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Protein

Tyrosine-protein phosphatase non-receptor type

Gene

Ptpn6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei421SubstrateUniRule annotation1
Active sitei455Phosphocysteine intermediateUniRule annotation1
Binding sitei502SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor typeUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:Ptpn6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96055 Ptpn6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

MaxQBiQ3UCJ0
PRIDEiQ3UCJ0

Expressioni

Gene expression databases

BgeeiENSMUSG00000004266
ExpressionAtlasiQ3UCJ0 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ3UCJ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 102SH2InterPro annotationAdd BLAST97
Domaini112 – 215SH2InterPro annotationAdd BLAST104
Domaini246 – 517Tyrosine-protein phosphataseInterPro annotationAdd BLAST272
Domaini432 – 508TYR_PHOSPHATASE_2InterPro annotationAdd BLAST77

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.UniRule annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0790 Eukaryota
COG5599 LUCA
HOGENOMiHOG000273907
HOVERGENiHBG000223
OMAiQAKGEPW
OrthoDBiEOG091G0VZ3

Family and domain databases

Gene3Di3.30.505.10, 2 hits
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR012152 Tyr_Pase_non-rcpt_typ-6/11
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00017 SH2, 2 hits
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000929 Tyr-Ptase_nr_6, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
PR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SM00252 SH2, 2 hits
SUPFAMiSSF52799 SSF52799, 1 hit
SSF55550 SSF55550, 2 hits
PROSITEiView protein in PROSITE
PS50001 SH2, 2 hits
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

Q3UCJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRGWFHRD LSGPDAETLL KGRGVPGSFL ARPSRKNQGD FSLSVRVDDQ
60 70 80 90 100
VTHIRIQNSG DFYDLYGGEK FATLTELVEY YTQQQGILQD RDGTIIHLKY
110 120 130 140 150
PLNCSDPTSE RWYHGHISGG QAESLLQAKG EPWTFLVRES LSQPGDFVLS
160 170 180 190 200
VLNDQPKAGP GSPLRVTHIK VMCEGGRYTV GGSETFDSLT DLVEHFKKTG
210 220 230 240 250
IEEASGAFVY LRQPYYATRV NAADIENRVL ELNKKQESED TAKAGFWEEF
260 270 280 290 300
ESLQKQEVKN LHQRLEGQRP ENKSKNRYKN ILPFDHSRVI LQGRDSNIPG
310 320 330 340 350
SDYINANYVK NQLLGPDENS KTYIASQGCL DATVNDFWQM AWQENTRVIV
360 370 380 390 400
MTTREVEKGR NKCVPYWPEV GTQRVYGLYS VTNSREHDTA EYKLRTLQIS
410 420 430 440 450
PLDNGDLVRE IWHYQYLSWP DHGVPSEPGG VLSFLDQINQ RQESLPHAGP
460 470 480 490 500
IIVHCSAGIG RTGTIIVIDM LMESISTKGL DCDIDIQKTI QMVRAQRSGM
510 520 530 540 550
VQTEAQYKFI YVAIAQFIET TKKKLEIIQS QKGQESEYGN ITYPPAVRSA
560 570 580 590
HAKASRTSSK HKEEVYENVH SKSKKEEKVK KQRSADKEKN KGSLKRK
Length:597
Mass (Da):67,717
Last modified:October 11, 2005 - v1
Checksum:iE8491CE77E06E989
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132509 mRNA Translation: BAE21210.1
AK150509 mRNA Translation: BAE29622.1
RefSeqiNP_001071173.1, NM_001077705.2
UniGeneiMm.271799

Genome annotation databases

GeneIDi15170
UCSCiuc009drj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiQ3UCJ0_MOUSE
AccessioniPrimary (citable) accession number: Q3UCJ0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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