UniProtKB - Q3UBY5 (Q3UBY5_MOUSE)
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Protein
Submitted name:
Cathepsin C, isoform CRA_b
Gene
Ctsc
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- chaperone binding Source: Ensembl
- chloride ion binding Source: Ensembl
- cysteine-type peptidase activity Source: UniProtKB-KW
- identical protein binding Source: Ensembl
- peptidase activator activity involved in apoptotic process Source: Ensembl
- phosphatase binding Source: Ensembl
- protein self-association Source: Ensembl
- serine-type endopeptidase activity Source: Ensembl
GO - Biological processi
- aging Source: Ensembl
- positive regulation of apoptotic signaling pathway Source: Ensembl
- positive regulation of proteolysis involved in cellular protein catabolic process Source: Ensembl
- response to organic substance Source: Ensembl
- T cell mediated cytotoxicity Source: Ensembl
Keywordsi
Molecular function | Hydrolase, Protease, Thiol proteaseSAAS annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Cathepsin C, isoform CRA_bImported |
Gene namesi | Name:CtscImported ORF Names:mCG_113517Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:109553. Ctsc. |
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | UniRule annotationAdd BLAST | 24 | |
ChainiPRO_5013983616 | 25 – 462 | UniRule annotationAdd BLAST | 438 |
Interactioni
GO - Molecular functioni
- chaperone binding Source: Ensembl
- identical protein binding Source: Ensembl
- phosphatase binding Source: Ensembl
- protein self-association Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 230 – 457 | Pept_C1InterPro annotationAdd BLAST | 228 |
Sequence similaritiesi
Keywords - Domaini
SignalUniRule annotationPhylogenomic databases
eggNOGi | KOG1543. Eukaryota. COG4870. LUCA. |
HOVERGENi | HBG005248. |
KOi | K01275. |
OMAi | YDDFLHY. |
OrthoDBi | EOG091G06TT. |
Family and domain databases
Gene3Di | 2.40.128.80. 1 hit. |
InterProi | View protein in InterPro IPR014882. CathepsinC_exc. IPR036496. CathepsinC_exc_dom_sf. IPR025661. Pept_asp_AS. IPR000169. Pept_cys_AS. IPR025660. Pept_his_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C. |
PANTHERi | PTHR12411. PTHR12411. 1 hit. |
Pfami | View protein in Pfam PF08773. CathepsinC_exc. 1 hit. PF00112. Peptidase_C1. 1 hit. |
PRINTSi | PR00705. PAPAIN. |
SMARTi | View protein in SMART SM00645. Pept_C1. 1 hit. |
SUPFAMi | SSF75001. SSF75001. 1 hit. |
PROSITEi | View protein in PROSITE PS00640. THIOL_PROTEASE_ASN. 1 hit. PS00139. THIOL_PROTEASE_CYS. 1 hit. PS00639. THIOL_PROTEASE_HIS. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q3UBY5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGPWTHSLRA VLLLVLLGVC TVRSDTPANC TYPDLLGTWV FQVGPRSSRS
60 70 80 90 100
DINCSVMEAT EEKVVVHLKK LDTAYDELGN SGHFTLIYNQ GFEIVLNDYK
110 120 130 140 150
WFAFFKYEVR GHTAISYCHE TMTGWVHDVL GRNWACFVGK KVESHIEKVN
160 170 180 190 200
MNAAHLGGLQ ERYSERLYTH NHNFVKAINT VQKSWTATAY KEYEKMSLRD
210 220 230 240 250
LIRRSGHSQR IPRPKPAPMT DEIQQQILNL PESWDWRNVQ GVNYVSPVRN
260 270 280 290 300
QESCGSCYSF ASMGMLEARI RILTNNSQTP ILSPQEVVSC SPYAQGCDGG
310 320 330 340 350
FPYLIAGKYA QDFGVVEESC FPYTAKDSPC KPRENCLRYY SSDYYYVGGF
360 370 380 390 400
YGGCNEALMK LELVKHGPMA VAFEVHDDFL HYHSGIYHHT GLSDPFNPFE
410 420 430 440 450
LTNHAVLLVG YGRDPVTGIE YWIIKNSWGS NWGESGYFRI RRGTDECAIE
460
SIAVAAIPIP KL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK146858 mRNA. Translation: BAE27487.1. AK150761 mRNA. Translation: BAE29829.1. CH466543 Genomic DNA. Translation: EDL06796.1. |
RefSeqi | NP_001298719.1. NM_001311790.1. NP_034112.3. NM_009982.5. |
UniGenei | Mm.322945. Mm.483300. Mm.89295. |
Genome annotation databases
GeneIDi | 13032. |
KEGGi | mmu:13032. |
Similar proteinsi
Entry informationi
Entry namei | Q3UBY5_MOUSE | |
Accessioni | Q3UBY5Primary (citable) accession number: Q3UBY5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | March 28, 2018 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |