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Protein

MIF4G domain-containing protein

Gene

Mif4gd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
MIF4G domain-containing protein
Gene namesi
Name:Mif4gd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1916924. Mif4gd.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222MIF4G domain-containing proteinPRO_0000337090Add
BLAST

Proteomic databases

EPDiQ3UBZ5.
MaxQBiQ3UBZ5.
PaxDbiQ3UBZ5.
PRIDEiQ3UBZ5.

PTM databases

iPTMnetiQ3UBZ5.
PhosphoSiteiQ3UBZ5.

Expressioni

Gene expression databases

BgeeiQ3UBZ5.
ExpressionAtlasiQ3UBZ5. baseline and differential.
GenevisibleiQ3UBZ5. MM.

Interactioni

Subunit structurei

Interacts with EIF4G1, EIF4G2 and SLBP; probably tethered by SLBP to the 3'-end of mRNAs ending with the histone stem-loop, it also interacts with EIF4G1 which is bound to their 5'-end.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ3UBZ5. 1 interaction.
STRINGi10090.ENSMUSP00000021087.

Structurei

3D structure databases

ProteinModelPortaliQ3UBZ5.
SMRiQ3UBZ5. Positions 8-217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 205203MIF4GAdd
BLAST

Sequence similaritiesi

Belongs to the MIF4GD family.Curated
Contains 1 MIF4G domain.Curated

Phylogenomic databases

eggNOGiKOG3942. Eukaryota.
ENOG410XQKW. LUCA.
GeneTreeiENSGT00630000089865.
HOGENOMiHOG000231168.
HOVERGENiHBG055294.
InParanoidiQ3UBZ5.
OMAiAAQKYYY.
OrthoDBiEOG7JX33W.
PhylomeDBiQ3UBZ5.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR016021. MIF4-like.
IPR003890. MIF4G-like_typ-3.
[Graphical view]
PfamiPF02854. MIF4G. 1 hit.
[Graphical view]
SMARTiSM00543. MIF4G. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UBZ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEASRDDYK IQSFDAETQQ LLKTALKDPG AVDLERVANV IVDHSLQDCV
60 70 80 90 100
FSKEAGRMCY AIIQAESKQA GQSVFRRGLL NRLQKEYDAR EQLRACSLQG
110 120 130 140 150
WVCYVTFICN IFDYLRVNNM PMMALVNPVY DCLFQLAQPE SLSREEEVDC
160 170 180 190 200
LVLQLHRVGE QLEKMNGQRM DELFILIRDG FLLPTDLSSL ARLLLLEMIE
210 220
FRAAGWKTTP AAHKYYYSEV SD
Length:222
Mass (Da):25,493
Last modified:October 11, 2005 - v1
Checksum:i2A0D56790F33701E
GO
Isoform 2 (identifier: Q3UBZ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-92: EYDAREQ → DWPSLRV
     93-222: Missing.

Note: No experimental confirmation available.
Show »
Length:92
Mass (Da):10,386
Checksum:i89B8828A611C2865
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171E → Q in AAH26740 (PubMed:15489334).Curated
Sequence conflicti30 – 301G → S in AAH26745 (PubMed:15489334).Curated
Sequence conflicti30 – 301G → S in AAH55812 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei86 – 927EYDAREQ → DWPSLRV in isoform 2. 1 PublicationVSP_033878
Alternative sequencei93 – 222130Missing in isoform 2. 1 PublicationVSP_033879Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150749 mRNA. Translation: BAE29819.1.
AL645470 Genomic DNA. Translation: CAM23004.1.
BC026740 mRNA. Translation: AAH26740.1.
BC026745 mRNA. Translation: AAH26745.1.
BC055812 mRNA. Translation: AAH55812.1.
CCDSiCCDS25643.1. [Q3UBZ5-1]
RefSeqiNP_001230513.1. NM_001243584.1. [Q3UBZ5-1]
NP_081438.4. NM_027162.4. [Q3UBZ5-1]
UniGeneiMm.390387.
Mm.489360.

Genome annotation databases

EnsembliENSMUST00000021087; ENSMUSP00000021087; ENSMUSG00000020743. [Q3UBZ5-1]
ENSMUST00000106507; ENSMUSP00000102116; ENSMUSG00000020743. [Q3UBZ5-1]
GeneIDi69674.
KEGGimmu:69674.
UCSCiuc007mib.1. mouse. [Q3UBZ5-1]
uc007mie.3. mouse. [Q3UBZ5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150749 mRNA. Translation: BAE29819.1.
AL645470 Genomic DNA. Translation: CAM23004.1.
BC026740 mRNA. Translation: AAH26740.1.
BC026745 mRNA. Translation: AAH26745.1.
BC055812 mRNA. Translation: AAH55812.1.
CCDSiCCDS25643.1. [Q3UBZ5-1]
RefSeqiNP_001230513.1. NM_001243584.1. [Q3UBZ5-1]
NP_081438.4. NM_027162.4. [Q3UBZ5-1]
UniGeneiMm.390387.
Mm.489360.

3D structure databases

ProteinModelPortaliQ3UBZ5.
SMRiQ3UBZ5. Positions 8-217.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3UBZ5. 1 interaction.
STRINGi10090.ENSMUSP00000021087.

PTM databases

iPTMnetiQ3UBZ5.
PhosphoSiteiQ3UBZ5.

Proteomic databases

EPDiQ3UBZ5.
MaxQBiQ3UBZ5.
PaxDbiQ3UBZ5.
PRIDEiQ3UBZ5.

Protocols and materials databases

DNASUi69674.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021087; ENSMUSP00000021087; ENSMUSG00000020743. [Q3UBZ5-1]
ENSMUST00000106507; ENSMUSP00000102116; ENSMUSG00000020743. [Q3UBZ5-1]
GeneIDi69674.
KEGGimmu:69674.
UCSCiuc007mib.1. mouse. [Q3UBZ5-1]
uc007mie.3. mouse. [Q3UBZ5-2]

Organism-specific databases

CTDi57409.
MGIiMGI:1916924. Mif4gd.

Phylogenomic databases

eggNOGiKOG3942. Eukaryota.
ENOG410XQKW. LUCA.
GeneTreeiENSGT00630000089865.
HOGENOMiHOG000231168.
HOVERGENiHBG055294.
InParanoidiQ3UBZ5.
OMAiAAQKYYY.
OrthoDBiEOG7JX33W.
PhylomeDBiQ3UBZ5.

Miscellaneous databases

ChiTaRSiMif4gd. mouse.
NextBioi330058.
PROiQ3UBZ5.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UBZ5.
ExpressionAtlasiQ3UBZ5. baseline and differential.
GenevisibleiQ3UBZ5. MM.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR016021. MIF4-like.
IPR003890. MIF4G-like_typ-3.
[Graphical view]
PfamiPF02854. MIF4G. 1 hit.
[Graphical view]
SMARTiSM00543. MIF4G. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Bone marrow.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: Czech II, FVB/N and NMRI.
    Tissue: Mammary tumor.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Liver, Lung and Testis.

Entry informationi

Entry nameiMI4GD_MOUSE
AccessioniPrimary (citable) accession number: Q3UBZ5
Secondary accession number(s): Q05CE9, Q7TMH3, Q8R333
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 11, 2005
Last modified: May 11, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.