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Protein

MIF4G domain-containing protein

Gene

Mif4gd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranslation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
MIF4G domain-containing protein
Gene namesi
Name:Mif4gd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1916924 Mif4gd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003370901 – 222MIF4G domain-containing proteinAdd BLAST222

Proteomic databases

EPDiQ3UBZ5
MaxQBiQ3UBZ5
PaxDbiQ3UBZ5
PRIDEiQ3UBZ5

PTM databases

iPTMnetiQ3UBZ5
PhosphoSitePlusiQ3UBZ5

Expressioni

Gene expression databases

BgeeiENSMUSG00000020743
ExpressionAtlasiQ3UBZ5 baseline and differential
GenevisibleiQ3UBZ5 MM

Interactioni

Subunit structurei

Interacts with EIF4G1, EIF4G2 and SLBP; probably tethered by SLBP to the 3'-end of mRNAs ending with the histone stem-loop, it also interacts with EIF4G1 which is bound to their 5'-end.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ3UBZ5, 1 interactor
STRINGi10090.ENSMUSP00000021087

Structurei

3D structure databases

ProteinModelPortaliQ3UBZ5
SMRiQ3UBZ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 205MIF4GAdd BLAST203

Sequence similaritiesi

Belongs to the MIF4GD family.Curated

Phylogenomic databases

eggNOGiKOG3942 Eukaryota
ENOG410XQKW LUCA
GeneTreeiENSGT00630000089865
HOGENOMiHOG000231168
HOVERGENiHBG055294
InParanoidiQ3UBZ5
OMAiCYTIIQA
OrthoDBiEOG091G05G0
PhylomeDBiQ3UBZ5

Family and domain databases

Gene3Di1.25.40.180, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
PfamiView protein in Pfam
PF02854 MIF4G, 1 hit
SMARTiView protein in SMART
SM00543 MIF4G, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UBZ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEASRDDYK IQSFDAETQQ LLKTALKDPG AVDLERVANV IVDHSLQDCV
60 70 80 90 100
FSKEAGRMCY AIIQAESKQA GQSVFRRGLL NRLQKEYDAR EQLRACSLQG
110 120 130 140 150
WVCYVTFICN IFDYLRVNNM PMMALVNPVY DCLFQLAQPE SLSREEEVDC
160 170 180 190 200
LVLQLHRVGE QLEKMNGQRM DELFILIRDG FLLPTDLSSL ARLLLLEMIE
210 220
FRAAGWKTTP AAHKYYYSEV SD
Length:222
Mass (Da):25,493
Last modified:October 11, 2005 - v1
Checksum:i2A0D56790F33701E
GO
Isoform 2 (identifier: Q3UBZ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-92: EYDAREQ → DWPSLRV
     93-222: Missing.

Note: No experimental confirmation available.
Show »
Length:92
Mass (Da):10,386
Checksum:i89B8828A611C2865
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17E → Q in AAH26740 (PubMed:15489334).Curated1
Sequence conflicti30G → S in AAH26745 (PubMed:15489334).Curated1
Sequence conflicti30G → S in AAH55812 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03387886 – 92EYDAREQ → DWPSLRV in isoform 2. 1 Publication7
Alternative sequenceiVSP_03387993 – 222Missing in isoform 2. 1 PublicationAdd BLAST130

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150749 mRNA Translation: BAE29819.1
AL645470 Genomic DNA No translation available.
BC026740 mRNA Translation: AAH26740.1
BC026745 mRNA Translation: AAH26745.1
BC055812 mRNA Translation: AAH55812.1
CCDSiCCDS25643.1 [Q3UBZ5-1]
RefSeqiNP_001230513.1, NM_001243584.1 [Q3UBZ5-1]
NP_081438.4, NM_027162.4 [Q3UBZ5-1]
UniGeneiMm.390387
Mm.489360

Genome annotation databases

EnsembliENSMUST00000021087; ENSMUSP00000021087; ENSMUSG00000020743 [Q3UBZ5-1]
ENSMUST00000106507; ENSMUSP00000102116; ENSMUSG00000020743 [Q3UBZ5-1]
GeneIDi69674
KEGGimmu:69674
UCSCiuc007mib.1 mouse [Q3UBZ5-1]
uc007mie.3 mouse [Q3UBZ5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMI4GD_MOUSE
AccessioniPrimary (citable) accession number: Q3UBZ5
Secondary accession number(s): Q05CE9, Q7TMH3, Q8R333
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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