Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tubulin--tyrosine ligase-like protein 12

Gene

Ttll12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei463ATPBy similarity1
Binding sitei465ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi445 – 448ATP bindingBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin--tyrosine ligase-like protein 12
Gene namesi
Name:Ttll12Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:3039573. Ttll12.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003261661 – 639Tubulin--tyrosine ligase-like protein 12Add BLAST639

Proteomic databases

EPDiQ3UDE2.
MaxQBiQ3UDE2.
PaxDbiQ3UDE2.
PeptideAtlasiQ3UDE2.
PRIDEiQ3UDE2.

PTM databases

iPTMnetiQ3UDE2.
PhosphoSitePlusiQ3UDE2.

Expressioni

Tissue specificityi

Widely expressed with highest levels in brain, kidney, liver, lung, muscle and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000016757.
CleanExiMM_TTLL12.
ExpressionAtlasiQ3UDE2. baseline and differential.
GenevisibleiQ3UDE2. MM.

Interactioni

Protein-protein interaction databases

BioGridi230183. 17 interactors.
IntActiQ3UDE2. 17 interactors.
MINTiMINT-8178494.
STRINGi10090.ENSMUSP00000016901.

Structurei

3D structure databases

ProteinModelPortaliQ3UDE2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini295 – 639TTLPROSITE-ProRule annotationAdd BLAST345

Phylogenomic databases

eggNOGiKOG2155. Eukaryota.
ENOG410XQ0A. LUCA.
GeneTreeiENSGT00390000006760.
HOGENOMiHOG000006517.
HOVERGENiHBG055617.
InParanoidiQ3UDE2.
KOiK16609.
OMAiPKIAQKY.
OrthoDBiEOG091G03PZ.
PhylomeDBiQ3UDE2.
TreeFamiTF313037.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
InterProiView protein in InterPro
IPR013815. ATP_grasp_subdomain_1.
IPR004344. TTL/TTLL_fam.
IPR027749. TTLL12.
PANTHERiPTHR12241:SF141. PTHR12241:SF141. 1 hit.
PfamiView protein in Pfam
PF03133. TTL. 1 hit.
PROSITEiView protein in PROSITE
PS51221. TTL. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3UDE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIQSGPQPG SPGRAERLNA RLLDEFVSLH GPTLRASGVP ERLWGRLLHK
60 70 80 90 100
LEHEVFDAGE MFGIMQVEEV EEAEDEAARE AQRKQPNPGG ELCYKVIVTS
110 120 130 140 150
ESGVRADDPN SIFLIDHAWT CRVEHARKQL QQVPGLLHRM ANLMGIEFHG
160 170 180 190 200
EVPSPEVVAL VLEEMWKFNQ TYQLAHGTAE EKVPVWYIMD EFGSRIQHSD
210 220 230 240 250
MPSFATAPFF YMPQQVAYTL LWPLRDLDTG EEVTRDFAYG EADPLIRKCM
260 270 280 290 300
LLPWAPADML DLSFSTPEPP AKYYQAILEE NKEKLPLAIS PVARPQGHVF
310 320 330 340 350
RVHCDVQQVL GHLTHPRFTF TDSEADADIF FHFSHFKDYM KLSQESPQVL
360 370 380 390 400
LNQFPCENLL TVKDCLASIA RRAGGPEGPP WLPRTFNLRT ELPQFVSYFQ
410 420 430 440 450
HRERRGEDNH WICKPWNLAR SLDTHVTNNL HSIIRHREST PKVVSKYIES
460 470 480 490 500
PVLFLREDVG NVKFDIRYIV LLRSVRPLRL FAYDVFWLRF SNRPFALDDL
510 520 530 540 550
DDYEKHFTVM NYDPDVVLKQ VHYNEFIPQF EKQYPEFPWS DVQAEIFKAF
560 570 580 590 600
TELFQVACAK PPPMGLCDYP SSRAMYAIDL MLNWDNHPDG KRVMQPQILE
610 620 630
VNFNPDCERA CRYHPSFFND VFSTLFLDET DNCHVTRII
Length:639
Mass (Da):74,043
Last modified:October 11, 2005 - v1
Checksum:i584D72AA05BCA837
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65M → K in AAH55368 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM690756 mRNA. Translation: CAM84333.1.
AK150116 mRNA. Translation: BAE29319.1.
AL583887 Genomic DNA. Translation: CAO77935.1.
BC055368 mRNA. Translation: AAH55368.1.
CCDSiCCDS27706.1.
RefSeqiNP_898838.2. NM_183017.2.
UniGeneiMm.46778.

Genome annotation databases

EnsembliENSMUST00000016901; ENSMUSP00000016901; ENSMUSG00000016757.
GeneIDi223723.
KEGGimmu:223723.
UCSCiuc007xbh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM690756 mRNA. Translation: CAM84333.1.
AK150116 mRNA. Translation: BAE29319.1.
AL583887 Genomic DNA. Translation: CAO77935.1.
BC055368 mRNA. Translation: AAH55368.1.
CCDSiCCDS27706.1.
RefSeqiNP_898838.2. NM_183017.2.
UniGeneiMm.46778.

3D structure databases

ProteinModelPortaliQ3UDE2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230183. 17 interactors.
IntActiQ3UDE2. 17 interactors.
MINTiMINT-8178494.
STRINGi10090.ENSMUSP00000016901.

PTM databases

iPTMnetiQ3UDE2.
PhosphoSitePlusiQ3UDE2.

Proteomic databases

EPDiQ3UDE2.
MaxQBiQ3UDE2.
PaxDbiQ3UDE2.
PeptideAtlasiQ3UDE2.
PRIDEiQ3UDE2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000016901; ENSMUSP00000016901; ENSMUSG00000016757.
GeneIDi223723.
KEGGimmu:223723.
UCSCiuc007xbh.2. mouse.

Organism-specific databases

CTDi23170.
MGIiMGI:3039573. Ttll12.

Phylogenomic databases

eggNOGiKOG2155. Eukaryota.
ENOG410XQ0A. LUCA.
GeneTreeiENSGT00390000006760.
HOGENOMiHOG000006517.
HOVERGENiHBG055617.
InParanoidiQ3UDE2.
KOiK16609.
OMAiPKIAQKY.
OrthoDBiEOG091G03PZ.
PhylomeDBiQ3UDE2.
TreeFamiTF313037.

Miscellaneous databases

PROiPR:Q3UDE2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000016757.
CleanExiMM_TTLL12.
ExpressionAtlasiQ3UDE2. baseline and differential.
GenevisibleiQ3UDE2. MM.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
InterProiView protein in InterPro
IPR013815. ATP_grasp_subdomain_1.
IPR004344. TTL/TTLL_fam.
IPR027749. TTLL12.
PANTHERiPTHR12241:SF141. PTHR12241:SF141. 1 hit.
PfamiView protein in Pfam
PF03133. TTL. 1 hit.
PROSITEiView protein in PROSITE
PS51221. TTL. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTTL12_MOUSE
AccessioniPrimary (citable) accession number: Q3UDE2
Secondary accession number(s): Q7TPC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 11, 2005
Last modified: May 10, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.