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Protein

Tubulin--tyrosine ligase-like protein 12

Gene

Ttll12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei463ATPBy similarity1
Binding sitei465ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi445 – 448ATP bindingBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-8955332 Carboxyterminal post-translational modifications of tubulin

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin--tyrosine ligase-like protein 12
Gene namesi
Name:Ttll12Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:3039573 Ttll12

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003261661 – 639Tubulin--tyrosine ligase-like protein 12Add BLAST639

Proteomic databases

EPDiQ3UDE2
MaxQBiQ3UDE2
PaxDbiQ3UDE2
PeptideAtlasiQ3UDE2
PRIDEiQ3UDE2

PTM databases

iPTMnetiQ3UDE2
PhosphoSitePlusiQ3UDE2

Expressioni

Tissue specificityi

Widely expressed with highest levels in brain, kidney, liver, lung, muscle and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000016757
CleanExiMM_TTLL12
ExpressionAtlasiQ3UDE2 baseline and differential
GenevisibleiQ3UDE2 MM

Interactioni

Protein-protein interaction databases

BioGridi230183, 17 interactors
IntActiQ3UDE2, 17 interactors
MINTiQ3UDE2
STRINGi10090.ENSMUSP00000016901

Structurei

3D structure databases

ProteinModelPortaliQ3UDE2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini295 – 639TTLPROSITE-ProRule annotationAdd BLAST345

Phylogenomic databases

eggNOGiKOG2155 Eukaryota
ENOG410XQ0A LUCA
GeneTreeiENSGT00390000006760
HOGENOMiHOG000006517
HOVERGENiHBG055617
InParanoidiQ3UDE2
KOiK16609
OMAiPKIAQKY
OrthoDBiEOG091G03PZ
PhylomeDBiQ3UDE2
TreeFamiTF313037

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR013815 ATP_grasp_subdomain_1
IPR004344 TTL/TTLL_fam
IPR027749 TTLL12
PANTHERiPTHR12241:SF13 PTHR12241:SF13, 1 hit
PfamiView protein in Pfam
PF03133 TTL, 1 hit
PROSITEiView protein in PROSITE
PS51221 TTL, 1 hit

Sequencei

Sequence statusi: Complete.

Q3UDE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIQSGPQPG SPGRAERLNA RLLDEFVSLH GPTLRASGVP ERLWGRLLHK
60 70 80 90 100
LEHEVFDAGE MFGIMQVEEV EEAEDEAARE AQRKQPNPGG ELCYKVIVTS
110 120 130 140 150
ESGVRADDPN SIFLIDHAWT CRVEHARKQL QQVPGLLHRM ANLMGIEFHG
160 170 180 190 200
EVPSPEVVAL VLEEMWKFNQ TYQLAHGTAE EKVPVWYIMD EFGSRIQHSD
210 220 230 240 250
MPSFATAPFF YMPQQVAYTL LWPLRDLDTG EEVTRDFAYG EADPLIRKCM
260 270 280 290 300
LLPWAPADML DLSFSTPEPP AKYYQAILEE NKEKLPLAIS PVARPQGHVF
310 320 330 340 350
RVHCDVQQVL GHLTHPRFTF TDSEADADIF FHFSHFKDYM KLSQESPQVL
360 370 380 390 400
LNQFPCENLL TVKDCLASIA RRAGGPEGPP WLPRTFNLRT ELPQFVSYFQ
410 420 430 440 450
HRERRGEDNH WICKPWNLAR SLDTHVTNNL HSIIRHREST PKVVSKYIES
460 470 480 490 500
PVLFLREDVG NVKFDIRYIV LLRSVRPLRL FAYDVFWLRF SNRPFALDDL
510 520 530 540 550
DDYEKHFTVM NYDPDVVLKQ VHYNEFIPQF EKQYPEFPWS DVQAEIFKAF
560 570 580 590 600
TELFQVACAK PPPMGLCDYP SSRAMYAIDL MLNWDNHPDG KRVMQPQILE
610 620 630
VNFNPDCERA CRYHPSFFND VFSTLFLDET DNCHVTRII
Length:639
Mass (Da):74,043
Last modified:October 11, 2005 - v1
Checksum:i584D72AA05BCA837
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65M → K in AAH55368 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM690756 mRNA Translation: CAM84333.1
AK150116 mRNA Translation: BAE29319.1
AL583887 Genomic DNA No translation available.
BC055368 mRNA Translation: AAH55368.1
CCDSiCCDS27706.1
RefSeqiNP_898838.2, NM_183017.2
UniGeneiMm.46778

Genome annotation databases

EnsembliENSMUST00000016901; ENSMUSP00000016901; ENSMUSG00000016757
GeneIDi223723
KEGGimmu:223723
UCSCiuc007xbh.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTTL12_MOUSE
AccessioniPrimary (citable) accession number: Q3UDE2
Secondary accession number(s): Q7TPC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health