Ctsc

Functionⁱ

GO - Molecular functionⁱ

chaperone binding Source: Ensembl
chloride ion binding Source: Ensembl
cysteine-type peptidase activity Source: UniProtKB-KW
identical protein binding Source: Ensembl
peptidase activator activity involved in apoptotic process Source: Ensembl
phosphatase binding Source: Ensembl
protein self-association Source: Ensembl
serine-type endopeptidase activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aging Source: Ensembl
positive regulation of apoptotic signaling pathway Source: Ensembl
positive regulation of proteolysis involved in cellular protein catabolic process Source: Ensembl
response to organic substance Source: Ensembl
T cell mediated cytotoxicity Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Thiol proteaseSAAS annotation

Molecular function

Hydrolase, Protease, Thiol proteaseSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Cathepsin C, isoform CRA_bImported
Gene namesⁱ	Name:CtscImported ORF Names:mCG_113517Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:109553 Ctsc

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 24	UniRule annotationAdd BLAST		24
ChainⁱPRO_5014205830	25 – 462	UniRule annotationAdd BLAST		438

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q3UBY5

MaxQBⁱ

Q3UBY5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000030560
ExpressionAtlasⁱ	Q3UBY5 baseline and differential

Interactionⁱ

GO - Molecular functionⁱ

chaperone binding Source: Ensembl
identical protein binding Source: Ensembl
phosphatase binding Source: Ensembl
protein self-association Source: Ensembl

View the complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

SMRⁱ	Q3UBY5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	230 – 457	Pept_C1InterPro annotationAdd BLAST		228

Sequence similaritiesⁱ

Belongs to the peptidase C1 family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

SignalUniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG1543 Eukaryota COG4870 LUCA
HOVERGENⁱ	HBG005248
KEGG Orthology (KO) More...KOⁱ	K01275
OMAⁱ	YDDFLHY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06TT

Family and domain databases

Gene3Dⁱ	2.40.128.80, 1 hit
InterProⁱ	View protein in InterPro IPR014882 CathepsinC_exc IPR036496 CathepsinC_exc_dom_sf IPR025661 Pept_asp_AS IPR000169 Pept_cys_AS IPR025660 Pept_his_AS IPR013128 Peptidase_C1A IPR000668 Peptidase_C1A_C
PANTHERⁱ	PTHR12411 PTHR12411, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08773 CathepsinC_exc, 1 hit PF00112 Peptidase_C1, 1 hit
PRINTSⁱ	PR00705 PAPAIN
SMARTⁱ	View protein in SMART SM00645 Pept_C1, 1 hit
SUPFAMⁱ	SSF75001 SSF75001, 1 hit
PROSITEⁱ	View protein in PROSITE PS00640 THIOL_PROTEASE_ASN, 1 hit PS00139 THIOL_PROTEASE_CYS, 1 hit PS00639 THIOL_PROTEASE_HIS, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q3UBY5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGPWTHSLRA VLLLVLLGVC TVRSDTPANC TYPDLLGTWV FQVGPRSSRS 
        60         70         80         90        100
DINCSVMEAT EEKVVVHLKK LDTAYDELGN SGHFTLIYNQ GFEIVLNDYK 
       110        120        130        140        150
WFAFFKYEVR GHTAISYCHE TMTGWVHDVL GRNWACFVGK KVESHIEKVN 
       160        170        180        190        200
MNAAHLGGLQ ERYSERLYTH NHNFVKAINT VQKSWTATAY KEYEKMSLRD 
       210        220        230        240        250
LIRRSGHSQR IPRPKPAPMT DEIQQQILNL PESWDWRNVQ GVNYVSPVRN 
       260        270        280        290        300
QESCGSCYSF ASMGMLEARI RILTNNSQTP ILSPQEVVSC SPYAQGCDGG 
       310        320        330        340        350
FPYLIAGKYA QDFGVVEESC FPYTAKDSPC KPRENCLRYY SSDYYYVGGF 
       360        370        380        390        400
YGGCNEALMK LELVKHGPMA VAFEVHDDFL HYHSGIYHHT GLSDPFNPFE 
       410        420        430        440        450
LTNHAVLLVG YGRDPVTGIE YWIIKNSWGS NWGESGYFRI RRGTDECAIE 
       460 
SIAVAAIPIP KL

Length:462

Mass (Da):52,376

Last modified:October 11, 2005 - v1

Checksum:ⁱ56574B38D7DF4710

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK146858 mRNA Translation: BAE27487.1 AK150761 mRNA Translation: BAE29829.1 CH466543 Genomic DNA Translation: EDL06796.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001298719.1, NM_001311790.1 NP_034112.3, NM_009982.5
UniGeneⁱ	Mm.322945 Mm.483300 Mm.89295

Genome annotation databases

GeneIDⁱ	13032
KEGGⁱ	mmu:13032

Protein	Similar proteins		Species	Score	Length
Q3UBY5	Dipeptidyl peptidase 1		MOUSE		462
Uncharacterized protein (Fragment)		MOUSE		447
Uncharacterized protein (Fragment)		MOUSE		66

Protein	Similar proteins		Species	Score	Length
Q3UBY5	Dipeptidyl peptidase 1	)	RAT		462
Dipeptidyl peptidase 1		MOUSE		462
UPI000A308B34		MUSPA		462
UPI000A31B141		MUSCR		462
Uncharacterized protein (Fragment)		MOUSE		447
+5

Protein	Similar proteins		Species	Score	Length
Q3UBY5	Dipeptidyl peptidase 1	)	HUMAN		463
UPI0001E556A3		MACMU		463
UPI000C2A8BAF		Ugandan red Colobus		463
Cathepsin C		MACNE		463
Cathepsin C		RHIRO		463
+328

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK146858 mRNA Translation: BAE27487.1 AK150761 mRNA Translation: BAE29829.1 CH466543 Genomic DNA Translation: EDL06796.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001298719.1, NM_001311790.1 NP_034112.3, NM_009982.5
UniGeneⁱ	Mm.322945 Mm.483300 Mm.89295

3D structure databases

SMRⁱ	Q3UBY5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q3UBY5

MaxQBⁱ

Q3UBY5

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	13032
KEGGⁱ	mmu:13032

Organism-specific databases

CTDⁱ	1075
MGIⁱ	MGI:109553 Ctsc

Phylogenomic databases

eggNOGⁱ	KOG1543 Eukaryota COG4870 LUCA
HOVERGENⁱ	HBG005248
KEGG Orthology (KO) More...KOⁱ	K01275
OMAⁱ	YDDFLHY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06TT

Miscellaneous databases

ChiTaRSⁱ	Ctsc mouse
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000030560
ExpressionAtlasⁱ	Q3UBY5 baseline and differential

Family and domain databases

Gene3Dⁱ	2.40.128.80, 1 hit
InterProⁱ	View protein in InterPro IPR014882 CathepsinC_exc IPR036496 CathepsinC_exc_dom_sf IPR025661 Pept_asp_AS IPR000169 Pept_cys_AS IPR025660 Pept_his_AS IPR013128 Peptidase_C1A IPR000668 Peptidase_C1A_C
PANTHERⁱ	PTHR12411 PTHR12411, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08773 CathepsinC_exc, 1 hit PF00112 Peptidase_C1, 1 hit
PRINTSⁱ	PR00705 PAPAIN
SMARTⁱ	View protein in SMART SM00645 Pept_C1, 1 hit
SUPFAMⁱ	SSF75001 SSF75001, 1 hit
PROSITEⁱ	View protein in PROSITE PS00640 THIOL_PROTEASE_ASN, 1 hit PS00139 THIOL_PROTEASE_CYS, 1 hit PS00639 THIOL_PROTEASE_HIS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q3UBY5_MOUSE
Accessionⁱ	Q3UBY5Primary (citable) accession number: Q3UBY5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 11, 2005
	Last sequence update:	October 11, 2005
	Last modified:	May 23, 2018
	This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

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UniProtKB - Q3UBY5 (Q3UBY5_MOUSE)

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Cathepsin C, isoform CRA_b

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Endoplasmic reticulum

Golgi apparatus

Lysosome

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ