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Protein

Transmembrane protein 109

Gene

Tmem109

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death (PubMed:20060811). Can form voltage-gated calcium and potassium channels in vitro (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi1.A.74.1.1. the mitsugumin 23 (mg23) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 109
Alternative name(s):
Mitsugumin-23
Short name:
Mg23
Gene namesi
Name:Tmem109
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1915789. Tmem109.

Subcellular locationi

  • Nucleus outer membrane By similarity; Multi-pass membrane protein By similarity
  • Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
  • Sarcoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 8350LumenalBy similarityAdd
BLAST
Transmembranei84 – 10421HelicalSequence analysisAdd
BLAST
Topological domaini105 – 13531CytoplasmicBy similarityAdd
BLAST
Transmembranei136 – 15621HelicalSequence analysisAdd
BLAST
Topological domaini157 – 18529LumenalBy similarityAdd
BLAST
Transmembranei186 – 20520HelicalSequence analysisAdd
BLAST
Topological domaini206 – 24338CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus, Sarcoplasmic reticulum

Pathology & Biotechi

Disruption phenotypei

Viable and normal in appearance.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Chaini34 – 243210Transmembrane protein 109PRO_0000044619Add
BLAST

Proteomic databases

EPDiQ3UBX0.
MaxQBiQ3UBX0.
PaxDbiQ3UBX0.
PeptideAtlasiQ3UBX0.
PRIDEiQ3UBX0.

PTM databases

iPTMnetiQ3UBX0.
PhosphoSiteiQ3UBX0.

Expressioni

Gene expression databases

BgeeiQ3UBX0.
CleanExiMM_TMEM109.
ExpressionAtlasiQ3UBX0. baseline and differential.
GenevisibleiQ3UBX0. MM.

Interactioni

Subunit structurei

Homooligomer. Interacts with CRYAB.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CRYABP025112EBI-2366300,EBI-739060From a different organism.

Protein-protein interaction databases

BioGridi212917. 14 interactions.
IntActiQ3UBX0. 16 interactions.
STRINGi10090.ENSMUSP00000039529.

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIBB. Eukaryota.
ENOG410XXDM. LUCA.
GeneTreeiENSGT00390000015704.
HOGENOMiHOG000126892.
HOVERGENiHBG083664.
InParanoidiQ3UBX0.
OMAiPGQVQTF.
OrthoDBiEOG79CZ16.
PhylomeDBiQ3UBX0.
TreeFamiTF332238.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UBX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAHSTPLW SRHLLKAVLM VLVALFLVHS ASAQSHREFA SPGQQKKETS
60 70 80 90 100
ADILTQIGRS LKEMLDTWLG PETMHVISET LLQVMWAISS AISVACFALS
110 120 130 140 150
GIAAQLLSAL GLDGEQLTQG LKLSPSQVQT LLLWGAAALV IYWLLSLLLG
160 170 180 190 200
LVLALLGRIL GGLKLVLFVA GFVALVRSVP DPSTRALMLL ALLTLFALLS
210 220 230 240
RLTGSRSSGS HLEAKVRGLE RQIEELRGRQ RRAAKMPRSM EEE
Length:243
Mass (Da):26,306
Last modified:December 20, 2005 - v2
Checksum:i31376625A07BF587
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti159 – 1591I → V in BAE29844 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150779 mRNA. Translation: BAE29844.1.
AK151850 mRNA. Translation: BAE30740.1.
AK152419 mRNA. Translation: BAE31204.1.
AK165990 mRNA. Translation: BAE38505.1.
BC022997 mRNA. Translation: AAH22997.1.
BC023901 mRNA. Translation: AAH23901.1.
BC025033 mRNA. Translation: AAH25033.1.
BC025815 mRNA. Translation: AAH25815.1.
CCDSiCCDS29590.1.
RefSeqiNP_598903.1. NM_134142.1.
XP_006527380.1. XM_006527317.1.
UniGeneiMm.251890.

Genome annotation databases

EnsembliENSMUST00000038128; ENSMUSP00000039529; ENSMUSG00000034659.
GeneIDi68539.
KEGGimmu:68539.
UCSCiuc008gre.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150779 mRNA. Translation: BAE29844.1.
AK151850 mRNA. Translation: BAE30740.1.
AK152419 mRNA. Translation: BAE31204.1.
AK165990 mRNA. Translation: BAE38505.1.
BC022997 mRNA. Translation: AAH22997.1.
BC023901 mRNA. Translation: AAH23901.1.
BC025033 mRNA. Translation: AAH25033.1.
BC025815 mRNA. Translation: AAH25815.1.
CCDSiCCDS29590.1.
RefSeqiNP_598903.1. NM_134142.1.
XP_006527380.1. XM_006527317.1.
UniGeneiMm.251890.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212917. 14 interactions.
IntActiQ3UBX0. 16 interactions.
STRINGi10090.ENSMUSP00000039529.

Protein family/group databases

TCDBi1.A.74.1.1. the mitsugumin 23 (mg23) family.

PTM databases

iPTMnetiQ3UBX0.
PhosphoSiteiQ3UBX0.

Proteomic databases

EPDiQ3UBX0.
MaxQBiQ3UBX0.
PaxDbiQ3UBX0.
PeptideAtlasiQ3UBX0.
PRIDEiQ3UBX0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038128; ENSMUSP00000039529; ENSMUSG00000034659.
GeneIDi68539.
KEGGimmu:68539.
UCSCiuc008gre.2. mouse.

Organism-specific databases

CTDi79073.
MGIiMGI:1915789. Tmem109.

Phylogenomic databases

eggNOGiENOG410IIBB. Eukaryota.
ENOG410XXDM. LUCA.
GeneTreeiENSGT00390000015704.
HOGENOMiHOG000126892.
HOVERGENiHBG083664.
InParanoidiQ3UBX0.
OMAiPGQVQTF.
OrthoDBiEOG79CZ16.
PhylomeDBiQ3UBX0.
TreeFamiTF332238.

Miscellaneous databases

ChiTaRSiTmem109. mouse.
PROiQ3UBX0.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UBX0.
CleanExiMM_TMEM109.
ExpressionAtlasiQ3UBX0. baseline and differential.
GenevisibleiQ3UBX0. MM.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Lung and Macrophage.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver, Mammary tumor and Retina.
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 38-46 AND 48-59, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.
  4. "Facilitation of DNA damage-induced apoptosis by endoplasmic reticulum protein mitsugumin23."
    Yamazaki T., Sasaki N., Nishi M., Takeshima H.
    Biochem. Biophys. Res. Commun. 392:196-200(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiTM109_MOUSE
AccessioniPrimary (citable) accession number: Q3UBX0
Secondary accession number(s): Q8R006
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: July 6, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.