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Q3UCQ1

- FOXK2_MOUSE

UniProt

Q3UCQ1 - FOXK2_MOUSE

Protein

Forkhead box protein K2

Gene

Foxk2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Recognizes the core sequence 5'-TAAACA-3'. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter By similarity.By similarity

    Cofactori

    Binds 1 magnesium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi301 – 3011Magnesium; via carbonyl oxygenBy similarity
    Metal bindingi302 – 3021Magnesium; via carbonyl oxygenBy similarity
    Metal bindingi304 – 3041Magnesium; via carbonyl oxygenBy similarity
    Metal bindingi307 – 3071Magnesium; via carbonyl oxygenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi249 – 34496Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB
    2. sequence-specific DNA binding Source: UniProtKB
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription

    Keywords - Ligandi

    DNA-binding, Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein K2
    Alternative name(s):
    Cellular transcription factor ILF-1
    Interleukin enhancer-binding factor 1
    Gene namesi
    Name:Foxk2Imported
    Synonyms:Ilf11 Publication
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1916087. Foxk2.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 651651Forkhead box protein K2PRO_0000261668Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241PhosphoserineBy similarity
    Modified residuei230 – 2301PhosphoserineBy similarity
    Modified residuei389 – 3891Phosphoserine1 Publication
    Modified residuei415 – 4151PhosphoserineBy similarity
    Modified residuei419 – 4191PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ3UCQ1.
    PRIDEiQ3UCQ1.

    PTM databases

    PhosphoSiteiQ3UCQ1.

    Expressioni

    Tissue specificityi

    Expressed in a wide range of adult brain regions, namely the piriform cortex, the major islands of Calleja and cells lining the lateral ventricles, the bed nucleus of stria terminalis, the paraventricular thalamic nucleus, habenula and all structures of the hippocampus. Also present in the hypothalamus, cerebral cortex and in the Purkinje cell layer in the cerebellum. Additionally expressed in dopamine neurons of the substantia and more sparsely in the ventral tegmental area.1 Publication

    Developmental stagei

    At E12.5, expressed ubiquitously in the developing central nervous system. This pattern persists at E14.5 and E16.5, with expression levels varying.1 Publication

    Gene expression databases

    BgeeiQ3UCQ1.
    CleanExiMM_FOXK2.
    GenevestigatoriQ3UCQ1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000101720.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3UCQ1.
    SMRiQ3UCQ1. Positions 247-344.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini48 – 11972FHAPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni291 – 30919DNA-binding; major grooveBy similarityAdd
    BLAST
    Regioni319 – 3235DNA-binding; minor grooveBy similarity
    Regioni339 – 3446DNA-binding; minor grooveBy similarity

    Domaini

    The C-terminal part of the DNA-binding domain may contribute to DNA recognition specificity.By similarity

    Sequence similaritiesi

    Contains 1 FHA domain.PROSITE-ProRule annotation
    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    GeneTreeiENSGT00750000117242.
    HOGENOMiHOG000072588.
    HOVERGENiHBG051649.
    InParanoidiB5AZX0.
    KOiK09404.
    OMAiHGQVNNA.
    OrthoDBiEOG7CRTS2.
    TreeFamiTF325718.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.60.200.20. 1 hit.
    InterProiIPR000253. FHA_dom.
    IPR008984. SMAD_FHA_domain.
    IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00498. FHA. 1 hit.
    PF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    SM00240. FHA. 1 hit.
    [Graphical view]
    SUPFAMiSSF49879. SSF49879. 1 hit.
    PROSITEiPS50006. FHA_DOMAIN. 1 hit.
    PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q3UCQ1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAAAALSGA GAPPAGGGAG GGGSPPGGWA VARLEGREFE YLMKKRSVTI    50
    GRNSSQGSVD VSMGHSSFIS RRHLEIFTPP GGGHSAAAPE PAQPRPDAGG 100
    DFYLRCLGKN GVFVDGVFQR RGAPPLQLPR VCTFRFPSTN IKITFTALSS 150
    EKREKQEAPE SPVKPVQPHI SPLTINIPDT MAHLISPLPS PTGTISAANS 200
    CPSSPRGAGS SGYKVGRVMP SDLSLMADNS QPENEKEASG GDSPKDDSKP 250
    PYSYAQLIVQ AITMAPDKQL TLNGIYTHIT KNYPYYRTAD KGWQNSIRHN 300
    LSLNRYFIKV PRSQEEPGKG SFWRIDPASE SKLVEQAFRK RRPRGVPCFR 350
    TPLGPLSSRS APASPNHAGV LSAHSSGAQT PESLSREGSP APLEPEPGAS 400
    QPKLAVIQEA RFAQSAPGSP LSSQPVLITV QRQLPPAIKP VTYTVATPVT 450
    TPTSQPPVVQ TVHVVHQIPA VSVTSVAGLA PANTYTVAGQ AVVTQAAVLA 500
    PPNPEPQENG DHREVRVKVE PVPAISPATL GAASRIIQTS QGTPVQTVTI 550
    VQQAPLGQHQ LPIKTVTQNG AHVVPMPTAV HSQVNNAAAS PLHMLATHAS 600
    ASASLPTKRQ NGDQAEQPEL KRVKAEDGES IVIALSVDAP PAAVREKAIQ 650
    N 651

    Note: No experimental confirmation available.Curated

    Length:651
    Mass (Da):68,446
    Last modified:July 27, 2011 - v3
    Checksum:iDFD83C2A8EF52EF0
    GO
    Isoform 21 Publication (identifier: Q3UCQ1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         517-586: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:581
    Mass (Da):61,211
    Checksum:i0CF8418986E7852C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti104 – 1041L → M in BAE29561. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei517 – 58670Missing in isoform 2. 1 PublicationVSP_052236Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU882160 mRNA. Translation: ACG63496.1.
    AL808021 Genomic DNA. Translation: CAM21743.1.
    AK150439 mRNA. Translation: BAE29561.1.
    CCDSiCCDS36393.2. [Q3UCQ1-1]
    RefSeqiNP_001074401.2. NM_001080932.2. [Q3UCQ1-1]
    XP_006534145.1. XM_006534082.1. [Q3UCQ1-2]
    UniGeneiMm.209750.

    Genome annotation databases

    EnsembliENSMUST00000106113; ENSMUSP00000101719; ENSMUSG00000039275. [Q3UCQ1-1]
    GeneIDi68837.
    KEGGimmu:68837.
    UCSCiuc007mvs.1. mouse. [Q3UCQ1-2]
    uc011yjl.1. mouse. [Q3UCQ1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU882160 mRNA. Translation: ACG63496.1 .
    AL808021 Genomic DNA. Translation: CAM21743.1 .
    AK150439 mRNA. Translation: BAE29561.1 .
    CCDSi CCDS36393.2. [Q3UCQ1-1 ]
    RefSeqi NP_001074401.2. NM_001080932.2. [Q3UCQ1-1 ]
    XP_006534145.1. XM_006534082.1. [Q3UCQ1-2 ]
    UniGenei Mm.209750.

    3D structure databases

    ProteinModelPortali Q3UCQ1.
    SMRi Q3UCQ1. Positions 247-344.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000101720.

    PTM databases

    PhosphoSitei Q3UCQ1.

    Proteomic databases

    PaxDbi Q3UCQ1.
    PRIDEi Q3UCQ1.

    Protocols and materials databases

    DNASUi 68837.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000106113 ; ENSMUSP00000101719 ; ENSMUSG00000039275 . [Q3UCQ1-1 ]
    GeneIDi 68837.
    KEGGi mmu:68837.
    UCSCi uc007mvs.1. mouse. [Q3UCQ1-2 ]
    uc011yjl.1. mouse. [Q3UCQ1-1 ]

    Organism-specific databases

    CTDi 3607.
    MGIi MGI:1916087. Foxk2.

    Phylogenomic databases

    eggNOGi COG5025.
    GeneTreei ENSGT00750000117242.
    HOGENOMi HOG000072588.
    HOVERGENi HBG051649.
    InParanoidi B5AZX0.
    KOi K09404.
    OMAi HGQVNNA.
    OrthoDBi EOG7CRTS2.
    TreeFami TF325718.

    Miscellaneous databases

    NextBioi 328023.
    PROi Q3UCQ1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3UCQ1.
    CleanExi MM_FOXK2.
    Genevestigatori Q3UCQ1.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.60.200.20. 1 hit.
    InterProi IPR000253. FHA_dom.
    IPR008984. SMAD_FHA_domain.
    IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00498. FHA. 1 hit.
    PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    SM00240. FHA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49879. SSF49879. 1 hit.
    PROSITEi PS50006. FHA_DOMAIN. 1 hit.
    PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Foxk2 is the mammalian homolog of yeast Fkh2, but is functionally distinct."
      Wijchers P.J.E.C., van der Heidee L.P., van den Akker W.M.R., Adolfs Y., Durston A.J., Hoekman M.F.M., Burbach J.P.H., Smidt M.P.
      Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Midbrain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 69-651 (ISOFORM 2).
      Strain: C57BL/6JImported.
      Tissue: Bone marrowImported.
    4. "Identification of forkhead transcription factors in cortical and dopaminergic areas of the adult murine brain."
      Wijchers P.J.E.C., Hoekman M.F.M., Burbach J.P.H., Smidt M.P.
      Brain Res. 1068:23-33(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-389, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiFOXK2_MOUSE
    AccessioniPrimary (citable) accession number: Q3UCQ1
    Secondary accession number(s): A2AN27, B5AZX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 88 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3