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Unreviewed, UniProtKB/TrEMBL Q3UCJ0 (Q3UCJ0_MOUSE)

Last modified February 9, 2010. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesSubmitted name:
    Putative uncharacterized protein EMBL BAE29622.1
Gene names
Name: Ptpn6 MGI 96055
OrganismMus musculus (Mouse) EMBL BAE29622.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length597 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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Ontologies

Keywords
   Molecular functionHydrolase RuleBase RU000691V2
Gene Ontology (GO)
   Biological processB cell receptor signaling pathway

Inferred from mutant phenotype. Source: MGI

cytokine-mediated signaling pathway

Traceable author statement. Source: MGI

intracellular signaling cascade

Inferred from direct assay. Source: MGI

natural killer cell mediated cytotoxicity

Inferred from mutant phenotype. Source: MGI

negative regulation of MAP kinase activity

Inferred from mutant phenotype. Source: MGI

negative regulation of MAPKKK cascade

Inferred from mutant phenotype. Source: MGI

negative regulation of T cell proliferation

Inferred from mutant phenotype. Source: MGI

negative regulation of T cell receptor signaling pathway

Inferred from mutant phenotype. Source: MGI

negative regulation of humoral immune response mediated by circulating immunoglobulin

Inferred from mutant phenotype. Source: MGI

negative regulation of peptidyl-tyrosine phosphorylation

Inferred from mutant phenotype. Source: MGI

protein amino acid dephosphorylation

Inferred from direct assay. Source: MGI

regulation of B cell differentiation

Inferred from mutant phenotype. Source: MGI

response to wounding

Inferred from electronic annotation. Source: Compara

   Cellular componentalpha-beta T cell receptor complex

Inferred from direct assay. Source: MGI

cytoplasm

Traceable author statement. Source: MGI

   Molecular functionSH2 domain binding

Inferred from direct assay. Source: MGI

SH3 domain binding

Inferred from direct assay. Source: MGI

phosphotyrosine binding

Inferred from physical interaction. Source: MGI

protein tyrosine phosphatase activity

Inferred from direct assay. Source: MGI

Complete GO annotation...

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Sequences

Sequence LengthMass (Da)Tools
Q3UCJ0-1 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: E8491CE77E06E989

FASTA59767,717
        10         20         30         40         50         60 
MLSRGWFHRD LSGPDAETLL KGRGVPGSFL ARPSRKNQGD FSLSVRVDDQ VTHIRIQNSG 

        70         80         90        100        110        120 
DFYDLYGGEK FATLTELVEY YTQQQGILQD RDGTIIHLKY PLNCSDPTSE RWYHGHISGG 

       130        140        150        160        170        180 
QAESLLQAKG EPWTFLVRES LSQPGDFVLS VLNDQPKAGP GSPLRVTHIK VMCEGGRYTV 

       190        200        210        220        230        240 
GGSETFDSLT DLVEHFKKTG IEEASGAFVY LRQPYYATRV NAADIENRVL ELNKKQESED 

       250        260        270        280        290        300 
TAKAGFWEEF ESLQKQEVKN LHQRLEGQRP ENKSKNRYKN ILPFDHSRVI LQGRDSNIPG 

       310        320        330        340        350        360 
SDYINANYVK NQLLGPDENS KTYIASQGCL DATVNDFWQM AWQENTRVIV MTTREVEKGR 

       370        380        390        400        410        420 
NKCVPYWPEV GTQRVYGLYS VTNSREHDTA EYKLRTLQIS PLDNGDLVRE IWHYQYLSWP 

       430        440        450        460        470        480 
DHGVPSEPGG VLSFLDQINQ RQESLPHAGP IIVHCSAGIG RTGTIIVIDM LMESISTKGL 

       490        500        510        520        530        540 
DCDIDIQKTI QMVRAQRSGM VQTEAQYKFI YVAIAQFIET TKKKLEIIQS QKGQESEYGN 

       550        560        570        580        590 
ITYPPAVRSA HAKASRTSSK HKEEVYENVH SKSKKEEKVK KQRSADKEKN KGSLKRK

« Hide

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References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J EMBL BAE29622.1.
Tissue: Bone marrow EMBL BAE29622.1 and Skin EMBL BAE21210.1.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK132509 mRNA. Translation: BAE21210.1.
AK150509 mRNA. Translation: BAE29622.1.
IPIIPI00225419.
RefSeqNP_001071173.1.
UniGeneMm.271799

3D structure databases

SMRQ3UCJ0. Positions 6-528.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3UCJ0.

Proteomic databases

PRIDEQ3UCJ0.

Genome annotation databases

EnsemblENSMUST00000004377; ENSMUSP00000004377; ENSMUSG00000004266; Mus musculus. [Genome view]
GeneID15170.
KEGGmmu:15170.
UCSCuc009drj.1. mouse.

Organism-specific databases

CTD15170.
MGIMGI:96055. Ptpn6.

Phylogenomic databases

HOGENOMHBG379880.
HOVERGENQ3UCJ0.
InParanoidQ3UCJ0.

Gene expression databases

ArrayExpressQ3UCJ0.
BgeeQ3UCJ0.
GenevestigatorQ3UCJ0.

Family and domain databases

InterProIPR000387. Dual-sp/Tyr_phosphatase.
IPR000980. SH2.
IPR016130. Tyr_Pase_AS.
IPR012152. Tyr_Pase_non-rcpt_typ-6/11.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
Gene3DG3DSA:3.30.505.10. SH2. 2 hits.
PfamPF00017. SH2. 2 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFPIRSF000929. Tyr-Ptase_nr_6. 1 hit.
PRINTSPR00700. PRTYPHPHTASE.
PR00401. SH2DOMAIN.
SMARTSM00194. PTPc. 1 hit.
SM00252. SH2. 2 hits.
[Graphical view]
PROSITEPS50001. SH2. 2 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio287680.
SOURCESearch...

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Entry information

Entry nameQ3UCJ0_MOUSE
AccessionPrimary (citable) accession number: Q3UCJ0
Entry history
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: February 9, 2010
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information