3039573. Ttll12.

Phylogenomic databases

eggNOGiKOG2155. Eukaryota.
ENOG410XQ0A. LUCA.
GeneTreeiENSGT00390000006760.
HOGENOMiHOG000006517.
HOVERGENiHBG055617.
InParanoidiQ3UDE2.
KOiK16609.
OMAiPKIAQKY.
OrthoDBiEOG7KDF98.
PhylomeDBiQ3UDE2.
TreeFamiTF313037.

Miscellaneous databases

PROiQ3UDE2.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UDE2.
CleanExiMM_TTLL12.
ExpressionAtlasiQ3UDE2. baseline and differential.
GenevisibleiQ3UDE2. MM.

Family and domain databases

InterProiIPR004344. TTL/TTLL_fam.
IPR027749. TTLL12.
[Graphical view]
PANTHERiPTHR12241:SF13. PTHR12241:SF13. 1 hit.
PfamiPF03133. TTL. 1 hit.
[Graphical view]
PROSITEiPS51221. TTL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A targeted multienzyme mechanism for selective microtubule polyglutamylation."
    van Dijk J., Rogowski K., Miro J., Lacroix B., Edde B., Janke C.
    Mol. Cell 26:437-448(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6JImported.
    Tissue: BrainImported.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C3H/HeImported.
    Tissue: OsteoblastImported.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiTTL12_MOUSE
AccessioniPrimary (citable) accession number: Q3UDE2
Secondary accession number(s): Q7TPC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 11, 2005
Last modified: June 8, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.