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Protein

PTB-containing, cubilin and LRP1-interacting protein

Gene

Pid1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Increases proliferation of preadipocytes without affecting adipocytic differentiation.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
PTB-containing, cubilin and LRP1-interacting protein
Short name:
P-CLI1
Alternative name(s):
Phosphotyrosine interaction domain-containing protein 1
Gene namesi
Name:Pid1
Synonyms:Pcli1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2138391. Pid1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: BHF-UCL
  • nucleoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217PTB-containing, cubilin and LRP1-interacting proteinPRO_0000274901Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei202 – 2021PhosphoserineCombined sources
Modified residuei203 – 2031PhosphoserineCombined sources
Modified residuei214 – 2141PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3UBG2.
PaxDbiQ3UBG2.
PRIDEiQ3UBG2.

PTM databases

iPTMnetiQ3UBG2.
PhosphoSiteiQ3UBG2.

Expressioni

Gene expression databases

BgeeiQ3UBG2.
ExpressionAtlasiQ3UBG2. baseline and differential.
GenevisibleiQ3UBG2. MM.

Interactioni

Subunit structurei

Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with LRP1 and CUBN.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000127716.

Structurei

3D structure databases

ProteinModelPortaliQ3UBG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 217158PIDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PID domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4448. Eukaryota.
ENOG410YZ8H. LUCA.
GeneTreeiENSGT00510000048154.
HOGENOMiHOG000115472.
HOVERGENiHBG054924.
InParanoidiQ3UBG2.
OMAiTVIFHEP.
OrthoDBiEOG7J4470.
PhylomeDBiQ3UBG2.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR006020. PTB/PI_dom.
[Graphical view]
PfamiPF14719. PID_2. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS01179. PID. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UBG2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWQPATERLQ HFQTMLKSKL NVLTLKKEPI PAVLFHEPEA IELCTTTPLM
60 70 80 90 100
KARTHSGCKV TYLGKVSTTG MQFLSGCTEK PVIELWKKHT LAREDVFPAN
110 120 130 140 150
ALLEIRPFQV WLHHLDHKGE ATVHMDTFQV ARIAYCTADH NVSPNIFAWV
160 170 180 190 200
YREINDDLSY QMDCHAVQCE SKLEAKKLAH AMMEAFKKTF HSMKSDGRIH
210
RSSSSEEASQ ELESDDG
Length:217
Mass (Da):24,784
Last modified:February 6, 2007 - v2
Checksum:i8362BA0722BE4CC9
GO
Isoform 2 (identifier: Q3UBG2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MWQPATERLQHFQTM → M

Show »
Length:203
Mass (Da):23,029
Checksum:i265E0509B57E511B
GO

Sequence cautioni

The sequence AAH54112.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH80290.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE30002.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE30254.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti216 – 2161D → G in AAH54112 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1515MWQPA…HFQTM → M in isoform 2. 1 PublicationVSP_022913Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150971 mRNA. Translation: BAE30002.1. Different initiation.
AK151267 mRNA. Translation: BAE30254.1. Different initiation.
AK162081 mRNA. Translation: BAE36714.1.
BC054112 mRNA. Translation: AAH54112.1. Different initiation.
BC080290 mRNA. Translation: AAH80290.1. Different initiation.
CCDSiCCDS15104.2. [Q3UBG2-1]
RefSeqiNP_001003948.2. NM_001003948.2. [Q3UBG2-1]
UniGeneiMm.187470.

Genome annotation databases

EnsembliENSMUST00000168574; ENSMUSP00000127716; ENSMUSG00000045658. [Q3UBG2-1]
ENSMUST00000176559; ENSMUSP00000135164; ENSMUSG00000045658. [Q3UBG2-2]
GeneIDi98496.
KEGGimmu:98496.
UCSCiuc007bst.2. mouse. [Q3UBG2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150971 mRNA. Translation: BAE30002.1. Different initiation.
AK151267 mRNA. Translation: BAE30254.1. Different initiation.
AK162081 mRNA. Translation: BAE36714.1.
BC054112 mRNA. Translation: AAH54112.1. Different initiation.
BC080290 mRNA. Translation: AAH80290.1. Different initiation.
CCDSiCCDS15104.2. [Q3UBG2-1]
RefSeqiNP_001003948.2. NM_001003948.2. [Q3UBG2-1]
UniGeneiMm.187470.

3D structure databases

ProteinModelPortaliQ3UBG2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000127716.

PTM databases

iPTMnetiQ3UBG2.
PhosphoSiteiQ3UBG2.

Proteomic databases

MaxQBiQ3UBG2.
PaxDbiQ3UBG2.
PRIDEiQ3UBG2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000168574; ENSMUSP00000127716; ENSMUSG00000045658. [Q3UBG2-1]
ENSMUST00000176559; ENSMUSP00000135164; ENSMUSG00000045658. [Q3UBG2-2]
GeneIDi98496.
KEGGimmu:98496.
UCSCiuc007bst.2. mouse. [Q3UBG2-1]

Organism-specific databases

CTDi55022.
MGIiMGI:2138391. Pid1.

Phylogenomic databases

eggNOGiKOG4448. Eukaryota.
ENOG410YZ8H. LUCA.
GeneTreeiENSGT00510000048154.
HOGENOMiHOG000115472.
HOVERGENiHBG054924.
InParanoidiQ3UBG2.
OMAiTVIFHEP.
OrthoDBiEOG7J4470.
PhylomeDBiQ3UBG2.

Miscellaneous databases

PROiQ3UBG2.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UBG2.
ExpressionAtlasiQ3UBG2. baseline and differential.
GenevisibleiQ3UBG2. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR006020. PTB/PI_dom.
[Graphical view]
PfamiPF14719. PID_2. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS01179. PID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Bone marrow and Egg.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 37-217 (ISOFORMS 1/2).
    Strain: C57BL/6J.
    Tissue: Brain and Embryo.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203 AND SER-214, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202; SER-203 AND SER-214, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Liver and Testis.

Entry informationi

Entry nameiPCLI1_MOUSE
AccessioniPrimary (citable) accession number: Q3UBG2
Secondary accession number(s): Q3UAR0, Q68EE9, Q7TPS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: June 8, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.