Ctsc

Functionⁱ

GO - Molecular functionⁱ

chaperone binding Source: Ensembl
chloride ion binding Source: Ensembl
cysteine-type peptidase activity Source: UniProtKB-KW
identical protein binding Source: Ensembl
peptidase activator activity involved in apoptotic process Source: Ensembl
phosphatase binding Source: Ensembl
protein self-association Source: Ensembl
serine-type endopeptidase activity Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

aging Source: Ensembl
positive regulation of apoptotic signaling pathway Source: Ensembl
positive regulation of proteolysis involved in cellular protein catabolic process Source: Ensembl
response to organic substance Source: Ensembl
T cell mediated cytotoxicity Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Thiol proteaseSAAS annotation

Molecular function

Hydrolase, Protease, Thiol proteaseSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Cathepsin C, isoform CRA_bImported Submitted name: Putative uncharacterized proteinImported
Gene namesⁱ	Name:CtscImported ORF Names:mCG_113517Imported
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:109553. Ctsc.

Subcellular locationⁱ

GO - Cellular componentⁱ

centrosome Source: Ensembl
endoplasmic reticulum Source: Ensembl
extracellular exosome Source: Ensembl
extracellular space Source: Ensembl
Golgi apparatus Source: Ensembl
lysosome Source: Ensembl
membrane Source: Ensembl
nucleoplasm Source: Ensembl

Complete GO annotation...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 24	UniRule annotationAdd BLAST		24
ChainⁱPRO_5009998622	25 – 462	UniRule annotationAdd BLAST		438

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q3UBY5.

MaxQBⁱ

Q3UBY5.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000030560.
ExpressionAtlasⁱ	Q3UBY5. baseline and differential.

Interactionⁱ

GO - Molecular functionⁱ

chaperone binding Source: Ensembl
identical protein binding Source: Ensembl
phosphatase binding Source: Ensembl
protein self-association Source: Ensembl

Complete GO annotation...

Structureⁱ

3D structure databases

SMRⁱ	Q3UBY5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	230 – 457	Pept_C1InterPro annotationAdd BLAST		228

Sequence similaritiesⁱ

Belongs to the peptidase C1 family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

SignalUniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG1543. Eukaryota. COG4870. LUCA.
HOVERGENⁱ	HBG005248.
KEGG Orthology (KO) More...KOⁱ	K01275.
OMAⁱ	YHHTGLR.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06TT.

Family and domain databases

Gene3Dⁱ	2.40.128.80. 1 hit.
InterProⁱ	View protein in InterPro IPR014882. CathepsinC_exc. IPR033161. DPP_I. IPR025661. Pept_asp_AS. IPR000169. Pept_cys_AS. IPR025660. Pept_his_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C.
PANTHERⁱ	PTHR12411. PTHR12411. 1 hit. PTHR12411:SF448. PTHR12411:SF448. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08773. CathepsinC_exc. 1 hit. PF00112. Peptidase_C1. 1 hit.
PRINTSⁱ	PR00705. PAPAIN.
SMARTⁱ	View protein in SMART SM00645. Pept_C1. 1 hit.
SUPFAMⁱ	SSF75001. SSF75001. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00640. THIOL_PROTEASE_ASN. 1 hit. PS00139. THIOL_PROTEASE_CYS. 1 hit. PS00639. THIOL_PROTEASE_HIS. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q3UBY5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGPWTHSLRA VLLLVLLGVC TVRSDTPANC TYPDLLGTWV FQVGPRSSRS 
        60         70         80         90        100
DINCSVMEAT EEKVVVHLKK LDTAYDELGN SGHFTLIYNQ GFEIVLNDYK 
       110        120        130        140        150
WFAFFKYEVR GHTAISYCHE TMTGWVHDVL GRNWACFVGK KVESHIEKVN 
       160        170        180        190        200
MNAAHLGGLQ ERYSERLYTH NHNFVKAINT VQKSWTATAY KEYEKMSLRD 
       210        220        230        240        250
LIRRSGHSQR IPRPKPAPMT DEIQQQILNL PESWDWRNVQ GVNYVSPVRN 
       260        270        280        290        300
QESCGSCYSF ASMGMLEARI RILTNNSQTP ILSPQEVVSC SPYAQGCDGG 
       310        320        330        340        350
FPYLIAGKYA QDFGVVEESC FPYTAKDSPC KPRENCLRYY SSDYYYVGGF 
       360        370        380        390        400
YGGCNEALMK LELVKHGPMA VAFEVHDDFL HYHSGIYHHT GLSDPFNPFE 
       410        420        430        440        450
LTNHAVLLVG YGRDPVTGIE YWIIKNSWGS NWGESGYFRI RRGTDECAIE 
       460 
SIAVAAIPIP KL

Length:462

Mass (Da):52,376

Last modified:October 11, 2005 - v1

Checksum:ⁱ56574B38D7DF4710

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK146858 mRNA. Translation: BAE27487.1. AK150761 mRNA. Translation: BAE29829.1. CH466543 Genomic DNA. Translation: EDL06796.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001298719.1. NM_001311790.1. NP_034112.3. NM_009982.5.
UniGeneⁱ	Mm.322945. Mm.483300. Mm.89295.

Genome annotation databases

GeneIDⁱ	13032.
KEGGⁱ	mmu:13032.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK146858 mRNA. Translation: BAE27487.1. AK150761 mRNA. Translation: BAE29829.1. CH466543 Genomic DNA. Translation: EDL06796.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001298719.1. NM_001311790.1. NP_034112.3. NM_009982.5.
UniGeneⁱ	Mm.322945. Mm.483300. Mm.89295.

3D structure databases

SMRⁱ	Q3UBY5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q3UBY5.

MaxQBⁱ

Q3UBY5.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	13032.
KEGGⁱ	mmu:13032.

Organism-specific databases

CTDⁱ	1075.
MGIⁱ	MGI:109553. Ctsc.

Phylogenomic databases

eggNOGⁱ	KOG1543. Eukaryota. COG4870. LUCA.
HOVERGENⁱ	HBG005248.
KEGG Orthology (KO) More...KOⁱ	K01275.
OMAⁱ	YHHTGLR.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06TT.

Miscellaneous databases

ChiTaRSⁱ	Ctsc. mouse.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000030560.
ExpressionAtlasⁱ	Q3UBY5. baseline and differential.

Family and domain databases

Gene3Dⁱ	2.40.128.80. 1 hit.
InterProⁱ	View protein in InterPro IPR014882. CathepsinC_exc. IPR033161. DPP_I. IPR025661. Pept_asp_AS. IPR000169. Pept_cys_AS. IPR025660. Pept_his_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C.
PANTHERⁱ	PTHR12411. PTHR12411. 1 hit. PTHR12411:SF448. PTHR12411:SF448. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08773. CathepsinC_exc. 1 hit. PF00112. Peptidase_C1. 1 hit.
PRINTSⁱ	PR00705. PAPAIN.
SMARTⁱ	View protein in SMART SM00645. Pept_C1. 1 hit.
SUPFAMⁱ	SSF75001. SSF75001. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00640. THIOL_PROTEASE_ASN. 1 hit. PS00139. THIOL_PROTEASE_CYS. 1 hit. PS00639. THIOL_PROTEASE_HIS. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q3UBY5_MOUSE
Accessionⁱ	Q3UBY5Primary (citable) accession number: Q3UBY5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 11, 2005
	Last sequence update:	October 11, 2005
	Last modified:	July 5, 2017
	This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

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Supporting data

UniProtKB - Q3UBY5 (Q3UBY5_MOUSE)

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Cathepsin C, isoform CRA_b

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ