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Protein

DNA ligase

Gene

Lig3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotation
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-110381 Resolution of AP sites via the single-nucleotide replacement pathway
R-MMU-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
R-MMU-5685939 HDR through MMEJ (alt-NHEJ)
R-MMU-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:Lig3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:109152 Lig3

Expressioni

Gene expression databases

BgeeiENSMUSG00000020697

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 186PARP-typeInterPro annotationAdd BLAST93
Domaini584 – 718DNA_LIGASE_A3InterPro annotationAdd BLAST135
Domaini935 – 1011BRCTInterPro annotationAdd BLAST77

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG4437 Eukaryota
COG1793 LUCA
GeneTreeiENSGT00860000133792
HOVERGENiHBG005515

Family and domain databases

CDDicd00027 BRCT, 1 hit
Gene3Di1.10.3260.10, 1 hit
3.30.1740.10, 1 hit
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR031916 LIG3_BRCT
IPR012340 NA-bd_OB-fold
IPR001510 Znf_PARP
IPR036957 Znf_PARP_sf
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
PF16759 LIG3_BRCT, 1 hit
PF00645 zf-PARP, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 1 hit
SM01336 zf-PARP, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
SSF52113 SSF52113, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit
PS00347 PARP_ZN_FINGER_1, 1 hit
PS50064 PARP_ZN_FINGER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q3UC82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLAFKILFP RNLCALGRKE LCLFPEQNRW AAISQFSQWS ETNLLGGCCL
60 70 80 90 100
LQRRKPVLAL QRGHLRPRAT HLTFWPGSHV GLCTGPCAMA EQRFCVDYAK
110 120 130 140 150
RGTAGCKKCK EKIVKGVCRI GKVVPNPFSE SGGDMKEWYH IKCMFEKLER
160 170 180 190 200
ARATTKKIED LTELEGWEEL EDNEKEQISQ HIADLSSKAA ATPKKKAAVQ
210 220 230 240 250
AKLTTTGQVT SPVKGASFIT STNPRKFSGF SAKPNNSEQA PSSPAPGTSL
260 270 280 290 300
SASKCDPKHK DCLLREFRKL CAMVAENPSY NTKTQIIHDF LQKGSTGDGF
310 320 330 340 350
HGDVYLTVKL LLPGVIKSVY NLNDKQIVKL FSRIFNCNPD DMARDLEQGD
360 370 380 390 400
VSETIRIFFE QSKSFPPAAK SLLTIQEVDA FLLHLSKLTK EDEQQQALQD
410 420 430 440 450
IASRCTANDL KCIIRLIKHD LKMNSGAKHV LDALDPNAYE AFKASRNLQD
460 470 480 490 500
VVERVLHNEQ EVEKDPGRRR ALRVQASLMT PVQPMLAEAC KSIEYAMKKC
510 520 530 540 550
PNGMFSEIKY DGERVQVHKK GDHFSYFSRS LKPVLPHKVA HFKDYIPKAF
560 570 580 590 600
PGGQSMILDS EVLLIDNNTG KPLPFGTLGV HKKAAFQDAN VCLFVFDCIY
610 620 630 640 650
FNDVSLMDRP LCERRKFLHD NMVEIRNRIM FSEMKQVTKA SDLADMINRV
660 670 680 690 700
IREGLEGLVL KDVKGTYEPG KRHWLKVKKD YLNEGAMADT ADLVVLGAFY
710 720 730 740 750
GQGSKGGMMS IFLMGCYDPD SQKWCTVTKC AGGHDDATLA RLQKELVMVK
760 770 780 790 800
ISKDPSKIPS WLKINKIYYP DFIVPDPKKA AVWEITGAEF SRSEAHTADG
810 820 830 840 850
ISIRFPRCTR IRDDKDWKSA TNLPQLKELY QLSKDKADFA VVAGDEASPT
860 870 880 890 900
TGGSSGENEG TAGSAGPCKG PPSKSSASAK TTEQKLNSPS SRGGIKPIPK
910 920 930 940 950
HSPMKPGEKL AVKSSPVKVG MKRKATDETP CLKKVLLDVF TGVRLYLPPS
960 970 980 990 1000
TPDFKRLKRY FVAFDGDLVQ EFDMGSATHV LGNREKNTDA QLVSSEWIWA
1010
CIRKRRLIAP C
Length:1,011
Mass (Da):112,710
Last modified:October 11, 2005 - v1
Checksum:iFDE0301DC5CCE099
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645594 Genomic DNA No translation available.
AK150644 mRNA Translation: BAE29732.1
RefSeqiNP_001278175.1, NM_001291246.1
NP_001278176.1, NM_001291247.1
UniGeneiMm.277136

Genome annotation databases

EnsembliENSMUST00000173347; ENSMUSP00000134300; ENSMUSG00000020697
ENSMUST00000173727; ENSMUSP00000133849; ENSMUSG00000020697
GeneIDi16882
UCSCiuc007knb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiQ3UC82_MOUSE
AccessioniPrimary (citable) accession number: Q3UC82
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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