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Q3UD82 (PARP8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Poly [ADP-ribose] polymerase 8
Short name=PARP-8
EC=2.4.2.30
Gene names
Name:Parp8
Synonyms:D13Ertd275e
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length852 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

Post-translational modification

Phosphorylated upon DNA damage, probably by ATM or ATR By similarity.

Sequence similarities

Contains 1 PARP catalytic domain.

Sequence caution

The sequence AAH21315.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH21881.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   LigandNAD
   Molecular functionGlycosyltransferase
Transferase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular functionNAD+ ADP-ribosyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 852852Poly [ADP-ribose] polymerase 8
PRO_0000252434

Regions

Domain615 – 842228PARP catalytic
Compositional bias467 – 4715Poly-Ser

Amino acid modifications

Modified residue7581Phosphoserine By similarity
Modified residue7681Phosphoserine By similarity

Experimental info

Sequence conflict1431N → D in BAE29166. Ref.1
Sequence conflict3301D → E in AAH21881. Ref.2
Sequence conflict5701P → L in BAB28711. Ref.1
Sequence conflict7641N → S in BAE29166. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q3UD82 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 32184686DE3A27A8

FASTA85295,560
        10         20         30         40         50         60 
MGMCSRQERI QKDIDVVIQK SRAEKDCLFA DFRYSDSTFT FTYVGGPKSV SYSVHVSEDY 

        70         80         90        100        110        120 
PDNTYVSSSE NDEDVLVTTD PIPVIFHRIA TELRKTNDIN CCLSIRSKLQ KENGEESRQN 

       130        140        150        160        170        180 
STVEEDSEGD NDSEEFYYGG QVNYDGELHK HPQLEADLSA VRELYGPHAV SLREYGAIDD 

       190        200        210        220        230        240 
VDIDLHIDVS FLDEEIAVAW EVIRTEPIIV RLHCSLTQYL NGPVPTVDVF QISTKERFGL 

       250        260        270        280        290        300 
GHQLKKIMQT FVSQQWKQSK DKSNCPHGKK LSEKKVKSPL HLFSTLRRSP SYPPPGCGKS 

       310        320        330        340        350        360 
KSKLKPEQDG ISKTHKLLRR TCSSTVKADD MCAKSHRTFG RSLSSDPRAE QAMSTIKSHK 

       370        380        390        400        410        420 
LLGRPCPSAG KQEDCLTLKS HKLLTRSCSG DPRCEHNTNL KPHKLLSRSY SSNLRMEELY 

       430        440        450        460        470        480 
GLKNHKLLSK SYSSAPKTSK MEHFKEPNAE GRRLSLTSGL IGILTPSSSS SQPPTNGAKS 

       490        500        510        520        530        540 
IPIRDRGFLV QTIEFAEQRI PVLNEYCVVC DEPHVFQNGP MLRPTVCERE LCVFAFQTLG 

       550        560        570        580        590        600 
VMNEAADEIA TGAQVVDLLV SMCRSALESP RKVVIFEPYP SVVDPNDPQM LAFNPRKKNY 

       610        620        630        640        650        660 
DRVMKALDSI TSIREMTQAP YLEIKKQMDK QDPLAHPLLQ WVISSNRSHI VKLPVNRQLK 

       670        680        690        700        710        720 
FMHTPHQFLL LSSPPAKESN FRAAKKLFGS TFAFHGSHIE NWHSILRNGL VVASNTRLQL 

       730        740        750        760        770        780 
HGAMYGSGIY LSPMSSISFG YSGMNKKQKV SSKDEPASSS KSSNASQSQK KGQQSQFLQS 

       790        800        810        820        830        840 
RNLKCIALCE VITSPDLHKH GEIWVVPNTD HVCTRFFFVY EDGQVGDANI NTQEGGIHKE 

       850 
ILRVIGNQTA TG

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone marrow and Embryo.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK013206 mRNA. Translation: BAB28711.2.
AK149918 mRNA. Translation: BAE29166.1.
AK150113 mRNA. Translation: BAE29317.1.
AK150208 mRNA. Translation: BAE29379.1.
BC021315 mRNA. Translation: AAH21315.1. Different initiation.
BC021881 mRNA. Translation: AAH21881.1. Different initiation.
IPIIPI00756916.
UniGeneMm.274466.

3D structure databases

ProteinModelPortalQ3UD82.
SMRQ3UD82. Positions 667-745.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3UD82.

PTM databases

PhosphoSiteQ3UD82.

Proteomic databases

PRIDEQ3UD82.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc007ryi.1. mouse.

Organism-specific databases

MGIMGI:1098713. Parp8.

Phylogenomic databases

HOGENOMHBG445795.
HOVERGENHBG057572.
InParanoidQ3UD82.
OrthoDBEOG4CG07K.

Gene expression databases

ArrayExpressQ3UD82.
BgeeQ3UD82.
CleanExMM_PARP8.
GenevestigatorQ3UD82.
GermOnlineENSMUSG00000021725. Mus musculus.

Family and domain databases

InterProIPR012317. Poly(ADP-ribose)pol_cat_dom.
[Graphical view]
PfamPF00644. PARP. 1 hit.
[Graphical view]
PROSITEPS51059. PARP_CATALYTIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry namePARP8_MOUSE
AccessionPrimary (citable) accession number: Q3UD82
Secondary accession number(s): Q3UDE4 expand/collapse secondary AC list , Q3UDU5, Q8VCB5, Q9CYY3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 11, 2005
Last modified: September 21, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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